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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4awsFMNNADH:flavin oxidoreductase Sye1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4awsFMNNADH:flavin oxidoreductase Sye1/1.000
4awtFMNNADH:flavin oxidoreductase Sye1/0.686
2gouFMNNADH:flavin oxidoreductase Sye1/0.666
2gqaFMNNADH:flavin oxidoreductase Sye1/0.613
4jicFMNGTN Reductase/0.524
1h50FMNPentaerythritol tetranitrate reductase/0.514
3p8iFMNPentaerythritol tetranitrate reductase/0.505
1icsFMN12-oxophytodienoate reductase 11.3.1.420.498
3p62FMNPentaerythritol tetranitrate reductase/0.490
2abbFMNPentaerythritol tetranitrate reductase/0.484
4a3uFMNNADH:flavin oxidoreductase/NADH oxidase/0.484
1h63FMNPentaerythritol tetranitrate reductase/0.478
3p67FMNPentaerythritol tetranitrate reductase/0.470
3f03FMNPentaerythritol tetranitrate reductase/0.467
4e2dFMNDehydrogenase/0.465
4e2bFMNDehydrogenase/0.464
1vyrFMNPentaerythritol tetranitrate reductase/0.462
1x1bSAHC-20 methyltransferase/0.451
2hs6FMN12-oxophytodienoate reductase 31.3.1.420.450
4qaiFMNNADPH dehydrogenase/0.450
1oycFMNNADPH dehydrogenase 11.6.99.10.449
1k02FMNNADPH dehydrogenase 11.6.99.10.447
1vjiFMN12-oxophytodienoate reductase 11.3.1.420.447
3p82FMNPentaerythritol tetranitrate reductase/0.447
1bwlFMNNADPH dehydrogenase 11.6.99.10.446
1h51FMNPentaerythritol tetranitrate reductase/0.445
2gesCOKPantothenate kinase2.7.1.330.444
1icqFMN12-oxophytodienoate reductase 11.3.1.420.441