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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4avwG18Tankyrase-22.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4avwG18Tankyrase-22.4.2.301.000
4l33F70Tankyrase-22.4.2.300.731
4hkiFLNTankyrase-22.4.2.300.705
4hlf15ZTankyrase-22.4.2.300.672
4buiW2ETankyrase-22.4.2.300.667
4bufF36Tankyrase-22.4.2.300.658
5aku29FTankyrase-22.4.2.300.657
4l321VFTankyrase-22.4.2.300.655
4l2f1V3Tankyrase-22.4.2.300.638
4buxF35Tankyrase-22.4.2.300.635
4l0s1UZTankyrase-22.4.2.300.633
4l2k1V8Tankyrase-22.4.2.300.633
4bueJQFTankyrase-22.4.2.300.629
4hlm16STankyrase-22.4.2.300.624
4but31FTankyrase-22.4.2.300.622
4iueAJ4Tankyrase-22.4.2.300.621
3u9y09LTankyrase-22.4.2.300.618
4l0i1UWTankyrase-22.4.2.300.614
4j21AJ6Tankyrase-22.4.2.300.609
4kzl20DTankyrase-22.4.2.300.605
4l31F08Tankyrase-22.4.2.300.602
4l0t1V0Tankyrase-22.4.2.300.599
4hlh20DTankyrase-22.4.2.300.597
4bj9UHBTankyrase-22.4.2.300.596
4bus32FTankyrase-22.4.2.300.596
4l2g1V4Tankyrase-22.4.2.300.593
4bud29FTankyrase-22.4.2.300.592
3p0pNNFTankyrase-22.4.2.300.583
4kzuA73Tankyrase-22.4.2.300.578
4pnrG18Tankyrase-22.4.2.300.577
4hl515WTankyrase-22.4.2.300.575
3kr8XAVTankyrase-22.4.2.300.565
4buv16ITankyrase-22.4.2.300.563
4krs1SXTankyrase-12.4.2.300.558
4tkg09LTankyrase-22.4.2.300.556
4l0v1V1Tankyrase-22.4.2.300.554
4buwF33Tankyrase-22.4.2.300.550
4bs4A64Tankyrase-22.4.2.300.545
4bjbP34Tankyrase-22.4.2.300.536
4hmhF94Tankyrase-22.4.2.300.533
4msk2C8Tankyrase-12.4.2.300.522
4pnmNU1Tankyrase-22.4.2.300.518
4j3lAJ5Tankyrase-22.4.2.300.497
4tjy3GNTankyrase-22.4.2.300.497
4l091URTankyrase-22.4.2.300.489
4j3mAJ8Tankyrase-22.4.2.300.477
4k4eK4ETankyrase-12.4.2.300.476
2bbqPFGThymidylate synthase/0.466
3mauPLRPutative sphingosine-1-phosphate lyase/0.466
1xk9P34Exotoxin A2.4.2.360.464
4i9i1DYTankyrase-12.4.2.300.459
4avuLDRTankyrase-22.4.2.300.449
4nbb9CATerminal oxygenase component of carbazole/0.449
3b82NADExotoxin A2.4.2.360.448
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.448
1x8lOXRRetinol dehydratase/0.445
2gevCOKPantothenate kinase2.7.1.330.445
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.445
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.444
3rsv3RSBeta-secretase 13.4.23.460.442
2ed4FAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.441
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.441
3otwCOAPhosphopantetheine adenylyltransferase/0.441