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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aseAV9Vascular endothelial growth factor receptor 22.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4aseAV9Vascular endothelial growth factor receptor 22.7.10.11.000
3vhkBPKVascular endothelial growth factor receptor 22.7.10.10.601
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.568
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.546
3hng8STVascular endothelial growth factor receptor 12.7.10.10.543
2hyySTITyrosine-protein kinase ABL12.7.10.20.541
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.526
3dtwA96Vascular endothelial growth factor receptor 22.7.10.10.516
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.514
2xir00JVascular endothelial growth factor receptor 22.7.10.10.514
4eyjN61Mitogen-activated protein kinase 132.7.11.240.508
3efl706Vascular endothelial growth factor receptor 22.7.10.10.506
2qu6857Vascular endothelial growth factor receptor 22.7.10.10.500
3cp9C19Vascular endothelial growth factor receptor 22.7.10.10.495
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.494
3lfbZ87Mitogen-activated protein kinase 14/0.489
3ce31FNHepatocyte growth factor receptor2.7.10.10.488
3eta351Insulin receptor2.7.10.10.486
4o2z046Mitogen-activated protein kinase/0.483
5hi2BAXSerine/threonine-protein kinase B-raf2.7.11.10.480
1iepSTITyrosine-protein kinase ABL12.7.10.20.475
3hv5R24Mitogen-activated protein kinase 14/0.475
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.465
3g0fB49Mast/stem cell growth factor receptor Kit2.7.10.10.463
4kaoKAOFocal adhesion kinase 12.7.10.20.461
2p2i608Vascular endothelial growth factor receptor 22.7.10.10.457
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.457
2og81N8Tyrosine-protein kinase Lck2.7.10.20.449
3ctj320Hepatocyte growth factor receptor2.7.10.10.449
3zsh469Mitogen-activated protein kinase 14/0.443
3gcsBAXMitogen-activated protein kinase 14/0.442