sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4aqc	88A	Tyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4aqc	88A	Tyrosine-protein kinase JAK2	/	1.000
4hge	15V	Tyrosine-protein kinase JAK2	/	0.573
3lpb	NVB	Tyrosine-protein kinase JAK2	/	0.563
4f08	1RS	Tyrosine-protein kinase JAK2	/	0.510
3zc6	VFC	Tyrosine-protein kinase JAK3	2.7.10.2	0.506
4e6d	0NU	Tyrosine-protein kinase JAK2	/	0.506
4ji9	1M3	Tyrosine-protein kinase JAK2	/	0.496
4i5c	C5I	Tyrosine-protein kinase JAK1	/	0.493
4jia	1K3	Tyrosine-protein kinase JAK2	/	0.466
4ehz	JAK	Tyrosine-protein kinase JAK1	/	0.454
4e6q	0NV	Tyrosine-protein kinase JAK2	/	0.449
4hvi	19S	Tyrosine-protein kinase JAK3	2.7.10.2	0.444