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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aotGW8Serine/threonine-protein kinase 102.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4aotGW8Serine/threonine-protein kinase 102.7.11.11.000
4jbqVX6Aurora kinase A2.7.11.10.481
4o0uADNAurora kinase A2.7.11.10.474
2c6eHPMAurora kinase A2.7.11.10.465
2vrx447Aurora kinase B-A2.7.11.10.456
4jboWPHAurora kinase A2.7.11.10.451
4jbpYPHAurora kinase A2.7.11.10.451
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.449
3k5uPFQAurora kinase A2.7.11.10.445