sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4anb	YQY	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4anb	YQY	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	1.000
4an9	2P7	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.648
4an2	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.591
3v04	V04	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.580
4an3	5Y0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.580
3v01	3V0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.557
2p55	MRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.545
1s9j	BBM	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.524
3e8n	VRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.519
3pp1	IZG	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.513
3os3	3OS	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.491
4lmn	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.489
3dy7	1CX	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.486
3dv3	MEK	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.477
3sls	77D	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.449
5dhh	DGW	Nociceptin receptor	/	0.444