sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4an3	5Y0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4an3	5Y0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	1.000
4an9	2P7	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.559
3v01	3V0	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.499
1s9j	BBM	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.493
3v04	V04	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.487
4anb	YQY	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.484
4an2	EUI	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.481
2p55	MRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.466
3os3	3OS	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.466
3e8n	VRA	Dual specificity mitogen-activated protein kinase kinase 1	2.7.12.2	0.462