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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4afjSJJGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4afjSJJGlycogen synthase kinase-3 beta2.7.11.261.000
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.632
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.590
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.589
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.584
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.583
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.576
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.574
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.552
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.551
3du8553Glycogen synthase kinase-3 beta2.7.11.260.546
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.540
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.535
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.529
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.528
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.521
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.521
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.520
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.516
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.515
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.511
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.509
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.507
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.504
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.503
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.503
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.491
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.490
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.487
3zh8C58Protein kinase C iota type2.7.11.130.482
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.481
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.480
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.478
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.478
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.474
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.474
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.473
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.471
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.471
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.470
1m2pHNACasein kinase II subunit alpha2.7.11.10.465
2cchATPCyclin-dependent kinase 22.7.11.220.465
3vf9477Tyrosine-protein kinase SYK2.7.10.20.465
4jboWPHAurora kinase A2.7.11.10.463
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.463
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.463
3be9P04Casein kinase II subunit alpha2.7.11.10.462
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.462
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.460
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.460
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.459
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.459
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.459
3eb0DRKUncharacterized protein/0.458
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.458
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.457
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.457
2i0ePDSProtein kinase C beta type2.7.11.130.457
4bchT7ZCyclin-dependent kinase 92.7.11.220.456
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.455
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.455
4c02TAKActivin receptor type-12.7.11.300.454
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.454
2pvnP63Casein kinase II subunit alpha2.7.11.10.453
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.453
2btsU32Cyclin-dependent kinase 22.7.11.220.452
3oroAGSSerine/threonine protein kinase/0.452
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.450
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.449
4o0wADNAurora kinase A2.7.11.10.449
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.448
1pkdUCNCyclin-dependent kinase 22.7.11.220.448
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.448
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.448
3gubGUBDeath-associated protein kinase 12.7.11.10.448
3a7hATPSerine/threonine-protein kinase 242.7.11.10.447
3iw4LW4Protein kinase C alpha type2.7.11.130.447
3zep1NXTyrosine-protein kinase JAK32.7.10.20.447
4qo9627Serine/threonine-protein kinase 242.7.11.10.447
2pvhP19Casein kinase II subunit alpha2.7.11.10.446
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.446
4j97ACPFibroblast growth factor receptor 2/0.446
3oom507Activin receptor type-12.7.11.300.445
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.445
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.445
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
2hog710Serine/threonine-protein kinase Chk12.7.11.10.444
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.444
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.443
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.443
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.443
5dpvSKEAurora kinase A2.7.11.10.443
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4gmy0X5Tyrosine-protein kinase JAK2/0.442
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.441
4g170VNCasein kinase I isoform gamma-32.7.11.10.441
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.440
2iw84SPCyclin-dependent kinase 22.7.11.220.440
2qo9ANPEphrin type-A receptor 32.7.10.10.440
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.440
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.440