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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4af6FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.21.000
3vo2FADFerredoxin--NADP reductase/0.676
3zc3FADFerredoxin--NADP reductase1.18.1.20.635
1bx1FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.627
4af7FADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.626
2b5oFADFerredoxin--NADP reductase1.18.1.20.622
1gawFADFerredoxin/0.616
1fnbFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.615
1h42FADFerredoxin--NADP reductase1.18.1.20.611
1gjrFADFerredoxin--NADP reductase1.18.1.20.609
1sm4FADFerredoxin--NADP reductase/0.602
1fncFDAFerredoxin--NADP reductase, chloroplastic1.18.1.20.596
1w35FADFerredoxin--NADP reductase1.18.1.20.592
1gaqFADFerredoxin/0.588
1bjkFADFerredoxin--NADP reductase1.18.1.20.586
3mhpFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.586
1e62FADFerredoxin--NADP reductase1.18.1.20.583
1go2FADFerredoxin--NADP reductase1.18.1.20.583
4bprFADFerredoxin--NADP reductase1.18.1.20.583
3fpkFADFerredoxin-NADP reductase/0.582
3zbtFADFerredoxin--NADP reductase1.18.1.20.581
4c43FADFerredoxin--NADP reductase1.18.1.20.578
1ogiFADFerredoxin--NADP reductase1.18.1.20.573
1qgyFADFerredoxin--NADP reductase1.18.1.20.572
2ok8FADFerredoxin--NADP reductase, apicoplast/0.572
1e64FADFerredoxin--NADP reductase1.18.1.20.571
3w5uFADFerredoxin/0.567
1queFADFerredoxin--NADP reductase1.18.1.20.565
1w87FADFerredoxin--NADP reductase1.18.1.20.563
2rc6FADFerredoxin--NADP reductase/0.559
1qh0FADFerredoxin--NADP reductase1.18.1.20.558
1fndFADFerredoxin--NADP reductase, chloroplastic1.18.1.20.550
1h85FADFerredoxin--NADP reductase1.18.1.20.550
4yaoFADNADPH--cytochrome P450 reductase/0.545
1ewyFADFerredoxin--NADP reductase1.18.1.20.543
1amoFADNADPH--cytochrome P450 reductase/0.535
1gr1FADFerredoxin--NADP reductase1.18.1.20.535
4uajFADNa(+)-translocating NADH-quinone reductase subunit F/0.532
1gvhFADFlavohemoprotein/0.528
1ja1FADNADPH--cytochrome P450 reductase/0.528
1j9zFADNADPH--cytochrome P450 reductase/0.523
1ogjFADFerredoxin--NADP reductase1.18.1.20.519
1e63FADFerredoxin--NADP reductase1.18.1.20.518
1bx0FADFerredoxin--NADP reductase, chloroplastic1.18.1.20.517
1b2rFADFerredoxin--NADP reductase1.18.1.20.515
3jqrFADFerredoxin--NADP reductase, apicoplast/0.513
4y9uFADNADPH--cytochrome P450 reductase/0.510
2rc5FADFerredoxin--NADP reductase/0.508
3qftFADNADPH--cytochrome P450 reductase/0.507
3qfsFADNADPH--cytochrome P450 reductase/0.501
1qgzFADFerredoxin--NADP reductase1.18.1.20.494
1fdrFADFerredoxin--NADP reductase1.18.1.20.490
3hl0NADMaleylacetate reductase/0.484
3ojxFADNADPH--cytochrome P450 reductase/0.484
3qfcFADNADPH--cytochrome P450 reductase/0.477
2bpoFADNADPH--cytochrome P450 reductase/0.476
2r6hFADNa(+)-translocating NADH-quinone reductase subunit F/0.475
2xncFADFerredoxin--NADP reductase, leaf isozyme, chloroplastic1.18.1.20.472
1cqxFADFlavohemoprotein/0.471
1f20FADNitric oxide synthase, brain1.14.13.390.466
1w19T1P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.466
1nquRDL6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.465
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.465
4jlj1NMDeoxycytidine kinase2.7.1.740.465
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.463
1g6kNADGlucose 1-dehydrogenase1.1.1.470.461
1w19T5P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.460
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.460
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.460
4jlm1NNDeoxycytidine kinase2.7.1.740.460
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.458
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.457
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.456
2cndFADNitrate reductase [NADH]1.7.1.10.455
3ske054Genome polyprotein2.7.7.480.455
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.455
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.454
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.453
3mjrAC2Deoxycytidine kinase2.7.1.740.453
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.453
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.449
3exfTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.449
3exfTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.449
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
4fk8FADFerredoxin--NADP reductase/0.449
5a4vQUEGlutathione S-transferase F22.5.1.180.449
5ah5LSSLeucine--tRNA ligase/0.449
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.447
4b4w9L9Bifunctional protein FolD/0.447
4b66FADL-ornithine N(5)-monooxygenase/0.447
4n4wSNTSmoothened homolog/0.447
1tllFADNitric oxide synthase, brain1.14.13.390.446
4uy6SAHHistidine N-alpha-methyltransferase/0.446
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.443
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
3dvaTPWPyruvate dehydrogenase E1 component subunit alpha1.2.4.10.442
3dvaTPWPyruvate dehydrogenase E1 component subunit beta1.2.4.10.442
4l1xNAPAldo-keto reductase family 1 member C2/0.442
2vnjFADNADPH:ferredoxin reductase/0.441
3p0fBAUUridine phosphorylase 22.4.2.30.441
3q9bB3NAcetylpolyamine amidohydrolase/0.441
4phlPILPhosphodiesterase/0.441
1krhFADBenzoate 1,2-dioxygenase electron transfer component1.18.1.30.440
1tilATPAnti-sigma F factor/0.440
3c1oNAPEugenol synthase/0.440
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.440