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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4acm7YGCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4acm7YGCyclin-dependent kinase 22.7.11.221.000
4fks46KCyclin-dependent kinase 22.7.11.220.712
2r3lSCWCyclin-dependent kinase 22.7.11.220.645
3sw418KCyclin-dependent kinase 22.7.11.220.637
3r9dX6BCyclin-dependent kinase 22.7.11.220.629
2w06FRVCyclin-dependent kinase 22.7.11.220.628
3rpv26ZCyclin-dependent kinase 22.7.11.220.628
1y91CT9Cyclin-dependent kinase 22.7.11.220.624
2xmyCDKCyclin-dependent kinase 22.7.11.220.623
3s1h56ZCyclin-dependent kinase 22.7.11.220.615
3iggEFQCyclin-dependent kinase 22.7.11.220.614
3rak03ZCyclin-dependent kinase 22.7.11.220.607
3rmf20ZCyclin-dependent kinase 22.7.11.220.598
3rjc06ZCyclin-dependent kinase 22.7.11.220.596
2b52D42Cyclin-dependent kinase 22.7.11.220.594
3sw719KCyclin-dependent kinase 22.7.11.220.594
3qtuX44Cyclin-dependent kinase 22.7.11.220.591
4ek816KCyclin-dependent kinase 22.7.11.220.588
2w1hL0FCyclin-dependent kinase 22.7.11.220.583
3qtxX43Cyclin-dependent kinase 22.7.11.220.578
4fkq42KCyclin-dependent kinase 22.7.11.220.578
4fkv61KCyclin-dependent kinase 22.7.11.220.576
4fko20KCyclin-dependent kinase 22.7.11.220.575
2a0cCK9Cyclin-dependent kinase 22.7.11.220.574
3qzgX67Cyclin-dependent kinase 22.7.11.220.574
4fkr45KCyclin-dependent kinase 22.7.11.220.572
1pxmCK5Cyclin-dependent kinase 22.7.11.220.569
2r3kSCQCyclin-dependent kinase 22.7.11.220.569
4fkw62KCyclin-dependent kinase 22.7.11.220.568
3rni21ZCyclin-dependent kinase 22.7.11.220.567
3rk507ZCyclin-dependent kinase 22.7.11.220.566
4fkj11KCyclin-dependent kinase 22.7.11.220.565
1ke5LS1Cyclin-dependent kinase 22.7.11.220.564
3rk708ZCyclin-dependent kinase 22.7.11.220.563
3lfnA27Cyclin-dependent kinase 22.7.11.220.562
4bgh3I6Cyclin-dependent kinase 22.7.11.220.562
2uznC96Cyclin-dependent kinase 22.7.11.220.561
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.561
4fkpLS5Cyclin-dependent kinase 22.7.11.220.561
2btsU32Cyclin-dependent kinase 22.7.11.220.560
1oirHDYCyclin-dependent kinase 22.7.11.220.559
1pxoCK7Cyclin-dependent kinase 22.7.11.220.558
2vv9IM9Cyclin-dependent kinase 22.7.11.220.558
3py0SU9Cyclin-dependent kinase 22.7.11.220.558
3qqhX0ACyclin-dependent kinase 22.7.11.220.558
3qtrX36Cyclin-dependent kinase 22.7.11.220.558
3r8lZ30Cyclin-dependent kinase 22.7.11.220.557
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.555
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.555
1ke7LS3Cyclin-dependent kinase 22.7.11.220.554
1urwI1PCyclin-dependent kinase 22.7.11.220.554
3ral04ZCyclin-dependent kinase 22.7.11.220.554
1oitHDTCyclin-dependent kinase 22.7.11.220.552
3rk909ZCyclin-dependent kinase 22.7.11.220.549
3unk0BYCyclin-dependent kinase 22.7.11.220.549
1di8DTQCyclin-dependent kinase 22.7.11.220.547
4fki09KCyclin-dependent kinase 22.7.11.220.546
3rm618ZCyclin-dependent kinase 22.7.11.220.545
3pxyJWSCyclin-dependent kinase 22.7.11.220.544
3qtzX42Cyclin-dependent kinase 22.7.11.220.543
4fkt48KCyclin-dependent kinase 22.7.11.220.543
1g5sI17Cyclin-dependent kinase 22.7.11.220.542
2c6iDT1Cyclin-dependent kinase 22.7.11.220.541
3uli1N3Cyclin-dependent kinase 22.7.11.220.541
2r3jSCJCyclin-dependent kinase 22.7.11.220.540
3unj0BXCyclin-dependent kinase 22.7.11.220.540
1ckpPVBCyclin-dependent kinase 22.7.11.220.539
2uzoC62Cyclin-dependent kinase 22.7.11.220.538
2btrU73Cyclin-dependent kinase 22.7.11.220.537
1h1r6CPCyclin-dependent kinase 22.7.11.220.536
2c6o4SPCyclin-dependent kinase 22.7.11.220.535
3qu0X40Cyclin-dependent kinase 22.7.11.220.535
1pxlCK4Cyclin-dependent kinase 22.7.11.220.534
2bheBRYCyclin-dependent kinase 22.7.11.220.534
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.533
1gih1PUCyclin-dependent kinase 22.7.11.220.532
3fz1B98Cyclin-dependent kinase 22.7.11.220.531
4fkg4CKCyclin-dependent kinase 22.7.11.220.531
4ez30S0Cyclin-dependent kinase 22.7.11.220.530
3r1yX76Cyclin-dependent kinase 22.7.11.220.529
1h1s4SPCyclin-dependent kinase 22.7.11.220.528
1w0xOLOCyclin-dependent kinase 22.7.11.220.528
2a4lRRCCyclin-dependent kinase 22.7.11.220.528
2duv371Cyclin-dependent kinase 22.7.11.220.527
1ke6LS2Cyclin-dependent kinase 22.7.11.220.526
2r64740Cyclin-dependent kinase 22.7.11.220.524
3ezvEZVCyclin-dependent kinase 22.7.11.220.523
3r8vZ62Cyclin-dependent kinase 22.7.11.220.522
1v1k3FPCyclin-dependent kinase 22.7.11.220.521
3qxoX65Cyclin-dependent kinase 22.7.11.220.521
2vthLZ2Cyclin-dependent kinase 22.7.11.220.520
3pj8404Cyclin-dependent kinase 22.7.11.220.520
3lfqA28Cyclin-dependent kinase 22.7.11.220.518
1ke8LS4Cyclin-dependent kinase 22.7.11.220.517
1ke9LS5Cyclin-dependent kinase 22.7.11.220.516
2iw84SPCyclin-dependent kinase 22.7.11.220.516
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.516
2vttLZDCyclin-dependent kinase 22.7.11.220.516
3s2pPMUCyclin-dependent kinase 22.7.11.220.515
4eon1ROCyclin-dependent kinase 22.7.11.220.513
1oguST8Cyclin-dependent kinase 22.7.11.220.512
3rpo24ZCyclin-dependent kinase 22.7.11.220.512
2r3mSCXCyclin-dependent kinase 22.7.11.220.511
1p2a5BNCyclin-dependent kinase 22.7.11.220.510
2r3iSCFCyclin-dependent kinase 22.7.11.220.510
2w17I19Cyclin-dependent kinase 22.7.11.220.509
1ykr628Cyclin-dependent kinase 22.7.11.220.508
3qruX19Cyclin-dependent kinase 22.7.11.220.508
3qzhX69Cyclin-dependent kinase 22.7.11.220.508
3r9oZ71Cyclin-dependent kinase 22.7.11.220.508
3rkb12ZCyclin-dependent kinase 22.7.11.220.508
3ti1B49Cyclin-dependent kinase 22.7.11.220.507
1gii1PUCyclin-dependent kinase 22.7.11.220.505
4lyn1YGCyclin-dependent kinase 22.7.11.220.505
2fvdLIACyclin-dependent kinase 22.7.11.220.504
3r73X87Cyclin-dependent kinase 22.7.11.220.503
1pxpCK8Cyclin-dependent kinase 22.7.11.220.502
3qqlX03Cyclin-dependent kinase 22.7.11.220.502
3qxpX64Cyclin-dependent kinase 22.7.11.220.502
3sqq99ZCyclin-dependent kinase 22.7.11.220.502
4ek610KCyclin-dependent kinase 22.7.11.220.502
3qwjX6ACyclin-dependent kinase 22.7.11.220.501
4fklCK2Cyclin-dependent kinase 22.7.11.220.501
3r1sX73Cyclin-dependent kinase 22.7.11.220.500
3rpy27ZCyclin-dependent kinase 22.7.11.220.500
2b55D31Cyclin-dependent kinase 22.7.11.220.498
3r7iX9ICyclin-dependent kinase 22.7.11.220.498
1pxkCK3Cyclin-dependent kinase 22.7.11.220.497
2j9mPY8Cyclin-dependent kinase 22.7.11.220.497
2c6lDT4Cyclin-dependent kinase 22.7.11.220.496
3ezrEZRCyclin-dependent kinase 22.7.11.220.496
1vyzN5BCyclin-dependent kinase 22.7.11.220.494
3qqkX02Cyclin-dependent kinase 22.7.11.220.494
1b38ATPCyclin-dependent kinase 22.7.11.220.491
1fvv107Cyclin-dependent kinase 22.7.11.220.491
2x1nX1NCyclin-dependent kinase 22.7.11.220.491
2vu3LZECyclin-dependent kinase 22.7.11.220.488
2xnbY8LCyclin-dependent kinase 22.7.11.220.488
3rm719ZCyclin-dependent kinase 22.7.11.220.488
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.488
1h0vUN4Cyclin-dependent kinase 22.7.11.220.487
3r7yZ04Cyclin-dependent kinase 22.7.11.220.487
1oiuN76Cyclin-dependent kinase 22.7.11.220.486
4nj32KDCyclin-dependent kinase 22.7.11.220.486
1fvt106Cyclin-dependent kinase 22.7.11.220.485
1h0w207Cyclin-dependent kinase 22.7.11.220.485
2exmZIPCyclin-dependent kinase 22.7.11.220.485
4eomATPCyclin-dependent kinase 22.7.11.220.485
3qx2X63Cyclin-dependent kinase 22.7.11.220.484
2b53D23Cyclin-dependent kinase 22.7.11.220.483
2bhhRYUCyclin-dependent kinase 22.7.11.220.483
3wblPDYCyclin-dependent kinase 22.7.11.220.483
1vyw292Cyclin-dependent kinase 22.7.11.220.482
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.482
3ddpRC8Cyclin-dependent kinase 22.7.11.220.482
3r7uX96Cyclin-dependent kinase 22.7.11.220.482
1oi9N20Cyclin-dependent kinase 22.7.11.220.481
1oiyN41Cyclin-dependent kinase 22.7.11.220.481
1h1pCMGCyclin-dependent kinase 22.7.11.220.480
3lfsA07Cyclin-dependent kinase 22.7.11.220.478
3r9hZ67Cyclin-dependent kinase 22.7.11.220.478
4fx360KCyclin-dependent kinase 22.7.11.220.478
3s0o50ZCyclin-dependent kinase 22.7.11.220.477
4eor4SPCyclin-dependent kinase 22.7.11.220.477
5dr6SKEAurora kinase A2.7.11.10.476
2r3p3SCCyclin-dependent kinase 22.7.11.220.475
3ddqRRCCyclin-dependent kinase 22.7.11.220.475
3r83Z14Cyclin-dependent kinase 22.7.11.220.475
4qmpDKISerine/threonine-protein kinase 242.7.11.10.475
3gxlQIGTGF-beta receptor type-12.7.11.300.474
1gij2PUCyclin-dependent kinase 22.7.11.220.473
2c6tDT5Cyclin-dependent kinase 22.7.11.220.473
2vtsLZCCyclin-dependent kinase 22.7.11.220.473
3tnwF18Cyclin-dependent kinase 22.7.11.220.473
1e9hINRCyclin-dependent kinase 22.7.11.220.472
4kd11QKCyclin-dependent kinase 22.7.11.220.472
2b7aIZATyrosine-protein kinase JAK2/0.471
2c5yMTWCyclin-dependent kinase 22.7.11.220.471
2eufLQQCyclin-dependent kinase 62.7.11.220.471
4eos1ROCyclin-dependent kinase 22.7.11.220.471
1dm2HMDCyclin-dependent kinase 22.7.11.220.470
3qtqX35Cyclin-dependent kinase 22.7.11.220.470
3qqfX07Cyclin-dependent kinase 22.7.11.220.469
1pyePM1Cyclin-dependent kinase 22.7.11.220.468
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.468
1vjy460TGF-beta receptor type-12.7.11.300.467
3r8pZ46Cyclin-dependent kinase 22.7.11.220.467
3r8zZ63Cyclin-dependent kinase 22.7.11.220.467
4dgo0JWCasein kinase II subunit alpha2.7.11.10.467
1b39ATPCyclin-dependent kinase 22.7.11.220.466
1y8yCT7Cyclin-dependent kinase 22.7.11.220.466
2c6kDT2Cyclin-dependent kinase 22.7.11.220.466
3ig7EFPCyclin-dependent kinase 22.7.11.220.466
3r7vZ02Cyclin-dependent kinase 22.7.11.220.466
1w8cN69Cyclin-dependent kinase 22.7.11.220.465
2ds11CDCyclin-dependent kinase 22.7.11.220.465
3roy22ZCyclin-dependent kinase 22.7.11.220.465
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.465
1e1xNW1Cyclin-dependent kinase 22.7.11.220.464
2b54D05Cyclin-dependent kinase 22.7.11.220.464
3ggfGVDSerine/threonine-protein kinase 26/0.464
3r6xX84Cyclin-dependent kinase 22.7.11.220.464
2iw94SPCyclin-dependent kinase 22.7.11.220.463
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.463
3dogNNNCyclin-dependent kinase 22.7.11.220.462
3sheI85MAP kinase-activated protein kinase 32.7.11.10.461
4eok4SPCyclin-dependent kinase 22.7.11.220.461
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.461
1qmzATPCyclin-dependent kinase 22.7.11.220.460
4ii5ADPCyclin-dependent kinase 22.7.11.220.460
5aniES4Cyclin-dependent kinase 22.7.11.220.460
1xjdSTUProtein kinase C theta type2.7.11.130.459
2c5nCK8Cyclin-dependent kinase 22.7.11.220.459
3r1qX75Cyclin-dependent kinase 22.7.11.220.459
3raiX85Cyclin-dependent kinase 22.7.11.220.459
1r78FMDCyclin-dependent kinase 22.7.11.220.458
2uzeC95Cyclin-dependent kinase 22.7.11.220.458
3r71X86Cyclin-dependent kinase 22.7.11.220.458
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.457
3tiz3TICyclin-dependent kinase 22.7.11.220.457
1pkdUCNCyclin-dependent kinase 22.7.11.220.456
3bhtMFRCyclin-dependent kinase 22.7.11.220.456
3r7eX88Cyclin-dependent kinase 22.7.11.220.456
1oiqHDUCyclin-dependent kinase 22.7.11.220.455
2dwbANPAurora kinase A2.7.11.10.454
3ql8X01Cyclin-dependent kinase 22.7.11.220.454
3qrtX14Cyclin-dependent kinase 22.7.11.220.454
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.454
5cp4CAMCamphor 5-monooxygenase1.14.15.10.454
2r3gSC9Cyclin-dependent kinase 22.7.11.220.453
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.453
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.453
2vtqLZACyclin-dependent kinase 22.7.11.220.452
3be9P04Casein kinase II subunit alpha2.7.11.10.452
3qwkX62Cyclin-dependent kinase 22.7.11.220.452
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.452
2uzlC94Cyclin-dependent kinase 22.7.11.220.451
4z5wILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.451
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.450
2i40BLZCyclin-dependent kinase 22.7.11.220.450
3at4CCKCasein kinase II subunit alpha2.7.11.10.450
4bcmT7ZCyclin-dependent kinase 22.7.11.220.450
2cchATPCyclin-dependent kinase 22.7.11.220.449
3iok1P6Tyrosine-protein kinase JAK2/0.449
3r28XA0Cyclin-dependent kinase 22.7.11.220.449
3rahO1ZCyclin-dependent kinase 22.7.11.220.449
4bcpT3CCyclin-dependent kinase 22.7.11.220.449
4c4jX21Dual specificity protein kinase TTK2.7.12.10.449
2pvlP55Casein kinase II subunit alpha2.7.11.10.448
2wihP48Cyclin-dependent kinase 22.7.11.220.448
3vt7VDXVitamin D3 receptor/0.448
4aqc88ATyrosine-protein kinase JAK2/0.448
4dgnLU2Casein kinase II subunit alpha2.7.11.10.448
1hckATPCyclin-dependent kinase 22.7.11.220.447
2wxvWXVCyclin-dependent kinase 22.7.11.220.447
3nieANPMitogen-activated protein kinase/0.447
4anmWULCasein kinase II subunit alpha2.7.11.10.447
3oom507Activin receptor type-12.7.11.300.446
1ojtFADDihydrolipoyl dehydrogenase/0.445
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.445
2wotZZGTGF-beta receptor type-12.7.11.300.445
3zh8C58Protein kinase C iota type2.7.11.130.445
4ei40Q2Tyrosine-protein kinase JAK1/0.445
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.444
3qtwX3ACyclin-dependent kinase 22.7.11.220.444
3rzb02ZCyclin-dependent kinase 22.7.11.220.444
4eooATPCyclin-dependent kinase 22.7.11.220.443
1h1q2A6Cyclin-dependent kinase 22.7.11.220.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.442
3r9nZ68Cyclin-dependent kinase 22.7.11.220.442
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.441
1aq1STUCyclin-dependent kinase 22.7.11.220.440
2gjlFMNNitronate monooxygenase1.13.12.160.440
2uzbC75Cyclin-dependent kinase 22.7.11.220.440
3axwTIDCasein kinase II subunit alpha2.7.11.10.440
4hge15VTyrosine-protein kinase JAK2/0.440