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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4acg6LQGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4acg6LQGlycogen synthase kinase-3 beta2.7.11.261.000
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.610
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.587
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.569
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.566
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.562
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.552
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.543
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.539
3du8553Glycogen synthase kinase-3 beta2.7.11.260.535
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.534
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.528
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.524
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.521
4bgg844Activin receptor type-12.7.11.300.520
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.519
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.512
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.511
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.507
4dymIYZActivin receptor type-12.7.11.300.503
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.503
4c02TAKActivin receptor type-12.7.11.300.500
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.499
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.497
3mtfA3FActivin receptor type-12.7.11.300.496
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.494
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.491
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.489
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.489
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.487
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.486
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.486
4bchT7ZCyclin-dependent kinase 92.7.11.220.485
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.484
3eb0DRKUncharacterized protein/0.484
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.484
4jboWPHAurora kinase A2.7.11.10.482
2j4z626Aurora kinase A2.7.11.10.481
2dwbANPAurora kinase A2.7.11.10.480
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.480
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.480
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.479
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.478
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.478
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.478
3i60E86Mitogen-activated protein kinase 12.7.11.240.477
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.477
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.477
2jedLG8Protein kinase C theta type2.7.11.130.476
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.474
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.474
2pvnP63Casein kinase II subunit alpha2.7.11.10.474
3oom507Activin receptor type-12.7.11.300.474
4bznUGXSerine/threonine-protein kinase pim-12.7.11.10.474
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.474
5dr9SKEAurora kinase A2.7.11.10.473
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.472
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.471
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.471
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.470
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.470
3be9P04Casein kinase II subunit alpha2.7.11.10.470
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.469
4i22IREEpidermal growth factor receptor2.7.10.10.469
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.469
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.467
1q1rFADPutidaredoxin reductase1.18.1.50.466
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.466
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.466
3iw4LW4Protein kinase C alpha type2.7.11.130.466
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.466
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.465
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.465
1dawANPCasein kinase II subunit alpha2.7.11.10.464
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.464
2pvhP19Casein kinase II subunit alpha2.7.11.10.463
3q9xEMOCasein kinase II subunit alpha2.7.11.10.463
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.463
5e8xSTUTGF-beta receptor type-12.7.11.300.463
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.462
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.462
3sheI85MAP kinase-activated protein kinase 32.7.11.10.462
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.462
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.461
2b52D42Cyclin-dependent kinase 22.7.11.220.461
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.461
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.461
3zdu38RCyclin-dependent kinase-like 32.7.11.220.460
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.460
4i0t1B6Tyrosine-protein kinase SYK2.7.10.20.460
3bhtMFRCyclin-dependent kinase 22.7.11.220.459
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.459
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.459
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.459
1oguST8Cyclin-dependent kinase 22.7.11.220.458
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.458
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.458
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.457
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.457
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.456
3rni21ZCyclin-dependent kinase 22.7.11.220.455
4jbpYPHAurora kinase A2.7.11.10.455
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.455
5e8ySTUTGF-beta receptor type-22.7.11.300.455
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.454
3hmm855TGF-beta receptor type-12.7.11.300.454
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.454
3zh8C58Protein kinase C iota type2.7.11.130.454
4gmy0X5Tyrosine-protein kinase JAK2/0.454
4aguD15Cyclin-dependent kinase-like 1/0.453
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.453
5drdATPAurora kinase A2.7.11.10.453
2cchATPCyclin-dependent kinase 22.7.11.220.452
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.452
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.452
3e5aVX6Aurora kinase A2.7.11.10.452
3l9nL9NcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.452
1y91CT9Cyclin-dependent kinase 22.7.11.220.451
2csnCKICasein kinase I homolog 12.7.11.10.451
2uzlC94Cyclin-dependent kinase 22.7.11.220.451
4dgmAGICasein kinase II subunit alpha2.7.11.10.451
4fv6E57Mitogen-activated protein kinase 12.7.11.240.451
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.450
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.450
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.450
4n6z2HWSerine/threonine-protein kinase pim-12.7.11.10.450
1di8DTQCyclin-dependent kinase 22.7.11.220.449
1oiuN76Cyclin-dependent kinase 22.7.11.220.449
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.449
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.449
4qmySTUSerine/threonine-protein kinase 242.7.11.10.449
1lp4ANPCasein kinase II subunit alpha2.7.11.10.448
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.448
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.448
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.448
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
4dgo0JWCasein kinase II subunit alpha2.7.11.10.448
4jia1K3Tyrosine-protein kinase JAK2/0.448
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
5dosATPAurora kinase A2.7.11.10.448
1oi9N20Cyclin-dependent kinase 22.7.11.220.447
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.447
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.447
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.447
4j97ACPFibroblast growth factor receptor 2/0.447
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.446
2hog710Serine/threonine-protein kinase Chk12.7.11.10.446
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.446
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.446
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.446
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
4anmWULCasein kinase II subunit alpha2.7.11.10.446
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.446
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.445
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.445
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.445
2w1eL0EAurora kinase A2.7.11.10.445
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.445
3rmf20ZCyclin-dependent kinase 22.7.11.220.445
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.445
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.445
4lm5Q17Serine/threonine-protein kinase pim-12.7.11.10.445
1h1s4SPCyclin-dependent kinase 22.7.11.220.444
2ptfFMNUncharacterized protein MTH_863/0.444
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.444
4hvh19RTyrosine-protein kinase JAK32.7.10.20.444
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.444
1mq4ADPAurora kinase A2.7.11.10.443
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.443
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.443
2c5nCK8Cyclin-dependent kinase 22.7.11.220.443
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.443
2vv9IM9Cyclin-dependent kinase 22.7.11.220.443
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.443
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.443
4jajXU1Aurora kinase A2.7.11.10.443
4qmzB49Serine/threonine-protein kinase 242.7.11.10.443
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.442
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.442
4fkv61KCyclin-dependent kinase 22.7.11.220.442
1fvv107Cyclin-dependent kinase 22.7.11.220.441
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.441
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.441
2h96893Mitogen-activated protein kinase 82.7.11.240.441
2iw84SPCyclin-dependent kinase 22.7.11.220.441
2w17I19Cyclin-dependent kinase 22.7.11.220.441
2xikJ60Serine/threonine-protein kinase 252.7.11.10.441
3bu5ATPInsulin receptor2.7.10.10.441
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.441
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.441
4hvi19STyrosine-protein kinase JAK32.7.10.20.441
4jbqVX6Aurora kinase A2.7.11.10.441
1oiyN41Cyclin-dependent kinase 22.7.11.220.440
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.440
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.440
2w1fL0FAurora kinase A2.7.11.10.440
3efwAK8Aurora kinase A2.7.11.10.440
3qu0X40Cyclin-dependent kinase 22.7.11.220.440
3r9dX6BCyclin-dependent kinase 22.7.11.220.440
3r9oZ71Cyclin-dependent kinase 22.7.11.220.440
3vf80JETyrosine-protein kinase SYK2.7.10.20.440
4grb0XGCasein kinase II subunit alpha2.7.11.10.440
4jqeANPCasein kinase II subunit alpha2.7.11.10.440