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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4acdGR9Glycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4acdGR9Glycogen synthase kinase-3 beta2.7.11.261.000
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.591
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.572
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.562
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.560
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.554
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.554
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.547
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.534
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.527
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.527
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.526
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.523
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.519
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.514
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.512
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.508
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.506
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.503
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.490
3du8553Glycogen synthase kinase-3 beta2.7.11.260.488
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.486
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.480
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.478
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.476
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.474
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.473
3eb0DRKUncharacterized protein/0.471
4jboWPHAurora kinase A2.7.11.10.463
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.454
3mtfA3FActivin receptor type-12.7.11.300.453
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
4bcmT7ZCyclin-dependent kinase 22.7.11.220.451
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
4dgmAGICasein kinase II subunit alpha2.7.11.10.450
4bgg844Activin receptor type-12.7.11.300.449
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.449
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.446
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.444
4fv6E57Mitogen-activated protein kinase 12.7.11.240.444
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.443
2vu3LZECyclin-dependent kinase 22.7.11.220.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.441
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3rak03ZCyclin-dependent kinase 22.7.11.220.440