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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4abzT1CTetracycline repressor protein class D

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4abzT1CTetracycline repressor protein class D/1.000
2xpvMIYTetracycline repressor protein class D/0.701
5fkmTDCTetracycline repressor protein class D/0.667
2xpwOTCTetracycline repressor protein class D/0.655
2trtTACTetracycline repressor protein class D/0.642
4auxXTCTetracycline repressor protein class D/0.642
2tctCTCTetracycline repressor protein class D/0.634
1orkATCTetracycline repressor protein class D/0.628
5fklTDCTetracycline repressor protein class D/0.625
2o7oDXTTetracycline repressor protein class D/0.610
4d7mTDCTetracycline repressor protein class D/0.582
4b3aTACTetracycline repressor protein class D/0.581
2xpuTDCTetracycline repressor protein class D/0.580
2xb5I7TTetracycline repressor protein class D/0.570
4b1rITCTetracycline repressor protein class D/0.559
2vkeTACTetracycline repressor protein class D/0.550
2xrlDXTTetracycline repressor protein class D/0.548
4v2gITCTetracycline repressor protein class D/0.529
5fknTDCTetracycline repressor protein class D/0.522
2x9dITCTetracycline repressor protein class D/0.508
2x6o2TCTetracycline repressor protein class D/0.499
2fj1CTCTetracycline repressor protein class D/0.498
4ac0MIYTetracycline repressor protein class B from transposon Tn10/0.492
2vprTDCTetracycline repressor protein class H/0.478
5fkoTDCTetracycline repressor protein class D/0.470
2vkvTDCTetracycline repressor protein class D/0.459
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.458
4v2gCTCTetracycline repressor protein class D/0.445
3ohh3HHBeta-secretase 13.4.23.460.444