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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4aa5NQBMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4aa5NQBMitogen-activated protein kinase 14/1.000
4aa4QC0Mitogen-activated protein kinase 14/0.676
4aacAAVMitogen-activated protein kinase 14/0.652
3nww3NWMitogen-activated protein kinase 14/0.649
2qd9LGFMitogen-activated protein kinase 14/0.624
4kiq1RAMitogen-activated protein kinase 14/0.614
3fln3FNMitogen-activated protein kinase 14/0.607
3iphG11Mitogen-activated protein kinase 14/0.601
2balPQAMitogen-activated protein kinase 14/0.598
3fklFKLMitogen-activated protein kinase 14/0.597
3hl7I47Mitogen-activated protein kinase 14/0.593
4lopSB4Mitogen-activated protein kinase 14/0.591
3mpt1GKMitogen-activated protein kinase 14/0.582
3dt1P40Mitogen-activated protein kinase 14/0.563
3mvl38PMitogen-activated protein kinase 14/0.560
3fmh533Mitogen-activated protein kinase 14/0.558
2rg5279Mitogen-activated protein kinase 14/0.556
3fskRO6Mitogen-activated protein kinase 14/0.555
3fi4FI4Mitogen-activated protein kinase 14/0.554
4kin1M8Mitogen-activated protein kinase 14/0.551
3flwFLWMitogen-activated protein kinase 14/0.550
4kip1R9Mitogen-activated protein kinase 14/0.545
1zz2B11Mitogen-activated protein kinase 14/0.544
2rg6287Mitogen-activated protein kinase 14/0.543
3fmkFMKMitogen-activated protein kinase 14/0.543
3flyFLYMitogen-activated protein kinase 14/0.542
4looSB4Mitogen-activated protein kinase 14/0.541
3flzFLZMitogen-activated protein kinase 14/0.537
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.534
3ocgOCGMitogen-activated protein kinase 14/0.530
3hvcGG5Mitogen-activated protein kinase 14/0.526
3uvqFS8Mitogen-activated protein kinase 14/0.521
3hllI45Mitogen-activated protein kinase 14/0.519
3l8xN4DMitogen-activated protein kinase 14/0.517
4loqSB4Mitogen-activated protein kinase 14/0.516
3roc29AMitogen-activated protein kinase 14/0.510
1zyjBI5Mitogen-activated protein kinase 14/0.506
3s4qNK0Mitogen-activated protein kinase 14/0.504
3w33W19Epidermal growth factor receptor2.7.10.10.498
3mpaSB2Mitogen-activated protein kinase 14/0.497
3mvm39PMitogen-activated protein kinase 14/0.494
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.492
1ywrLI9Mitogen-activated protein kinase 14/0.489
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.484
2zb0GK3Mitogen-activated protein kinase 14/0.484
3uyt0CKCasein kinase I isoform delta2.7.11.10.483
3uvp048Mitogen-activated protein kinase 14/0.480
3gc9B45Mitogen-activated protein kinase 112.7.11.240.479
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
2ghlLIBMitogen-activated protein kinase 14/0.472
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.471
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.470
3fwfCAMCamphor 5-monooxygenase1.14.15.10.470
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.468
1ouk084Mitogen-activated protein kinase 14/0.466
1m17AQ4Epidermal growth factor receptor2.7.10.10.465
3hp552PMitogen-activated protein kinase 14/0.465
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.465
2itpAEEEpidermal growth factor receptor2.7.10.10.464
4nks2M2Fibroblast growth factor receptor 1/0.464
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.464
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.463
3cppCAMCamphor 5-monooxygenase1.14.15.10.463
3kf7L9GMitogen-activated protein kinase 14/0.463
1yw2PGJMitogen-activated protein kinase 14/0.462
4eh60ONMitogen-activated protein kinase 14/0.462
4kbc1QJCasein kinase I isoform delta2.7.11.10.461
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.460
2itnANPEpidermal growth factor receptor2.7.10.10.460
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.460
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
3bv3P39Mitogen-activated protein kinase 14/0.458
2of2547Tyrosine-protein kinase Lck2.7.10.20.457
3gc7B45Mitogen-activated protein kinase 14/0.457
3gfeP37Mitogen-activated protein kinase 14/0.457
3mwuBK3Calmodulin-domain protein kinase 1, putative/0.456
4eym0RXMitogen-activated protein kinase 132.7.11.240.456
4nk92K5Fibroblast growth factor receptor 1/0.455
1bl6SB6Mitogen-activated protein kinase 14/0.454
2oorNADNAD(P) transhydrogenase subunit alpha part 11.6.1.20.454
3fmn530Mitogen-activated protein kinase 14/0.454
3uibSB2Putative mitogen-activated protein kinase/0.454
4b99R4LMitogen-activated protein kinase 72.7.11.240.454
4eh70OOMitogen-activated protein kinase 14/0.454
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.453
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.453
2y6o1N1Ephrin type-A receptor 42.7.10.10.452
4f650S9Fibroblast growth factor receptor 1/0.451
2vynNADGlyceraldehyde-3-phosphate dehydrogenase A/0.450
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.450
2qo9ANPEphrin type-A receptor 32.7.10.10.449
4h4zFADBiphenyl dioxygenase ferredoxin reductase subunit/0.449
4hjoAQ4Epidermal growth factor receptor2.7.10.10.449
3lxiCAMCytochrome P450/0.448
3vjoANPEpidermal growth factor receptor2.7.10.10.448
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
4jq7KJQEpidermal growth factor receptor2.7.10.10.448
2qblCAMCamphor 5-monooxygenase1.14.15.10.447
3gubGUBDeath-associated protein kinase 12.7.11.10.447
3l63CAMCamphor 5-monooxygenase1.14.15.10.447
4fod0UVALK tyrosine kinase receptor2.7.10.10.447
4l4fCAMCamphor 5-monooxygenase1.14.15.10.447
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2zaxCAMCamphor 5-monooxygenase1.14.15.10.446
3fwiCAMCamphor 5-monooxygenase1.14.15.10.446
4i22IREEpidermal growth factor receptor2.7.10.10.446
4kkyCAMCamphor 5-monooxygenase1.14.15.10.446
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.445
4fob0USALK tyrosine kinase receptor2.7.10.10.445
1dz6CAMCamphor 5-monooxygenase1.14.15.10.444
2gs7ANPEpidermal growth factor receptor2.7.10.10.444
3vryB43Tyrosine-protein kinase HCK2.7.10.20.444
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.444
1phePIYCamphor 5-monooxygenase1.14.15.10.443
1eh4IC1Casein kinase I homolog 12.7.11.10.442
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.442
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.442
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.442
4c02TAKActivin receptor type-12.7.11.300.442
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
4kbk1QGCasein kinase I isoform delta2.7.11.10.442
1c3x8IGPurine nucleoside phosphorylase2.4.2.10.441
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.441
2a1mCAMCamphor 5-monooxygenase1.14.15.10.441
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.441
3o8tBMUMitogen-activated protein kinase 14/0.441
3wrlCAMCamphor 5-monooxygenase1.14.15.10.441
4i231C9Epidermal growth factor receptor2.7.10.10.441
4ic7ANPMitogen-activated protein kinase 72.7.11.240.441
4o2z046Mitogen-activated protein kinase/0.441
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.441
1ywnLIFVascular endothelial growth factor receptor 22.7.10.10.440
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.440