sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4aa4	QC0	Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
4aa4	QC0	Mitogen-activated protein kinase 14	/	1.000
4aac	AAV	Mitogen-activated protein kinase 14	/	0.781
3fkl	FKL	Mitogen-activated protein kinase 14	/	0.536
4aa5	NQB	Mitogen-activated protein kinase 14	/	0.530
3flw	FLW	Mitogen-activated protein kinase 14	/	0.509
3fln	3FN	Mitogen-activated protein kinase 14	/	0.504
2bal	PQA	Mitogen-activated protein kinase 14	/	0.499
3fsk	RO6	Mitogen-activated protein kinase 14	/	0.498
4kip	1R9	Mitogen-activated protein kinase 14	/	0.495
4kiq	1RA	Mitogen-activated protein kinase 14	/	0.479
3iph	G11	Mitogen-activated protein kinase 14	/	0.474
3nww	3NW	Mitogen-activated protein kinase 14	/	0.471
3hl7	I47	Mitogen-activated protein kinase 14	/	0.458
3u8w	09J	Mitogen-activated protein kinase 14	/	0.452
3mvl	38P	Mitogen-activated protein kinase 14	/	0.442