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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4a9yAQZMitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2bakAQZMitogen-activated protein kinase 14/1.000
4a9yAQZMitogen-activated protein kinase 14/1.000
3lfcZ86Mitogen-activated protein kinase 14/0.551
3hv3R49Mitogen-activated protein kinase 14/0.530
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.522
3gcq1BUMitogen-activated protein kinase 14/0.521
3lfeZ84Mitogen-activated protein kinase 14/0.516
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.511
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.496
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.494
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.481
3ctj320Hepatocyte growth factor receptor2.7.10.10.476
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.476
3iw8HIZMitogen-activated protein kinase 14/0.475
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.470
1x8b824Wee1-like protein kinase2.7.10.20.469
1uwhBAXSerine/threonine-protein kinase B-raf2.7.11.10.466
2jc6QPPCalcium/calmodulin-dependent protein kinase type 1D2.7.11.170.465
2ociTYCValacyclovir hydrolase3.10.464
1lcoPPYCytochrome b2, mitochondrial1.1.2.30.463
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.462
1pmn984Mitogen-activated protein kinase 102.7.11.240.460
1blzACVIsopenicillin N synthase1.21.3.10.459
4eevL1XHepatocyte growth factor receptor2.7.10.10.459
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
2gtnLIEMitogen-activated protein kinase 14/0.457
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.456
3bi6396Wee1-like protein kinase2.7.10.20.456
4eh60ONMitogen-activated protein kinase 14/0.456
4h1e10JBeta-secretase 13.4.23.460.456
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.454
4tyj0LIFibroblast growth factor receptor 42.7.10.10.453
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.452
2gjnFMNNitronate monooxygenase1.13.12.160.451
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.451
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
3ttiKBIMitogen-activated protein kinase 102.7.11.240.450
2ewaSB2Mitogen-activated protein kinase 14/0.449
2p33J07Mitogen-activated protein kinase 102.7.11.240.447
3gc9B45Mitogen-activated protein kinase 112.7.11.240.447
3tubFPUTyrosine-protein kinase SYK2.7.10.20.447
4y93746Tyrosine-protein kinase/0.447
2z2w770Wee1-like protein kinase2.7.10.20.446
4y95746Tyrosine-protein kinase/0.446
1f4gTP4Thymidylate synthase/0.444
2hog710Serine/threonine-protein kinase Chk12.7.11.10.444
3rthRTHBeta-secretase 13.4.23.460.444
3zw9NADPeroxisomal bifunctional enzyme1.1.1.350.444
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.443
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.442
3rsv3RSBeta-secretase 13.4.23.460.442
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
4qrc0LIFibroblast growth factor receptor 42.7.10.10.440