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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.11.000
4a9uA9USerine/threonine-protein kinase Chk22.7.11.10.574
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.561
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.561
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.537
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.536
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.528
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.526
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.526
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.522
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.504
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.498
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.491
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.491
3gubGUBDeath-associated protein kinase 12.7.11.10.489
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.488
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.486
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.485
4bdaVFBSerine/threonine-protein kinase Chk22.7.11.10.484
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.483
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.482
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.481
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.478
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.477
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.473
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.471
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.470
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.470
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.462
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3pxkPXKFocal adhesion kinase 12.7.10.20.461
4i22IREEpidermal growth factor receptor2.7.10.10.461
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.460
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.460
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.459
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.459
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.458
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.458
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.457
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.456
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.456
4fod0UVALK tyrosine kinase receptor2.7.10.10.455
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.454
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.454
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.453
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4bdeCWSSerine/threonine-protein kinase Chk22.7.11.10.453
3ekp478Gag-Pol polyprotein3.4.23.160.452
4ct2ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.452
3bheBZNGag-Pol polyprotein3.4.23.160.451
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.450
3slkNDPPolyketide synthase extender module 2/0.450
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.450
4qgiROCGag-Pol polyprotein3.4.23.160.450
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.449
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.449
1vikBAYGag-Pol polyprotein/0.447
2hog710Serine/threonine-protein kinase Chk12.7.11.10.447
2ijmATPFocal adhesion kinase 12.7.10.20.447
3oxcROCProtease/0.447
2qd6065Gag-Pol polyprotein3.4.23.160.446
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.446
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.445
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.445
3em4DR7Gag-Pol polyprotein3.4.23.160.444
1w1rZEACytokinin dehydrogenase 11.5.99.120.443
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.442
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.441
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.441
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.440
2vu3LZECyclin-dependent kinase 22.7.11.220.440
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.440
3rk507ZCyclin-dependent kinase 22.7.11.220.440
4qmzB49Serine/threonine-protein kinase 242.7.11.10.440