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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4a4qUX9Pol protein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
4a4qUX9Pol protein/1.000
3zpsEQMGag-Pol polyprotein3.4.23.160.694
3zpuM8BGag-Pol polyprotein3.4.23.160.666
2pk5075Protease/0.634
4hdfG52Gag-Pol polyprotein3.4.23.160.631
2bqvA1AProtease/0.608
3zptM8YGag-Pol polyprotein3.4.23.160.608
1ec3MS3Gag-Pol polyprotein3.4.23.160.606
4a6bQG8Gag-Pol polyprotein3.4.23.160.599
1w5xBE5Gag-Pol polyprotein3.4.23.160.592
4kb9G79Protease/0.592
1rl8RITGag-Pol polyprotein3.4.23.160.591
2xyfG40Gag-Pol polyprotein/0.590
3ggaGGWGag-Pol polyprotein/0.588
2cem2AHPol protein/0.586
2uxzHI1Gag-Pol polyprotein3.4.23.160.585
3k4vROCGag-Pol polyprotein3.4.23.160.582
1vikBAYGag-Pol polyprotein/0.581
2bpv1INGag-Pol polyprotein3.4.23.160.581
1ebwBEIGag-Pol polyprotein3.4.23.160.579
1d4sTPVGag-Pol polyprotein3.4.23.160.575
2cen4AHProtease/0.575
2uy0HV1Gag-Pol polyprotein3.4.23.160.574
1iiq0ZRGag-Pol polyprotein3.4.23.160.571
3em4DR7Gag-Pol polyprotein3.4.23.160.567
2a4fAAUV-1 protease/0.561
2aoe0Q4Gag-Pol polyprotein3.4.23.160.561
1ec2BEJGag-Pol polyprotein3.4.23.160.560
1w5yBE6Gag-Pol polyprotein3.4.23.160.558
2aquDR7Gag-Pol polyprotein3.4.23.160.554
2p3b3TLV-1 PROTEASE protein/0.554
2p3b3TLV-1 protease/0.554
2ien017Gag-Pol polyprotein3.4.23.160.553
1ebyBEBGag-Pol polyprotein3.4.23.160.552
2bpw1INGag-Pol polyprotein3.4.23.160.552
2upjU02Gag-Pol polyprotein3.4.23.160.552
2f81017Gag-Pol polyprotein3.4.23.160.550
2fxeDR7Gag-Pol polyprotein3.4.23.160.550
3ekp478Gag-Pol polyprotein3.4.23.160.549
1d4yTPVGag-Pol polyprotein3.4.23.160.548
4djpM73Pol polyprotein/0.547
1ec1BEEGag-Pol polyprotein3.4.23.160.546
3ndtROCGag-Pol polyprotein3.4.23.160.546
1hvkA79Gag-Pol polyprotein/0.545
2pk6O33V-1 protease/0.544
1difA85Gag-Pol polyprotein/0.543
3a2oKNJGag-Pol polyprotein3.4.23.160.542
3hzc2NCProtease/0.542
3kdcJZPGag-Pol polyprotein3.4.23.160.540
4njvRITProtease/0.540
7upjINUGag-Pol polyprotein3.4.23.160.540
2xyeCXGGag-Pol polyprotein/0.538
3s85LK0Gag-Pol polyprotein/0.538
3sa755AProtease/0.538
1hxbROCGag-Pol polyprotein3.4.23.160.537
2idw017Protease/0.537
2qd6065Gag-Pol polyprotein3.4.23.160.537
3ndxRITGag-Pol polyprotein3.4.23.160.537
1d4jMSCGag-Pol polyprotein3.4.23.160.536
2ieo017Protease/0.536
3bva2NCGag-Pol polyprotein3.4.23.160.535
3tl9ROCGag-Pol polyprotein3.4.23.160.535
1tcxIM1Gag-Pol polyprotein3.4.23.160.534
4rvj478Protease/0.534
3ggxGGXGag-Pol polyprotein/0.533
3mxeK54Gag-Pol polyprotein3.4.23.160.533
4djoMK5Pol polyprotein/0.533
3ok9G52Gag-Pol polyprotein3.4.23.160.532
1hvlA76Gag-Pol polyprotein/0.531
1ivp1ZKGag-Pol polyprotein/0.531
2qi6MZ8Gag-Pol polyprotein/0.531
3linE13Protease/0.531
1hvjA78Gag-Pol polyprotein/0.530
3i2l2NCProtease/0.530
2wl05AHGag-Pol polyprotein/0.529
1t7i017Gag-Pol polyprotein3.4.23.160.528
1xl5190Gag-Pol polyprotein3.4.23.160.528
1hosPHPGag-Pol polyprotein/0.525
3ndwRITGag-Pol polyprotein3.4.23.160.524
1ebzBECGag-Pol polyprotein3.4.23.160.523
3oxxDR7Gag-Pol polyprotein3.4.23.160.523
2fdd385Pol protein/0.522
2nmyROCProtease/0.522
3o9bK2APol polyprotein/0.522
3dk1G05Gag-Pol polyprotein3.4.23.160.521
3oxcROCProtease/0.521
4qgiROCGag-Pol polyprotein3.4.23.160.521
1sdvMK1Gag-Pol polyprotein3.4.23.160.519
3ekqROCGag-Pol polyprotein3.4.23.160.519
1wbmBLLPol protein/0.518
3sa6F71Protease/0.518
2bpz3INGag-Pol polyprotein3.4.23.160.517
4dfg0JVGag-Pol polyprotein3.4.23.160.517
4njuTPVProtease/0.517
2qi3MZ5Gag-Pol polyprotein/0.516
1n49RITGag-Pol polyprotein3.4.23.160.515
3kfn3TLGag-Pol polyprotein/0.515
3kfr3TLGag-Pol polyprotein/0.515
3lzs017Gag-Pol polyprotein3.4.23.160.515
3qn8NI7Gag-Pol polyprotein3.4.23.160.515
2fxdDR7Pol polyprotein/0.514
3sa323XProtease/0.514
1yt9OISGag-Pol polyprotein/0.513
2a1eIPFGag-Pol polyprotein3.4.23.160.513
2bpy3INGag-Pol polyprotein3.4.23.160.513
2qnnQN1Gag-Pol polyprotein3.4.23.160.513
2nnkROCProtease/0.512
3gi6D78Gag-Pol polyprotein/0.512
3nxe2NCProtease/0.512
3em3478Gag-Pol polyprotein3.4.23.160.511
2pqzG0GGag-Pol polyprotein3.4.23.160.509
3ekt017Gag-Pol polyprotein3.4.23.160.509
1hvsA77Gag-Pol polyprotein/0.507
1k2b0Q4Gag-Pol polyprotein3.4.23.160.507
1vijBAYGag-Pol polyprotein/0.507
3kf03TLGag-Pol polyprotein/0.507
1hiv1ZKGag-Pol polyprotein/0.506
2qd8065Gag-Pol polyprotein3.4.23.160.506
4ye3G04Gag-Pol polyprotein3.4.23.160.506
1ec0BEDGag-Pol polyprotein3.4.23.160.505
1wbk568Pol protein/0.505
1k1u0Q4Gag-Pol polyprotein3.4.23.160.504
3sa5A69Protease/0.504
4hdbG52Gag-Pol polyprotein3.4.23.160.504
1fgc2NCGag-Pol polyprotein3.4.23.160.503
1hviA77Protease/0.503
1ohr1UNV-1 PROTEASE protein/0.503
2z54AB1Gag-Pol polyprotein3.4.23.160.503
3d1yROCGag-Pol polyprotein3.4.23.160.503
3nyg2NCGag-Pol polyprotein3.4.23.160.503
1bdlIM1Gag-Pol polyprotein3.4.23.160.502
1ff02NCGag-Pol polyprotein3.4.23.160.502
3kddJZQGag-Pol polyprotein3.4.23.160.502
3pwm017Gag-Pol polyprotein3.4.23.160.502
1c6zROCProtease/0.501
2q5kAB1Protease/0.501
2wkz5AHGag-Pol polyprotein/0.501
3bxsDRSGag-Pol polyprotein3.4.23.160.501
4djr0KJPol polyprotein/0.501
1bv7XV6Gag-Pol polyprotein3.4.23.160.500
1zsr0ZTGag-Pol polyprotein3.4.23.160.500
3liqE14Protease/0.500
2rkfAB1Pol protein/0.499
3bvb017Gag-Pol polyprotein3.4.23.160.499
3sabF78Protease/0.499
3vfa031Gag-Pol polyprotein3.4.23.160.499
4gb20LQGag-Pol polyprotein2.7.7.490.499
2f3kRO1Protease/0.498
3ekyDR7Gag-Pol polyprotein3.4.23.160.498
3jw2017Gag-Pol polyprotein3.4.23.160.498
3kfs3TLGag-Pol polyprotein/0.498
3nduROCGag-Pol polyprotein3.4.23.160.498
3sa4F72Protease/0.498
1d4kPI8Gag-Pol polyprotein3.4.23.160.497
1ffi2NCGag-Pol polyprotein3.4.23.160.497
1fg62NCGag-Pol polyprotein3.4.23.160.497
3o9cK20Pol polyprotein/0.497
1daz0Q4Gag-Pol polyprotein3.4.23.160.496
2b7zMK1Gag-Pol polyprotein/0.496
3tog079Gag-Pol polyprotein2.7.7.490.496
3ttp017Gag-Pol polyprotein3.4.23.160.496
3uhl2NCGag-Pol polyprotein3.4.23.160.496
3vf5031Gag-Pol polyprotein3.4.23.160.496
4djqM86Pol polyprotein/0.496
2qd7065Gag-Pol polyprotein3.4.23.160.495
3ekwDR7Gag-Pol polyprotein3.4.23.160.495
3pwrROCGag-Pol polyprotein3.4.23.160.495
1sbgIM1Gag-Pol polyprotein/0.494
3nuo478Gag-Pol polyprotein3.4.23.160.494
3vfb031Gag-Pol polyprotein3.4.23.160.494
4i8zG08Gag-Pol polyprotein3.4.23.160.494
3d1xROCGag-Pol polyprotein3.4.23.160.493
1d4hBEHGag-Pol polyprotein3.4.23.160.492
1sh9RITGag-Pol polyprotein3.4.23.160.492
2i4wKGQProtease/0.492
2pyn1UNGag-Pol polyprotein3.4.23.160.492
3nu9478Gag-Pol polyprotein3.4.23.160.492
3sacAF8Protease/0.492
1b6kPI5Gag-Pol polyprotein3.4.23.160.491
1c70L75Protease/0.491
1d4iBEGGag-Pol polyprotein3.4.23.160.491
1hshMK1Gag-Pol polyprotein/0.491
3nwq2NCGag-Pol polyprotein3.4.23.160.491
3qrsNK8Gag-Pol polyprotein3.4.23.160.491
2f8g017Gag-Pol polyprotein3.4.23.160.490
3dcrKVSProtease/0.490
3litE15Protease/0.490
4hdpG52Gag-Pol polyprotein3.4.23.160.490
1b6pPI7Gag-Pol polyprotein3.4.23.160.489
1npa3NHGag-Pol polyprotein3.4.23.160.489
1npwLGZGag-Pol polyprotein3.4.23.160.489
3o9fK2DGag-Pol polyprotein/0.489
3s56ROCProtease/0.489
3sa9A68Protease/0.489
1hxwRITGag-Pol polyprotein/0.488
3cyxROCGag-Pol polyprotein3.4.23.160.488
3s54017Protease/0.488
1hpoUNIGag-Pol polyprotein3.4.23.160.487
1jld0PPGag-Pol polyprotein/0.487
1dw60Q4Gag-Pol polyprotein3.4.23.160.486
2avm2NCGag-Pol polyprotein3.4.23.160.486
2p3d3TLProtease/0.486
2qi7MZ9Gag-Pol polyprotein/0.486
2r5pMK1Gag-Pol polyprotein/0.486
3cyw017Gag-Pol polyprotein3.4.23.160.486
3em6017Gag-Pol polyprotein3.4.23.160.486
3livE16Protease/0.486
2fde385Gag-Pol polyprotein3.4.23.160.485
3dckKVIProtease/0.485
3el51UNGag-Pol polyprotein/0.485
3o9eA60Pol polyprotein/0.485
4dqe017Gag-Pol polyprotein/0.485
1m0b0ZQGag-Pol polyprotein3.4.23.160.484
2qnpQN2Gag-Pol polyprotein3.4.23.160.484
3bgbLJGGag-Pol polyprotein3.4.23.160.484
3cktYDPGag-Pol polyprotein3.4.23.160.484
3gi4K60Gag-Pol polyprotein/0.484
1a9mU0EGag-Pol polyprotein/0.483
1hsgMK1Gag-Pol polyprotein/0.483
3fx5KNIGag-Pol polyprotein3.4.23.160.483
3qp0NI8Gag-Pol polyprotein3.4.23.160.483
3st5G89Gag-Pol polyprotein3.4.23.160.483
4hegG52Gag-Pol polyprotein3.4.23.160.483
1a8k0Q4Gag-Pol polyprotein3.4.23.160.482
1bai0Q4Gag-Pro polyprotein/0.482
1fg80Q4Gag-Pol polyprotein3.4.23.160.482
2cej1AHPol protein/0.482
2o4pTPVProtease/0.482
2i4xKGQProtease/0.481
3nu4478Gag-Pol polyprotein3.4.23.160.481
4j55031Gag-Pol polyprotein3.4.23.160.481
1bdrIM1Gag-Pol polyprotein3.4.23.160.480
1w5vBE3Gag-Pol polyprotein3.4.23.160.480
2aidTHKGag-Pol polyprotein3.4.23.160.480
2i4dQFIProtease/0.480
2qi5MZ7Gag-Pol polyprotein/0.480
3aidARQGag-Pol polyprotein3.4.23.160.480
3el9DR7Gag-Pol polyprotein3.4.23.160.480
3jvwDMPGag-Pol polyprotein3.4.23.160.480
3qbfJHGGag-Pol polyprotein3.4.23.160.480
3t113T1Gag-Pol polyprotein3.4.23.160.480
2bb9AKCGag-Pol polyprotein3.4.23.160.479
2fleAIProtease/0.479
2hb3GRLProtease/0.479
2nnpROCProtease/0.479
2qhcAB1Protease/0.479
3sa8K83Protease/0.479
2hs2017Protease/0.478
3lzu017Gag-Pol polyprotein3.4.23.160.478
4a6cQG9Gag-Pol polyprotein3.4.23.160.478
4j5j478Gag-Pol polyprotein3.4.23.160.478
9hvp0E9Gag-Pol polyprotein/0.478
1t3r017Gag-Pol polyprotein3.4.23.160.477
2b60RITPol polyprotein/0.477
3o9gF53Gag-Pol polyprotein/0.477
3oxw017Gag-Pol polyprotein3.4.23.160.477
1ajvNMBGag-Pol polyprotein3.4.23.160.476
1izhQ50Protease/0.476
1sdtMK1Gag-Pol polyprotein3.4.23.160.476
2avsMK1Gag-Pol polyprotein3.4.23.160.476
2qci065Gag-Pol polyprotein3.4.23.160.476
3nls016Gag-Pol polyprotein3.4.23.160.476
4dqc017Gag-Pol polyprotein/0.476
2f80017Gag-Pol polyprotein3.4.23.160.475
2qhzMZ2Gag-Pol polyprotein/0.475
2qnqQN3Gag-Pol polyprotein3.4.23.160.475
1a940Q4Gag-Pol polyprotein3.4.23.160.474
1fej2NCGag-Pol polyprotein3.4.23.160.474
1msmJE2Gag-Pol polyprotein3.4.23.160.474
2avvMK1Gag-Pol polyprotein3.4.23.160.474
2i4uDJRProtease/0.474
3s43478Protease/0.474
4njt017Protease/0.474
1hiiC20Gag-Pol polyprotein/0.473
1sguMK1Gag-Pol polyprotein3.4.23.160.473
1z1hHBBGag-Pol polyprotein3.4.23.160.473
2q641UNGag-Pol polyprotein3.4.23.160.473
3t3c017Gag-Pol polyprotein3.4.23.160.473
1ida0POGag-Pol polyprotein3.4.23.470.472
3el4ROCGag-Pol polyprotein3.4.23.160.472
3toh079Gag-Pol polyprotein2.7.7.490.472
1mtrPI6Gag-Pol polyprotein3.4.23.160.471
1odw0E8Gag-Pol polyprotein3.4.23.160.471
2bpxMK1Gag-Pol polyprotein3.4.23.160.471
3gi5K62Gag-Pol polyprotein/0.471
4njsG08Protease/0.471
1z1rHBHGag-Pol polyprotein3.4.23.160.470
3ggu017Gag-Pol polyprotein3.4.23.160.470
1iziQ50Gag-Pol polyprotein3.4.23.160.469
2i4vDJRV-1 protease/0.469
2r5q1UNGag-Pol polyprotein/0.469
1b6mPI6Gag-Pol polyprotein3.4.23.160.468
3djkG55Gag-Pol polyprotein3.4.23.160.468
3nwxKVSGag-Pol polyprotein3.4.23.160.468
3saa77FProtease/0.468
3vf7031Gag-Pol polyprotein3.4.23.160.468
1odyLP1Gag-Pol polyprotein3.4.23.160.467
2q3kMUWGag-Pol polyprotein/0.467
2qak1UNGag-Pol polyprotein3.4.23.160.467
1c6x3INProtease/0.466
1g35AHFGag-Pol polyprotein3.4.23.160.466
3d1z017Gag-Pol polyprotein3.4.23.160.466
4q1y017Gag-Pol polyprotein3.4.23.160.466
1d4lPI9Gag-Pol polyprotein3.4.23.160.465
1muiAB1Protease/0.465
3o9dK19Pol polyprotein/0.465
3upjU03Gag-Pol polyprotein/0.465
1sduMK1Gag-Pol polyprotein3.4.23.160.464
1zsf0ZSGag-Pol polyprotein3.4.23.160.464
2hc0AB2Protease/0.464
3ekv478Gag-Pol polyprotein3.4.23.160.464
3qrmNK7Gag-Pol polyprotein3.4.23.160.464
1fff0Q4Gag-Pol polyprotein3.4.23.160.463
1hpxKNIGag-Pol polyprotein/0.463
2q54MU1Protease/0.463
3el1DR7Gag-Pol polyprotein3.4.23.160.463
3i6oGR6Gag-Pol polyprotein3.4.23.160.463
3jvy017Gag-Pol polyprotein3.4.23.160.463
3oxv478Gag-Pol polyprotein3.4.23.160.463
1mesDMPGag-Pol polyprotein3.4.23.160.461
3o9iA61Gag-Pol polyprotein/0.461
3oy4017Gag-Pol polyprotein3.4.23.160.461
4k4p3TLGag-Pol polyprotein/0.460
1a8g2Z4Gag-Pol polyprotein3.4.23.160.459
1kzkJE2Gag-Pol polyprotein3.4.23.160.459
3r4b74TGag-Pol polyprotein/0.459
1idb0DOGag-Pol polyprotein/0.458
3qroNK9Gag-Pol polyprotein3.4.23.160.458
3ufnROCGag-Pol polyprotein/0.458
3wsjMK1Protease/0.458
1ajxAH1Gag-Pol polyprotein3.4.23.160.457
2p3c3TLProtease/0.457
1g2kNM1Gag-Pol polyprotein3.4.23.160.456
2qi4MZ6Gag-Pol polyprotein/0.456
3bheBZNGag-Pol polyprotein3.4.23.160.456
3bgcLJHGag-Pol polyprotein3.4.23.160.455
3mws017Pol protein/0.454
4q1w017Gag-Pol polyprotein3.4.23.160.454
2qhyMZ1Gag-Pol polyprotein/0.453
6upjNIUGag-Pol polyprotein/0.453
1hihC20Gag-Pol polyprotein/0.452
4dqh017Gag-Pol polyprotein/0.452
1sivPSIGag-Pol polyprotein/0.451
1proA88Gag-Pol polyprotein/0.450
2bbbHH1Gag-Pol polyprotein3.4.23.160.450
2p3a3TLPol protein/0.450
2qi0MZ3Gag-Pol polyprotein/0.450
2z4o065Gag-Pol polyprotein3.4.23.160.450
1k6vXN2Gag-Pol polyprotein3.4.23.160.449
3lixE17Protease/0.449
3qaaG04Gag-Pol polyprotein3.4.23.160.449
1c6yMK1Protease/0.448
2r43G3GGag-Pol polyprotein3.4.23.160.448
3mxdK53Gag-Pol polyprotein3.4.23.160.448
1ebk0Q4Gag-Pol polyprotein3.4.23.160.447
1meuDMPGag-Pol polyprotein3.4.23.160.447
1mrwK57Gag-Pol polyprotein3.4.23.160.447
1qbrXV6Gag-Pol polyprotein3.4.23.160.447
1qbu846Gag-Pol polyprotein3.4.23.160.447
1t7kBH0Gag-Pol polyprotein3.4.23.160.447
2r38G4GGag-Pol polyprotein3.4.23.160.447
3nu5478Gag-Pol polyprotein3.4.23.160.447
1bwaXV6Gag-Pol polyprotein3.4.23.160.446
1ivq0PXGag-Pol polyprotein/0.446
2qi1MZ4Gag-Pol polyprotein/0.446
3qpjN4IGag-Pol polyprotein3.4.23.160.446
3so9017Pol protein/0.446
1bdqIM1Gag-Pol polyprotein3.4.23.160.445
1hvrXK2Gag-Pol polyprotein/0.445
3i7eDJRGag-Pol polyprotein/0.445
3o9aK14Pol polyprotein/0.445
3ucb017Gag-Pol polyprotein/0.445
1b6lPI4Gag-Pol polyprotein3.4.23.160.444
2psuMUUProtease/0.444
3ekx1UNGag-Pol polyprotein3.4.23.160.444
1hbvGANGag-Pol polyprotein/0.443
2r3wG3GGag-Pol polyprotein3.4.23.160.443
1msnJE2Gag-Pol polyprotein3.4.23.160.442
3d20017Gag-Pol polyprotein3.4.23.160.442
3o9hK2EGag-Pol polyprotein/0.442
4dqb017Gag-Pol polyprotein/0.442
4hla017Gag-Pol polyprotein3.4.23.160.442
1tcwIM1Gag-Pol polyprotein/0.441
3el01UNGag-Pol polyprotein3.4.23.160.441
1npvL27Gag-Pol polyprotein3.4.23.160.440
1qbsDMPGag-Pol polyprotein3.4.23.160.440
3bxrDRRGag-Pol polyprotein3.4.23.160.440
3nu6478Gag-Pol polyprotein3.4.23.160.440
4j54G52Gag-Pol polyprotein3.4.23.160.440