sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Distribution of Cavity similarities measured by Shaper

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Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
3zzn	ADP	L-lactate dehydrogenase

Complex with similar cavities

PDB ID	HET	Uniprot Name	EC Number	Cavity Similarity	Align
3zzn	ADP	L-lactate dehydrogenase	/	1.000
3h3f	NAI	L-lactate dehydrogenase A chain	1.1.1.27	0.539
4l4s	NAI	L-lactate dehydrogenase A chain	1.1.1.27	0.529
2x0i	NAI	Malate dehydrogenase	/	0.502
2a92	NAI	L-lactate dehydrogenase	/	0.492
4rls	NAI	L-lactate dehydrogenase A chain	1.1.1.27	0.482
3wsw	NAD	L-lactate dehydrogenase	/	0.477
1ez4	NAD	L-lactate dehydrogenase	1.1.1.27	0.475
3pqf	NAD	L-lactate dehydrogenase	1.1.1.27	0.468
4i1i	NAD	Malate dehydrogenase	/	0.454
1bdm	NAX	Malate dehydrogenase	/	0.447
1lbc	CYZ	Glutamate receptor 2	/	0.447
4mdh	NAD	Malate dehydrogenase, cytoplasmic	1.1.1.37	0.443
1wzi	NDP	Malate dehydrogenase	/	0.441