Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zt0 | ZT0 | Integrase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3zt0 | ZT0 | Integrase | / | 1.000 | |
| 4ck2 | NVU | Integrase | / | 0.653 | |
| 3zsr | O3N | Integrase | / | 0.649 | |
| 4cez | O3N | Integrase | / | 0.649 | |
| 4cgj | NZL | Integrase | / | 0.628 | |
| 4cea | ZSW | Integrase | / | 0.622 | |
| 4cjr | FYM | Integrase | / | 0.621 | |
| 3zsv | ZSV | Integrase | / | 0.616 | |
| 4ceb | ZSV | Integrase | / | 0.616 | |
| 4ceq | QCH | Integrase | / | 0.616 | |
| 4cig | X0P | Integrase | / | 0.611 | |
| 4cfb | OM3 | Integrase | / | 0.609 | |
| 4cgg | K5Q | Integrase | / | 0.604 | |
| 4ced | 9NS | Integrase | / | 0.600 | |
| 4cjf | RVN | Integrase | / | 0.598 | |
| 3zsw | ZSW | Integrase | / | 0.597 | |
| 4ce9 | O3N | Integrase | / | 0.592 | |
| 3zsz | OM2 | Integrase | / | 0.591 | |
| 4cgd | 8P3 | Integrase | / | 0.589 | |
| 4ceo | G0T | Integrase | / | 0.587 | |
| 3zsy | OM3 | Integrase | / | 0.584 | |
| 4cef | D0T | Integrase | / | 0.582 | |
| 4ces | NFW | Integrase | / | 0.582 | |
| 4cjp | 4D2 | Integrase | / | 0.582 | |
| 4cf8 | V7H | Integrase | / | 0.579 | |
| 4ck1 | OM1 | Integrase | / | 0.576 | |
| 4cif | JDX | Integrase | / | 0.574 | |
| 3zsq | O4N | Integrase | / | 0.572 | |
| 4cf0 | O5U | Integrase | / | 0.572 | |
| 4cf2 | 3GM | Integrase | / | 0.571 | |
| 4cfc | 7NV | Integrase | / | 0.571 | |
| 4cfa | WOP | Integrase | / | 0.570 | |
| 4ck3 | K1T | Integrase | / | 0.570 | |
| 3zt3 | ZT4 | Integrase | / | 0.569 | |
| 4chy | C5Q | Integrase | / | 0.567 | |
| 4cje | Q31 | Integrase | / | 0.567 | |
| 4cer | VL4 | Integrase | / | 0.565 | |
| 4cju | JNS | Integrase | / | 0.565 | |
| 3zcm | PX3 | Integrase | / | 0.564 | |
| 4cj3 | E4F | Integrase | / | 0.561 | |
| 4cjs | L0Y | Integrase | / | 0.561 | |
| 4cf1 | IY7 | Integrase | / | 0.558 | |
| 4cgh | LOZ | Integrase | / | 0.556 | |
| 4cfd | S8Y | Integrase | / | 0.553 | |
| 4cjk | H39 | Integrase | / | 0.552 | |
| 4cjq | VXO | Integrase | / | 0.551 | |
| 4cie | Y7N | Integrase | / | 0.548 | |
| 4chq | CWU | Integrase | / | 0.547 | |
| 4cj5 | 4VW | Integrase | / | 0.534 | |
| 4cgi | NZL | Integrase | / | 0.533 | |
| 4cec | 2SS | Integrase | / | 0.521 | |
| 3zsx | N44 | Integrase | / | 0.520 | |
| 3zt2 | ZT2 | Integrase | / | 0.519 | |
| 4cj4 | S3G | Integrase | / | 0.509 | |
| 4cee | B0T | Integrase | / | 0.505 | |
| 2nry | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.487 | |
| 4mf0 | 29Z | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.487 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.479 | |
| 5dos | ATP | Aurora kinase A | 2.7.11.1 | 0.479 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.478 | |
| 3zt1 | OM1 | Integrase | / | 0.478 | |
| 1di8 | DTQ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.476 | |
| 4bf2 | STU | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.476 | |
| 4jbq | VX6 | Aurora kinase A | 2.7.11.1 | 0.476 | |
| 1q41 | IXM | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.475 | |
| 2vti | LZ3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.475 | |
| 3uic | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.475 | |
| 2bxm | IMN | Serum albumin | / | 0.474 | |
| 2rg6 | 287 | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 3nww | 3NW | Mitogen-activated protein kinase 14 | / | 0.474 | |
| 1rfu | ADP | Pyridoxal kinase | 2.7.1.35 | 0.473 | |
| 2wxv | WXV | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.473 | |
| 1nvs | UCM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 4u97 | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.472 | |
| 4ft7 | H3K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.471 | |
| 1u54 | ACP | Activated CDC42 kinase 1 | / | 0.469 | |
| 2brm | DFZ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.469 | |
| 3r7e | X88 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.469 | |
| 4aqc | 88A | Tyrosine-protein kinase JAK2 | / | 0.469 | |
| 2rh9 | IGP | Tryptophan synthase alpha chain | / | 0.468 | |
| 4c34 | STU | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.467 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.465 | |
| 3elj | GS7 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.465 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.465 | |
| 3s2p | PMU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.465 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.464 | |
| 3ixp | 834 | Ecdysone receptor | / | 0.464 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.463 | |
| 4aot | GW8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.463 | |
| 2e9n | 76A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.462 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.462 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3f7z | 34O | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
| 3vid | 4TT | Vascular endothelial growth factor receptor 2 | 2.7.10.1 | 0.462 | |
| 4mwh | ATP | Casein kinase II subunit alpha | 2.7.11.1 | 0.462 | |
| 2np8 | CC3 | Aurora kinase A | 2.7.11.1 | 0.461 | |
| 3dhe | AND | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.461 | |
| 3qzi | X72 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.461 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.461 | |
| 1nhz | 486 | Glucocorticoid receptor | / | 0.460 | |
| 1py5 | PY1 | TGF-beta receptor type-1 | 2.7.11.30 | 0.460 | |
| 2rhg | IGP | Tryptophan synthase alpha chain | / | 0.460 | |
| 3r04 | UNQ | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.460 | |
| 4dgn | LU2 | Casein kinase II subunit alpha | 2.7.11.1 | 0.460 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.460 | |
| 2aqk | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.459 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.459 | |
| 2y9q | ANP | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.459 | |
| 3r7u | X96 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 3tuc | FPW | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.459 | |
| 4a06 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.459 | |
| 4rrv | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.459 | |
| 5drd | ATP | Aurora kinase A | 2.7.11.1 | 0.459 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 2cch | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.458 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.458 | |
| 3gob | HXX | DdmC | / | 0.458 | |
| 3gxl | QIG | TGF-beta receptor type-1 | 2.7.11.30 | 0.458 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.458 | |
| 3ttj | JBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.458 | |
| 4bdh | WVI | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.458 | |
| 4jbp | YPH | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.458 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.458 | |
| 5ack | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.458 | |
| 5dt3 | ATP | Aurora kinase A | 2.7.11.1 | 0.458 | |
| 3fkl | FKL | Mitogen-activated protein kinase 14 | / | 0.457 | |
| 3tti | KBI | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.457 | |
| 3zep | 1NX | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.457 | |
| 4ft5 | H2K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.457 | |
| 4kb8 | 1QO | Casein kinase I isoform delta | 2.7.11.1 | 0.457 | |
| 5dt4 | ATP | Aurora kinase A | 2.7.11.1 | 0.457 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 2y6o | 1N1 | Ephrin type-A receptor 4 | 2.7.10.1 | 0.456 | |
| 3be9 | P04 | Casein kinase II subunit alpha | 2.7.11.1 | 0.456 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.456 | |
| 3r6x | X84 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4ez3 | 0S0 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.456 | |
| 4nb6 | 444 | Nuclear receptor ROR-gamma | / | 0.456 | |
| 1nvq | UCN | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 1r6g | 442 | Thyroid hormone receptor beta | / | 0.455 | |
| 2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.455 | |
| 2vz6 | FEF | Calcium/calmodulin-dependent protein kinase type II subunit alpha | 2.7.11.17 | 0.455 | |
| 2x1n | X1N | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3ddq | RRC | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 3qu0 | X40 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4fv6 | E57 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.455 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.455 | |
| 1aq1 | STU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 1jtv | TES | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 1sdu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 1zem | NAD | Xylitol dehydrogenase | / | 0.454 | |
| 2bhh | RYU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 2ejv | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 2iws | NP4 | ATP-dependent molecular chaperone HSP82 | / | 0.454 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.454 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.454 | |
| 2wed | PP6 | Penicillopepsin-1 | 3.4.23.20 | 0.454 | |
| 2wih | P48 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.454 | |
| 3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.454 | |
| 3iph | G11 | Mitogen-activated protein kinase 14 | / | 0.454 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.454 | |
| 3lfq | A28 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.454 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.454 | |
| 3vtb | TKA | Vitamin D3 receptor | / | 0.454 | |
| 4l8u | 9AZ | Serum albumin | / | 0.454 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.453 | |
| 1k8y | 13P | Tryptophan synthase alpha chain | / | 0.453 | |
| 2dwb | ANP | Aurora kinase A | 2.7.11.1 | 0.453 | |
| 2qo9 | ANP | Ephrin type-A receptor 3 | 2.7.10.1 | 0.453 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.453 | |
| 2xik | J60 | Serine/threonine-protein kinase 25 | 2.7.11.1 | 0.453 | |
| 2xnb | Y8L | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.453 | |
| 3n6u | TSU | HTH-type transcriptional regulator TsaR | / | 0.453 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.453 | |
| 3vt5 | YI2 | Vitamin D3 receptor | / | 0.453 | |
| 4bdc | ODH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.453 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.453 | |
| 4fsw | HK6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.453 | |
| 4h8n | NDP | NADPH-dependent conjugated polyketone reductase C2 | / | 0.453 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 1me8 | RVP | Inosine-5'-monophosphate dehydrogenase | / | 0.452 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
| 3fly | FLY | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 3hdm | MMG | Serine/threonine-protein kinase Sgk1 | 2.7.11.1 | 0.452 | |
| 3ma3 | 01I | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.452 | |
| 3ork | AGS | Serine/threonine protein kinase | / | 0.452 | |
| 3qzg | X67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 3rk5 | 07Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4ewq | MWL | Mitogen-activated protein kinase 14 | / | 0.452 | |
| 4fkr | 45K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.452 | |
| 4foc | 0UU | ALK tyrosine kinase receptor | 2.7.10.1 | 0.452 | |
| 4fsz | HK8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.452 | |
| 4ia3 | BIV | Vitamin D3 receptor A | / | 0.452 | |
| 4jub | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.452 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.452 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.452 | |
| 5e8w | STU | TGF-beta receptor type-1 | 2.7.11.30 | 0.452 | |
| 1bsv | NDP | GDP-L-fucose synthase | / | 0.451 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 2brg | DFY | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 3clb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.451 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.451 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.451 | |
| 3qaa | G04 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3t3c | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 4boe | CLR | Japanin | / | 0.451 | |
| 4loq | SB4 | Mitogen-activated protein kinase 14 | / | 0.451 | |
| 4qmy | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.451 | |
| 1dr2 | TAP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1j7k | ATP | Holliday junction ATP-dependent DNA helicase RuvB | / | 0.450 | |
| 2iw8 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 2ovh | AS0 | Progesterone receptor | / | 0.450 | |
| 3bfb | 9OD | Pheromone-binding protein ASP1 | / | 0.450 | |
| 3iok | 1P6 | Tyrosine-protein kinase JAK2 | / | 0.450 | |
| 3le6 | 2BZ | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 3qtq | X35 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 3vf8 | 0JE | Tyrosine-protein kinase SYK | 2.7.10.2 | 0.450 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.450 | |
| 4l4x | NDP | AmphI | / | 0.450 | |
| 4y93 | 746 | Tyrosine-protein kinase | / | 0.450 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.449 | |
| 1gzu | NMN | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | 2.7.7.1 | 0.449 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.449 | |
| 1u4d | DBQ | Activated CDC42 kinase 1 | / | 0.449 | |
| 2cgx | 3D3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.449 | |
| 2o7p | NAP | Riboflavin biosynthesis protein RibD | / | 0.449 | |
| 2wip | P49 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3dt1 | P40 | Mitogen-activated protein kinase 14 | / | 0.449 | |
| 3qwk | X62 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3vw6 | IM6 | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.449 | |
| 3zuy | TCH | Transporter | / | 0.449 | |
| 4c02 | TAK | Activin receptor type-1 | 2.7.11.30 | 0.449 | |
| 4d03 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 4i6g | FAD | Cryptochrome-2 | / | 0.449 | |
| 4qmp | DKI | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.449 | |
| 4qmz | B49 | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.449 | |
| 5dr2 | ATP | Aurora kinase A | 2.7.11.1 | 0.449 | |
| 4k5y | 1Q5 | Corticotropin-releasing factor receptor 1 | / | 0.449 | |
| 1fp2 | HMO | Isoflavone-7-O-methyltransferase 8 | 2.1.1.150 | 0.448 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.448 | |
| 1szm | BI4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.448 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.448 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3kpz | ZNE | Vitamin D3 receptor | / | 0.448 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.448 | |
| 4aw1 | ATP | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.448 | |
| 4gj3 | 0XP | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.448 | |
| 4oac | ADP | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.448 | |
| 4p8r | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.448 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.448 | |
| 5dn3 | ATP | Aurora kinase A | 2.7.11.1 | 0.448 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 1ppj | ANY | Cytochrome b | / | 0.447 | |
| 1x2h | LPA | Lipoate-protein ligase A | 6.3.1.20 | 0.447 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.447 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.447 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3ggf | GVD | Serine/threonine-protein kinase 26 | / | 0.447 | |
| 3rm6 | 18Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.447 | |
| 4dgo | 0JW | Casein kinase II subunit alpha | 2.7.11.1 | 0.447 | |
| 4fg8 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.447 | |
| 4fkw | 62K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.447 | |
| 4zca | ADP | Kinesin-like protein KIF11 | / | 0.447 | |
| 5ajq | DB8 | Serine/threonine-protein kinase 10 | 2.7.11.1 | 0.447 | |
| 1m78 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1njs | KEU | Trifunctional purine biosynthetic protein adenosine-3 | 2.1.2.2 | 0.446 | |
| 1og5 | SWF | Cytochrome P450 2C9 | / | 0.446 | |
| 1ol7 | ADP | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 1qy5 | NEC | Endoplasmin | / | 0.446 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.446 | |
| 2brb | PFQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.446 | |
| 2oax | SNL | Mineralocorticoid receptor | / | 0.446 | |
| 2w1f | L0F | Aurora kinase A | 2.7.11.1 | 0.446 | |
| 3d84 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3mfs | ANP | Peripheral plasma membrane protein CASK | 2.7.11.1 | 0.446 | |
| 3nug | NAD | Pyridoxal 4-dehydrogenase | 1.1.1.107 | 0.446 | |
| 3r8l | Z30 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3sw4 | 18K | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 3vt3 | VDX | Vitamin D3 receptor | / | 0.446 | |
| 4bgh | 3I6 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
| 4fg9 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.446 | |
| 4gii | 0X6 | Non-receptor tyrosine-protein kinase TYK2 | 2.7.10.2 | 0.446 | |
| 4hvi | 19S | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.446 | |
| 5dp2 | NAP | CurF | / | 0.446 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.445 | |
| 1bdq | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.445 | |
| 2exc | JNK | Mitogen-activated protein kinase 10 | 2.7.11.24 | 0.445 | |
| 2o65 | MYF | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
| 2wmx | ZY6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 2y5s | 78H | Dihydropteroate synthase | / | 0.445 | |
| 3ekv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.445 | |
| 3ral | 04Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
| 3vt7 | VDX | Vitamin D3 receptor | / | 0.445 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.445 | |
| 4fod | 0UV | ALK tyrosine kinase receptor | 2.7.10.1 | 0.445 | |
| 4ia7 | BIV | Vitamin D3 receptor A | / | 0.445 | |
| 4q72 | FAD | Bifunctional protein PutA | / | 0.445 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.444 | |
| 1o6y | ACP | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.444 | |
| 1phh | FAD | p-hydroxybenzoate hydroxylase | / | 0.444 | |
| 1xjd | STU | Protein kinase C theta type | 2.7.11.13 | 0.444 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.444 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.444 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.444 | |
| 2pzi | AXX | Serine/threonine-protein kinase PknG | 2.7.11.1 | 0.444 | |
| 2wec | PP5 | Penicillopepsin-1 | 3.4.23.20 | 0.444 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.444 | |
| 3a7j | ADP | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.444 | |
| 3fr8 | NDP | Ketol-acid reductoisomerase, chloroplastic | 1.1.1.86 | 0.444 | |
| 3g5q | FAD | Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO | / | 0.444 | |
| 3r1q | X75 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3rk9 | 09Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.444 | |
| 3uxh | UXH | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.444 | |
| 3w55 | 1FM | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.444 | |
| 4rrh | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.444 | |
| 4wdb | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.444 | |
| 1e7q | NAP | GDP-L-fucose synthase | / | 0.443 | |
| 1lp4 | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1zrz | BI1 | Protein kinase C iota type | 2.7.11.13 | 0.443 | |
| 2brh | DFW | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2chx | 090 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.443 | |
| 2emu | SAH | Diphthine synthase | / | 0.443 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 2wmt | ZYT | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2xa4 | AZ5 | Tyrosine-protein kinase JAK2 | / | 0.443 | |
| 2ym5 | YM5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2ym8 | YM8 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2z54 | AB1 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3cd3 | STU | Tyrosine-protein kinase Fes/Fps | 2.7.10.2 | 0.443 | |
| 3d75 | NBB | Pheromone-binding protein ASP1 | / | 0.443 | |
| 3ics | COA | Coenzyme A disulfide reductase | / | 0.443 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.443 | |
| 3m42 | HGF | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.443 | |
| 3pjc | PJC | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.443 | |
| 3qxo | X65 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 3rbq | GLY_ALA_GLY_DAO | Protein unc-119 homolog A | / | 0.443 | |
| 3s56 | ROC | Protease | / | 0.443 | |
| 3up0 | D7S | aceDAF-12 | / | 0.443 | |
| 3vt8 | YI3 | Vitamin D3 receptor | / | 0.443 | |
| 4a6n | FAD | TetX family tetracycline inactivation enzyme | / | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.443 | |
| 4eh9 | IRG | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 4l7f | 1V5 | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.443 | |
| 4ruj | VDX | Vitamin D3 receptor A | / | 0.443 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.443 | |
| 1e9h | INR | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1hpv | 478 | Gag-Pol polyprotein | / | 0.442 | |
| 1ia3 | TQ5 | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1p2a | 5BN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 1qcf | PP1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.442 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.442 | |
| 2ceo | T44 | Thyroxine-binding globulin | / | 0.442 | |
| 2hcd | BIV | Vitamin D3 receptor A | / | 0.442 | |
| 2hy8 | 1ST | Serine/threonine-protein kinase PAK 1 | 2.7.11.1 | 0.442 | |
| 2ijg | FAD | Cryptochrome DASH, chloroplastic/mitochondrial | / | 0.442 | |
| 2q9f | C3S | Cholesterol 24-hydroxylase | / | 0.442 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 2rio | ADP | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.442 | |
| 2v9j | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.442 | |
| 2wmu | ZYU | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
| 2xch | CKG | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3a60 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.442 | |
| 3ddp | RC8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.442 | |
| 3k5u | PFQ | Aurora kinase A | 2.7.11.1 | 0.442 | |
| 3kga | LX9 | MAP kinase-activated protein kinase 2 | 2.7.11.1 | 0.442 | |
| 3qd4 | 3Q6 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.442 | |
| 3rpv | 26Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
| 4bcr | WY1 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 4ix4 | ADP | Uncharacterized protein | / | 0.442 | |
| 4ix6 | ADP | Uncharacterized protein | / | 0.442 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.442 | |
| 4qmx | H8H | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.442 | |
| 4r8q | ADP | Mitotic checkpoint serine/threonine-protein kinase BUB1 | 2.7.11.1 | 0.442 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 1gij | 2PU | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 1hsh | MK1 | Gag-Pol polyprotein | / | 0.441 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1pzh | NAD | Lactate dehydrogenase | / | 0.441 | |
| 2e9o | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2e9u | A25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2hl2 | SSA | Threonine--tRNA ligase | 6.1.1.3 | 0.441 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 2iw9 | 4SP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.441 | |
| 2q70 | DC8 | Estrogen receptor | / | 0.441 | |
| 2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.441 | |
| 2xrw | ANP | Mitogen-activated protein kinase 8 | 2.7.11.24 | 0.441 | |
| 2ym3 | YM3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3a14 | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.441 | |
| 3f5p | 741 | Insulin-like growth factor 1 receptor | 2.7.10.1 | 0.441 | |
| 3i60 | E86 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.441 | |
| 3qd0 | 3Q4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
| 3tki | S25 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.441 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.441 | |
| 4dea | NHI | Aurora kinase A | 2.7.11.1 | 0.441 | |
| 4eji | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.441 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.441 | |
| 4jb1 | FAD | UDP-N-acetylenolpyruvoylglucosamine reductase | / | 0.441 | |
| 4ks8 | B49 | Serine/threonine-protein kinase PAK 6 | 2.7.11.1 | 0.441 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.441 | |
| 4v2g | ITC | Tetracycline repressor protein class D | / | 0.441 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 4z63 | ILE_THR_GLN_TYS_TYS | Phytosulfokine receptor 1 | 2.7.11.1 | 0.441 | |
| 5itz | GTP | Tubulin alpha-1B chain | / | 0.441 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.440 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.440 | |
| 1m2p | HNA | Casein kinase II subunit alpha | 2.7.11.1 | 0.440 | |
| 1oiy | N41 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1pye | PM1 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 1ung | ALH | Cyclin-dependent-like kinase 5 | 2.7.11.1 | 0.440 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 2b55 | D31 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 2igo | FAD | Pyranose 2-oxidase | / | 0.440 | |
| 2uxu | NAR | HTH-type transcriptional regulator TtgR | / | 0.440 | |
| 2w8y | 486 | Progesterone receptor | / | 0.440 | |
| 2xck | MH4 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.440 | |
| 2ym4 | 4YM | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 3ge1 | ADP | Glycerol kinase | / | 0.440 | |
| 3r9h | Z67 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 3t2z | FAD | Sulfide-quinone reductase | / | 0.440 | |
| 3tqa | NDP | Dihydrofolate reductase | / | 0.440 | |
| 3uli | 1N3 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.440 | |
| 4dqu | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.440 | |
| 4kip | 1R9 | Mitogen-activated protein kinase 14 | / | 0.440 | |
| 4m87 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.440 | |
| 4nfn | 2KC | Tau-tubulin kinase 1 | 2.7.11.1 | 0.440 | |
| 4o4f | ATP | Kinase | / | 0.440 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.440 | |
| 5dpv | SKE | Aurora kinase A | 2.7.11.1 | 0.440 |