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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zsh469Mitogen-activated protein kinase 14

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zsh469Mitogen-activated protein kinase 14/1.000
3hub469Mitogen-activated protein kinase 14/0.512
3fl4FL4Mitogen-activated protein kinase 14/0.507
3fknFKNMitogen-activated protein kinase 14/0.484
2gfsPQBMitogen-activated protein kinase 14/0.476
3ds6A17Mitogen-activated protein kinase 14/0.475
3fkoFKOMitogen-activated protein kinase 14/0.470
1zzlTZYMitogen-activated protein kinase 14/0.464
3hng8STVascular endothelial growth factor receptor 12.7.10.10.462
3mpaSB2Mitogen-activated protein kinase 14/0.460
3itzP66Mitogen-activated protein kinase 14/0.459
3lfbZ87Mitogen-activated protein kinase 14/0.457
3hp552PMitogen-activated protein kinase 14/0.456
3vnt0JAVascular endothelial growth factor receptor 22.7.10.10.453
4aseAV9Vascular endothelial growth factor receptor 22.7.10.10.451
3efl706Vascular endothelial growth factor receptor 22.7.10.10.444
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.443
2xir00JVascular endothelial growth factor receptor 22.7.10.10.442