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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.261.000
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.723
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.618
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.612
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.600
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.596
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.593
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.579
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.566
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.565
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.558
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.556
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.555
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.554
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.553
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.538
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.537
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.535
3du8553Glycogen synthase kinase-3 beta2.7.11.260.535
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.533
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.529
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.529
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.528
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.525
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.525
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.522
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.519
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.517
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.516
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.514
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.514
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.512
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.510
2i0ePDSProtein kinase C beta type2.7.11.130.510
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.510
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.509
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.507
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.505
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.501
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.500
3eb0DRKUncharacterized protein/0.495
2hog710Serine/threonine-protein kinase Chk12.7.11.10.492
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.491
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.489
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.489
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.489
3zh8C58Protein kinase C iota type2.7.11.130.487
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.486
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.486
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.485
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.482
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.482
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.479
3vf9477Tyrosine-protein kinase SYK2.7.10.20.479
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.478
5dr9SKEAurora kinase A2.7.11.10.478
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.476
2vd5BI8Myotonin-protein kinase2.7.11.10.475
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.475
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.475
4o0wADNAurora kinase A2.7.11.10.475
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.475
4wboANWRhodopsin kinase/0.475
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.474
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.474
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.474
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.473
2cchATPCyclin-dependent kinase 22.7.11.220.472
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.472
2xp2VGHALK tyrosine kinase receptor2.7.10.10.472
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.472
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.472
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.471
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.470
4qmySTUSerine/threonine-protein kinase 242.7.11.10.470
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.469
1zrzBI1Protein kinase C iota type2.7.11.130.468
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.467
3zep1NXTyrosine-protein kinase JAK32.7.10.20.466
4c62XWWTyrosine-protein kinase JAK2/0.466
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2itpAEEEpidermal growth factor receptor2.7.10.10.464
2itqITQEpidermal growth factor receptor2.7.10.10.464
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.463
4bchT7ZCyclin-dependent kinase 92.7.11.220.463
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.463
4hvh19RTyrosine-protein kinase JAK32.7.10.20.463
4jrvKJVEpidermal growth factor receptor2.7.10.10.463
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.462
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.462
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.462
4jboWPHAurora kinase A2.7.11.10.462
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.462
1m17AQ4Epidermal growth factor receptor2.7.10.10.461
3a62STURibosomal protein S6 kinase beta-12.7.11.10.461
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.461
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.460
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.460
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.460
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.460
4bgg844Activin receptor type-12.7.11.300.460
4i22IREEpidermal growth factor receptor2.7.10.10.460
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.459
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.458
3cxw7CPSerine/threonine-protein kinase pim-12.7.11.10.458
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.458
3juqAJDPhenazine biosynthesis protein A/B/0.458
3mtfA3FActivin receptor type-12.7.11.300.458
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.458
4nj32KDCyclin-dependent kinase 22.7.11.220.458
2xa4AZ5Tyrosine-protein kinase JAK2/0.457
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.457
4fob0USALK tyrosine kinase receptor2.7.10.10.457
4fyn0VETyrosine-protein kinase SYK2.7.10.20.457
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.456
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.455
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.455
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.455
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.454
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.454
1ouk084Mitogen-activated protein kinase 14/0.453
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.453
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.453
3oom507Activin receptor type-12.7.11.300.453
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.453
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.452
2ittAEEEpidermal growth factor receptor2.7.10.10.452
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.452
4dgmAGICasein kinase II subunit alpha2.7.11.10.451
1ykdCMPAdenylate cyclase/0.450
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.450
3a60STURibosomal protein S6 kinase beta-12.7.11.10.450
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.450
4oacADPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.450
2brbPFQSerine/threonine-protein kinase Chk12.7.11.10.449
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.449
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4bcqTJFCyclin-dependent kinase 22.7.11.220.449
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.449
4j97ACPFibroblast growth factor receptor 2/0.449
4jbpYPHAurora kinase A2.7.11.10.449
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.449
4riyADPEpidermal growth factor receptor2.7.10.10.449
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.448
4ccbOFGALK tyrosine kinase receptor2.7.10.10.448
4cd0AWJALK tyrosine kinase receptor2.7.10.10.448
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.447
2chlDKICasein kinase I isoform gamma-32.7.11.10.447
2i40BLZCyclin-dependent kinase 22.7.11.220.447
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.447
3blrCPBCyclin-dependent kinase 92.7.11.220.447
3emg685Tyrosine-protein kinase SYK2.7.10.20.447
3hllI45Mitogen-activated protein kinase 14/0.447
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.447
4jia1K3Tyrosine-protein kinase JAK2/0.447
1pjcNADAlanine dehydrogenase/0.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.446
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.446
3oroAGSSerine/threonine protein kinase/0.446
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.445
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.444
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.444
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1di8DTQCyclin-dependent kinase 22.7.11.220.443
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4b99R4LMitogen-activated protein kinase 72.7.11.240.443
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.443
4hvi19STyrosine-protein kinase JAK32.7.10.20.443
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.443
4qnaX11Serine/threonine-protein kinase 242.7.11.10.443
2b7aIZATyrosine-protein kinase JAK2/0.442
2pvnP63Casein kinase II subunit alpha2.7.11.10.442
2wxvWXVCyclin-dependent kinase 22.7.11.220.442
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.442
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.442
4c9pCAMCytochrome P450/0.442
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.442
5cp4CAMCamphor 5-monooxygenase1.14.15.10.442
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2jedLG8Protein kinase C theta type2.7.11.130.441
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2w05FRTCyclin-dependent kinase 22.7.11.220.441
2wipP49Cyclin-dependent kinase 22.7.11.220.441
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
4g2fC07Ephrin type-A receptor 32.7.10.10.441
4hyu1BKMitogen-activated protein kinase 82.7.11.240.441
4l9i8PRRhodopsin kinase/0.441
4q73FADBifunctional protein PutA/0.441
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.440
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.440
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.440
2xru400Aurora kinase A2.7.11.10.440
3tucFPWTyrosine-protein kinase SYK2.7.10.20.440
4bcmT7ZCyclin-dependent kinase 22.7.11.220.440
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
4cztCPSCBL-interacting serine/threonine-protein kinase 232.7.11.10.440