sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3zos | 0LI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3zos | 0LI | Epithelial discoidin domain-containing receptor 1 | 2.7.10.1 | 1.000 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.461 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.459 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.457 | |
| 3h0a | D30 | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 3t1t | GDP | Probable gliding protein mglA | / | 0.455 | |
| 4xgi | NAD | Glutamate dehydrogenase | / | 0.455 | |
| 1a72 | PAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.453 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.452 | |
| 4kne | 1CY | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1uyr | D1L | Acetyl-CoA carboxylase | / | 0.448 | |
| 2aaz | CB3 | Thymidylate synthase | 2.1.1.45 | 0.447 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.447 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.446 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.446 | |
| 3pgq | GY3 | Acetyl-CoA carboxylase | / | 0.446 | |
| 4ktf | 1TM | Cytochrome P450 | / | 0.446 | |
| 3t2k | FAD | Sulfide-quinone reductase | / | 0.445 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.445 | |
| 4jbi | NDP | Alcohol dehydrogenase (Zinc) | / | 0.445 | |
| 4kuh | CAA | 3-hydroxybutyryl-CoA dehydrogenase | / | 0.445 | |
| 4njs | G08 | Protease | / | 0.445 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.444 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 2i4x | KGQ | Protease | / | 0.443 | |
| 4em9 | TCE | Peroxisome proliferator-activated receptor gamma | / | 0.442 | |
| 1u2d | NAD | NAD(P) transhydrogenase subunit alpha part 1 | 1.6.1.2 | 0.441 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.441 | |
| 4cd2 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 4feh | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.441 | |
| 1u7t | TDT | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.440 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.440 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.440 | |
| 4klr | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 4z34 | ON7 | Lysophosphatidic acid receptor 1 | / | 0.440 |