sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3znc | BZ1 | Carbonic anhydrase 4 | 4.2.1.1 | 1.000 | |
| 3kig | DA4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.623 | |
| 3dcs | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.621 | |
| 5flt | VJJ | Carbonic anhydrase 2 | 4.2.1.1 | 0.612 | |
| 3k2f | NKX | Carbonic anhydrase 2 | 4.2.1.1 | 0.605 | |
| 3dc3 | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.604 | |
| 2eu3 | FF3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.603 | |
| 3b4f | TUO | Carbonic anhydrase 2 | 4.2.1.1 | 0.602 | |
| 1if6 | FBU | Carbonic anhydrase 2 | 4.2.1.1 | 0.600 | |
| 1bnn | AL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.595 | |
| 1g1d | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 1zsb | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 3igp | DT7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.593 | |
| 1i91 | INQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 1if5 | FBT | Carbonic anhydrase 2 | 4.2.1.1 | 0.592 | |
| 1jd0 | AZM | Carbonic anhydrase 12 | 4.2.1.1 | 0.592 | |
| 3qyk | IE2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.591 | |
| 1bn4 | AL9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 1i9m | INW | Carbonic anhydrase 2 | 4.2.1.1 | 0.590 | |
| 3f7u | AG4 | Carbonic anhydrase 4 | 4.2.1.1 | 0.590 | |
| 4x5s | AZM | Carbonic anhydrase (Carbonate dehydratase) | / | 0.590 | |
| 1g52 | F2B | Carbonic anhydrase 2 | 4.2.1.1 | 0.587 | |
| 1bnt | AL2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 1i90 | INM | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3bet | CTF | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3m98 | E02 | Carbonic anhydrase 2 | 4.2.1.1 | 0.586 | |
| 3f4x | KLT | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 3m67 | E36 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 4m2r | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.584 | |
| 1bnw | TPD | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 3po6 | DT9 | Carbonic anhydrase 2 | 4.2.1.1 | 0.583 | |
| 2weh | FB1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.582 | |
| 1bnq | AL4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 3m5e | JDR | Carbonic anhydrase 2 | 4.2.1.1 | 0.581 | |
| 1cil | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.580 | |
| 4lu3 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.580 | |
| 2h15 | B19 | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 2weo | FBW | Carbonic anhydrase 2 | 4.2.1.1 | 0.579 | |
| 3m2n | J74 | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 4kap | 1QV | Carbonic anhydrase 2 | 4.2.1.1 | 0.578 | |
| 1xq0 | 4TR | Carbonic anhydrase 2 | 4.2.1.1 | 0.576 | |
| 3eft | 3BS | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 3s9t | E49 | Carbonic anhydrase 2 | 4.2.1.1 | 0.575 | |
| 4itp | 1GD | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 4k13 | ETS | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 4m2v | BZ1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.574 | |
| 1okl | MNS | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 3daz | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 4ilx | 1EZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.573 | |
| 3mdz | EZL | Carbonic anhydrase 7 | 4.2.1.1 | 0.572 | |
| 1bn1 | AL5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 1if4 | FBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 1if8 | SBS | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 1ttm | 667 | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 4kni | E1E | Carbonic anhydrase 2 | 4.2.1.1 | 0.571 | |
| 3ffp | LC1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 3m2y | BE0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.570 | |
| 1i9q | IOF | Carbonic anhydrase 2 | 4.2.1.1 | 0.569 | |
| 3fw3 | ETS | Carbonic anhydrase 4 | 4.2.1.1 | 0.568 | |
| 4ito | MPX | Carbonic anhydrase 2 | 4.2.1.1 | 0.568 | |
| 1bn3 | AL6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 2x7t | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 4iwz | 1GO | Carbonic anhydrase 2 | 4.2.1.1 | 0.567 | |
| 3oim | VZ5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.566 | |
| 3sbi | E90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.565 | |
| 1g4o | BSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.562 | |
| 3mzc | S6I | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 3sbh | E65 | Carbonic anhydrase 2 | 4.2.1.1 | 0.560 | |
| 3myq | E27 | Carbonic anhydrase 2 | 4.2.1.1 | 0.559 | |
| 4kp8 | E1G | Carbonic anhydrase 12 | 4.2.1.1 | 0.559 | |
| 1g45 | FSB | Carbonic anhydrase 2 | 4.2.1.1 | 0.558 | |
| 1kwq | SG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.558 | |
| 3t84 | SG6 | Carbonic anhydrase 2 | 4.2.1.1 | 0.557 | |
| 1bnm | AL8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 2h4n | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 3oys | OYS | Carbonic anhydrase 2 | 4.2.1.1 | 0.555 | |
| 3ml2 | SU0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 3n2p | AYX | Carbonic anhydrase 2 | 4.2.1.1 | 0.553 | |
| 4kp5 | E1F | Carbonic anhydrase 12 | 4.2.1.1 | 0.553 | |
| 3s8x | E59 | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 3sax | E50 | Carbonic anhydrase 2 | 4.2.1.1 | 0.552 | |
| 4pxx | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.551 | |
| 3nb5 | R21 | Carbonic anhydrase 2 | 4.2.1.1 | 0.550 | |
| 1g4j | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.549 | |
| 3d9z | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.549 | |
| 1g54 | FFB | Carbonic anhydrase 2 | 4.2.1.1 | 0.548 | |
| 1i9n | IOA | Carbonic anhydrase 2 | 4.2.1.1 | 0.548 | |
| 1oq5 | CEL | Carbonic anhydrase 2 | 4.2.1.1 | 0.547 | |
| 1okn | STB | Carbonic anhydrase 2 | 4.2.1.1 | 0.546 | |
| 1bnv | AL7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 1i8z | INL | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 3mhi | J90 | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 3t82 | SG4 | Carbonic anhydrase 2 | 4.2.1.1 | 0.545 | |
| 3dd8 | 2C7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.544 | |
| 1xpz | 4TZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 3m40 | J45 | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 3n4b | WWZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.543 | |
| 3mho | J43 | Carbonic anhydrase 2 | 4.2.1.1 | 0.542 | |
| 1kwr | SG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 2weg | FBV | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 3hku | TOR | Carbonic anhydrase 2 | 4.2.1.1 | 0.539 | |
| 3mmf | D9H | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 4bf6 | X0Q | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 4n16 | CHD | Carbonic anhydrase 2 | 4.2.1.1 | 0.538 | |
| 3mna | DWH | Carbonic anhydrase 2 | 4.2.1.1 | 0.536 | |
| 2wej | FB2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 3ni5 | C1H | Carbonic anhydrase 2 | 4.2.1.1 | 0.535 | |
| 4uov | AZM | Carbonate dehydratase | / | 0.535 | |
| 3f7b | AG5 | Carbonic anhydrase 4 | 4.2.1.1 | 0.533 | |
| 3n0n | P9B | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3n3j | WWV | Carbonic anhydrase 2 | 4.2.1.1 | 0.533 | |
| 3mhl | J71 | Carbonic anhydrase 2 | 4.2.1.1 | 0.529 | |
| 4ht2 | V50 | Carbonic anhydrase 12 | 4.2.1.1 | 0.526 | |
| 3m96 | E38 | Carbonic anhydrase 2 | 4.2.1.1 | 0.525 | |
| 2x7u | WZA | Carbonic anhydrase 2 | 4.2.1.1 | 0.523 | |
| 4knj | E1F | Carbonic anhydrase 2 | 4.2.1.1 | 0.523 | |
| 2wd2 | MS5 | Carbonic anhydrase 2 | 4.2.1.1 | 0.519 | |
| 3bl1 | BL1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.516 | |
| 1yda | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.515 | |
| 1cny | EG3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.512 | |
| 1cnw | EG1 | Carbonic anhydrase 2 | 4.2.1.1 | 0.511 | |
| 1if7 | SBR | Carbonic anhydrase 2 | 4.2.1.1 | 0.511 | |
| 3dd0 | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.511 | |
| 2pow | I7C | Carbonic anhydrase 2 | 4.2.1.1 | 0.510 | |
| 1okm | SAB | Carbonic anhydrase 2 | 4.2.1.1 | 0.509 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.508 | |
| 3oy0 | OY0 | Carbonic anhydrase 2 | 4.2.1.1 | 0.507 | |
| 3t85 | SG7 | Carbonic anhydrase 2 | 4.2.1.1 | 0.506 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.505 | |
| 1i9p | IOE | Carbonic anhydrase 2 | 4.2.1.1 | 0.502 | |
| 3dcc | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.501 | |
| 4k0z | MZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.501 | |
| 1rj6 | AZM | Carbonic anhydrase 14 | 4.2.1.1 | 0.500 | |
| 3zbs | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.500 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.495 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.493 | |
| 3d8w | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.493 | |
| 4knm | E1E | Carbonic anhydrase 13 | 4.2.1.1 | 0.493 | |
| 4mo8 | 2VQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.491 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.489 | |
| 4bf1 | 9FK | Carbonic anhydrase 2 | 4.2.1.1 | 0.489 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.488 | |
| 3l14 | I7B | Carbonic anhydrase 2 | 4.2.1.1 | 0.488 | |
| 1cnx | EG2 | Carbonic anhydrase 2 | 4.2.1.1 | 0.487 | |
| 3oik | WZB | Carbonic anhydrase 2 | 4.2.1.1 | 0.486 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.484 | |
| 3mhc | ARZ | Carbonic anhydrase 2 | 4.2.1.1 | 0.481 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.480 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 3oyq | OYQ | Carbonic anhydrase 2 | 4.2.1.1 | 0.478 | |
| 4l0q | NAD | Alcohol dehydrogenase class-3 | / | 0.477 | |
| 4n1g | CEI | Obelin | / | 0.477 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 1szf | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.476 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.474 | |
| 1bnu | AL3 | Carbonic anhydrase 2 | 4.2.1.1 | 0.473 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.473 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.473 | |
| 2q1q | OSP | Carbonic anhydrase 2 | 4.2.1.1 | 0.472 | |
| 1tow | CRZ | Fatty acid-binding protein, adipocyte | / | 0.471 | |
| 4yco | FMN | tRNA-dihydrouridine(16) synthase | / | 0.471 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.469 | |
| 3own | 3OX | Renin | 3.4.23.15 | 0.469 | |
| 4w5k | PLP | Aspartate aminotransferase, mitochondrial | / | 0.469 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.468 | |
| 4e2b | FMN | Dehydrogenase | / | 0.468 | |
| 1q45 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.467 | |
| 2hs6 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.467 | |
| 3dcw | EZL | Carbonic anhydrase 2 | 4.2.1.1 | 0.467 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.467 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 2hs8 | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.466 | |
| 2vyq | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.466 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.466 | |
| 1bl4 | AP1 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.465 | |
| 1dmy | AZM | Carbonic anhydrase 5A, mitochondrial | 4.2.1.1 | 0.465 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.465 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.465 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.464 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.463 | |
| 4lnb | ED5 | CaaX farnesyltransferase beta subunit Ram1 | / | 0.463 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.462 | |
| 3rz8 | RZ8 | Carbonic anhydrase 2 | 4.2.1.1 | 0.462 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.461 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.461 | |
| 3sxj | SAM | Putative methyltransferase | / | 0.461 | |
| 3v2j | AZM | Carbonic anhydrase 2 | 4.2.1.1 | 0.461 | |
| 4k0t | D9Z | Carbonic anhydrase 2 | 4.2.1.1 | 0.461 | |
| 4rp8 | ASC | Ascorbate-specific PTS system EIIC component | / | 0.461 | |
| 1n4p | CYS_VAL_ILE_LEU_GER | Geranylgeranyl transferase type-1 subunit beta | 2.5.1.59 | 0.460 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.460 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.460 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.460 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.460 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.459 | |
| 3dbu | D8W | Carbonic anhydrase 2 | 4.2.1.1 | 0.459 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.458 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.458 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4jic | FMN | GTN Reductase | / | 0.458 | |
| 1icq | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.457 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.457 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4e2d | FMN | Dehydrogenase | / | 0.457 | |
| 4iae | 1DX | Alr2278 protein | / | 0.457 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.457 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.456 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.456 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.456 | |
| 1sa4 | JAN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.456 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.456 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.456 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.456 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.455 | |
| 2a0x | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.455 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.455 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.455 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.455 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.455 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.454 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.454 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.454 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.454 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.454 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.454 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.454 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.453 | |
| 4lut | DCS | Alanine racemase | / | 0.453 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.452 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.452 | |
| 4yj2 | GTP | Tubulin alpha-1B chain | / | 0.452 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.451 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2qim | ZEA | Class 10 plant pathogenesis-related protein | / | 0.451 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.451 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.451 | |
| 2yoz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.451 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.451 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.450 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.450 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.450 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.450 | |
| 2yp0 | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.450 | |
| 3akn | 11D | Fatty acid-binding protein, intestinal | / | 0.450 | |
| 3hgo | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.450 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.449 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.449 | |
| 3b4y | F42 | F420-dependent glucose-6-phosphate dehydrogenase | / | 0.449 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3o5r | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.449 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.449 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.449 | |
| 4lzw | THM | Uridine phosphorylase | / | 0.449 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.449 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.448 | |
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 0.448 | |
| 3eks | CY9 | Actin-5C | / | 0.448 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 1ju9 | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.447 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.447 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.447 | |
| 1xva | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.447 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.447 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.447 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
| 3bj8 | COA | Diamine acetyltransferase 1 | / | 0.447 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.447 | |
| 3p82 | FMN | Pentaerythritol tetranitrate reductase | / | 0.447 | |
| 1c7o | PPG | Hemolysin | / | 0.446 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.446 | |
| 1mzc | BNE | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
| 1w34 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.446 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.446 | |
| 2g1o | 2IG | Renin | 3.4.23.15 | 0.446 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.446 | |
| 3ksq | Z96 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.446 | |
| 3nl6 | TPS | Uncharacterized protein | / | 0.446 | |
| 4bis | 8HQ | Lysine-specific demethylase 4A | 1.14.11 | 0.446 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.446 | |
| 4iah | 1DX | Alr2278 protein | / | 0.446 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.446 | |
| 5hbr | COA | Acyl-CoA synthetase (NDP forming) | / | 0.446 | |
| 1amo | FAD | NADPH--cytochrome P450 reductase | / | 0.445 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.445 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.445 | |
| 2gby | BRN | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 2xtn | GTP | GTPase IMAP family member 2 | / | 0.445 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3p80 | P80 | Pentaerythritol tetranitrate reductase | / | 0.445 | |
| 3pdq | KC6 | Lysine-specific demethylase 4A | 1.14.11 | 0.445 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.445 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.445 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.444 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.444 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.444 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.444 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.444 | |
| 1yqs | BSA | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.444 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.444 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.444 | |
| 3ewk | FAD | Sensory box histidine kinase/response regulator | / | 0.444 | |
| 3otb | DGT | Probable tRNA(His) guanylyltransferase | 2.7.7.79 | 0.444 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.444 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 6std | MS2 | Scytalone dehydratase | 4.2.1.94 | 0.444 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.443 | |
| 2g1y | 5IG | Renin | 3.4.23.15 | 0.443 | |
| 2zvc | SAH | Precorrin-3 C17-methyltransferase | / | 0.443 | |
| 3gwf | NAP | Cyclohexanone monooxygenase | / | 0.443 | |
| 3hxf | BD9 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.443 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.443 | |
| 4lay | I63 | Peptidyl-prolyl cis-trans isomerase FKBP4 | 5.2.1.8 | 0.443 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.442 | |
| 2iml | FMN | Uncharacterized protein | / | 0.442 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.442 | |
| 3c36 | KAI | Glutamate receptor ionotropic, kainate 1 | / | 0.442 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3dz4 | C8M | S-adenosylmethionine decarboxylase proenzyme | 4.1.1.50 | 0.442 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 3hgs | FMN | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.442 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.442 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.442 | |
| 3std | MQ0 | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.441 | |
| 1bvr | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 1e2n | RCA | Thymidine kinase | / | 0.441 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.441 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 3qft | FAD | NADPH--cytochrome P450 reductase | / | 0.441 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.441 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.441 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.441 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1nvt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 1udy | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 2e1z | B4P | Propionate kinase | / | 0.440 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.440 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.440 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.440 | |
| 4bfz | ZVZ | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 |