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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zewSTUEphrin type-B receptor 42.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zewSTUEphrin type-B receptor 42.7.10.11.000
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.553
2henADPEphrin type-B receptor 22.7.10.10.530
2qoqANPEphrin type-A receptor 32.7.10.10.518
2x9fX9FEphrin type-B receptor 42.7.10.10.509
2j0lANPFocal adhesion kinase 12.7.10.20.506
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.506
4gk4L90Ephrin type-A receptor 32.7.10.10.505
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.504
2qo7ANPEphrin type-A receptor 32.7.10.10.503
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.498
2yn8STUEphrin type-B receptor 42.7.10.10.497
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.495
4jia1K3Tyrosine-protein kinase JAK2/0.494
2xvdAS6Ephrin type-B receptor 42.7.10.10.492
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.491
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.491
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.490
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.483
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.478
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.478
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.477
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.475
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.475
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.473
2ijmADPFocal adhesion kinase 12.7.10.20.473
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.472
2qocANPEphrin type-A receptor 32.7.10.10.472
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.472
2j0m4STFocal adhesion kinase 12.7.10.20.469
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.468
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.467
4y93746Tyrosine-protein kinase/0.467
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.466
5dosATPAurora kinase A2.7.11.10.466
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.465
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3my5RFZCyclin-dependent kinase 22.7.11.220.462
1yvj4STTyrosine-protein kinase JAK32.7.10.20.461
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.461
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.461
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.460
3at4CCKCasein kinase II subunit alpha2.7.11.10.459
3i60E86Mitogen-activated protein kinase 12.7.11.240.459
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.459
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.459
1bygSTUTyrosine-protein kinase CSK/0.458
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.458
2yaaATPDeath-associated protein kinase 2/0.458
4bcmT7ZCyclin-dependent kinase 22.7.11.220.458
5av2KMPDeath-associated protein kinase 12.7.11.10.457
2ijmATPFocal adhesion kinase 12.7.10.20.455
3u4uLNHCasein kinase II subunit alpha2.7.11.10.455
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.455
4fv6E57Mitogen-activated protein kinase 12.7.11.240.454
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.454
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.452
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.452
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.451
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
2v7a627Tyrosine-protein kinase ABL12.7.10.20.449
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.449
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.449
4k8aK8AFocal adhesion kinase 12.7.10.20.448
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.448
2ckeIQUDeath-associated protein kinase 2/0.447
3uvqFS8Mitogen-activated protein kinase 14/0.447
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.447
4j99ACPFibroblast growth factor receptor 2/0.447
3lltANPProtein serine/threonine kinase-1/0.446
4hvi19STyrosine-protein kinase JAK32.7.10.20.446
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.445
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.444
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.444
3c4xATPRhodopsin kinase/0.443
4aqc88ATyrosine-protein kinase JAK2/0.443
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.443
4gk3L87Ephrin type-A receptor 32.7.10.10.443
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.442
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.442
4im01FVSerine/threonine-protein kinase TBK12.7.11.10.442
3nynSGVG protein-coupled receptor kinase 62.7.11.160.441
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.441
3be9P04Casein kinase II subunit alpha2.7.11.10.440
3pxkPXKFocal adhesion kinase 12.7.10.20.440
4gk2L66Ephrin type-A receptor 32.7.10.10.440