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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.261.000
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.562
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.548
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.543
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.538
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.531
3eb0DRKUncharacterized protein/0.530
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.528
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.525
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.523
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.523
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.522
3zh8C58Protein kinase C iota type2.7.11.130.518
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.514
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.511
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.508
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.508
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.507
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.505
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.503
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.500
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.497
4bgh3I6Cyclin-dependent kinase 22.7.11.220.495
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.493
1eh4IC1Casein kinase I homolog 12.7.11.10.492
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.492
1y91CT9Cyclin-dependent kinase 22.7.11.220.490
2h96893Mitogen-activated protein kinase 82.7.11.240.490
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.490
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.490
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.489
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.489
4yuqKS1Calmodulin-like domain protein kinase/0.488
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.486
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.486
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.484
4e4m0NHTyrosine-protein kinase JAK2/0.484
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.483
5dr9SKEAurora kinase A2.7.11.10.483
4dymIYZActivin receptor type-12.7.11.300.482
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.481
2btsU32Cyclin-dependent kinase 22.7.11.220.481
2evaADNMitogen-activated protein kinase kinase kinase 72.7.11.250.481
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.481
3nlb5BESerine/threonine-protein kinase Chk12.7.11.10.481
3uyt0CKCasein kinase I isoform delta2.7.11.10.481
1ke5LS1Cyclin-dependent kinase 22.7.11.220.480
2xa4AZ5Tyrosine-protein kinase JAK2/0.480
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.478
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.477
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.477
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.477
1h1s4SPCyclin-dependent kinase 22.7.11.220.476
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.476
3sheI85MAP kinase-activated protein kinase 32.7.11.10.475
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.475
3w33W19Epidermal growth factor receptor2.7.10.10.475
2hog710Serine/threonine-protein kinase Chk12.7.11.10.474
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.474
3vryB43Tyrosine-protein kinase HCK2.7.10.20.474
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.474
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.473
2zoq5IDMitogen-activated protein kinase 32.7.11.240.473
4bcoT6QCyclin-dependent kinase 22.7.11.220.473
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.473
1unlRRCCyclin-dependent-like kinase 52.7.11.10.472
2b52D42Cyclin-dependent kinase 22.7.11.220.472
3gxlQIGTGF-beta receptor type-12.7.11.300.472
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.471
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.471
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.471
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.471
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.471
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.471
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.470
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.470
3ddpRC8Cyclin-dependent kinase 22.7.11.220.469
3hx4ANPCalmodulin-domain protein kinase 1/0.469
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.469
2pvnP63Casein kinase II subunit alpha2.7.11.10.468
3du8553Glycogen synthase kinase-3 beta2.7.11.260.468
3vs3VSETyrosine-protein kinase HCK2.7.10.20.468
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.468
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.467
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.467
2vu3LZECyclin-dependent kinase 22.7.11.220.467
3hmm855TGF-beta receptor type-12.7.11.300.467
4kbk1QGCasein kinase I isoform delta2.7.11.10.467
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.467
3be9P04Casein kinase II subunit alpha2.7.11.10.466
3i60E86Mitogen-activated protein kinase 12.7.11.240.466
4qmzB49Serine/threonine-protein kinase 242.7.11.10.466
5e8xSTUTGF-beta receptor type-12.7.11.300.465
1oi9N20Cyclin-dependent kinase 22.7.11.220.464
3s2pPMUCyclin-dependent kinase 22.7.11.220.464
4eor4SPCyclin-dependent kinase 22.7.11.220.464
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.464
1ke7LS3Cyclin-dependent kinase 22.7.11.220.463
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.463
2r64740Cyclin-dependent kinase 22.7.11.220.463
3ezvEZVCyclin-dependent kinase 22.7.11.220.463
4aa4QC0Mitogen-activated protein kinase 14/0.463
4ckiADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.463
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.462
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.462
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.462
4fv6E57Mitogen-activated protein kinase 12.7.11.240.462
4lopSB4Mitogen-activated protein kinase 14/0.462
4qmpDKISerine/threonine-protein kinase 242.7.11.10.462
1h1r6CPCyclin-dependent kinase 22.7.11.220.461
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.461
3gubGUBDeath-associated protein kinase 12.7.11.10.461
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.461
4g170VNCasein kinase I isoform gamma-32.7.11.10.461
4y93746Tyrosine-protein kinase/0.461
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.460
2q9fC3SCholesterol 24-hydroxylase/0.460
2w05FRTCyclin-dependent kinase 22.7.11.220.460
3mdmFJZCholesterol 24-hydroxylase/0.460
3qtzX42Cyclin-dependent kinase 22.7.11.220.460
4c02TAKActivin receptor type-12.7.11.300.460
1ke6LS2Cyclin-dependent kinase 22.7.11.220.459
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.459
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.459
1oguST8Cyclin-dependent kinase 22.7.11.220.458
2i0y5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.458
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.458
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.458
4c62XWWTyrosine-protein kinase JAK2/0.458
4enhFVXCholesterol 24-hydroxylase/0.458
4fko20KCyclin-dependent kinase 22.7.11.220.458
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.458
1vyzN5BCyclin-dependent kinase 22.7.11.220.457
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.457
2vv9IM9Cyclin-dependent kinase 22.7.11.220.457
2x9fX9FEphrin type-B receptor 42.7.10.10.457
4egnTWOCytochrome P450/0.457
5e8ySTUTGF-beta receptor type-22.7.11.300.457
2brnDF1Serine/threonine-protein kinase Chk12.7.11.10.456
3r83Z14Cyclin-dependent kinase 22.7.11.220.456
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.456
4e730NRMitogen-activated protein kinase 82.7.11.240.456
4j97ACPFibroblast growth factor receptor 2/0.456
2wouZZFTGF-beta receptor type-12.7.11.300.455
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.455
3ddqRRCCyclin-dependent kinase 22.7.11.220.455
3rak03ZCyclin-dependent kinase 22.7.11.220.455
3sqq99ZCyclin-dependent kinase 22.7.11.220.455
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.455
4hvh19RTyrosine-protein kinase JAK32.7.10.20.455
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.455
2iw94SPCyclin-dependent kinase 22.7.11.220.454
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.454
4f650S9Fibroblast growth factor receptor 1/0.454
1oiuN76Cyclin-dependent kinase 22.7.11.220.453
1wvxBD4Death-associated protein kinase 12.7.11.10.453
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.453
2uzlC94Cyclin-dependent kinase 22.7.11.220.453
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.453
3ocpCMPcGMP-dependent protein kinase 12.7.11.120.453
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.453
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.453
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.453
4fv9E71Mitogen-activated protein kinase 12.7.11.240.453
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.453
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.453
1lsjNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.452
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.452
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.452
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.452
3a62STURibosomal protein S6 kinase beta-12.7.11.10.452
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.452
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.452
4ez50RSCyclin-dependent kinase 62.7.11.220.452
4fob0USALK tyrosine kinase receptor2.7.10.10.452
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.452
1oiyN41Cyclin-dependent kinase 22.7.11.220.451
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.451
2v7a627Tyrosine-protein kinase ABL12.7.10.20.451
3dogNNNCyclin-dependent kinase 22.7.11.220.451
4ic7ANPMitogen-activated protein kinase 72.7.11.240.451
4y8wSTRSteroid 21-hydroxylase/0.451
5e8wSTUTGF-beta receptor type-12.7.11.300.451
1zeoC01Peroxisome proliferator-activated receptor gamma/0.450
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.450
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.450
3r9oZ71Cyclin-dependent kinase 22.7.11.220.450
4gk2L66Ephrin type-A receptor 32.7.10.10.450
2a0cCK9Cyclin-dependent kinase 22.7.11.220.449
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.449
2qo9ANPEphrin type-A receptor 32.7.10.10.449
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.449
3mtfA3FActivin receptor type-12.7.11.300.449
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.449
4c9pCAMCytochrome P450/0.449
4e6d0NUTyrosine-protein kinase JAK2/0.449
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.449
4loqSB4Mitogen-activated protein kinase 14/0.449
1a59COA2-methylcitrate synthase/0.448
1fvv107Cyclin-dependent kinase 22.7.11.220.448
1gii1PUCyclin-dependent kinase 22.7.11.220.448
1r78FMDCyclin-dependent kinase 22.7.11.220.448
1zthADPRIO-type serine/threonine-protein kinase Rio12.7.11.10.448
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.448
2y6o1N1Ephrin type-A receptor 42.7.10.10.448
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.448
3qu0X40Cyclin-dependent kinase 22.7.11.220.448
4deeADPAurora kinase A2.7.11.10.448
4dgmAGICasein kinase II subunit alpha2.7.11.10.448
4fki09KCyclin-dependent kinase 22.7.11.220.448
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.447
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.447
1yvj4STTyrosine-protein kinase JAK32.7.10.20.447
2eufLQQCyclin-dependent kinase 62.7.11.220.447
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.447
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.447
3phiNDPShikimate dehydrogenase (NADP(+))/0.447
3r8lZ30Cyclin-dependent kinase 22.7.11.220.447
3rmf20ZCyclin-dependent kinase 22.7.11.220.447
4ek1CAMCamphor 5-monooxygenase1.14.15.10.447
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.447
4gk3L87Ephrin type-A receptor 32.7.10.10.447
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.447
4ux9ANPMitogen-activated protein kinase 82.7.11.240.447
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.446
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.446
2iw84SPCyclin-dependent kinase 22.7.11.220.446
2pvhP19Casein kinase II subunit alpha2.7.11.10.446
2pvmP29Casein kinase II subunit alpha2.7.11.10.446
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.446
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.446
4fyo0VFTyrosine-protein kinase SYK2.7.10.20.446
4g160VMCasein kinase I isoform gamma-32.7.11.10.446
4kip1R9Mitogen-activated protein kinase 14/0.446
1xjdSTUProtein kinase C theta type2.7.11.130.445
2dekSAHDiphthine synthase/0.445
2qocANPEphrin type-A receptor 32.7.10.10.445
2wotZZGTGF-beta receptor type-12.7.11.300.445
3qtrX36Cyclin-dependent kinase 22.7.11.220.445
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.445
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.445
4jboWPHAurora kinase A2.7.11.10.445
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.444
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.444
1rfvADPPyridoxal kinase2.7.1.350.444
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.444
2jedLG8Protein kinase C theta type2.7.11.130.444
2w06FRVCyclin-dependent kinase 22.7.11.220.444
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.444
3lqfNADGalactitol dehydrogenase/0.444
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.444
3qlrNDPDihydrofolate reductase1.5.1.30.444
3tk3CPZCytochrome P450 2B41.14.14.10.444
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.444
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4bcpT3CCyclin-dependent kinase 22.7.11.220.444
4c58824Cyclin-G-associated kinase2.7.11.10.444
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.444
4ft5H2KSerine/threonine-protein kinase Chk12.7.11.10.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
1bygSTUTyrosine-protein kinase CSK/0.443
1jpaANPEphrin type-B receptor 22.7.10.10.443
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.443
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.443
2x1nX1NCyclin-dependent kinase 22.7.11.220.443
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.443
2yn8STUEphrin type-B receptor 42.7.10.10.443
3efwAK8Aurora kinase A2.7.11.10.443
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.443
3lfnA27Cyclin-dependent kinase 22.7.11.220.443
3oibFDAPutative acyl-CoA dehydrogenase/0.443
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.443
4fod0UVALK tyrosine kinase receptor2.7.10.10.443
4iva1J5Tyrosine-protein kinase JAK2/0.443
4jldADPAdenylate kinase/0.443
4ks7X4ZSerine/threonine-protein kinase PAK 62.7.11.10.443
1v0pPVBCell division control protein 2 homolog2.7.11.220.442
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.442
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
2uzoC62Cyclin-dependent kinase 22.7.11.220.442
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.442
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.442
2yexYEXSerine/threonine-protein kinase Chk12.7.11.10.442
3hdmMMGSerine/threonine-protein kinase Sgk12.7.11.10.442
3qwkX62Cyclin-dependent kinase 22.7.11.220.442
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.442
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.442
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.442
4jkyADPAdenylate kinase/0.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.442
1o76CAMCamphor 5-monooxygenase1.14.15.10.441
2r3lSCWCyclin-dependent kinase 22.7.11.220.441
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.441
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.441
2y8lADP5'-AMP-activated protein kinase subunit gamma-1/0.441
2znnS44Peroxisome proliferator-activated receptor alpha/0.441
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.441
3lxiCAMCytochrome P450/0.441
3rni21ZCyclin-dependent kinase 22.7.11.220.441
3sw418KCyclin-dependent kinase 22.7.11.220.441
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.441
4dgnLU2Casein kinase II subunit alpha2.7.11.10.441
4nk92K5Fibroblast growth factor receptor 1/0.441
4wsqKSAAP2-associated protein kinase 12.7.11.10.441
1a8pFADFerredoxin--NADP reductase/0.440
1bzfTMQDihydrofolate reductase1.5.1.30.440
1vikBAYGag-Pol polyprotein/0.440
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.440
2qblCAMCamphor 5-monooxygenase1.14.15.10.440
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.440
3kvxFMYMitogen-activated protein kinase 102.7.11.240.440
4aua4AUCyclin-dependent kinase 62.7.11.220.440
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.440