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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3x1wGDPRas-related protein Rap-1b

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3x1wGDPRas-related protein Rap-1b/1.000
4dsuGDPGTPase KRas/0.543
4nyiGNPGTPase HRas/0.499
4dxaGSPRas-related protein Rap-1b/0.494
2gilGTPRas-related protein Rab-6A/0.490
3oivGNPGTPase HRas/0.487
3qbtGNPRas-related protein Rab-8A/0.485
3rs5GNPGTPase HRas/0.485
3kkqGDPRas-related protein M-Ras/0.474
4nyjGNPGTPase HRas/0.471
1cxzGSPTransforming protein RhoA/0.470
3v4fGNPGTPase HRas/0.469
1uadGNPRas-related protein Ral-A/0.466
3oiuGNPGTPase HRas/0.465
4dsnGCPGTPase KRas/0.465
1s1cGNPTransforming protein RhoA/0.463
4l9sGDPGTPase HRas/0.463
4dsoGSPGTPase KRas/0.460
3lbnGNPGTPase HRas/0.459
4tq9GDPGTPase KRas/0.457
1ow3GDPTransforming protein RhoA/0.455
4lhwGNPRas-related protein Rab-8A/0.453
4epwGDPGTPase KRas/0.451
3tgpGNPGTPase HRas/0.450
4q02GDPGTPase KRas/0.449
3e5hGNPRas-related protein Rab-28/0.448
4lv6GDPGTPase KRas/0.447
1z0aGDPRas-related protein Rab-2A/0.446
2rggGNPGTPase HRas/0.445
3eg5GNPCell division control protein 42 homolog/0.444
3kucGDPRas-related protein Rap-1A/0.444
1kmqGNPTransforming protein RhoA/0.443
3kkoGNPRas-related protein M-Ras/0.442
3kudGDPGTPase HRas/0.442
4l8gGDPGTPase KRas/0.442
1zc3GNPRas-related protein Ral-A/0.441
4hdqGNPRas-related protein Rap-1b/0.441