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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3wowANPCasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3wowANPCasein kinase II subunit alpha2.7.11.11.000
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.538
4grb0XGCasein kinase II subunit alpha2.7.11.10.537
3be9P04Casein kinase II subunit alpha2.7.11.10.534
3at4CCKCasein kinase II subunit alpha2.7.11.10.532
3q9xEMOCasein kinase II subunit alpha2.7.11.10.528
3axwTIDCasein kinase II subunit alpha2.7.11.10.524
2pvlP55Casein kinase II subunit alpha2.7.11.10.513
5cshATPCasein kinase II subunit alpha2.7.11.10.513
5cvhADPCasein kinase II subunit alpha2.7.11.10.511
3nga3NGCasein kinase II subunit alpha2.7.11.10.510
4jr7GNPCasein kinase II subunit alpha2.7.11.10.506
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.505
5cvfATPCasein kinase II subunit alpha2.7.11.10.504
1dawANPCasein kinase II subunit alpha2.7.11.10.503
2pvhP19Casein kinase II subunit alpha2.7.11.10.499
1pjkANPCasein kinase II subunit alpha2.7.11.10.498
4dgmAGICasein kinase II subunit alpha2.7.11.10.498
4dgo0JWCasein kinase II subunit alpha2.7.11.10.497
4dgnLU2Casein kinase II subunit alpha2.7.11.10.493
4gub0Y4Casein kinase II subunit alpha2.7.11.10.491
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.489
1dayGNPCasein kinase II subunit alpha2.7.11.10.486
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.486
3u4uLNHCasein kinase II subunit alpha2.7.11.10.486
2pvnP63Casein kinase II subunit alpha2.7.11.10.485
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.484
4ez50RSCyclin-dependent kinase 62.7.11.220.483
3nszANPCasein kinase II subunit alpha2.7.11.10.482
4lfiGNPCasein kinase II subunit alpha2.7.11.10.482
4qmlANPSerine/threonine-protein kinase 242.7.11.10.482
3at3ATKCasein kinase II subunit alpha2.7.11.10.480
3owk18ECasein kinase II subunit alpha2.7.11.10.480
5cu6ATPCasein kinase II subunit alpha2.7.11.10.480
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.479
2btsU32Cyclin-dependent kinase 22.7.11.220.478
4anmWULCasein kinase II subunit alpha2.7.11.10.478
4jqeANPCasein kinase II subunit alpha2.7.11.10.473
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.472
4ii5ADPCyclin-dependent kinase 22.7.11.220.471
4ix5ANPUncharacterized protein/0.471
1lp4ANPCasein kinase II subunit alpha2.7.11.10.470
1qmzATPCyclin-dependent kinase 22.7.11.220.465
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.465
4k33ACPFibroblast growth factor receptor 32.7.10.10.465
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.465
1m2pHNACasein kinase II subunit alpha2.7.11.10.464
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.463
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.463
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.461
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.460
1om1IQACasein kinase II subunit alpha2.7.11.10.459
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.459
4jia1K3Tyrosine-protein kinase JAK2/0.457
5auwQUEDeath-associated protein kinase 12.7.11.10.457
3okxSAMS-adenosyl-L-methionine-binding protein RPA0152/0.456
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.455
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.455
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3zxtACPDeath-associated protein kinase 12.7.11.10.453
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.452
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.451
2pywADPMethylthioribose kinase2.7.1.1000.450
3pe2E1BCasein kinase II subunit alpha2.7.11.10.450
4bcmT7ZCyclin-dependent kinase 22.7.11.220.450
2henADPEphrin type-B receptor 22.7.10.10.449
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.449
4aguD15Cyclin-dependent kinase-like 1/0.449
2hog710Serine/threonine-protein kinase Chk12.7.11.10.448
2nomDUTPoly(A) polymerase, putative/0.448
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.448
4yekTHMThymidine phosphorylase/0.448
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.447
2izrBRKCasein kinase I isoform gamma-32.7.11.10.447
3adaNADSubunit alpha of sarocosine oxidase/0.447
3rak03ZCyclin-dependent kinase 22.7.11.220.447
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.447
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.447
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.446
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.443
2w17I19Cyclin-dependent kinase 22.7.11.220.443
2zjwREFCasein kinase II subunit alpha2.7.11.10.443
3sw719KCyclin-dependent kinase 22.7.11.220.443
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
5kghACOPredicted acetyltransferase/0.443
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.442
4riyADPEpidermal growth factor receptor2.7.10.10.442
2etm7PYFocal adhesion kinase 12.7.10.20.441
3mb714ICasein kinase II subunit alpha2.7.11.10.441
3uli1N3Cyclin-dependent kinase 22.7.11.220.441
4gvjADPNon-receptor tyrosine-protein kinase TYK22.7.10.20.441
4y0xADPSerine/threonine-protein kinase PknG2.7.11.10.441
1di8DTQCyclin-dependent kinase 22.7.11.220.440
1pkdUCNCyclin-dependent kinase 22.7.11.220.440
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.440
3copADPGlycogen synthase2.4.1.210.440
3rmf20ZCyclin-dependent kinase 22.7.11.220.440
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.440
4b4oNDPEpimerase family protein SDR39U1/0.440