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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w3dATPActin, gamma-enteric smooth muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3w3dATPActin, gamma-enteric smooth muscle/1.000
1c0fATPMajor actin/0.514
4k42ADPActin, alpha skeletal muscle/0.512
3m1fATPActin, alpha skeletal muscle/0.511
3m6gATPActin, alpha skeletal muscle/0.510
1lotATPActin, alpha skeletal muscle/0.504
3ffkATPActin, alpha skeletal muscle/0.500
1h1vATPActin, alpha skeletal muscle/0.493
4pkhADPActin, alpha skeletal muscle/0.492
2a41ATPActin, alpha skeletal muscle/0.485
4jhdANPActin-5C/0.483
1kxpATPActin, alpha skeletal muscle/0.479
1mduATPActin, alpha skeletal muscle/0.473
2q36ATPActin, alpha skeletal muscle/0.471
4pkiATPActin, alpha skeletal muscle/0.471
3mn9ATPActin-5C/0.470
3mn6ATPActin-5C/0.468
4m63ATPActin-5C/0.465
3u9dATPActin, alpha skeletal muscle/0.464
3tu5ATPActin, alpha skeletal muscle/0.458
5ce3ATPActin/0.456
2v51ATPActin, alpha skeletal muscle/0.445
1ijjATPActin, alpha skeletal muscle/0.440