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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vs6VSHTyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vs6VSHTyrosine-protein kinase HCK2.7.10.21.000
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.663
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.634
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.624
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.606
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.603
3vryB43Tyrosine-protein kinase HCK2.7.10.20.603
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.592
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.592
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.591
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.586
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.573
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.570
4y93746Tyrosine-protein kinase/0.567
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.563
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.556
4hjoAQ4Epidermal growth factor receptor2.7.10.10.555
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.549
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.541
3w33W19Epidermal growth factor receptor2.7.10.10.541
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.530
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.527
1bygSTUTyrosine-protein kinase CSK/0.525
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.524
1xkkFMMEpidermal growth factor receptor2.7.10.10.522
4i22IREEpidermal growth factor receptor2.7.10.10.517
4id71G0Activated CDC42 kinase 1/0.517
4y95746Tyrosine-protein kinase/0.516
2hk51BMTyrosine-protein kinase HCK2.7.10.20.515
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.511
2gs7ANPEpidermal growth factor receptor2.7.10.10.508
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.507
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.504
2of4979Tyrosine-protein kinase Lck2.7.10.20.503
3l8p0CEAngiopoietin-1 receptor2.7.10.10.501
3ttjJBIMitogen-activated protein kinase 102.7.11.240.500
4nka2K7Fibroblast growth factor receptor 1/0.499
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.499
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.498
2c6eHPMAurora kinase A2.7.11.10.491
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.491
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.490
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.490
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
4nk92K5Fibroblast growth factor receptor 1/0.487
3uvqFS8Mitogen-activated protein kinase 14/0.486
5aaaVGHALK tyrosine kinase receptor2.7.10.10.485
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.484
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.483
2itnANPEpidermal growth factor receptor2.7.10.10.483
2of2547Tyrosine-protein kinase Lck2.7.10.20.483
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.483
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.483
3w18N13Aurora kinase A2.7.11.10.482
4pd6URINucleoside permease/0.482
3poz03PEpidermal growth factor receptor2.7.10.10.481
4aotGW8Serine/threonine-protein kinase 102.7.11.10.481
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.480
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.478
2w05FRTCyclin-dependent kinase 22.7.11.220.477
4erwSTUCyclin-dependent kinase 22.7.11.220.477
3w2sW2REpidermal growth factor receptor2.7.10.10.476
4gk2L66Ephrin type-A receptor 32.7.10.10.476
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.475
1osvCHCBile acid receptor/0.474
3a60STURibosomal protein S6 kinase beta-12.7.11.10.474
4c62XWWTyrosine-protein kinase JAK2/0.474
5e8wSTUTGF-beta receptor type-12.7.11.300.474
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.473
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.471
4fob0USALK tyrosine kinase receptor2.7.10.10.470
4g1wG1WMitogen-activated protein kinase 82.7.11.240.470
4riyADPEpidermal growth factor receptor2.7.10.10.470
2c3qGTXGlutathione S-transferase theta-12.5.1.180.468
3ac2KSETyrosine-protein kinase Lck2.7.10.20.468
4hvh19RTyrosine-protein kinase JAK32.7.10.20.468
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.467
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.467
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
1ot7CHCBile acid receptor/0.466
1u54ACPActivated CDC42 kinase 1/0.466
2wotZZGTGF-beta receptor type-12.7.11.300.466
3ds6A17Mitogen-activated protein kinase 14/0.466
4k2xFADPolyketide oxygenase/hydroxylase/0.466
4kip1R9Mitogen-activated protein kinase 14/0.466
1idb0DOGag-Pol polyprotein/0.465
1rw8580TGF-beta receptor type-12.7.11.300.465
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.465
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.465
3ogqAB1Pol polyprotein/0.465
2cig1DGDihydrofolate reductase1.5.1.30.464
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.464
3fln3FNMitogen-activated protein kinase 14/0.464
4b99R4LMitogen-activated protein kinase 72.7.11.240.464
4c61LMMTyrosine-protein kinase JAK2/0.464
4gmy0X5Tyrosine-protein kinase JAK2/0.464
4wa9AXITyrosine-protein kinase ABL12.7.10.20.464
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.464
3r9dX6BCyclin-dependent kinase 22.7.11.220.463
3mg3ECHOrange carotenoid-binding protein/0.462
3oom507Activin receptor type-12.7.11.300.462
3s4qNK0Mitogen-activated protein kinase 14/0.462
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.462
1mesDMPGag-Pol polyprotein3.4.23.160.461
3gxlQIGTGF-beta receptor type-12.7.11.300.461
3vjoANPEpidermal growth factor receptor2.7.10.10.461
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.461
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.460
2vwz7X6Ephrin type-B receptor 42.7.10.10.460
3le62BZCyclin-dependent kinase 22.7.11.220.460
4aa5NQBMitogen-activated protein kinase 14/0.460
4anqVGHALK tyrosine kinase receptor2.7.10.10.460
4hge15VTyrosine-protein kinase JAK2/0.460
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.459
2znq401Peroxisome proliferator-activated receptor delta/0.459
3icrCOACoenzyme A disulfide reductase/0.459
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.459
3tmz06XCytochrome P450 2B41.14.14.10.459
3w2cN15Aurora kinase A2.7.11.10.459
2itqITQEpidermal growth factor receptor2.7.10.10.458
3l9hEMQKinesin-like protein KIF11/0.458
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.458
4ansVGHALK tyrosine kinase receptor2.7.10.10.458
4idv13VMitogen-activated protein kinase kinase kinase 142.7.11.250.458
4kiq1RAMitogen-activated protein kinase 14/0.458
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.458
1bveDMPGag-Pol polyprotein3.4.23.160.457
2xp2VGHALK tyrosine kinase receptor2.7.10.10.457
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.457
3hp552PMitogen-activated protein kinase 14/0.457
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.457
2pwlACPFibroblast growth factor receptor 2/0.456
2vwx7X4Ephrin type-B receptor 42.7.10.10.456
2vx07X7Ephrin type-B receptor 42.7.10.10.456
2yfxVGHALK tyrosine kinase receptor2.7.10.10.456
3gc9B45Mitogen-activated protein kinase 112.7.11.240.456
4kl9NDPDihydrofolate reductase1.5.1.30.456
2y00Y01Beta-1 adrenergic receptor/0.455
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.455
5e8jSAHmRNA cap guanine-N7 methyltransferase2.1.1.560.455
1iyzNDPProbable quinone oxidoreductase/0.454
1u4dDBQActivated CDC42 kinase 1/0.454
2nu9COASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.454
4kz01UJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.454
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.454
2eb3ANPEpidermal growth factor receptor2.7.10.10.453
2p33J07Mitogen-activated protein kinase 102.7.11.240.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
4z35ON9Lysophosphatidic acid receptor 1/0.453
1bvgDMPGag-Pol polyprotein3.4.23.160.452
1y5rC0RCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.452
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.452
3fskRO6Mitogen-activated protein kinase 14/0.452
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.452
4nks2M2Fibroblast growth factor receptor 1/0.452
4yuqKS1Calmodulin-like domain protein kinase/0.452
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.451
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.451
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.451
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.451
3fklFKLMitogen-activated protein kinase 14/0.451
4c4g7RODual specificity protein kinase TTK2.7.12.10.451
4gk4L90Ephrin type-A receptor 32.7.10.10.451
1hpoUNIGag-Pol polyprotein3.4.23.160.450
2gr1FADFerredoxin reductase/0.450
3iphG11Mitogen-activated protein kinase 14/0.450
4a6bQG8Gag-Pol polyprotein3.4.23.160.450
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.450
1dkfBMSRetinoic acid receptor alpha/0.449
1ot7IU5Bile acid receptor/0.449
1zmdNAIDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.449
3bqr4RBDeath-associated protein kinase 3/0.449
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.449
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.449
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.449
2bfyH1NAurora kinase B-A2.7.11.10.448
2j9mPY8Cyclin-dependent kinase 22.7.11.220.448
2r64740Cyclin-dependent kinase 22.7.11.220.448
3flwFLWMitogen-activated protein kinase 14/0.448
3nww3NWMitogen-activated protein kinase 14/0.448
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.448
4tuvCPZCytochrome P450 1191.140.448
4xldBRLPeroxisome proliferator-activated receptor gamma/0.448
4xumIMNPeroxisome proliferator-activated receptor gamma/0.448
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.448
5e8xSTUTGF-beta receptor type-12.7.11.300.448
1gih1PUCyclin-dependent kinase 22.7.11.220.447
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.447
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.447
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.447
2hnzPC0Gag-Pol polyprotein2.7.7.490.447
2ittAEEEpidermal growth factor receptor2.7.10.10.447
2yaaATPDeath-associated protein kinase 2/0.447
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.447
3b70NAPEnoyl reductase LovC10.447
3gu7ADPDeath-associated protein kinase 12.7.11.10.447
4aa4QC0Mitogen-activated protein kinase 14/0.447
4cd0AWJALK tyrosine kinase receptor2.7.10.10.447
4mxaBK7Calmodulin-like domain protein kinase isoenzyme gamma, related/0.447
1ai9NDPDihydrofolate reductase1.5.1.30.446
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.446
1qbsDMPGag-Pol polyprotein3.4.23.160.446
2j7t274Serine/threonine-protein kinase 102.7.11.10.446
2vww7X2Ephrin type-B receptor 42.7.10.10.446
2znnS44Peroxisome proliferator-activated receptor alpha/0.446
3axwTIDCasein kinase II subunit alpha2.7.11.10.446
3ol5SAWCamphor 5-monooxygenase1.14.15.10.446
4bb432WEphrin type-B receptor 42.7.10.10.446
4jv81M1Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.446
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.445
1zemNADXylitol dehydrogenase/0.445
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.445
3iaeD7KBenzaldehyde lyase/0.445
3nx4NAPPutative oxidoreductase/0.445
3pgqGY3Acetyl-CoA carboxylase/0.445
3sm2478Putative gag-pro-pol polyprotein/0.445
4bb3KKAIsopenicillin N synthase1.21.3.10.445
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.445
1eqhFLPProstaglandin G/H synthase 11.14.99.10.444
1meuDMPGag-Pol polyprotein3.4.23.160.444
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.444
2vn0TDZCytochrome P450 2C8/0.444
2zybKSLTyrosine-protein kinase Lck2.7.10.20.444
3l8xN4DMitogen-activated protein kinase 14/0.444
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.444
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.444
4gk3L87Ephrin type-A receptor 32.7.10.10.444
1pjkANPCasein kinase II subunit alpha2.7.11.10.443
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.443
2itvANPEpidermal growth factor receptor2.7.10.10.443
2itzIREEpidermal growth factor receptor2.7.10.10.443
2vwu7X1Ephrin type-B receptor 42.7.10.10.443
3h0aD30Peroxisome proliferator-activated receptor gamma/0.443
4cd2FOLDihydrofolate reductase1.5.1.30.443
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
4j5j478Gag-Pol polyprotein3.4.23.160.443
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.443
4nc3ERM5-hydroxytryptamine receptor 2B/0.443
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.443
1c1dNAIPhenylalanine dehydrogenase/0.442
1m75CAAHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.442
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.442
3h86AP5Adenylate kinase/0.442
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.442
3upjU03Gag-Pol polyprotein/0.442
3wmxNADNAD dependent epimerase/dehydratase/0.442
4g2fC07Ephrin type-A receptor 32.7.10.10.442
4nr42LKCREB-binding protein/0.442
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.441
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.441
3b6zCO7Enoyl reductase LovC10.441
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.441
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.441
3mvl38PMitogen-activated protein kinase 14/0.441
3oriAGSSerine/threonine protein kinase/0.441
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.441
3zewSTUEphrin type-B receptor 42.7.10.10.441
4an35Y0Dual specificity mitogen-activated protein kinase kinase 12.7.12.20.441
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.441
4c4h7RODual specificity protein kinase TTK2.7.12.10.441
4l4xNDPAmphI/0.441
4nj32KDCyclin-dependent kinase 22.7.11.220.441
1q1wFADPutidaredoxin reductase1.18.1.50.440
1sozVAL_TYR_GLN_PHESerine endoprotease DegS3.4.21.1070.440
2balPQAMitogen-activated protein kinase 14/0.440
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.440
2vwy7X5Ephrin type-B receptor 42.7.10.10.440
2vx17X8Ephrin type-B receptor 42.7.10.10.440
2w4iVGAGlutamate racemase/0.440
3ictCOACoenzyme A disulfide reductase/0.440
4bqrIBHEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
5aacVGHALK tyrosine kinase receptor2.7.10.10.440