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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vs2VSBTyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vs2VSBTyrosine-protein kinase HCK2.7.10.21.000
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.557
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.553
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.525
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.495
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.493
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.486
3vs1VSATyrosine-protein kinase HCK2.7.10.20.482
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.477
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.449