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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vjoANPEpidermal growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vjoANPEpidermal growth factor receptor2.7.10.11.000
2itwITQEpidermal growth factor receptor2.7.10.10.648
2itnANPEpidermal growth factor receptor2.7.10.10.629
4gk3L87Ephrin type-A receptor 32.7.10.10.628
2eb3ANPEpidermal growth factor receptor2.7.10.10.624
4i231C9Epidermal growth factor receptor2.7.10.10.617
2itxANPEpidermal growth factor receptor2.7.10.10.616
1m17AQ4Epidermal growth factor receptor2.7.10.10.613
2itvANPEpidermal growth factor receptor2.7.10.10.611
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.604
2ituITQEpidermal growth factor receptor2.7.10.10.599
2y6o1N1Ephrin type-A receptor 42.7.10.10.599
2ittAEEEpidermal growth factor receptor2.7.10.10.596
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.591
4jq7KJQEpidermal growth factor receptor2.7.10.10.589
2hk51BMTyrosine-protein kinase HCK2.7.10.20.586
2qo9ANPEphrin type-A receptor 32.7.10.10.585
2of4979Tyrosine-protein kinase Lck2.7.10.20.584
4riyADPEpidermal growth factor receptor2.7.10.10.584
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.582
4jr3KJREpidermal growth factor receptor2.7.10.10.581
2vwu7X1Ephrin type-B receptor 42.7.10.10.580
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.578
4jq8KJ8Epidermal growth factor receptor2.7.10.10.575
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.575
2qoqANPEphrin type-A receptor 32.7.10.10.572
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.570
2xyuQ9GEphrin type-A receptor 42.7.10.10.569
3ac3KSHTyrosine-protein kinase Lck2.7.10.20.568
3ad6KSCTyrosine-protein kinase Lck2.7.10.20.568
4g2fC07Ephrin type-A receptor 32.7.10.10.568
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.566
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.565
2of2547Tyrosine-protein kinase Lck2.7.10.20.562
3ac1KZITyrosine-protein kinase Lck2.7.10.20.561
4gk4L90Ephrin type-A receptor 32.7.10.10.557
4jrvKJVEpidermal growth factor receptor2.7.10.10.556
1y57MPZProto-oncogene tyrosine-protein kinase Src2.7.10.20.555
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.555
4bb432WEphrin type-B receptor 42.7.10.10.551
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.550
2yn8STUEphrin type-B receptor 42.7.10.10.550
2itpAEEEpidermal growth factor receptor2.7.10.10.549
2itqITQEpidermal growth factor receptor2.7.10.10.549
2vwx7X4Ephrin type-B receptor 42.7.10.10.544
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.543
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.542
2xvdAS6Ephrin type-B receptor 42.7.10.10.541
2zm4KSMTyrosine-protein kinase Lck2.7.10.20.541
4gk2L66Ephrin type-A receptor 32.7.10.10.541
1zrzBI1Protein kinase C iota type2.7.11.130.538
3ac2KSETyrosine-protein kinase Lck2.7.10.20.538
4wkqIREEpidermal growth factor receptor2.7.10.10.538
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.537
3acjKSSTyrosine-protein kinase Lck2.7.10.20.536
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.535
3vjnANPEpidermal growth factor receptor2.7.10.10.535
2zybKSLTyrosine-protein kinase Lck2.7.10.20.534
3zewSTUEphrin type-B receptor 42.7.10.10.533
1qpePP2Tyrosine-protein kinase Lck2.7.10.20.532
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.532
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.531
2vx07X7Ephrin type-B receptor 42.7.10.10.531
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.529
2itzIREEpidermal growth factor receptor2.7.10.10.528
4hjoAQ4Epidermal growth factor receptor2.7.10.10.528
2vww7X2Ephrin type-B receptor 42.7.10.10.526
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.525
2qocANPEphrin type-A receptor 32.7.10.10.524
4id71G0Activated CDC42 kinase 1/0.523
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.522
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.520
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.520
4y95746Tyrosine-protein kinase/0.520
1uu8BI13-phosphoinositide-dependent protein kinase 12.7.11.10.519
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.519
2vwz7X6Ephrin type-B receptor 42.7.10.10.519
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.519
4j97ACPFibroblast growth factor receptor 2/0.519
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.518
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.517
3el8PD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.517
1u54ACPActivated CDC42 kinase 1/0.516
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.516
3a7hATPSerine/threonine-protein kinase 242.7.11.10.515
4nks2M2Fibroblast growth factor receptor 1/0.515
2balPQAMitogen-activated protein kinase 14/0.514
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.514
5aacVGHALK tyrosine kinase receptor2.7.10.10.513
5ackATP3-phosphoinositide-dependent protein kinase 12.7.11.10.513
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.512
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.511
5e8xSTUTGF-beta receptor type-12.7.11.300.511
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.510
1bygSTUTyrosine-protein kinase CSK/0.509
3gc9B45Mitogen-activated protein kinase 112.7.11.240.509
2vwv7X3Ephrin type-B receptor 42.7.10.10.508
1mqbANPEphrin type-A receptor 22.7.10.10.507
2qo7ANPEphrin type-A receptor 32.7.10.10.507
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.507
3uvqFS8Mitogen-activated protein kinase 14/0.507
2xp2VGHALK tyrosine kinase receptor2.7.10.10.506
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.506
2vwy7X5Ephrin type-B receptor 42.7.10.10.505
2vx17X8Ephrin type-B receptor 42.7.10.10.505
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.505
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.505
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.504
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.504
2x9fX9FEphrin type-B receptor 42.7.10.10.504
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.504
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
2henADPEphrin type-B receptor 22.7.10.10.503
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.503
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.502
5aaaVGHALK tyrosine kinase receptor2.7.10.10.502
2hog710Serine/threonine-protein kinase Chk12.7.11.10.501
4wboANWRhodopsin kinase/0.501
5aabVGHALK tyrosine kinase receptor2.7.10.10.500
2g2fAGSTyrosine-protein kinase ABL12.7.10.20.499
2py3ACPFibroblast growth factor receptor 2/0.499
3tucFPWTyrosine-protein kinase SYK2.7.10.20.499
4nka2K7Fibroblast growth factor receptor 1/0.498
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.497
1rw8580TGF-beta receptor type-12.7.11.300.497
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.497
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.496
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.496
4fob0USALK tyrosine kinase receptor2.7.10.10.496
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.495
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.494
2pwlACPFibroblast growth factor receptor 2/0.493
4c02TAKActivin receptor type-12.7.11.300.492
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.492
4gmy0X5Tyrosine-protein kinase JAK2/0.492
4i22IREEpidermal growth factor receptor2.7.10.10.492
4kiq1RAMitogen-activated protein kinase 14/0.492
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.492
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.492
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.491
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.491
3w33W19Epidermal growth factor receptor2.7.10.10.491
1di9MSQMitogen-activated protein kinase 14/0.490
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.490
2wotZZGTGF-beta receptor type-12.7.11.300.490
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.490
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.489
3cr0809Wee1-like protein kinase2.7.10.20.488
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.488
2gs7ANPEpidermal growth factor receptor2.7.10.10.487
4kba1QMCasein kinase I isoform delta2.7.11.10.487
2izuP01Casein kinase I isoform gamma-32.7.11.10.486
2yfxVGHALK tyrosine kinase receptor2.7.10.10.486
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.486
4qnaX11Serine/threonine-protein kinase 242.7.11.10.486
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.485
4d9t0JGRibosomal protein S6 kinase alpha-32.7.11.10.485
4aw530KEphrin type-B receptor 42.7.10.10.484
4ccbOFGALK tyrosine kinase receptor2.7.10.10.484
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.484
1agwSU2Fibroblast growth factor receptor 1/0.483
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.483
3ml8ML8Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.483
3vryB43Tyrosine-protein kinase HCK2.7.10.20.483
3w2sW2REpidermal growth factor receptor2.7.10.10.483
4anqVGHALK tyrosine kinase receptor2.7.10.10.483
4aa4QC0Mitogen-activated protein kinase 14/0.482
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.482
4qo9627Serine/threonine-protein kinase 242.7.11.10.482
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.481
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.481
2zazGK1Mitogen-activated protein kinase 14/0.481
3fklFKLMitogen-activated protein kinase 14/0.481
4ansVGHALK tyrosine kinase receptor2.7.10.10.481
4g6nEK0Mitogen-activated protein kinase 12.7.11.240.481
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.480
4jia1K3Tyrosine-protein kinase JAK2/0.480
4qms1N1Serine/threonine-protein kinase 242.7.11.10.480
4yuqKS1Calmodulin-like domain protein kinase/0.480
1e90MYCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.479
1snuSTUTyrosine-protein kinase ITK/TSK2.7.10.20.479
3mpt1GKMitogen-activated protein kinase 14/0.479
3w2o03PEpidermal growth factor receptor2.7.10.10.479
4aa5NQBMitogen-activated protein kinase 14/0.479
4c62XWWTyrosine-protein kinase JAK2/0.479
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.479
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.479
1u3dFADCryptochrome-1/0.478
3dt1P40Mitogen-activated protein kinase 14/0.478
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.478
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.477
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.477
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.477
2ym44YMSerine/threonine-protein kinase Chk12.7.11.10.477
3flsFLSMitogen-activated protein kinase 14/0.477
3gfeP37Mitogen-activated protein kinase 14/0.477
3iphG11Mitogen-activated protein kinase 14/0.477
3uvp048Mitogen-activated protein kinase 14/0.477
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.476
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.476
4q5jANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.476
1u3cFADCryptochrome-1/0.475
2c4g514Cyclin-dependent kinase 22.7.11.220.475
3gubGUBDeath-associated protein kinase 12.7.11.10.475
4cd0AWJALK tyrosine kinase receptor2.7.10.10.475
4hyu1BKMitogen-activated protein kinase 82.7.11.240.475
4iwq1FVSerine/threonine-protein kinase TBK12.7.11.10.475
1nzdUPGDNA beta-glucosyltransferase/0.474
3op5REBSerine/threonine-protein kinase VRK12.7.11.10.474
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.474
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.474
1tvoFRZMitogen-activated protein kinase 12.7.11.240.473
2acxANPG protein-coupled receptor kinase 62.7.11.160.473
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.473
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.473
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4fz60VGTyrosine-protein kinase SYK2.7.10.20.473
4rqkATP3-phosphoinositide-dependent protein kinase 12.7.11.10.473
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.472
2wouZZFTGF-beta receptor type-12.7.11.300.472
3fln3FNMitogen-activated protein kinase 14/0.472
3s4qNK0Mitogen-activated protein kinase 14/0.472
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.472
4ftlH0KSerine/threonine-protein kinase Chk12.7.11.10.472
4fv9E71Mitogen-activated protein kinase 12.7.11.240.472
1u4dDBQActivated CDC42 kinase 1/0.471
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.471
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.471
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.471
4b99R4LMitogen-activated protein kinase 72.7.11.240.471
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.471
4eqcXR1Serine/threonine-protein kinase PAK 12.7.11.10.471
4joa3DKALK tyrosine kinase receptor2.7.10.10.471
4y93746Tyrosine-protein kinase/0.471
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.470
1xkkFMMEpidermal growth factor receptor2.7.10.10.470
2pvyACPFibroblast growth factor receptor 2/0.470
2qhn582Serine/threonine-protein kinase Chk12.7.11.10.470
2vd5BI8Myotonin-protein kinase2.7.11.10.470
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.470
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.470
4ic7ANPMitogen-activated protein kinase 72.7.11.240.470
4wq4ATPtRNA N6-adenosine threonylcarbamoyltransferase/0.470
2bujSTUSerine/threonine-protein kinase 16/0.469
2izrBRKCasein kinase I isoform gamma-32.7.11.10.469
2qblCAMCamphor 5-monooxygenase1.14.15.10.469
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.469
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.469
3uibSB2Putative mitogen-activated protein kinase/0.469
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.469
4ftaH5KSerine/threonine-protein kinase Chk12.7.11.10.469
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.469
4gyzD5MTyrosyl-DNA phosphodiesterase 23.1.40.469
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.469
2oji33AMitogen-activated protein kinase 12.7.11.240.468
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.468
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.468
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.468
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.468
3kf7L9GMitogen-activated protein kinase 14/0.468
3krwBA1Beta-adrenergic receptor kinase 12.7.11.150.468
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.468
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.468
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.468
2j0m4STFocal adhesion kinase 12.7.10.20.467
2pzpACPFibroblast growth factor receptor 2/0.467
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.467
2wxvWXVCyclin-dependent kinase 22.7.11.220.467
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.467
3erkSB4Mitogen-activated protein kinase 12.7.11.240.467
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.467
4c58824Cyclin-G-associated kinase2.7.11.10.467
4ccuAWFALK tyrosine kinase receptor2.7.10.10.467
4ckjADNProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.467
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.467
4lgh0JNProto-oncogene tyrosine-protein kinase Src2.7.10.20.467
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4appN53Serine/threonine-protein kinase PAK 42.7.11.10.466
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.466
4fsyHK7Serine/threonine-protein kinase Chk12.7.11.10.466
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.466
5e8wSTUTGF-beta receptor type-12.7.11.300.466
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.465
1pjkANPCasein kinase II subunit alpha2.7.11.10.465
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.465
2wmvZYVSerine/threonine-protein kinase Chk12.7.11.10.465
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.465
4c57FEFCyclin-G-associated kinase2.7.11.10.465
4fnzNZFALK tyrosine kinase receptor2.7.10.10.465
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.465
2f4jVX6Tyrosine-protein kinase ABL12.7.10.20.464
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.464
3a62STURibosomal protein S6 kinase beta-12.7.11.10.464
3fskRO6Mitogen-activated protein kinase 14/0.464
4bcqTJFCyclin-dependent kinase 22.7.11.220.464
4fod0UVALK tyrosine kinase receptor2.7.10.10.464
4izy1J2Mitogen-activated protein kinase 82.7.11.240.464
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.464
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.463
3iodA6DPantothenate synthetase6.3.2.10.463
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
4l23X6KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.463
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.463
2brmDFZSerine/threonine-protein kinase Chk12.7.11.10.462
2j0lANPFocal adhesion kinase 12.7.10.20.462
3pvwQRXBeta-adrenergic receptor kinase 12.7.11.150.462
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.462
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.462
4erkOLOMitogen-activated protein kinase 12.7.11.240.462
4h4qFADBiphenyl dioxygenase ferredoxin reductase subunit/0.462
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.462
4lggVGGProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
2c6eHPMAurora kinase A2.7.11.10.461
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.461
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.461
4f640S8Fibroblast growth factor receptor 1/0.461
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.461
4xhgADPUncharacterized protein/0.461
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.460
3itzP66Mitogen-activated protein kinase 14/0.460
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.460
4iebANPCalmodulin-domain protein kinase 1/0.460
4qmzB49Serine/threonine-protein kinase 242.7.11.10.460
2gjlFMNNitronate monooxygenase1.13.12.160.459
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.459
2vrx447Aurora kinase B-A2.7.11.10.459
2ylxFADPhenylacetone monooxygenase1.14.13.920.459
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.459
3t8oATPRhodopsin kinase/0.459
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.459
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.459
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.459
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.459
4fuxE75Mitogen-activated protein kinase 12.7.11.240.459
4qmlANPSerine/threonine-protein kinase 242.7.11.10.459
4tuvCPZCytochrome P450 1191.140.459
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.458
2i0ePDSProtein kinase C beta type2.7.11.130.458
2jedLG8Protein kinase C theta type2.7.11.130.458
3a1nNADNDP-sugar epimerase/0.458
3el7PD3Proto-oncogene tyrosine-protein kinase Src2.7.10.20.458
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.458
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.457
1u28NAPNAD(P) transhydrogenase subunit beta1.6.1.20.457
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.457
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.457
2wipP49Cyclin-dependent kinase 22.7.11.220.457
3c4xATPRhodopsin kinase/0.457
3gxlQIGTGF-beta receptor type-12.7.11.300.457
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.457
3zw3ZW3Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.457
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.457
4tv3ML9Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform/0.457
1uu9BI33-phosphoinositide-dependent protein kinase 12.7.11.10.456
2etm7PYFocal adhesion kinase 12.7.10.20.456
2i1m5CNMacrophage colony-stimulating factor 1 receptor2.7.10.10.456
2j7t274Serine/threonine-protein kinase 102.7.11.10.456
2zb0GK3Mitogen-activated protein kinase 14/0.456
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.456
3otuBI43-phosphoinositide-dependent protein kinase 12.7.11.10.456
3w0pADPHygromycin-B 4-O-kinase2.7.1.1630.456
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.456
4ddhMS0Pantothenate synthetase6.3.2.10.456
4gt3ATPMitogen-activated protein kinase 12.7.11.240.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
1i59ADPChemotaxis protein CheA2.7.13.30.455
1j39UPGDNA beta-glucosyltransferase/0.455
1rx8FOLDihydrofolate reductase1.5.1.30.455
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.455
1tezFADDeoxyribodipyrimidine photo-lyase4.1.99.30.455
2ghlLIBMitogen-activated protein kinase 14/0.455
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.455
3poz03PEpidermal growth factor receptor2.7.10.10.455
4btkDTQTau-tubulin kinase 12.7.11.10.455
4e5yNDPGDP-L-fucose synthase1.1.1.2710.455
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.455
4hys1BJMitogen-activated protein kinase 82.7.11.240.455
4kip1R9Mitogen-activated protein kinase 14/0.455
1ia3TQ5Dihydrofolate reductase1.5.1.30.454
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.454
1t88CAMCamphor 5-monooxygenase1.14.15.10.454
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.454
3bkbSTUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.454
3imeBZ2Pantothenate synthetase6.3.2.10.454
3nr4PYVAbscisic acid receptor PYL2/0.454
3t4nADP5'-AMP-activated protein kinase subunit gamma/0.454
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.454
4fhk0U0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
4kbc1QJCasein kinase I isoform delta2.7.11.10.454
1ouk084Mitogen-activated protein kinase 14/0.453
2jn3JN3Fatty acid-binding protein, liver/0.453
2qtvGNPSmall COPII coat GTPase SAR13.6.50.453
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.453
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3imgBZ3Pantothenate synthetase6.3.2.10.453
3nuuJOZ3-phosphoinositide-dependent protein kinase 12.7.11.10.453
3zvvXAZPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.453
4n6hEJ4Delta-type opioid receptor/0.453
1bxoPP7Penicillopepsin-13.4.23.200.452
2hmaSAMtRNA-specific 2-thiouridylase MnmA/0.452
2izt23DCasein kinase I isoform gamma-32.7.11.10.452
2pzrACPFibroblast growth factor receptor 2/0.452
3flwFLWMitogen-activated protein kinase 14/0.452
4dce0JFALK tyrosine kinase receptor2.7.10.10.452
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.452
4feq0T8Tyrosine-protein kinase receptor TYRO32.7.10.10.452
4ftq4HKSerine/threonine-protein kinase Chk12.7.11.10.452
4y8wSTRSteroid 21-hydroxylase/0.452
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.451
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.451
1ywrLI9Mitogen-activated protein kinase 14/0.451
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.451
2v7a627Tyrosine-protein kinase ABL12.7.10.20.451
3i60E86Mitogen-activated protein kinase 12.7.11.240.451
3imgBZ2Pantothenate synthetase6.3.2.10.451
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.451
4jqeANPCasein kinase II subunit alpha2.7.11.10.451
4otpADPSerine/threonine-protein kinase RIO12.7.11.10.451
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.451
1ir3ANPInsulin receptor2.7.10.10.450
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.450
2a1nCAMCamphor 5-monooxygenase1.14.15.10.450
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.450
3qaiXNNKetohexokinase/0.450
3umvFADDeoxyribodipyrimidine photo-lyase4.1.99.30.450
4g090VDHistidinol dehydrogenase/0.450
4gu94GUFocal adhesion kinase 12.7.10.20.450
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.449
2pz5ACPFibroblast growth factor receptor 2/0.449
3biz61EWee1-like protein kinase2.7.10.20.449
3gggNADPrephenate dehydrogenase/0.449
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.449
3w0oADPHygromycin-B 4-O-kinase2.7.1.1630.449
4c59FEFCyclin-G-associated kinase2.7.11.10.449
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.449
1nzfUPGDNA beta-glucosyltransferase/0.448
2bakAQZMitogen-activated protein kinase 14/0.448
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.448
3da24MDCarbonic anhydrase 134.2.1.10.448
3ibqATPPyridoxal kinase/0.448
3mdvCL6Cholesterol 24-hydroxylase/0.448
3mvm39PMitogen-activated protein kinase 14/0.448
3ocgOCGMitogen-activated protein kinase 14/0.448
3q92XNBKetohexokinase/0.448
4a9yAQZMitogen-activated protein kinase 14/0.448
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.448
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.448
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.447
1rfvADPPyridoxal kinase2.7.1.350.447
1xddAAYIntegrin alpha-L/0.447
1yw2PGJMitogen-activated protein kinase 14/0.447
2j0j4STFocal adhesion kinase 12.7.10.20.447
2rhrEMOPutative ketoacyl reductase1.3.10.447
3cgbCOACoenzyme A disulfide reductase/0.447
3js2VM1Fibroblast growth factor receptor 1/0.447
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.447
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.447
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.447
4enhFVXCholesterol 24-hydroxylase/0.447
4fv8E63Mitogen-activated protein kinase 12.7.11.240.447
4hvh19RTyrosine-protein kinase JAK32.7.10.20.447
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.447
5eccNAPDehydrofolate reductase type I/0.447
1di8DTQCyclin-dependent kinase 22.7.11.220.446
1dnpFADDeoxyribodipyrimidine photo-lyase4.1.99.30.446
1nytNAPShikimate dehydrogenase (NADP(+))/0.446
2c475IDCasein kinase I isoform gamma-2/0.446
2p5uNADUDP-glucose 4-epimerase/0.446
2rg6287Mitogen-activated protein kinase 14/0.446
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.446
3adaNADSubunit alpha of sarocosine oxidase/0.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
3coy53HPantothenate synthetase6.3.2.10.446
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.446
4n9iPCGCatabolite expression activator/0.446
2fhnBNIAvidin-related protein 4/5/0.445
2oo5TXDNAD(P) transhydrogenase subunit alpha part 11.6.1.20.445
3lqfNADGalactitol dehydrogenase/0.445
3mtfA3FActivin receptor type-12.7.11.300.445
3ns2PYVAbscisic acid receptor PYL2/0.445
3opdHIEHeat shock protein 83/0.445
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4gb90WRPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.445
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
1dz6CAMCamphor 5-monooxygenase1.14.15.10.444
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.444
1kvsUPGUDP-glucose 4-epimerase5.1.3.20.444
3abaFLICytochrome P450/0.444
3d7tSTUTyrosine-protein kinase CSK/0.444
3du8553Glycogen synthase kinase-3 beta2.7.11.260.444
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.444
3h0sB38Acetyl-CoA carboxylase/0.444
3k145352-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase/0.444
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.444
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3zpuM8BGag-Pol polyprotein3.4.23.160.444
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4fryNADPutative signal-transduction protein with CBS domains/0.444
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.444
4j16NADNAD/NADP transhydrogenase alpha subunit 1/0.444
4kin1M8Mitogen-activated protein kinase 14/0.444
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.444
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.444
1fnnADPORC1-type DNA replication protein/0.443
1fpqSAMIsoliquiritigenin 2'-O-methyltransferase/0.443
1h69FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.443
2v4lABJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3emg685Tyrosine-protein kinase SYK2.7.10.20.443
3pre3REPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.443
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.443
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.443
3wrhCAMCamphor 5-monooxygenase1.14.15.10.443
4c3pACPAurora kinase A2.7.11.10.443
4eqrFADCoenzyme A disulfide reductase/0.443
1dhjMTXDihydrofolate reductase1.5.1.30.442
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
1pmeSB2Mitogen-activated protein kinase 12.7.11.240.442
1ppjANYCytochrome b/0.442
2e9zUTPGenome polyprotein/0.442
2zbaZBATrichothecene 3-O-acetyltransferase/0.442
3bheBZNGag-Pol polyprotein3.4.23.160.442
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.442
3igoANPCalmodulin-domain protein kinase 1, putative/0.442
3q9wEMOCasein kinase II subunit alpha2.7.11.10.442
3w0nANPHygromycin-B 4-O-kinase2.7.1.1630.442
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4bcmT7ZCyclin-dependent kinase 22.7.11.220.442
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.442
4g1wG1WMitogen-activated protein kinase 82.7.11.240.442
4kb81QNCasein kinase I isoform delta2.7.11.10.442
4xiwAZMCarbonic anhydrase, alpha type/0.442
1e8xATPPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
1finATPCyclin-dependent kinase 22.7.11.220.441
1iidNHMGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
1yjqNAP2-dehydropantoate 2-reductase1.1.1.1690.441
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.441
2vgoAD5Aurora kinase B-A2.7.11.10.441
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.441
2z7lS91Mitogen-activated protein kinase 12.7.11.240.441
3nj0PYVAbscisic acid receptor PYL2/0.441
4ezk0SDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.441
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.441
4j1tNADNAD/NADP transhydrogenase alpha subunit 1/0.441
4jldADPAdenylate kinase/0.441
4lopSB4Mitogen-activated protein kinase 14/0.441
4qmySTUSerine/threonine-protein kinase 242.7.11.10.441
1t85CAMCamphor 5-monooxygenase1.14.15.10.440
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.440
2a4zBYMPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
2fypRDEEndoplasmin/0.440
2nr4FMNConserved protein/0.440
2v59LZKBiotin carboxylase6.3.4.140.440
3bgqVX2Serine/threonine-protein kinase pim-12.7.11.10.440
3l8xN4DMitogen-activated protein kinase 14/0.440
3oom507Activin receptor type-12.7.11.300.440
4b8mVX6Aurora kinase B-A2.7.11.10.440
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4in44IDKelch-like ECH-associated protein 1/0.440