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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v8s0HDRho-associated protein kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3v8s0HDRho-associated protein kinase 12.7.11.11.000
2etkHFSRho-associated protein kinase 12.7.11.10.537
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.517
3nynSGVG protein-coupled receptor kinase 62.7.11.160.495
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.492
4othDRNSerine/threonine-protein kinase N1/0.466
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.464
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.459
4c35NU3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.456
4uakADPSerine/threonine-protein kinase MRCK beta2.7.11.10.456
3a8wATPProtein kinase C iota type2.7.11.130.447
4l445FIRibosomal protein S6 kinase beta-12.7.11.10.447
1c6x3INProtease/0.446
1fvv107Cyclin-dependent kinase 22.7.11.220.446
2vrx447Aurora kinase B-A2.7.11.10.444
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.442
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.442
4fkt48KCyclin-dependent kinase 22.7.11.220.442