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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v36NAPAldose reductase1.1.1.21

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3v36NAPAldose reductase1.1.1.211.000
2iq0NAPAldose reductase1.1.1.210.647
1x96NAPAldose reductase1.1.1.210.645
2acqNAPAldose reductase1.1.1.210.644
1z8aNAPAldose reductase1.1.1.210.641
1x98NAPAldose reductase1.1.1.210.632
1adsNAPAldose reductase1.1.1.210.613
3q65NAPAldose reductase1.1.1.210.611
2j8tNAPAldose reductase1.1.1.210.610
2pfhNDPAldose reductase1.1.1.210.609
1az2NAPAldose reductase1.1.1.210.608
2acsNAPAldose reductase1.1.1.210.605
3q67NAPAldose reductase1.1.1.210.597
1ah4NAPAldose reductase1.1.1.210.590
2pevNDPAldose reductase1.1.1.210.584
2acuNAPAldose reductase1.1.1.210.583
2pf8NDPAldose reductase1.1.1.210.572
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.538
3qkzNAPAldose reductase-related protein 11.1.1.210.534
3o3rNAPAldose reductase-related protein 11.1.1.210.533
4g5dNDPProstaglandin F synthase1.1.1.1880.514
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.500
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.489
2hdjNDPAldo-keto reductase family 1 member C2/0.489
1c9wNAPAldose reductase-related protein 2/0.488
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.484
3h7rNAPAldo-keto reductase family 4 member C8/0.479
4xo7NAPAldo-keto reductase family 1 member C2/0.478
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.477
2hejNDPAldo-keto reductase family 1 member C211.1.10.474
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.468
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.463
1s1rNAPAldo-keto reductase family 1 member C3/0.462
1zgdNAPChalcone reductase/0.453
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
4dz5NAPAldo-keto reductase family 1 member C3/0.448
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4jtqNAPAldo-keto reductase family 1 member C2/0.441
4l1xNAPAldo-keto reductase family 1 member C2/0.440