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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.30

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.301.000
5cb3APRO-acetyl-ADP-ribose deacetylase/0.510
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.500
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.300.482
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.480
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.475
5fsxADPUncharacterized protein/0.472
3iidAPRCore histone macro-H2A.1/0.456
1tysDHFThymidylate synthase/0.455
1v4sMRKGlucokinase2.7.1.20.455
3b6zCO7Enoyl reductase LovC10.454
1tysTMPThymidylate synthase/0.449
2bpoNAPNADPH--cytochrome P450 reductase/0.447
3bgxTMPThymidylate synthase/0.444
1pd9CO4Dihydrofolate reductase1.5.1.30.443
4el5D1MGlycogen phosphorylase, muscle form2.4.1.10.443
5dp2NAPCurF/0.442
3lsmSFDPyranose 2-oxidase/0.441
3oafOAGDihydrofolate reductase1.5.1.30.440