sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3v0x | ANH | Cationic trypsin | 3.4.21.4 | 1.000 | |
| 2viv | VG2 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.616 | |
| 1sqt | UI3 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.600 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.591 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.591 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.588 | |
| 2a2x | NA9 | Prothrombin | 3.4.21.5 | 0.578 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.577 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.577 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.575 | |
| 1zsk | 421 | Coagulation factor XI | 3.4.21.27 | 0.573 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.572 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.572 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.570 | |
| 1iqg | XME | Coagulation factor X | 3.4.21.6 | 0.567 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.567 | |
| 4fue | 7UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.566 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.565 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.565 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.564 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.563 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.562 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.560 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.558 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.558 | |
| 1vja | 7IN | Urokinase-type plasminogen activator | 3.4.21.73 | 0.556 | |
| 2g00 | 4QC | Coagulation factor X | 3.4.21.6 | 0.556 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.553 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.552 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.550 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.549 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.549 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.548 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.548 | |
| 1owe | 675 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.548 | |
| 2zeb | 11M | Tryptase alpha/beta-1 | 3.4.21.59 | 0.548 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.547 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.547 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.546 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.546 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.544 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.543 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.539 | |
| 4btu | 6XS | Coagulation factor X | 3.4.21.6 | 0.534 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.534 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.532 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.530 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.530 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.529 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.528 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.528 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.527 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.527 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.524 | |
| 1gmc | PRO_GLY_ALA_TYR | Chymotrypsinogen A | 3.4.21.1 | 0.523 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.523 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.521 | |
| 3o0q | ADN | Vitamin B12-dependent ribonucleotide reductase | / | 0.520 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.519 | |
| 4d8n | 0HM | Kallikrein-6 | 3.4.21 | 0.519 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.518 | |
| 3ig6 | 438 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.517 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.517 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.517 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.516 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.511 | |
| 1ejn | AGB | Urokinase-type plasminogen activator | 3.4.21.73 | 0.509 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.507 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.506 | |
| 2cji | GSK | Coagulation factor X | 3.4.21.6 | 0.505 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.504 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.504 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.503 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.503 | |
| 4j0v | 1H7 | Beta-secretase 1 | 3.4.23.46 | 0.503 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.502 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.501 | |
| 2y5g | FJD | Coagulation factor X | 3.4.21.6 | 0.501 | |
| 1nfy | RTR | Coagulation factor X | 3.4.21.6 | 0.499 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.499 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.499 | |
| 3plp | BBA | Cationic trypsin | 3.4.21.4 | 0.499 | |
| 2vig | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.1 | 0.498 | |
| 3nxx | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.498 | |
| 1iqe | XMB | Coagulation factor X | 3.4.21.6 | 0.497 | |
| 1kts | C24 | Prothrombin | 3.4.21.5 | 0.497 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.497 | |
| 4eag | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.497 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.496 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.495 | |
| 1lde | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.494 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.494 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.494 | |
| 4frk | DWD | Beta-secretase 1 | 3.4.23.46 | 0.494 | |
| 3doc | NAD | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.493 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.493 | |
| 4eud | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.493 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.493 | |
| 2viy | VG3 | Beta-secretase 1 | 3.4.23.46 | 0.491 | |
| 3ixk | 929 | Beta-secretase 1 | 3.4.23.46 | 0.491 | |
| 4bti | 7R9 | Coagulation factor X | 3.4.21.6 | 0.491 | |
| 1psa | 0ZL | Pepsin A | 3.4.23.1 | 0.490 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.490 | |
| 2ome | NAD | C-terminal-binding protein 2 | / | 0.490 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.489 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.488 | |
| 1w13 | SM1 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.488 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.487 | |
| 4kgk | GTP | Uncharacterized protein | / | 0.487 | |
| 1f92 | UKP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.486 | |
| 1kbo | 340 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.486 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.486 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.486 | |
| 1bil | 0IU | Renin | 3.4.23.15 | 0.485 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.485 | |
| 1i7p | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.485 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.485 | |
| 2y82 | 930 | Coagulation factor X | 3.4.21.6 | 0.485 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.485 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.485 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.484 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.484 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.483 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.483 | |
| 2xhd | 7T9 | Glutamate receptor 2 | / | 0.483 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.483 | |
| 4nvk | 2NY | Peroxidase | / | 0.483 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.482 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.482 | |
| 2ag5 | NAD | 3-hydroxybutyrate dehydrogenase type 2 | / | 0.482 | |
| 2g1s | 4IG | Renin | 3.4.23.15 | 0.482 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.482 | |
| 4nbw | NAD | Short-chain dehydrogenase/reductase SDR | / | 0.482 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.481 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.481 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.481 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.481 | |
| 1lbc | CYZ | Glutamate receptor 2 | / | 0.480 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 1ra8 | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.480 | |
| 3fst | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.480 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.480 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.479 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.479 | |
| 1zpt | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.479 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.479 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.479 | |
| 4l4x | NDP | AmphI | / | 0.479 | |
| 4mok | FAD | Pyranose 2-oxidase | / | 0.479 | |
| 1bdl | IM1 | Gag-Pol polyprotein | 3.4.23.16 | 0.478 | |
| 1e3s | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.478 | |
| 2wf4 | ZY4 | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 3duy | AFJ | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.478 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.478 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.478 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.477 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.477 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.477 | |
| 2emu | SAH | Diphthine synthase | / | 0.476 | |
| 3daa | PDD | D-alanine aminotransferase | 2.6.1.21 | 0.476 | |
| 4b1c | 1B1 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 4j0t | 6T9 | Beta-secretase 1 | 3.4.23.46 | 0.476 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.476 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.476 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.475 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.475 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.475 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.475 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.475 | |
| 3veu | 0GO | Beta-secretase 1 | 3.4.23.46 | 0.475 | |
| 5czy | SAM | Eukaryotic huntingtin interacting protein B | / | 0.475 | |
| 1cul | FOK | Adenylate cyclase type 2 | / | 0.474 | |
| 1cul | FOK | Adenylate cyclase type 5 | / | 0.474 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.474 | |
| 1ra3 | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.474 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.474 | |
| 2fn7 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.474 | |
| 2ilv | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.474 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.474 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.474 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.474 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.474 | |
| 4i1i | NAD | Malate dehydrogenase | / | 0.474 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.473 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.473 | |
| 2dc1 | NAD | Probable L-aspartate dehydrogenase | / | 0.473 | |
| 2q1u | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.473 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.473 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.473 | |
| 3aut | NAI | Glucose 1-dehydrogenase 4 | 1.1.1.47 | 0.473 | |
| 3t64 | DU3 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.473 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.473 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.472 | |
| 1ndh | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.472 | |
| 1zp4 | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.472 | |
| 2ahr | NAP | Pyrroline-5-carboxylate reductase | / | 0.472 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.472 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.472 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.472 | |
| 2wez | ZYE | Beta-secretase 1 | 3.4.23.46 | 0.472 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.472 | |
| 3ndc | SAH | Precorrin-4 C(11)-methyltransferase | 2.1.1.133 | 0.472 | |
| 3pw8 | ACO | 1,2-phenylacetyl-CoA epoxidase, subunit A | 1.14.13.149 | 0.472 | |
| 4dpt | AGS | Mevalonate diphosphate decarboxylase | / | 0.472 | |
| 4i8z | G08 | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.472 | |
| 2a94 | AP0 | L-lactate dehydrogenase | 1.1.1.27 | 0.471 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.471 | |
| 3fr5 | I4A | Fatty acid-binding protein, adipocyte | / | 0.471 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.471 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.471 | |
| 4f6r | GDP | Tubulin beta chain | / | 0.471 | |
| 4xfj | ANP | Argininosuccinate synthase | / | 0.471 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.470 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.470 | |
| 1npd | NAD | Quinate/shikimate dehydrogenase | / | 0.470 | |
| 1qf4 | RPD | Adenylosuccinate synthetase | / | 0.470 | |
| 2ejz | SAH | Diphthine synthase | / | 0.470 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.470 | |
| 3g70 | A5T | Renin | 3.4.23.15 | 0.470 | |
| 4e32 | DWN | Methyltransferase | / | 0.470 | |
| 1drf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.469 | |
| 1tj1 | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.469 | |
| 1typ | FAD | Trypanothione reductase | 1.8.1.12 | 0.469 | |
| 2cft | PLP | Pyridoxal phosphate phosphatase | / | 0.469 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.469 | |
| 2ien | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 2qbu | SAH | Precorrin-2 methyltransferase | / | 0.469 | |
| 2y5h | Y5H | Coagulation factor X | 3.4.21.6 | 0.469 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.469 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.469 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.469 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.469 | |
| 5a1t | NAI | L-lactate dehydrogenase | / | 0.469 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.468 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.468 | |
| 1ib0 | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.468 | |
| 2bfq | AR6 | [Protein ADP-ribosylglutamate] hydrolase AF_1521 | 3.2.2 | 0.468 | |
| 2nni | MTK | Cytochrome P450 2C8 | / | 0.468 | |
| 3dv5 | BAV | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3k5d | XLI | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 3ndj | JHZ | Methyltransferase | / | 0.468 | |
| 3pft | FMN | Flavin reductase | / | 0.468 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.468 | |
| 4ewo | 996 | Beta-secretase 1 | 3.4.23.46 | 0.468 | |
| 4fub | 4UP | Urokinase-type plasminogen activator | 3.4.21.73 | 0.468 | |
| 5adh | APR | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.468 | |
| 1dhf | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.467 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.467 | |
| 2ph6 | 712 | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 2q5g | 1FA | Peroxisome proliferator-activated receptor delta | / | 0.467 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.467 | |
| 3k5f | AYH | Beta-secretase 1 | 3.4.23.46 | 0.467 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.467 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.467 | |
| 3zbr | NAP | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.467 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.467 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.467 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.466 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 2w3b | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.466 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.466 | |
| 3lpk | Z76 | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 3m0o | FAD | Monomeric sarcosine oxidase | 1.5.3.1 | 0.466 | |
| 3rv7 | RVB | Salicylate synthase | / | 0.466 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.466 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.466 | |
| 4e2d | FMN | Dehydrogenase | / | 0.466 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4lxk | 1YT | Beta-secretase 1 | 3.4.23.46 | 0.466 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.466 | |
| 4qxq | 1YE | Stimulator of interferon genes protein | / | 0.466 | |
| 1lrj | UD1 | UDP-glucose 4-epimerase | 5.1.3.2 | 0.465 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.465 | |
| 2f3r | G5P | Guanylate kinase | 2.7.4.8 | 0.465 | |
| 2fs4 | PZ1 | Renin | 3.4.23.15 | 0.465 | |
| 2rc4 | ACO | Histone acetyltransferase KAT6A | / | 0.465 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.465 | |
| 2vj6 | VG5 | Beta-secretase 1 | 3.4.23.46 | 0.465 | |
| 3c14 | FOK | Adenylate cyclase type 2 | / | 0.465 | |
| 3c14 | FOK | Adenylate cyclase type 5 | / | 0.465 | |
| 3qt6 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.465 | |
| 4f4q | FAD | Decaprenylphosphoryl-beta-D-ribose oxidase | / | 0.465 | |
| 4tyq | AP5 | Adenylate kinase | / | 0.465 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.464 | |
| 1q1r | FAD | Putidaredoxin reductase | 1.18.1.5 | 0.464 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.464 | |
| 2a1h | GBN | Branched-chain-amino-acid aminotransferase, mitochondrial | 2.6.1.42 | 0.464 | |
| 2ffq | GSP | Ras-related protein Rab-6B | / | 0.464 | |
| 3bts | NAD | Galactose/lactose metabolism regulatory protein GAL80 | / | 0.464 | |
| 3ens | ENS | Coagulation factor X | 3.4.21.6 | 0.464 | |
| 3ik6 | HCZ | Glutamate receptor 2 | / | 0.464 | |
| 3rpe | FAD | Putative modulator of drug activity | / | 0.464 | |
| 3te5 | NAI | 5'-AMP-activated protein kinase subunit gamma | / | 0.464 | |
| 4acu | QN7 | Beta-secretase 1 | 3.4.23.46 | 0.464 | |
| 1a8r | GTP | GTP cyclohydrolase 1 | 3.5.4.16 | 0.463 | |
| 1dxy | NAD | D-2-hydroxyisocaproate dehydrogenase | 1.1.1 | 0.463 | |
| 1f17 | NAI | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.463 | |
| 1g1a | NAD | dTDP-glucose 4,6-dehydratase | / | 0.463 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.463 | |
| 1rfv | ADP | Pyridoxal kinase | 2.7.1.35 | 0.463 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.463 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.463 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.463 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3ehe | NAD | UDP-glucose 4-epimerase (GalE-1) | / | 0.463 | |
| 3gvh | NAD | Malate dehydrogenase | / | 0.463 | |
| 3gvi | ADP | Malate dehydrogenase | / | 0.463 | |
| 3k5c | 0BI | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3k5g | BJC | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.463 | |
| 3s7b | NH5 | N-lysine methyltransferase SMYD2 | / | 0.463 | |
| 3uyl | TYD | Probable NDP-rhamnosyltransferase | / | 0.463 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 4fco | 0U4 | Beta-secretase 1 | 3.4.23.46 | 0.463 | |
| 4k28 | NAD | Shikimate dehydrogenase family protein | / | 0.463 | |
| 4opi | FDA | Conserved Archaeal protein | / | 0.463 | |
| 4rlh | 0WE | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.463 | |
| 4rvn | COA | Phenylacetate-coenzyme A ligase | / | 0.463 | |
| 4ure | 1PS | Cyclohexanol dehydrogenase | / | 0.463 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.462 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.462 | |
| 1ra3 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.462 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.462 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.462 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.462 | |
| 3iqi | ASN_GLU_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.462 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.462 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.462 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.462 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4jnk | ZHK | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.462 | |
| 4nd4 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.462 | |
| 4qai | FMN | NADPH dehydrogenase | / | 0.462 | |
| 4yag | NAI | C alpha-dehydrogenase | / | 0.462 | |
| 2fxv | 5GP | Xanthine phosphoribosyltransferase | 2.4.2.22 | 0.461 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 2q3r | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.461 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.461 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.461 | |
| 3kji | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.461 | |
| 3lpj | Z75 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3nsh | 957 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3udq | 09E | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 3w8e | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.461 | |
| 3zid | GDP | Tubulin-like protein CetZ | / | 0.461 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.461 | |
| 4gdy | 0X1 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.461 | |
| 4i0i | 957 | Beta-secretase 1 | 3.4.23.46 | 0.461 | |
| 4nxu | ADP | Mitochondrial dynamics protein MID51 | / | 0.461 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.461 | |
| 1cs4 | FOK | Adenylate cyclase type 2 | / | 0.460 | |
| 1cs4 | FOK | Adenylate cyclase type 5 | / | 0.460 | |
| 1h6c | NDP | Glucose--fructose oxidoreductase | 1.1.99.28 | 0.460 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.460 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.460 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.460 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.460 | |
| 2v16 | C47 | Renin | 3.4.23.15 | 0.460 | |
| 2wf3 | ZY3 | Beta-secretase 1 | 3.4.23.46 | 0.460 | |
| 2x9d | ITC | Tetracycline repressor protein class D | / | 0.460 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3f3s | NAD | Lambda-crystallin homolog | / | 0.460 | |
| 3in6 | FMN | Uncharacterized protein | / | 0.460 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.460 | |
| 3tox | NAP | Putative oxidoreductase | / | 0.460 | |
| 3vuc | HHE | Renin | 3.4.23.15 | 0.460 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.460 | |
| 4fpy | 0V8 | Sialidase B | 3.2.1.18 | 0.460 | |
| 4jic | FMN | GTN Reductase | / | 0.460 | |
| 8dfr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.460 | |
| 1kvu | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.459 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.459 | |
| 2iby | COA | Acetyl-CoA acetyltransferase, mitochondrial | 2.3.1.9 | 0.459 | |
| 2ojt | UBA | Glutamate receptor ionotropic, kainate 1 | / | 0.459 | |
| 2xpu | TDC | Tetracycline repressor protein class D | / | 0.459 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.459 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.459 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.459 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.459 | |
| 3lqs | PSZ | D-alanine aminotransferase | 2.6.1.21 | 0.459 | |
| 3vf3 | 0GS | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 1gco | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.458 | |
| 1njf | ADP | DNA polymerase III subunit tau | 2.7.7.7 | 0.458 | |
| 1qcw | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.458 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.458 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.458 | |
| 2hu2 | NAD | C-terminal binding protein 1 | / | 0.458 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 2wf1 | ZY1 | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.458 | |
| 4dju | 0KK | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.458 | |
| 4k8s | 1QT | Beta-secretase 1 | 3.4.23.46 | 0.458 | |
| 5ein | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.458 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.458 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.457 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.457 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.457 | |
| 2is0 | I03 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 2wd9 | IBP | Acyl-coenzyme A synthetase ACSM2A, mitochondrial | 6.2.1.2 | 0.457 | |
| 2wf2 | ZY2 | Beta-secretase 1 | 3.4.23.46 | 0.457 | |
| 3d3w | NAP | L-xylulose reductase | 1.1.1.10 | 0.457 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3opx | U5P | Suppressor of disruption of TFIIS | / | 0.457 | |
| 3u9e | COA | Lmo1369 protein | / | 0.457 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.457 | |
| 4eak | ATP | 5'-AMP-activated protein kinase subunit gamma-1 | / | 0.457 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.457 | |
| 4eu9 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.457 | |
| 4fn4 | NAD | Short chain dehydrogenase | / | 0.457 | |
| 5cyo | GDP | Septin-9 | / | 0.457 | |
| 1ddr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 1dgm | ADN | Adenosine kinase | 2.7.1.20 | 0.456 | |
| 1f8f | NAD | Benzyl alcohol dehydrogenase | / | 0.456 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.456 | |
| 2qs3 | UBE | Glutamate receptor ionotropic, kainate 1 | / | 0.456 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.456 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.456 | |
| 3oqk | S52 | Renin | 3.4.23.15 | 0.456 | |
| 3ppr | 4CS | Glycine betaine/carnitine/choline-binding protein OpuCC | / | 0.456 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.456 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.456 | |
| 4rvd | SAM | D-mycarose 3-C-methyltransferase | / | 0.456 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.456 | |
| 1ep1 | FMN | Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit | 1.3.1.14 | 0.455 | |
| 1h74 | ADP | Homoserine kinase | 2.7.1.39 | 0.455 | |
| 1n77 | ATP | Glutamate--tRNA ligase | 6.1.1.17 | 0.455 | |
| 1nvm | NAD | Acetaldehyde dehydrogenase | 1.2.1.10 | 0.455 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.455 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.455 | |
| 1vbi | NAD | Malate/L-lactate dehydrogenase family protein | / | 0.455 | |
| 1xe6 | 5FP | Plasmepsin-2 | 3.4.23.39 | 0.455 | |
| 2b53 | D23 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 2c1b | CQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 2cnd | FAD | Nitrate reductase [NADH] | 1.7.1.1 | 0.455 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.455 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.455 | |
| 2hm1 | LIQ | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2p4j | 23I | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.455 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 3s7d | LEU_SER_LYS_LYS_MLZ | N-lysine methyltransferase SMYD2 | / | 0.455 | |
| 3sor | O58 | Coagulation factor XI | 3.4.21.27 | 0.455 | |
| 3vdq | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.455 | |
| 3vyd | VYD | Renin | 3.4.23.15 | 0.455 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.455 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.455 | |
| 4fhd | 0TT | Spore photoproduct lyase | / | 0.455 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.455 | |
| 4l82 | FMN | Uncharacterized protein | / | 0.455 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.455 | |
| 4wec | NAD | Short chain dehydrogenase | / | 0.455 | |
| 4y45 | F91 | Endothiapepsin | 3.4.23.22 | 0.455 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.454 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.454 | |
| 1gg5 | E09 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.454 | |
| 1hdc | CBO | 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase | 1.1.1.53 | 0.454 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2ex1 | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.454 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.454 | |
| 2ktd | PUC | Prostaglandin-H2 D-isomerase | 5.3.99.2 | 0.454 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.454 | |
| 2w9h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.454 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3dzk | NMN | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.454 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.454 | |
| 3mkn | DNB | Pyrimidine-specific ribonucleoside hydrolase RihB | / | 0.454 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.454 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.454 | |
| 3vg1 | 0GT | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.454 | |
| 4k9h | 1QU | Beta-secretase 1 | 3.4.23.46 | 0.454 | |
| 4tlz | NAP | KtzI | / | 0.454 | |
| 4u0m | GTP | Cyclic GMP-AMP synthase | / | 0.454 | |
| 1cbf | SAH | Cobalt-precorrin-4 C(11)-methyltransferase | 2.1.1.271 | 0.453 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.453 | |
| 1wze | NAD | Malate dehydrogenase | / | 0.453 | |
| 2daa | DCS | D-alanine aminotransferase | 2.6.1.21 | 0.453 | |
| 2fr1 | NDP | 6-deoxyerythronolide-B synthase EryA1, modules 1 and 2 | / | 0.453 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.453 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 2iib | C5P | Alpha-2,3/2,6-sialyltransferase/sialidase | / | 0.453 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.453 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.453 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.453 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.453 | |
| 3cid | 318 | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.453 | |
| 4brg | GNP | Ectonucleoside triphosphate diphosphohydrolase I | / | 0.453 | |
| 4fm8 | 0UQ | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.453 | |
| 4y4j | LNR | Endothiapepsin | 3.4.23.22 | 0.453 | |
| 5l3s | GNP | Signal recognition particle receptor FtsY | / | 0.453 | |
| 1beu | IPL | Tryptophan synthase alpha chain | / | 0.452 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.452 | |
| 1jdt | MTA | Purine nucleoside phosphorylase | / | 0.452 | |
| 1p0h | COA | Mycothiol acetyltransferase | 2.3.1.189 | 0.452 | |
| 1qx4 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.452 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 1txz | APR | Probable ADP-ribose 1''-phosphate phosphatase YML087W | 3.1.3.84 | 0.452 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.452 | |
| 1xz8 | 5GP | Bifunctional protein PyrR | 2.4.2.9 | 0.452 | |
| 2b8l | 5HA | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 2c9z | QUE | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.452 | |
| 2h2a | DND | Probable nicotinate-nucleotide adenylyltransferase | / | 0.452 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.452 | |
| 2v13 | C40 | Renin | 3.4.23.15 | 0.452 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2x8h | FAD | Thioredoxin glutathione reductase | / | 0.452 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.452 | |
| 3go4 | SAH | Uncharacterized protein | / | 0.452 | |
| 3k1w | BFX | Renin | 3.4.23.15 | 0.452 | |
| 3lcm | FAD | Putative oxidoreductase | / | 0.452 | |
| 4exg | 916 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4fse | 0VA | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4h1e | 10J | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 4ke1 | 1R6 | Beta-secretase 1 | 3.4.23.46 | 0.452 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.452 | |
| 5jqh | CAU | Beta-2 adrenergic receptor | / | 0.452 | |
| 1iki | REY | D-alanyl-D-alanine carboxypeptidase | 3.4.16.4 | 0.451 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.451 | |
| 1mj9 | COA | Histone acetyltransferase ESA1 | / | 0.451 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.451 | |
| 1szg | FNS | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.451 | |
| 1xse | NDP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.451 | |
| 2bjf | DXC | Choloylglycine hydrolase | 3.5.1.24 | 0.451 | |
| 2dhf | DZF | Dihydrofolate reductase | 1.5.1.3 | 0.451 | |
| 2ek7 | SAH | Diphthine synthase | / | 0.451 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 2gcq | DOI | Adenylosuccinate synthetase | / | 0.451 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.451 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 2pcm | SAH | Diphthine synthase | / | 0.451 | |
| 2z4y | 252 | Geranylgeranyl pyrophosphate synthase | / | 0.451 | |
| 3dv1 | AR9 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3ixj | 586 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.451 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 4dmm | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.451 | |
| 4dpf | 0LG | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4eu5 | COA | Succinyl-CoA:acetate CoA-transferase | / | 0.451 | |
| 4gv0 | 8ME | Poly [ADP-ribose] polymerase 3 | 2.4.2.30 | 0.451 | |
| 4hbg | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.451 | |
| 4i9n | 1E5 | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.451 | |
| 4mv8 | ACP | Biotin carboxylase | 6.3.4.14 | 0.451 | |
| 5c1d | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.451 | |
| 5eb5 | FAD | (R)-mandelonitrile lyase 1 | 4.1.2.10 | 0.451 | |
| 5eio | NAP | [LysW]-L-2-aminoadipate 6-phosphate reductase | / | 0.451 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.450 | |
| 1fy7 | COA | Histone acetyltransferase ESA1 | / | 0.450 | |
| 1gee | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.450 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.450 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.450 | |
| 1q6t | 600 | Tyrosine-protein phosphatase non-receptor type 1 | 3.1.3.48 | 0.450 | |
| 2eud | GCQ | Ribonucleoside-diphosphate reductase large chain 1 | 1.17.4.1 | 0.450 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.450 | |
| 2hun | NAD | 336aa long hypothetical dTDP-glucose 4,6-dehydratase | / | 0.450 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.450 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.450 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.450 | |
| 2v3w | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.450 | |
| 2vkm | BSD | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3dm6 | 757 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.450 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.450 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3p19 | NDP | Putative blue fluorescent protein | / | 0.450 | |
| 3pi5 | 3P5 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3r2f | PB0 | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 3to6 | LYS_CMC | Histone acetyltransferase ESA1 | / | 0.450 | |
| 3zcn | ATP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.450 | |
| 4a4q | UX9 | Pol protein | / | 0.450 | |
| 4blr | UTP | NTPase P4 | / | 0.450 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4du8 | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.450 | |
| 4eb7 | PLP | Cysteine desulfurase IscS 2 | / | 0.450 | |
| 4gsu | DWZ | L,D-transpeptidase 2 | 2.3.2 | 0.450 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.450 | |
| 4twr | NAD | NAD binding site:NAD-dependent epimerase/dehydratase:UDP-glucose 4-epimerase | / | 0.450 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.450 | |
| 1h65 | GDP | Translocase of chloroplast 34 | 3.6.5 | 0.449 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.449 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.449 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.449 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.449 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.449 | |
| 2vat | COA | Acetyl-CoA--deacetylcephalosporin C acetyltransferase | 2.3.1.175 | 0.449 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.449 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.449 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.449 | |
| 3dga | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.449 | |
| 3hek | BD0 | Heat shock protein HSP 90-alpha | / | 0.449 | |
| 3k4c | FAD | Pyranose 2-oxidase | / | 0.449 | |
| 3kmx | G00 | Beta-secretase 1 | 3.4.23.46 | 0.449 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.449 | |
| 3m30 | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.449 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.449 | |
| 3otf | CMP | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | / | 0.449 | |
| 3r83 | Z14 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 3tr0 | 5GP | Guanylate kinase | / | 0.449 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.449 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 4gv7 | MEW | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 4hmz | 18T | dTDP-4-dehydro-6-deoxyglucose 3-epimerase | 5.1.3.27 | 0.449 | |
| 4j7h | TRH | PCZA361.3 | / | 0.449 | |
| 4lcj | NAD | C-terminal-binding protein 2 | / | 0.449 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.449 | |
| 4nbt | NAD | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.449 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.449 | |
| 4ycp | FMN | tRNA-dihydrouridine(16) synthase | / | 0.449 | |
| 5dw6 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.449 | |
| 1cbq | RE9 | Cellular retinoic acid-binding protein 2 | / | 0.448 | |
| 1e6w | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.448 | |
| 1jqi | CAA | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.448 | |
| 1nbo | NAD | Glyceraldehyde-3-phosphate dehydrogenase A, chloroplastic | 1.2.1.13 | 0.448 | |
| 1tyt | FAD | Trypanothione reductase | 1.8.1.12 | 0.448 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2b7a | IZA | Tyrosine-protein kinase JAK2 | / | 0.448 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.448 | |
| 2c12 | FAD | Nitroalkane oxidase | 1.7.3.1 | 0.448 | |
| 2e8q | SAH | Diphthine synthase | / | 0.448 | |
| 2ek4 | SAH | Diphthine synthase | / | 0.448 | |
| 2i3g | NAP | N-acetyl-gamma-glutamyl-phosphate reductase | 1.2.1.38 | 0.448 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.448 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 2p20 | PRX | Acetyl-coenzyme A synthetase | / | 0.448 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.448 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.448 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.448 | |
| 3hyo | ADP | Pyridoxal kinase | / | 0.448 | |
| 3ihk | TPP | Uncharacterized protein | / | 0.448 | |
| 3jun | AJD | Phenazine biosynthesis protein A/B | / | 0.448 | |
| 3kjr | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.448 | |
| 3ut5 | LOC | Tubulin beta chain | / | 0.448 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.448 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.448 | |
| 4i10 | 1BS | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4i1c | 1BE | Beta-secretase 1 | 3.4.23.46 | 0.448 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.448 | |
| 4rls | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.448 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.448 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.448 | |
| 1dhr | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.447 | |
| 1i5e | U5P | Uracil phosphoribosyltransferase | / | 0.447 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.447 | |
| 1nuq | NXX | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 | / | 0.447 | |
| 1teh | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.447 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.447 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.447 | |
| 1tqf | 32P | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 1udb | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1wxj | IPL | Tryptophan synthase alpha chain | / | 0.447 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 2ab8 | MTP | Adenosine kinase | 2.7.1.20 | 0.447 | |
| 2dxv | SAH | Diphthine synthase | / | 0.447 | |
| 2emr | SAH | Diphthine synthase | / | 0.447 | |
| 2hpv | FMN | FMN-dependent NADH-azoreductase | 1.7 | 0.447 | |
| 2hux | SAH | Diphthine synthase | / | 0.447 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.447 | |
| 2irz | I02 | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2oah | QIN | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 2wdz | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 2z7h | GG3 | Geranylgeranyl pyrophosphate synthase | / | 0.447 | |
| 2znq | 401 | Peroxisome proliferator-activated receptor delta | / | 0.447 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.447 | |
| 2zvb | SAH | Precorrin-3 C17-methyltransferase | / | 0.447 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.447 | |
| 3cvu | FAD | RE11660p | / | 0.447 | |
| 3hf3 | FMN | Chromate reductase | / | 0.447 | |
| 3iae | D7K | Benzaldehyde lyase | / | 0.447 | |
| 3iah | NAP | Putative oxoacyl-(Acyl carrier protein) reductase | / | 0.447 | |
| 3iqg | ASN_TRP_ASN_ILE | Cysteine synthase | 2.5.1.47 | 0.447 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.447 | |
| 3t2v | KKJ | Peptidoglycan recognition protein 1 | / | 0.447 | |
| 3t4e | NAD | Quinate/shikimate dehydrogenase | / | 0.447 | |
| 3tfy | COA | N-alpha-acetyltransferase 50 | 2.3.1 | 0.447 | |
| 3vye | VYE | Renin | 3.4.23.15 | 0.447 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.447 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.447 | |
| 4fnc | HMU | G/T mismatch-specific thymine DNA glycosylase | 3.2.2.29 | 0.447 | |
| 4h3g | 10Q | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4nes | UD1 | UDP-N-acetylglucosamine 2-epimerase | 5.1.3.14 | 0.447 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.447 | |
| 5c77 | SAH | Protein arginine N-methyltransferase SFM1 | / | 0.447 | |
| 4xnw | 2ID | P2Y purinoceptor 1 | / | 0.447 | |
| 1a4r | GNH | Cell division control protein 42 homolog | / | 0.446 | |
| 1bp6 | UMP | Thymidylate synthase | / | 0.446 | |
| 1f0x | FAD | D-lactate dehydrogenase | 1.1.1.28 | 0.446 | |
| 1hbv | GAN | Gag-Pol polyprotein | / | 0.446 | |
| 1i6k | TYM | Tryptophan--tRNA ligase | 6.1.1.2 | 0.446 | |
| 1ics | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.446 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 1u7t | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.446 | |
| 2ekl | NAD | D-3-phosphoglycerate dehydrogenase | / | 0.446 | |
| 2f3e | AXQ | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 2idk | C2F | Glycine N-methyltransferase | 2.1.1.20 | 0.446 | |
| 2q3e | NAI | UDP-glucose 6-dehydrogenase | 1.1.1.22 | 0.446 | |
| 2vpr | TDC | Tetracycline repressor protein class H | / | 0.446 | |
| 3b2s | B2S | Trichothecene 3-O-acetyltransferase | / | 0.446 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.446 | |
| 3kgc | LY7 | Glutamate receptor 2 | / | 0.446 | |
| 3v2u | ATP | Protein GAL3 | / | 0.446 | |
| 3wyc | NAP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.446 | |
| 3zei | AWH | O-acetylserine sulfhydrylase | / | 0.446 | |
| 4an4 | DUD | Putative glycosyl transferase | / | 0.446 | |
| 4bup | SAM | Histone-lysine N-methyltransferase KMT5B | 2.1.1.43 | 0.446 | |
| 4cfa | WOP | Integrase | / | 0.446 | |
| 4fsl | 0VB | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4gid | 0GH | Beta-secretase 1 | 3.4.23.46 | 0.446 | |
| 4kcf | AKM | FAD-dependent oxidoreductase | / | 0.446 | |
| 4n3c | UD1 | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.446 | |
| 4wfr | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.446 | |
| 4ynt | FDA | Glucose oxidase, putative | / | 0.446 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.446 | |
| 1blz | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1lvu | 9PP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.445 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.445 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.445 | |
| 2b58 | COA | Diamine acetyltransferase 1 | / | 0.445 | |
| 2e17 | SAH | Diphthine synthase | / | 0.445 | |
| 2iyf | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.445 | |
| 2ldb | NAD | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.445 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.445 | |
| 2y3p | SM8 | DNA gyrase subunit A | / | 0.445 | |
| 2ztu | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.445 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 3h2s | NDP | Putative NADH-flavin reductase | / | 0.445 | |
| 3tnl | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.445 | |
| 3zsx | N44 | Integrase | / | 0.445 | |
| 4dh6 | 0KN | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.445 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.445 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.445 | |
| 4x5h | FOL | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1icp | FMN | 12-oxophytodienoate reductase 1 | 1.3.1.42 | 0.444 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1n7h | NDP | GDP-mannose 4,6 dehydratase 2 | 4.2.1.47 | 0.444 | |
| 1nj6 | A5A | Proline--tRNA ligase | / | 0.444 | |
| 1pjc | NAD | Alanine dehydrogenase | / | 0.444 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.444 | |
| 1zp9 | ATP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.444 | |
| 2a92 | NAI | L-lactate dehydrogenase | / | 0.444 | |
| 2cts | COA | Citrate synthase, mitochondrial | 2.3.3.1 | 0.444 | |
| 2ddo | ATP | Pyridoxine/pyridoxal/pyridoxamine kinase | / | 0.444 | |
| 2gh5 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 2o23 | NAD | 3-hydroxyacyl-CoA dehydrogenase type-2 | 1.1.1.35 | 0.444 | |
| 2p9c | NAI | D-3-phosphoglycerate dehydrogenase | 1.1.1.95 | 0.444 | |
| 2pca | SAH | Diphthine synthase | / | 0.444 | |
| 2qn3 | F55 | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.444 | |
| 2vij | C44 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 2wns | OMP | Uridine 5'-monophosphate synthase | 2.4.2.10 | 0.444 | |
| 2x8i | X8I | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.444 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.444 | |
| 3kjg | ADP | CO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC | / | 0.444 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.444 | |
| 3x2f | NAI | Adenosylhomocysteinase | / | 0.444 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4el0 | D1K | Glycogen phosphorylase, muscle form | 2.4.1.1 | 0.444 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4kov | KOV | Uncharacterized protein | / | 0.444 | |
| 4qec | NAP | ElxO | / | 0.444 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.444 | |
| 4y9q | C2E | Uncharacterized protein | / | 0.444 | |
| 5c2t | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.444 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.443 | |
| 1civ | NAP | Malate dehydrogenase [NADP], chloroplastic | 1.1.1.82 | 0.443 | |
| 1f20 | NAP | Nitric oxide synthase, brain | 1.14.13.39 | 0.443 | |
| 1il0 | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.443 | |
| 1j1z | ATP | Argininosuccinate synthase | / | 0.443 | |
| 1juv | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1qf5 | RPL | Adenylosuccinate synthetase | / | 0.443 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.443 | |
| 1vl8 | NAP | Oxidoreductase, short chain dehydrogenase/reductase family | / | 0.443 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.443 | |
| 2a7r | 5GP | GMP reductase 2 | / | 0.443 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.443 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.443 | |
| 2g8y | NAD | Hydroxycarboxylate dehydrogenase B | / | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2ob0 | ACO | N-alpha-acetyltransferase 50 | / | 0.443 | |
| 2vnn | CM7 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2zu8 | GDD | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.443 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.443 | |
| 3dk9 | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.443 | |
| 3fuh | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.443 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.443 | |
| 3l9h | EMQ | Kinesin-like protein KIF11 | / | 0.443 | |
| 3lsm | SFD | Pyranose 2-oxidase | / | 0.443 | |
| 3nut | SAH | Precorrin-3 methylase | / | 0.443 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.443 | |
| 3ty3 | GGG | Homoisocitrate dehydrogenase | 1.1.1.87 | 0.443 | |
| 3uoz | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.443 | |
| 3wag | TYD | Glycosyltransferase | / | 0.443 | |
| 3zhy | FM6 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.443 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4b4v | L34 | Bifunctional protein FolD | / | 0.443 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.443 | |
| 4die | C5P | Cytidylate kinase | / | 0.443 | |
| 4dpy | 2P0 | Mevalonate diphosphate decarboxylase | / | 0.443 | |
| 4e2x | TYD | Methyltransferase | / | 0.443 | |
| 4emt | C2E | Stimulator of interferon genes protein | / | 0.443 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4i4z | 2NE | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.443 | |
| 4kp7 | 1UQ | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic | 1.1.1.267 | 0.443 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.443 | |
| 4lol | 1YE | Stimulator of interferon genes protein | / | 0.443 | |
| 4nv1 | 0FX | Formyl transferase | / | 0.443 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.443 | |
| 4tlz | FAD | KtzI | / | 0.443 | |
| 5dw5 | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.443 | |
| 4djh | JDC | Kappa-type opioid receptor | / | 0.443 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1daa | PLP | D-alanine aminotransferase | 2.6.1.21 | 0.442 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1f8w | FAD | NADH peroxidase | 1.11.1.1 | 0.442 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1kp2 | ATP | Argininosuccinate synthase | 6.3.4.5 | 0.442 | |
| 1p0h | ACO | Mycothiol acetyltransferase | 2.3.1.189 | 0.442 | |
| 1p4a | PCP | Pur operon repressor | / | 0.442 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.442 | |
| 1u71 | MXA | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 1x27 | ASP_TYR_VAL_HIS_PTR | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.442 | |
| 1z4u | PH9 | Polyprotein | / | 0.442 | |
| 2b37 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.442 | |
| 2dft | ADP | Shikimate kinase | 2.7.1.71 | 0.442 | |
| 2djx | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.442 | |
| 2fdp | FRP | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2fmo | FAD | 5,10-methylenetetrahydrofolate reductase | 1.5.1.20 | 0.442 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.442 | |
| 2hs4 | ACP | Phosphoribosylformylglycinamidine synthase subunit PurL | / | 0.442 | |
| 2p8h | MY9 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2q2q | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.442 | |
| 2wf0 | ZY0 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3a37 | ADP | ATPase GET3 | / | 0.442 | |
| 3c3n | FMN | Dihydroorotate dehydrogenase (fumarate) | 1.3.98.1 | 0.442 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.442 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.442 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.442 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 3lzs | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3qgf | 46F | Genome polyprotein | 2.7.7.48 | 0.442 | |
| 3rsv | 3RS | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3skg | PB8 | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3t7p | 7SP | Endothiapepsin | 3.4.23.22 | 0.442 | |
| 3uoy | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.442 | |
| 3w8r | ACP | Uridine kinase | / | 0.442 | |
| 3wb2 | YGP | Uncharacterized protein MJ0488 | / | 0.442 | |
| 4anx | 534 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4bqh | 9VU | UDP-N-acetylglucosamine pyrophosphorylase, putative | / | 0.442 | |
| 4fda | NAP | 3-oxoacyl-[acyl-carrier-protein] reductase | 1.1.1.100 | 0.442 | |
| 4g5d | NDP | Prostaglandin F synthase | 1.1.1.188 | 0.442 | |
| 4gcm | NAP | Thioredoxin reductase | 1.8.1.9 | 0.442 | |
| 4gtp | 7TP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.442 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.442 | |
| 4nfs | NAJ | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.442 | |
| 5dmh | ADP | 3-oxo-tetronate kinase | / | 0.442 | |
| 1cg4 | IMO | Adenylosuccinate synthetase | / | 0.441 | |
| 1e5q | NDP | Saccharopine dehydrogenase [NADP(+), L-glutamate-forming] | 1.5.1.10 | 0.441 | |
| 1iy8 | NAD | Levodione reductase | / | 0.441 | |
| 1j3k | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 1nhq | FAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 1qor | NDP | Quinone oxidoreductase 1 | / | 0.441 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.441 | |
| 1tll | FMN | Nitric oxide synthase, brain | 1.14.13.39 | 0.441 | |
| 1tys | TMP | Thymidylate synthase | / | 0.441 | |
| 1zxm | ANP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.441 | |
| 2d29 | FAD | Acyl-CoA dehydrogenase | / | 0.441 | |
| 2dfv | NAD | L-threonine 3-dehydrogenase | / | 0.441 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 2ibz | UQ6 | Cytochrome b | / | 0.441 | |
| 2p6i | SAH | Diphthine synthase | / | 0.441 | |
| 2wyv | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.441 | |
| 2xx9 | 1NF | Glutamate receptor 2 | / | 0.441 | |
| 2zcv | NDP | Quinone oxidoreductase 2 | 1.6.5.2 | 0.441 | |
| 3bgx | TMP | Thymidylate synthase | / | 0.441 | |
| 3bgx | MEF | Thymidylate synthase | / | 0.441 | |
| 3elb | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.441 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.441 | |
| 3jyp | NAD | Quinate/shikimate dehydrogenase (NAD(+)) | / | 0.441 | |
| 3k3e | PDB | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.441 | |
| 3m2r | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3m2r | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.441 | |
| 3m2v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.441 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.441 | |
| 3ooi | SAM | Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific | 2.1.1.43 | 0.441 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.441 | |
| 3t70 | DU4 | Deoxyuridine 5'-triphosphate nucleotidohydrolase | / | 0.441 | |
| 3udn | 09B | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 3wfj | NAD | 2-dehydropantoate 2-reductase | / | 0.441 | |
| 4eb5 | PLP | Cysteine desulfurase IscS 2 | / | 0.441 | |
| 4fuj | 1U9 | Urokinase-type plasminogen activator | 3.4.21.73 | 0.441 | |
| 4fxy | 0W2 | Neurolysin, mitochondrial | 3.4.24.16 | 0.441 | |
| 4jwp | ACO | GCN5-related N-acetyltransferase | / | 0.441 | |
| 4nau | AGS | Phosphopantetheine adenylyltransferase | / | 0.441 | |
| 4nv1 | TYD | Formyl transferase | / | 0.441 | |
| 5a3b | APR | SIR2 family protein | / | 0.441 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1bxk | NAD | dTDP-glucose 4,6-dehydratase 2 | / | 0.440 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 1dir | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.440 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 1e1k | FAD | NADPH:adrenodoxin oxidoreductase, mitochondrial | 1.18.1.6 | 0.440 | |
| 1grb | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.440 | |
| 1i6x | CMP | cAMP-activated global transcriptional regulator CRP | / | 0.440 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.440 | |
| 1j0x | NAD | Glyceraldehyde-3-phosphate dehydrogenase | 1.2.1.12 | 0.440 | |
| 1kc1 | NDP | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.440 | |
| 1nhh | ANP | DNA mismatch repair protein MutL | / | 0.440 | |
| 2a2c | ADP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.440 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2ft0 | ACO | dTDP-fucosamine acetyltransferase | / | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 2pb6 | SAH | Diphthine synthase | / | 0.440 | |
| 2uuv | FAD | Alkyldihydroxyacetonephosphate synthase | 2.5.1.26 | 0.440 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.440 | |
| 3ai3 | NDP | NADPH-sorbose reductase | / | 0.440 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.440 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.440 | |
| 3qlr | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3rq6 | APR | ADP-dependent (S)-NAD(P)H-hydrate dehydratase | / | 0.440 | |
| 3w8d | NAD | 3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4de3 | DN8 | Beta-lactamase | / | 0.440 | |
| 4egb | NAD | dTDP-glucose 4,6-dehydratase | / | 0.440 | |
| 4l1f | COS | Acyl-CoA dehydrogenase domain protein | / | 0.440 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.440 | |
| 4uwm | FMN | 3,6-diketocamphane 1,6 monooxygenase | 1.14.13 | 0.440 | |
| 4xr9 | NAD | CalS8 | / | 0.440 |