sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3uzx | AOM | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 1.000 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.714 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.667 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.651 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.648 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.644 | |
| 3uzz | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.638 | |
| 3cav | CI2 | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.599 | |
| 3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.599 | |
| 3cmf | PDN | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.585 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.527 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.520 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.517 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.517 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.514 | |
| 1lke | DOG | Bilin-binding protein | / | 0.510 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.508 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.506 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.506 | |
| 4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.505 | |
| 3k8q | 22A | Purine nucleoside phosphorylase | 2.4.2.1 | 0.503 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.501 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.501 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.501 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.501 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.500 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.500 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.499 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.498 | |
| 1ngs | TPP | Transketolase 1 | 2.2.1.1 | 0.496 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.495 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.494 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.494 | |
| 3nyt | ULP | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.494 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.494 | |
| 1r5h | AO2 | Methionine aminopeptidase 2 | / | 0.493 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.493 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.491 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.491 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.491 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.490 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.490 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.490 | |
| 3zc3 | FAD | Ferredoxin--NADP reductase | 1.18.1.2 | 0.490 | |
| 3q7f | ED2 | Uncharacterized protein | / | 0.489 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.489 | |
| 3zj7 | C1K | Strictosidine-O-beta-D-glucosidase | 3.2.1.105 | 0.489 | |
| 1kw8 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.488 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.487 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.486 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.486 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.486 | |
| 3u57 | DH8 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.486 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.486 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.484 | |
| 1ni1 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.483 | |
| 1q0z | AKA | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.483 | |
| 1trk | TPP | Transketolase 1 | 2.2.1.1 | 0.483 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.483 | |
| 2iod | MYC | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.481 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.481 | |
| 3sfy | 3FY | Uncharacterized protein | / | 0.481 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.480 | |
| 1ld7 | U66 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.480 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.480 | |
| 2r8o | T5X | Transketolase 1 | / | 0.480 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.480 | |
| 3zku | HCV | Isopenicillin N synthase | 1.21.3.1 | 0.480 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.480 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.479 | |
| 2r5n | TPP | Transketolase 1 | / | 0.479 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.478 | |
| 2e9a | B28 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.478 | |
| 3b8x | G4M | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.478 | |
| 3c1o | NAP | Eugenol synthase | / | 0.478 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.477 | |
| 2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.477 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.477 | |
| 2ipi | AKY | Aclacinomycin-N/aclacinomycin-A oxidase | / | 0.476 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.476 | |
| 3ntr | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.476 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.476 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.476 | |
| 1ld8 | U49 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.475 | |
| 1q23 | FUA | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.475 | |
| 2h3w | HC5 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.475 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.475 | |
| 3pke | Y10 | Methionine aminopeptidase 2 | / | 0.475 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit alpha | 1.2.4.4 | 0.474 | |
| 1umc | TDP | 2-oxoisovalerate dehydrogenase subunit beta | 1.2.4.4 | 0.474 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.473 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.473 | |
| 2pbz | ATP | Uncharacterized protein | / | 0.473 | |
| 2vbp | VB1 | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.473 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.473 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.473 | |
| 1r5g | AO1 | Methionine aminopeptidase 2 | / | 0.472 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.472 | |
| 1tkb | N1T | Transketolase 1 | 2.2.1.1 | 0.472 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.472 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.471 | |
| 2cmf | F11 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 3qeo | LLT | Deoxycytidine kinase | 2.7.1.74 | 0.471 | |
| 2f0y | 3MN | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.470 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 0.470 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.469 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.469 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.469 | |
| 2xiq | 5AD | Methylmalonyl-CoA mutase, mitochondrial | / | 0.469 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.469 | |
| 3ihg | VAK | Aklavinone 12-hydroxylase RdmE | / | 0.469 | |
| 4e2b | FMN | Dehydrogenase | / | 0.469 | |
| 2gmu | PDG | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.468 | |
| 3e33 | ED7 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.468 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.468 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.467 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.467 | |
| 3ou2 | SAH | SAM-dependent methyltransferase | / | 0.467 | |
| 3upt | TPP | Transketolase | / | 0.467 | |
| 4x7u | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.467 | |
| 4xo7 | ASD | Aldo-keto reductase family 1 member C2 | / | 0.467 | |
| 1kw9 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.466 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.466 | |
| 1o1t | 2NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.465 | |
| 1s63 | 778 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.465 | |
| 1yw9 | A84 | Methionine aminopeptidase 2 | / | 0.465 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.465 | |
| 2wzy | SQX | Soluble acetylcholine receptor | / | 0.465 | |
| 2zi6 | 3D1 | Deoxycytidine kinase | 2.7.1.74 | 0.465 | |
| 3bi2 | FAD | Polyamine oxidase FMS1 | / | 0.465 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.465 | |
| 3u9f | CLM | Chloramphenicol acetyltransferase | 2.3.1.28 | 0.465 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.465 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.465 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.465 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.464 | |
| 4c5o | FAD | Putative monooxygenase | / | 0.464 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.464 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.464 | |
| 4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.464 | |
| 2hps | CTZ | Ca2+-triggered coelenterazine-binding protein 1 | / | 0.463 | |
| 2iej | S48 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.463 | |
| 2zu9 | GDP | Mannosyl-3-phosphoglycerate synthase | 2.4.1.217 | 0.463 | |
| 3br3 | ET | HTH-type transcriptional regulator QacR | / | 0.463 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.463 | |
| 3myt | EQU | Steroid Delta-isomerase | 5.3.3.1 | 0.463 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.463 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 3eku | CY9 | Actin-5C | / | 0.462 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.462 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 1fap | RAP | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.461 | |
| 1fap | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.461 | |
| 1itz | TPP | Transketolase, chloroplastic | 2.2.1.1 | 0.461 | |
| 2vte | IK4 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.461 | |
| 2whq | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.461 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.461 | |
| 3uwe | VJJ | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.461 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.460 | |
| 1by5 | GLY_GLY_GLY_AHO_AHO_AHO_FE | Ferrichrome-iron receptor | / | 0.460 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.460 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.460 | |
| 2jl1 | NAP | Triphenylmethane reductase | / | 0.460 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3inr | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.460 | |
| 3iu8 | T03 | Methionine aminopeptidase 2 | / | 0.460 | |
| 3jun | AKD | Phenazine biosynthesis protein A/B | / | 0.460 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 3pka | Y02 | Methionine aminopeptidase 2 | / | 0.460 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 1jqd | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.459 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.459 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.459 | |
| 2jfh | LK1 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.459 | |
| 2p98 | YE7 | Methionine aminopeptidase | / | 0.459 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.459 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.459 | |
| 3jsi | WTC | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.459 | |
| 3u5y | SCG | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.459 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 4jtr | IBP | Aldo-keto reductase family 1 member C2 | / | 0.459 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1r58 | AO5 | Methionine aminopeptidase 2 | / | 0.458 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 2gg0 | U11 | Methionine aminopeptidase | / | 0.458 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.458 | |
| 3gf4 | UPG | UDP-galactopyranose mutase | 5.4.99.9 | 0.458 | |
| 3gx9 | TXD | Morphinone reductase | / | 0.458 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.458 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.458 | |
| 4o7g | ASC | Probable transmembrane ascorbate ferrireductase 2 | 1.16.5.1 | 0.458 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.458 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.457 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.457 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.457 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 1y60 | H4M | 5,6,7,8-tetrahydromethanopterin hydro-lyase | 4.2.1.147 | 0.457 | |
| 2g25 | TDK | Pyruvate dehydrogenase E1 component | 1.2.4.1 | 0.457 | |
| 2gms | P0P | Putative pyridoxamine 5-phosphate-dependent dehydrase | / | 0.457 | |
| 3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.457 | |
| 3cas | ASD | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.457 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.457 | |
| 3d27 | W29 | Methionine aminopeptidase | / | 0.457 | |
| 3djl | FAD | Putative acyl-CoA dehydrogenase AidB | 1.3.99 | 0.457 | |
| 3dr4 | G4M | GDP-perosamine synthase | / | 0.457 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.457 | |
| 3tqx | PLP | 2-amino-3-ketobutyrate coenzyme A ligase | / | 0.457 | |
| 3zj6 | VM2 | Raucaffricine-O-beta-D-glucosidase | 3.2.1.125 | 0.457 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.457 | |
| 1el4 | CTZ | Obelin | / | 0.456 | |
| 1rft | PXM | Pyridoxal kinase | 2.7.1.35 | 0.456 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.456 | |
| 2vut | NAD | Nitrogen metabolite repression protein nmrA | / | 0.456 | |
| 2xlp | NAP | Putative flavin-containing monooxygenase | / | 0.456 | |
| 3ivc | FG4 | Pantothenate synthetase | 6.3.2.1 | 0.456 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.456 | |
| 3ryk | TYD | dTDP-4-dehydrorhamnose 3,5-epimerase | / | 0.456 | |
| 3voi | RCB | Glucanase | / | 0.456 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.456 | |
| 4b68 | NAP | L-ornithine N(5)-monooxygenase | / | 0.456 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.456 | |
| 4dch | 4DC | Glucokinase | 2.7.1.2 | 0.456 | |
| 4drh | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.456 | |
| 4drh | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.456 | |
| 1c7o | PPG | Hemolysin | / | 0.455 | |
| 2q94 | A04 | Methionine aminopeptidase | / | 0.455 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.455 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.455 | |
| 3l9l | L9L | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.455 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.455 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.455 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.455 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.455 | |
| 5agy | GTB | Tau class glutathione S-transferase | / | 0.455 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.454 | |
| 1swg | BTN | Streptavidin | / | 0.454 | |
| 2aot | SAH | Histamine N-methyltransferase | 2.1.1.8 | 0.454 | |
| 2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.454 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.453 | |
| 1pyd | TDP | Pyruvate decarboxylase isozyme 1 | / | 0.453 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.453 | |
| 1x1b | SAH | C-20 methyltransferase | / | 0.453 | |
| 2wmd | ZZ0 | NmrA-like family domain-containing protein 1 | / | 0.453 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.453 | |
| 4bb2 | STR | Corticosteroid-binding globulin | / | 0.453 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.453 | |
| 1fds | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 2evm | FC2 | Methionine aminopeptidase | / | 0.452 | |
| 2gdz | NAD | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | 1.1.1.141 | 0.452 | |
| 2r8p | T6F | Transketolase 1 | / | 0.452 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 3nub | UD0 | UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase | 2.6.1.98 | 0.452 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.452 | |
| 1b8o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1mrq | STR | Aldo-keto reductase family 1 member C1 | / | 0.451 | |
| 1pfy | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.451 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 2a58 | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.451 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.451 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.451 | |
| 3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.451 | |
| 3cv6 | HXS | Aldo-keto reductase family 1 member C21 | / | 0.451 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.451 | |
| 3pkd | Y10 | Methionine aminopeptidase 2 | / | 0.451 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.451 | |
| 4wx2 | F6F | Tryptophan synthase alpha chain | / | 0.451 | |
| 4wx2 | F6F | Tryptophan synthase beta chain | 4.2.1.20 | 0.451 | |
| 1ef9 | 2CP | Methylmalonyl-CoA decarboxylase | 4.1.1.41 | 0.450 | |
| 1fxu | GU7 | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 1o9b | NAI | Quinate/shikimate dehydrogenase | / | 0.450 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.450 | |
| 2gg3 | U13 | Methionine aminopeptidase | / | 0.450 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.450 | |
| 2xpc | 051 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.450 | |
| 3bur | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.450 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.450 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 4gdp | FAD | Polyamine oxidase FMS1 | / | 0.450 | |
| 4ikt | TFV | Methionine aminopeptidase 1 | / | 0.450 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.450 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.449 | |
| 1jum | BER | HTH-type transcriptional regulator QacR | / | 0.449 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.449 | |
| 2g26 | 3LG | Renin | 3.4.23.15 | 0.449 | |
| 2ggb | U17 | Methionine aminopeptidase | / | 0.449 | |
| 2xvh | NAP | Putative flavin-containing monooxygenase | / | 0.449 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3p8i | FMN | Pentaerythritol tetranitrate reductase | / | 0.449 | |
| 3v0o | 4GW | Histo-blood group ABO system transferase | / | 0.449 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.449 | |
| 4usq | FAD | Pyridine nucleotide-disulfide oxidoreductase | / | 0.449 | |
| 5d6l | CAU | Beta-2 adrenergic receptor | / | 0.449 | |
| 1dgf | NDP | Catalase | 1.11.1.6 | 0.448 | |
| 1kw6 | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.448 | |
| 1pz1 | NAP | General stress protein 69 | / | 0.448 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.448 | |
| 2gfx | PMN | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.448 | |
| 3a25 | SAM | tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase | / | 0.448 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.448 | |
| 4a33 | PS8 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
| 4lh7 | 1X8 | DNA ligase | / | 0.448 | |
| 1mxf | MTX | Putative pteridine reductase 2 | / | 0.447 | |
| 1pke | 2FD | Purine nucleoside phosphorylase DeoD-type | / | 0.447 | |
| 1qyx | ASD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.447 | |
| 2flh | ZEA | Cytokinin-specific binding protein | / | 0.447 | |
| 2hxz | H7J | Cathepsin S | 3.4.22.27 | 0.447 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3dys | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
| 3nu0 | 3TU | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 3uay | ADN | Purine nucleoside phosphorylase DeoD-type | / | 0.447 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.447 | |
| 4h6p | FMN | Chromate reductase | / | 0.447 | |
| 4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.447 | |
| 4qem | HC4 | Phospholipase A2 VRV-PL-VIIIa | / | 0.447 | |
| 1eir | BPY | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.446 | |
| 1fml | RTL | Retinol dehydratase | / | 0.446 | |
| 1mmk | H4B | Phenylalanine-4-hydroxylase | 1.14.16.1 | 0.446 | |
| 1u2r | SO1 | Elongation factor 2 | / | 0.446 | |
| 2a0w | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2jbs | FMN | p-hydroxyphenylacetate 3-hydroxylase, oxygenase component | / | 0.446 | |
| 2x1h | X1H | Prostaglandin reductase 3 | 1 | 0.446 | |
| 3e4v | FMN | Uncharacterized protein | / | 0.446 | |
| 3iog | SDF | Metallo-beta-lactamase type 2 | / | 0.446 | |
| 3t4h | MD5 | Alpha-ketoglutarate-dependent dioxygenase AlkB | 1.14.11.33 | 0.446 | |
| 4f4d | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.446 | |
| 4qa2 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.446 | |
| 4qof | FMN | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.446 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.446 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 1ndi | COA | Carnitine O-acetyltransferase | 2.3.1.7 | 0.445 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.445 | |
| 1qzy | TDE | Methionine aminopeptidase 2 | / | 0.445 | |
| 2npf | MOU | Elongation factor 2 | / | 0.445 | |
| 2q92 | B23 | Methionine aminopeptidase | / | 0.445 | |
| 2vqq | TFG | Histone deacetylase 4 | 3.5.1.98 | 0.445 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.445 | |
| 3faz | NOS | Purine nucleoside phosphorylase | / | 0.445 | |
| 3pm1 | ET | HTH-type transcriptional regulator QacR | / | 0.445 | |
| 4f0e | 0RU | Poly [ADP-ribose] polymerase 15 | 2.4.2.30 | 0.445 | |
| 4iks | TFD | Methionine aminopeptidase 1 | / | 0.445 | |
| 4mk8 | 28Q | Genome polyprotein | 2.7.7.48 | 0.445 | |
| 5cxv | 0HK | Muscarinic acetylcholine receptor M1 | / | 0.445 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.444 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.444 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.444 | |
| 2jj8 | AZZ | Deoxynucleoside kinase | / | 0.444 | |
| 2vqb | NAP | Putative flavin-containing monooxygenase | / | 0.444 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.444 | |
| 3ogk | OGK | Coronatine-insensitive protein 1 | / | 0.444 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.444 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.444 | |
| 4fll | YZ6 | Methionine aminopeptidase 1 | / | 0.444 | |
| 4rel | KMP | Glycosyltransferase | / | 0.444 | |
| 4to2 | DGT | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 3.1.5 | 0.444 | |
| 4xbj | IN5 | Alanine racemase, biosynthetic | / | 0.444 | |
| 2rh1 | CAU | Beta-2 adrenergic receptor | / | 0.444 | |
| 1gpu | THD | Transketolase 1 | 2.2.1.1 | 0.443 | |
| 1nqu | RDL | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.443 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.443 | |
| 1o1s | 1NH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.443 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.443 | |
| 1s7g | NAD | NAD-dependent protein deacylase 2 | / | 0.443 | |
| 1tco | FK5 | Peptidyl-prolyl cis-trans isomerase FKBP1A | 5.2.1.8 | 0.443 | |
| 1tco | FK5 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | 3.1.3.16 | 0.443 | |
| 1til | ATP | Anti-sigma F factor | / | 0.443 | |
| 2gev | COK | Pantothenate kinase | 2.7.1.33 | 0.443 | |
| 2hzq | STR | Apolipoprotein D | / | 0.443 | |
| 2z1q | FAD | Acyl-CoA dehydrogenase | / | 0.443 | |
| 2z4w | 749 | Geranylgeranyl pyrophosphate synthase | / | 0.443 | |
| 3buv | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.443 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.443 | |
| 3lxe | TOR | Carbonic anhydrase 1 | 4.2.1.1 | 0.443 | |
| 4a3u | FMN | NADH:flavin oxidoreductase/NADH oxidase | / | 0.443 | |
| 4a87 | NAR | Major pollen allergen Bet v 1-A | / | 0.443 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.443 | |
| 4qij | 1HA | 1,4-dihydroxy-2-naphthoyl-CoA synthase | / | 0.443 | |
| 4rr7 | A3S | Probable threonine--tRNA ligase 2 | 6.1.1.3 | 0.443 | |
| 1fdu | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.442 | |
| 1jf0 | CZH | Obelin | / | 0.442 | |
| 1k02 | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.442 | |
| 1sd2 | MTH | S-methyl-5'-thioadenosine phosphorylase | / | 0.442 | |
| 1yw7 | A41 | Methionine aminopeptidase 2 | / | 0.442 | |
| 2bb3 | SAH | Cobalamin biosynthesis precorrin-6Y methylase (CbiE) | / | 0.442 | |
| 2ejz | SAH | Diphthine synthase | / | 0.442 | |
| 2fut | H1S | Heparin and heparin-sulfate lyase | / | 0.442 | |
| 2o1s | TDP | 1-deoxy-D-xylulose-5-phosphate synthase | 2.2.1.7 | 0.442 | |
| 2ok8 | FAD | Ferredoxin--NADP reductase, apicoplast | / | 0.442 | |
| 2poq | ISD | Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 1.3.1.20 | 0.442 | |
| 2r6j | NDP | Eugenol synthase 1 | 1.1.1.318 | 0.442 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.442 | |
| 2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 3ai0 | PNW | Beta-glucosidase | / | 0.442 | |
| 3arv | SAU | Chitinase A | / | 0.442 | |
| 3g72 | A6T | Renin | 3.4.23.15 | 0.442 | |
| 3ho9 | N3A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.442 | |
| 3jus | BCD | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.442 | |
| 3l3l | L3L | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.442 | |
| 4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.442 | |
| 4dri | RAP | Serine/threonine-protein kinase mTOR | 2.7.11.1 | 0.442 | |
| 4dri | RAP | Peptidyl-prolyl cis-trans isomerase FKBP5 | 5.2.1.8 | 0.442 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.442 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4nv1 | TYD | Formyl transferase | / | 0.442 | |
| 4x7z | ZM3 | Mycinamicin III 3''-O-methyltransferase | 2.1.1.237 | 0.442 | |
| 7std | CRP | Scytalone dehydratase | 4.2.1.94 | 0.442 | |
| 1akc | PPE | Aspartate aminotransferase, mitochondrial | 2.6.1.1 | 0.441 | |
| 1fmj | RTL | Retinol dehydratase | / | 0.441 | |
| 1h60 | STR | Pentaerythritol tetranitrate reductase | / | 0.441 | |
| 1m2x | MCO | Metallo-beta-lactamase type 2 | / | 0.441 | |
| 1mzc | BNE | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.441 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.441 | |
| 3bi5 | FAD | Polyamine oxidase FMS1 | / | 0.441 | |
| 3e30 | ED4 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3e32 | ED2 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 3mey | ATP | Amino acid--[acyl-carrier-protein] ligase 1 | 6.2.1.n2 | 0.441 | |
| 3w3n | RX8 | Toll-like receptor 8 | / | 0.441 | |
| 4eso | NAP | Putative oxidoreductase | / | 0.441 | |
| 4gtr | 7TR | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.441 | |
| 4jbs | P52 | Endoplasmic reticulum aminopeptidase 2 | 3.4.11 | 0.441 | |
| 4zwp | M44 | Xaa-Pro dipeptidase | 3.4.13.9 | 0.441 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.441 | |
| 1dig | L37 | C-1-tetrahydrofolate synthase, cytoplasmic | 1.5.1.5 | 0.440 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.440 | |
| 1eio | GCH | Gastrotropin | / | 0.440 | |
| 1fxv | PNN | Penicillin G acylase | 3.5.1.11 | 0.440 | |
| 1g63 | FMN | Epidermin decarboxylase | 4.1.1 | 0.440 | |
| 1lkd | BP6 | Biphenyl-2,3-diol 1,2-dioxygenase | 1.13.11.39 | 0.440 | |
| 1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
| 1x1a | SAM | C-20 methyltransferase | / | 0.440 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.440 | |
| 2g6p | HM2 | Methionine aminopeptidase 1 | / | 0.440 | |
| 3eu5 | GBO | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 3ggs | 2FD | Purine nucleoside phosphorylase | 2.4.2.1 | 0.440 | |
| 3ksl | SZH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.440 | |
| 3qi4 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.440 | |
| 3v0m | 5GW | Histo-blood group ABO system transferase | / | 0.440 | |
| 4es5 | MGT | Polymerase basic protein 2 | / | 0.440 | |
| 4odo | FK5 | Peptidyl-prolyl cis-trans isomerase | / | 0.440 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.440 | |
| 3d4s | TIM | Beta-2 adrenergic receptor | / | 0.440 |