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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3up3XCAaceDAF-12

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3up3XCAaceDAF-12/1.000
3up0D7SaceDAF-12/0.607
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.559
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.532
1y60H4M5,6,7,8-tetrahydromethanopterin hydro-lyase4.2.1.1470.470
4j6dTESCytochrome P450 monooxygenase/0.463
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.458
2zb45OPProstaglandin reductase 21.3.1.480.457
1pq944BOxysterols receptor LXR-beta/0.455
1dduCB3Thymidylate synthase/0.454
1x8lOXRRetinol dehydratase/0.453
1opbRETRetinol-binding protein 2/0.451
4a83DXCMajor pollen allergen Bet v 1-A/0.449
1f4fTP3Thymidylate synthase/0.448
1pqc444Oxysterols receptor LXR-beta/0.448
2gjlFMNNitronate monooxygenase1.13.12.160.448
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3bejMUFBile acid receptor/0.447
3wd9QPCcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.447
3vt5YI2Vitamin D3 receptor/0.446
4j6cSTRCytochrome P450 monooxygenase/0.446
1fwmCB3Thymidylate synthase/0.445
4bbxLKFcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
1fm4DXCMajor pollen allergen Bet v 1-L/0.440
3byzH11Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.440