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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3unk0BYCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3unk0BYCyclin-dependent kinase 22.7.11.221.000
3py0SU9Cyclin-dependent kinase 22.7.11.220.665
4fkq42KCyclin-dependent kinase 22.7.11.220.617
3unj0BXCyclin-dependent kinase 22.7.11.220.613
3r9dX6BCyclin-dependent kinase 22.7.11.220.592
1urwI1PCyclin-dependent kinase 22.7.11.220.584
3rpv26ZCyclin-dependent kinase 22.7.11.220.581
4fko20KCyclin-dependent kinase 22.7.11.220.578
3qu0X40Cyclin-dependent kinase 22.7.11.220.574
3rmf20ZCyclin-dependent kinase 22.7.11.220.572
2xmyCDKCyclin-dependent kinase 22.7.11.220.571
3sw719KCyclin-dependent kinase 22.7.11.220.570
4acm7YGCyclin-dependent kinase 22.7.11.220.570
3qtzX42Cyclin-dependent kinase 22.7.11.220.568
1ke6LS2Cyclin-dependent kinase 22.7.11.220.567
1di8DTQCyclin-dependent kinase 22.7.11.220.564
2w06FRVCyclin-dependent kinase 22.7.11.220.564
4ek816KCyclin-dependent kinase 22.7.11.220.561
1pxmCK5Cyclin-dependent kinase 22.7.11.220.559
3sw418KCyclin-dependent kinase 22.7.11.220.559
3qtxX43Cyclin-dependent kinase 22.7.11.220.558
3ral04ZCyclin-dependent kinase 22.7.11.220.558
4fkpLS5Cyclin-dependent kinase 22.7.11.220.556
3qzgX67Cyclin-dependent kinase 22.7.11.220.554
3rni21ZCyclin-dependent kinase 22.7.11.220.554
3rak03ZCyclin-dependent kinase 22.7.11.220.553
3ddpRC8Cyclin-dependent kinase 22.7.11.220.548
3s0o50ZCyclin-dependent kinase 22.7.11.220.548
3s1h56ZCyclin-dependent kinase 22.7.11.220.548
3rk507ZCyclin-dependent kinase 22.7.11.220.547
3qtuX44Cyclin-dependent kinase 22.7.11.220.544
3pxyJWSCyclin-dependent kinase 22.7.11.220.543
4bgh3I6Cyclin-dependent kinase 22.7.11.220.543
2btsU32Cyclin-dependent kinase 22.7.11.220.542
2w1hL0FCyclin-dependent kinase 22.7.11.220.539
3rjc06ZCyclin-dependent kinase 22.7.11.220.535
4ez30S0Cyclin-dependent kinase 22.7.11.220.534
1gii1PUCyclin-dependent kinase 22.7.11.220.531
1ke5LS1Cyclin-dependent kinase 22.7.11.220.531
4fki09KCyclin-dependent kinase 22.7.11.220.531
3r6xX84Cyclin-dependent kinase 22.7.11.220.530
3rpy27ZCyclin-dependent kinase 22.7.11.220.530
4fkr45KCyclin-dependent kinase 22.7.11.220.530
1h1s4SPCyclin-dependent kinase 22.7.11.220.528
3lfnA27Cyclin-dependent kinase 22.7.11.220.527
3qzhX69Cyclin-dependent kinase 22.7.11.220.527
2iw84SPCyclin-dependent kinase 22.7.11.220.525
3rk909ZCyclin-dependent kinase 22.7.11.220.525
4fkv61KCyclin-dependent kinase 22.7.11.220.525
3ddqRRCCyclin-dependent kinase 22.7.11.220.524
3r9oZ71Cyclin-dependent kinase 22.7.11.220.524
3qqhX0ACyclin-dependent kinase 22.7.11.220.523
3sqq99ZCyclin-dependent kinase 22.7.11.220.523
4ek610KCyclin-dependent kinase 22.7.11.220.522
3qqkX02Cyclin-dependent kinase 22.7.11.220.521
1oitHDTCyclin-dependent kinase 22.7.11.220.520
3r8lZ30Cyclin-dependent kinase 22.7.11.220.520
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.517
1h1r6CPCyclin-dependent kinase 22.7.11.220.516
3qxoX65Cyclin-dependent kinase 22.7.11.220.516
3rk708ZCyclin-dependent kinase 22.7.11.220.515
2c6iDT1Cyclin-dependent kinase 22.7.11.220.514
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.514
4fks46KCyclin-dependent kinase 22.7.11.220.514
3r28XA0Cyclin-dependent kinase 22.7.11.220.513
2iw94SPCyclin-dependent kinase 22.7.11.220.511
1g5sI17Cyclin-dependent kinase 22.7.11.220.510
1ke9LS5Cyclin-dependent kinase 22.7.11.220.510
1gih1PUCyclin-dependent kinase 22.7.11.220.509
4fkt48KCyclin-dependent kinase 22.7.11.220.509
3iggEFQCyclin-dependent kinase 22.7.11.220.508
3ezvEZVCyclin-dependent kinase 22.7.11.220.507
3tiz3TICyclin-dependent kinase 22.7.11.220.506
3r9hZ67Cyclin-dependent kinase 22.7.11.220.505
1gij2PUCyclin-dependent kinase 22.7.11.220.504
1ke7LS3Cyclin-dependent kinase 22.7.11.220.504
2a0cCK9Cyclin-dependent kinase 22.7.11.220.503
1oiyN41Cyclin-dependent kinase 22.7.11.220.502
1w0xOLOCyclin-dependent kinase 22.7.11.220.502
1oi9N20Cyclin-dependent kinase 22.7.11.220.499
1p2a5BNCyclin-dependent kinase 22.7.11.220.499
1v1k3FPCyclin-dependent kinase 22.7.11.220.499
2r3lSCWCyclin-dependent kinase 22.7.11.220.499
2btrU73Cyclin-dependent kinase 22.7.11.220.498
2c6o4SPCyclin-dependent kinase 22.7.11.220.498
1h0w207Cyclin-dependent kinase 22.7.11.220.497
2b52D42Cyclin-dependent kinase 22.7.11.220.496
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.496
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.496
3ti1B49Cyclin-dependent kinase 22.7.11.220.496
1ke8LS4Cyclin-dependent kinase 22.7.11.220.495
3roy22ZCyclin-dependent kinase 22.7.11.220.495
4fkw62KCyclin-dependent kinase 22.7.11.220.495
1e1xNW1Cyclin-dependent kinase 22.7.11.220.494
3r1sX73Cyclin-dependent kinase 22.7.11.220.494
3qruX19Cyclin-dependent kinase 22.7.11.220.492
3r73X87Cyclin-dependent kinase 22.7.11.220.492
1ckpPVBCyclin-dependent kinase 22.7.11.220.490
1vyzN5BCyclin-dependent kinase 22.7.11.220.490
2vv9IM9Cyclin-dependent kinase 22.7.11.220.490
4fx360KCyclin-dependent kinase 22.7.11.220.489
1e9hINRCyclin-dependent kinase 22.7.11.220.488
1h1pCMGCyclin-dependent kinase 22.7.11.220.488
1vyw292Cyclin-dependent kinase 22.7.11.220.488
2b55D31Cyclin-dependent kinase 22.7.11.220.488
4eor4SPCyclin-dependent kinase 22.7.11.220.488
1pxoCK7Cyclin-dependent kinase 22.7.11.220.486
2uzoC62Cyclin-dependent kinase 22.7.11.220.486
3pj8404Cyclin-dependent kinase 22.7.11.220.486
3rm719ZCyclin-dependent kinase 22.7.11.220.486
4fkj11KCyclin-dependent kinase 22.7.11.220.486
1oguST8Cyclin-dependent kinase 22.7.11.220.485
4eon1ROCyclin-dependent kinase 22.7.11.220.485
2j9mPY8Cyclin-dependent kinase 22.7.11.220.484
3r8vZ62Cyclin-dependent kinase 22.7.11.220.484
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.484
1oiuN76Cyclin-dependent kinase 22.7.11.220.483
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.483
2r64740Cyclin-dependent kinase 22.7.11.220.482
3qtqX35Cyclin-dependent kinase 22.7.11.220.482
3rm618ZCyclin-dependent kinase 22.7.11.220.482
4lyn1YGCyclin-dependent kinase 22.7.11.220.481
3ig7EFPCyclin-dependent kinase 22.7.11.220.480
3r1yX76Cyclin-dependent kinase 22.7.11.220.479
1fvt106Cyclin-dependent kinase 22.7.11.220.478
4fkg4CKCyclin-dependent kinase 22.7.11.220.478
1pxkCK3Cyclin-dependent kinase 22.7.11.220.477
2a4lRRCCyclin-dependent kinase 22.7.11.220.477
3qtrX36Cyclin-dependent kinase 22.7.11.220.477
2pvnP63Casein kinase II subunit alpha2.7.11.10.475
3s2pPMUCyclin-dependent kinase 22.7.11.220.475
3uli1N3Cyclin-dependent kinase 22.7.11.220.474
4dgo0JWCasein kinase II subunit alpha2.7.11.10.474
4qmpDKISerine/threonine-protein kinase 242.7.11.10.474
2xnbY8LCyclin-dependent kinase 22.7.11.220.473
3qx2X63Cyclin-dependent kinase 22.7.11.220.473
3r7vZ02Cyclin-dependent kinase 22.7.11.220.473
1oiqHDUCyclin-dependent kinase 22.7.11.220.472
1w8cN69Cyclin-dependent kinase 22.7.11.220.471
2bhhRYUCyclin-dependent kinase 22.7.11.220.470
2r3iSCFCyclin-dependent kinase 22.7.11.220.470
2vttLZDCyclin-dependent kinase 22.7.11.220.470
3ql8X01Cyclin-dependent kinase 22.7.11.220.470
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.469
2r3p3SCCyclin-dependent kinase 22.7.11.220.469
1pxpCK8Cyclin-dependent kinase 22.7.11.220.468
1pxlCK4Cyclin-dependent kinase 22.7.11.220.467
2w17I19Cyclin-dependent kinase 22.7.11.220.466
4bcpT3CCyclin-dependent kinase 22.7.11.220.466
2c5yMTWCyclin-dependent kinase 22.7.11.220.465
1dm2HMDCyclin-dependent kinase 22.7.11.220.464
2c6tDT5Cyclin-dependent kinase 22.7.11.220.464
3lfsA07Cyclin-dependent kinase 22.7.11.220.464
2r3kSCQCyclin-dependent kinase 22.7.11.220.463
2vthLZ2Cyclin-dependent kinase 22.7.11.220.463
2wpa889Cyclin-dependent kinase 22.7.11.220.463
3ezrEZRCyclin-dependent kinase 22.7.11.220.463
3raiX85Cyclin-dependent kinase 22.7.11.220.463
4eos1ROCyclin-dependent kinase 22.7.11.220.463
1h0vUN4Cyclin-dependent kinase 22.7.11.220.462
1pyePM1Cyclin-dependent kinase 22.7.11.220.462
1r78FMDCyclin-dependent kinase 22.7.11.220.462
1ykr628Cyclin-dependent kinase 22.7.11.220.462
2b54D05Cyclin-dependent kinase 22.7.11.220.462
3rpo24ZCyclin-dependent kinase 22.7.11.220.462
4eoi1ROCyclin-dependent kinase 22.7.11.220.462
3r1qX75Cyclin-dependent kinase 22.7.11.220.460
3r7eX88Cyclin-dependent kinase 22.7.11.220.460
3rzb02ZCyclin-dependent kinase 22.7.11.220.460
4eop1ROCyclin-dependent kinase 22.7.11.220.460
2vu3LZECyclin-dependent kinase 22.7.11.220.459
3r83Z14Cyclin-dependent kinase 22.7.11.220.459
4gj20XHNon-receptor tyrosine-protein kinase TYK22.7.10.20.459
3qwjX6ACyclin-dependent kinase 22.7.11.220.458
4eol1ROCyclin-dependent kinase 22.7.11.220.458
5aniES4Cyclin-dependent kinase 22.7.11.220.458
2r3o2SCCyclin-dependent kinase 22.7.11.220.457
3fz1B98Cyclin-dependent kinase 22.7.11.220.457
1b38ATPCyclin-dependent kinase 22.7.11.220.456
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.456
3lfqA28Cyclin-dependent kinase 22.7.11.220.456
2wxvWXVCyclin-dependent kinase 22.7.11.220.455
3qzfX66Cyclin-dependent kinase 22.7.11.220.454
1oirHDYCyclin-dependent kinase 22.7.11.220.453
3r7iX9ICyclin-dependent kinase 22.7.11.220.453
3rahO1ZCyclin-dependent kinase 22.7.11.220.452
4dgnLU2Casein kinase II subunit alpha2.7.11.10.452
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.451
1b39ATPCyclin-dependent kinase 22.7.11.220.450
1unlRRCCyclin-dependent-like kinase 52.7.11.10.448
3ggfGVDSerine/threonine-protein kinase 26/0.448
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.448
2bheBRYCyclin-dependent kinase 22.7.11.220.447
2r3r6SCCyclin-dependent kinase 22.7.11.220.447
3r8pZ46Cyclin-dependent kinase 22.7.11.220.447
4fklCK2Cyclin-dependent kinase 22.7.11.220.447
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.447
1aq1STUCyclin-dependent kinase 22.7.11.220.446
2exmZIPCyclin-dependent kinase 22.7.11.220.446
3qqfX07Cyclin-dependent kinase 22.7.11.220.446
3r8zZ63Cyclin-dependent kinase 22.7.11.220.446
3rpr25ZCyclin-dependent kinase 22.7.11.220.446
2eufLQQCyclin-dependent kinase 62.7.11.220.445
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.445
3qtwX3ACyclin-dependent kinase 22.7.11.220.444
3rkb12ZCyclin-dependent kinase 22.7.11.220.444
4kd11QKCyclin-dependent kinase 22.7.11.220.444
2uznC96Cyclin-dependent kinase 22.7.11.220.443
3be9P04Casein kinase II subunit alpha2.7.11.10.443
4eok4SPCyclin-dependent kinase 22.7.11.220.443
1h1q2A6Cyclin-dependent kinase 22.7.11.220.442
2r3mSCXCyclin-dependent kinase 22.7.11.220.442
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.442
1om1IQACasein kinase II subunit alpha2.7.11.10.441
2xikJ60Serine/threonine-protein kinase 252.7.11.10.441
3wblPDYCyclin-dependent kinase 22.7.11.220.441
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.441
2qbnCAMCamphor 5-monooxygenase1.14.15.10.440
3r7uX96Cyclin-dependent kinase 22.7.11.220.440