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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tubFPUTyrosine-protein kinase SYK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3tubFPUTyrosine-protein kinase SYK2.7.10.21.000
4agwNG7Proto-oncogene tyrosine-protein kinase Src2.7.10.20.534
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.531
3ctj320Hepatocyte growth factor receptor2.7.10.10.514
3ce31FNHepatocyte growth factor receptor2.7.10.10.498
4eevL1XHepatocyte growth factor receptor2.7.10.10.495
4qrc0LIFibroblast growth factor receptor 42.7.10.10.492
3fzt4JZProtein-tyrosine kinase 2-beta2.7.10.20.488
3eta351Insulin receptor2.7.10.10.480
3lfbZ87Mitogen-activated protein kinase 14/0.477
4eyjN61Mitogen-activated protein kinase 132.7.11.240.471
2oiqSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.469
4kaoKAOFocal adhesion kinase 12.7.10.20.463
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.458
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.457
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.456
4fnyI3KALK tyrosine kinase receptor2.7.10.10.452
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.449
2gjlFMNNitronate monooxygenase1.13.12.160.448
2og81N8Tyrosine-protein kinase Lck2.7.10.20.445
4c8b0LIReceptor-interacting serine/threonine-protein kinase 22.7.11.10.445
2hyySTITyrosine-protein kinase ABL12.7.10.20.440