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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tu5ATPActin, alpha skeletal muscle

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3tu5ATPActin, alpha skeletal muscle/1.000
1h1vATPActin, alpha skeletal muscle/0.585
3m6gATPActin, alpha skeletal muscle/0.568
4pkgATPActin, alpha skeletal muscle/0.563
4k42ADPActin, alpha skeletal muscle/0.562
1c0fATPMajor actin/0.539
4ci6ATPActin/0.538
1lotATPActin, alpha skeletal muscle/0.534
3ffkATPActin, alpha skeletal muscle/0.534
1ijjATPActin, alpha skeletal muscle/0.532
4pkhADPActin, alpha skeletal muscle/0.532
5ce3ATPActin/0.526
3mn6ATPActin-5C/0.522
1t44ATPActin, alpha skeletal muscle/0.521
2v51ATPActin, alpha skeletal muscle/0.521
2q36ATPActin, alpha skeletal muscle/0.518
3m1fATPActin, alpha skeletal muscle/0.518
3mn9ATPActin-5C/0.518
1rgiATPActin, alpha skeletal muscle/0.514
1qz5ATPActin, alpha skeletal muscle/0.512
4pkiATPActin, alpha skeletal muscle/0.509
4pl8ATPActin, alpha skeletal muscle/0.509
1mduATPActin, alpha skeletal muscle/0.506
1s22ATPActin, alpha skeletal muscle/0.501
4jhdANPActin-5C/0.497
1nmdATPMajor actin/0.496
4m63ATPActin-5C/0.495
3u9dATPActin, alpha skeletal muscle/0.492
4cbxATPActin-2/0.480
1kxpATPActin, alpha skeletal muscle/0.477
3u4lATPActin, cytoplasmic 1/0.467
3a5mATPMajor actin/0.466
4rwtANPActin-5C/0.463
2q97ATPActin, alpha skeletal muscle/0.454
1eqyATPActin, alpha skeletal muscle/0.453
1nm1ATPMajor actin/0.448
3el2ATPActin-5C/0.445
3w3dATPActin, gamma-enteric smooth muscle/0.442
3chwATPMajor actin/0.440