sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3ts4 | EEG | Macrophage metalloelastase | 3.4.24.65 | 1.000 | |
| 3ljg | EEF | Macrophage metalloelastase | 3.4.24.65 | 0.676 | |
| 4gql | R47 | Macrophage metalloelastase | 3.4.24.65 | 0.651 | |
| 4gr3 | R45 | Macrophage metalloelastase | 3.4.24.65 | 0.632 | |
| 3lik | EEG | Macrophage metalloelastase | 3.4.24.65 | 0.622 | |
| 4h76 | 10B | Macrophage metalloelastase | 3.4.24.65 | 0.615 | |
| 2woa | 576 | Macrophage metalloelastase | 3.4.24.65 | 0.612 | |
| 1utt | CP8 | Macrophage metalloelastase | 3.4.24.65 | 0.609 | |
| 2wo9 | 068 | Macrophage metalloelastase | 3.4.24.65 | 0.601 | |
| 4gr8 | R4C | Macrophage metalloelastase | 3.4.24.65 | 0.600 | |
| 4g9l | NGH | Stromelysin-1 | 3.4.24.17 | 0.599 | |
| 2hu6 | 37A | Macrophage metalloelastase | 3.4.24.65 | 0.594 | |
| 3lil | EEA | Macrophage metalloelastase | 3.4.24.65 | 0.594 | |
| 2oxw | ILE_ALA_GLY | Macrophage metalloelastase | 3.4.24.65 | 0.592 | |
| 2ovx | 4MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.586 | |
| 4gr0 | R4B | Macrophage metalloelastase | 3.4.24.65 | 0.582 | |
| 4i03 | L88 | Macrophage metalloelastase | 3.4.24.65 | 0.582 | |
| 2wo8 | 077 | Macrophage metalloelastase | 3.4.24.65 | 0.581 | |
| 4guy | KLJ | Macrophage metalloelastase | 3.4.24.65 | 0.581 | |
| 3i7i | 518 | Collagenase 3 | 3.4.24 | 0.579 | |
| 3kec | 3KE | Collagenase 3 | 3.4.24 | 0.579 | |
| 1hy7 | MBS | Stromelysin-1 | 3.4.24.17 | 0.578 | |
| 3i7g | 732 | Collagenase 3 | 3.4.24 | 0.572 | |
| 3kry | 3KR | Collagenase 3 | 3.4.24 | 0.572 | |
| 2woa | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.555 | |
| 1caq | DPS | Stromelysin-1 | 3.4.24.17 | 0.554 | |
| 2yig | 5EL | Collagenase 3 | 3.4.24 | 0.552 | |
| 1bqo | N25 | Stromelysin-1 | 3.4.24.17 | 0.548 | |
| 3kej | 3EJ | Collagenase 3 | 3.4.24 | 0.548 | |
| 1b8y | IN7 | Stromelysin-1 | 3.4.24.17 | 0.544 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.539 | |
| 1ciz | DPS | Stromelysin-1 | 3.4.24.17 | 0.538 | |
| 1you | PFD | Collagenase 3 | 3.4.24 | 0.536 | |
| 2ow2 | 8MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.536 | |
| 1d8m | BBH | Stromelysin-1 | 3.4.24.17 | 0.530 | |
| 4a7b | 3W5 | Collagenase 3 | 3.4.24 | 0.530 | |
| 1zvx | FIN | Neutrophil collagenase | 3.4.24.34 | 0.529 | |
| 1d7x | SPC | Stromelysin-1 | 3.4.24.17 | 0.528 | |
| 4ja1 | NGH | Stromelysin-1 | 3.4.24.17 | 0.528 | |
| 1xur | PB5 | Collagenase 3 | 3.4.24 | 0.526 | |
| 4a7b | 3W4 | Collagenase 3 | 3.4.24 | 0.524 | |
| 2ow1 | 7MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.523 | |
| 3kek | 3EK | Collagenase 3 | 3.4.24 | 0.523 | |
| 4dpe | NGH | Stromelysin-1 | 3.4.24.17 | 0.522 | |
| 1xud | PB4 | Collagenase 3 | 3.4.24 | 0.520 | |
| 1d8f | SPI | Stromelysin-1 | 3.4.24.17 | 0.516 | |
| 1ztq | 033 | Collagenase 3 | 3.4.24 | 0.515 | |
| 1g49 | 111 | Stromelysin-1 | 3.4.24.17 | 0.514 | |
| 2ovz | 5MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.514 | |
| 1biw | S80 | Stromelysin-1 | 3.4.24.17 | 0.512 | |
| 2ow9 | SP6 | Collagenase 3 | 3.4.24 | 0.510 | |
| 2ow0 | 6MR | Matrix metalloproteinase-9 | 3.4.24.35 | 0.509 | |
| 1gkc | NFH | Matrix metalloproteinase-9 | 3.4.24.35 | 0.507 | |
| 1b3d | S27 | Stromelysin-1 | 3.4.24.17 | 0.506 | |
| 3zxh | E41 | Collagenase 3 | 3.4.24 | 0.500 | |
| 1c8t | TR1 | Stromelysin-1 | 3.4.24.17 | 0.499 | |
| 2wo9 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.499 | |
| 1hov | I52 | 72 kDa type IV collagenase | 3.4.24.24 | 0.498 | |
| 1xuc | PB3 | Collagenase 3 | 3.4.24 | 0.495 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.495 | |
| 3o2x | 3O2 | Collagenase 3 | 3.4.24 | 0.488 | |
| 2d1n | FA4 | Collagenase 3 | 3.4.24 | 0.484 | |
| 1d5j | MM3 | Stromelysin-1 | 3.4.24.17 | 0.461 | |
| 1zdw | FLV | Prenyltransferase | / | 0.461 | |
| 3tsk | QEG | Macrophage metalloelastase | 3.4.24.65 | 0.459 | |
| 3oho | Z79 | Stromelysin-1 | 3.4.24.17 | 0.456 | |
| 2fhj | H4Z | Formylmethanofuran--tetrahydromethanopterin formyltransferase | 2.3.1.101 | 0.453 | |
| 4l4x | NDP | AmphI | / | 0.453 | |
| 3d91 | REM | Renin | 3.4.23.15 | 0.448 | |
| 3uku | C69 | Actin-related protein 3 | / | 0.447 | |
| 5dp2 | NAP | CurF | / | 0.446 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.445 | |
| 4bix | ADP | Sensor histidine kinase CpxA | / | 0.444 | |
| 4qi4 | FAD | Cellobiose dehydrogenase | / | 0.444 | |
| 1w6h | TIT | Plasmepsin-2 | 3.4.23.39 | 0.442 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.441 | |
| 3vyf | VYF | Renin | 3.4.23.15 | 0.441 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.440 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.440 |