Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3tamM06Gag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3tamM06Gag-Pol polyprotein2.7.7.491.000
3t195MAGag-Pol polyprotein2.7.7.490.756
3t1a5MAGag-Pol polyprotein2.7.7.490.704
3drpR8EGag-Pol polyprotein2.7.7.490.669
3lakKR1Gag-Pol polyprotein2.7.7.490.655
3c6tM14Gag-Pol polyprotein2.7.7.490.648
3dyaPZLGag-Pol polyprotein2.7.7.490.639
4h4m494Gag-Pol polyprotein2.7.7.490.639
2ynhEURGag-Pol polyprotein2.7.7.490.622
4rw4494Gag-Pol polyprotein2.7.7.490.620
4h4o506Gag-Pol polyprotein2.7.7.490.618
3c6uM22Gag-Pol polyprotein2.7.7.490.606
2ynfWHUGag-Pol polyprotein2.7.7.490.602
2be2R22Gag-Pol polyprotein2.7.7.490.601
4rw6494Gag-Pol polyprotein2.7.7.490.597
3dokGWJPol protein/0.578
3drrR8EGag-Pol polyprotein2.7.7.490.573
3lalKRVGag-Pol polyprotein2.7.7.490.569
3dleGFAGag-Pol polyprotein2.7.7.490.567
4mfb29TGag-Pol polyprotein2.7.7.490.564
3dmjGWEPol protein/0.561
3e01PZ2Gag-Pol polyprotein2.7.7.490.560
2b5j3ACGag-Pol polyprotein2.7.7.490.558
3dlgGWEGag-Pol polyprotein2.7.7.490.552
1rt1MKCGag-Pol polyprotein2.7.7.490.542
2wonZZEGag-Pol polyprotein2.7.7.490.532
3lamKRPGag-Pol polyprotein2.7.7.490.530
3di6PDZGag-Pol polyprotein2.7.7.490.517
3dolGWIPol protein/0.512
1jlaTNKGag-Pol polyprotein2.7.7.490.509
3i0sRT7Gag-Pol polyprotein2.7.7.490.496
1rtiHEFGag-Pol polyprotein2.7.7.490.488
4i2pG73Gag-Pol polyprotein2.7.7.490.485
1s1vTNKGag-Pol polyprotein2.7.7.490.472
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.472
4j6bPLOCytochrome P450 monooxygenase/0.468
4jbtASDCytochrome P450 monooxygenase/0.468
4j6dTESCytochrome P450 monooxygenase/0.467
4j6cSTRCytochrome P450 monooxygenase/0.465
2hw2RFPRifampin ADP-ribosyl transferase/0.463
4h6rFDAProline dehydrogenase/0.463
1c1c612Gag-Pol polyprotein2.7.7.490.462
4q0a4OAVitamin D3 receptor A/0.461
5d7pOCZNAD-dependent protein deacetylase sirtuin-23.5.10.461
2vf0F89Thymidylate synthase/0.459
3cwkREACellular retinoic acid-binding protein 2/0.459
4mr61K0Bromodomain-containing protein 2/0.459
2o4rVD5Vitamin D3 receptor/0.458
4b0j3MQ3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.458
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.457
2rkiTT1Gag-Pol polyprotein2.7.7.490.457
4wa9AXITyrosine-protein kinase ABL12.7.10.20.456
1og5SWFCytochrome P450 2C9/0.455
3bgrT27Gag-Pol polyprotein2.7.7.490.455
4fnyI3KALK tyrosine kinase receptor2.7.10.10.455
1fm69CRRetinoic acid receptor RXR-alpha/0.454
3oafOAGDihydrofolate reductase1.5.1.30.454
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
1db1VDXVitamin D3 receptor/0.453
3dr1C5DVitamin D3 receptor A/0.453
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
1dnaCB3Thymidylate synthase/0.452
1e7aPFLSerum albumin/0.452
3a1l2CCCytochrome P450/0.452
3h1jSMACytochrome b/0.452
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.452
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
2opsHBQGag-Pol polyprotein2.7.7.490.451
5envNADAlcohol dehydrogenase 11.1.1.10.451
3pwhZMAAdenosine receptor A2a/0.451
1tlcF89Thymidylate synthase/0.450
2jih097A disintegrin and metalloproteinase with thrombospondin motifs 13.4.240.450
3dhoB2MStreptogramin A acetyltransferase2.3.10.450
3h0a9RARetinoic acid receptor RXR-alpha/0.450
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.450
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
1tvrTB9Gag-Pol polyprotein2.7.7.490.448
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.448
2yiuSMACytochrome b/0.448
3nr4PYVAbscisic acid receptor PYL2/0.448
3q7dNPXProstaglandin G/H synthase 21.14.99.10.448
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.448
1fp2HMOIsoflavone-7-O-methyltransferase 82.1.1.1500.447
1uykPUXHeat shock protein HSP 90-alpha/0.447
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
3vt7VDXVitamin D3 receptor/0.446
4ia3BIVVitamin D3 receptor A/0.446
4ib4ERM5-hydroxytryptamine receptor 2B/0.446
4iui1GQEstrogen receptor/0.446
4japCOAAlpha-pyrone synthesis polyketide synthase-like Pks112.3.10.446
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.446
4qa0SHHHistone deacetylase 83.5.1.980.446
1tl3H20Gag-Pol polyprotein2.7.7.490.445
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.445
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.445
3wmxNADNAD dependent epimerase/dehydratase/0.445
4fhi0S4Vitamin D3 receptor A/0.445
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.445
1cbqRE9Cellular retinoic acid-binding protein 2/0.444
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1kmsLIHDihydrofolate reductase1.5.1.30.444
1ml6GBXGlutathione S-transferase A22.5.1.180.444
2r3yVAL_TYR_TRP_PHESerine endoprotease DegS3.4.21.1070.444
3cx5SMACytochrome b/0.444
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3h6k33TCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.444
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
1mp0NADAlcohol dehydrogenase class-31.1.1.10.443
3vrwYS5Vitamin D3 receptor/0.443
3vt65YIVitamin D3 receptor/0.443
4g47TZFMycocyclosin synthase1.14.21.90.443
5k2bZMAAdenosine receptor A2a/0.443
1dr5NAPDihydrofolate reductase1.5.1.30.442
1m78NDPDihydrofolate reductase1.5.1.30.442
3bzuA21Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3vt9YI4Vitamin D3 receptor/0.442
3w0aDS5Vitamin D3 receptor/0.442
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.441
4iteTEYVitamin D3 receptor/0.441
1rjkVDZVitamin D3 receptor/0.440
1rx1NAPDihydrofolate reductase1.5.1.30.440
1w1rZEACytokinin dehydrogenase 11.5.99.120.440
2zb45OPProstaglandin reductase 21.3.1.480.440
3c3xNAPEugenol synthase 11.1.1.3180.440
3otqMZLBifunctional epoxide hydrolase 23.3.2.100.440
3w5tLHPVitamin D3 receptor/0.440
4i9i1DYTankyrase-12.4.2.300.440
4l0qNADAlcohol dehydrogenase class-3/0.440