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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3t9i3T9Serine/threonine-protein kinase pim-12.7.11.11.000
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.520
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.511
1yi4ADNSerine/threonine-protein kinase pim-12.7.11.10.502
4twpAXITyrosine-protein kinase ABL12.7.10.20.494
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.492
2bilBI1Serine/threonine-protein kinase pim-12.7.11.10.491
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.491
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.486
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.484
3ds6A17Mitogen-activated protein kinase 14/0.480
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.476
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.475
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.473
4fnyI3KALK tyrosine kinase receptor2.7.10.10.470
1xwsBI1Serine/threonine-protein kinase pim-12.7.11.10.469
3umxQ18Serine/threonine-protein kinase pim-12.7.11.10.467
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.465
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.463
3uixQ17Serine/threonine-protein kinase pim-12.7.11.10.461
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.460
3jpv1DRSerine/threonine-protein kinase pim-12.7.11.10.460
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.459
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.456
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.456
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.455
4lmuQUESerine/threonine-protein kinase pim-12.7.11.10.455
3cy2MB9Serine/threonine-protein kinase pim-12.7.11.10.454
3t5iSER_SER_CMT_FARRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.451
4enyJ19Serine/threonine-protein kinase pim-12.7.11.10.450
3e5aVX6Aurora kinase A2.7.11.10.448
3vbq0F5Serine/threonine-protein kinase pim-12.7.11.10.448
3hng8STVascular endothelial growth factor receptor 12.7.10.10.447
2yixYIXMitogen-activated protein kinase 14/0.446
2xynVX6Abelson tyrosine-protein kinase 22.7.10.20.445
1m2pHNACasein kinase II subunit alpha2.7.11.10.444
3ctj320Hepatocyte growth factor receptor2.7.10.10.444
3fkoFKOMitogen-activated protein kinase 14/0.444
4yx6FMNOmega-3 polyunsaturated fatty acid synthase subunit PfaD/0.444
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.443
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.442
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.441
3tubFPUTyrosine-protein kinase SYK2.7.10.20.441
4gmy0X5Tyrosine-protein kinase JAK2/0.440
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.440