sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 1.000 | |
| 2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.675 | |
| 1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.673 | |
| 1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.671 | |
| 3len | ZST | Aldose reductase | 1.1.1.21 | 0.665 | |
| 1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.663 | |
| 2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.658 | |
| 2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.655 | |
| 4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.655 | |
| 2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.650 | |
| 2dux | ZST | Aldose reductase | 1.1.1.21 | 0.647 | |
| 2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.645 | |
| 2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.644 | |
| 1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.642 | |
| 3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.640 | |
| 3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.640 | |
| 2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.638 | |
| 2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.634 | |
| 3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.634 | |
| 3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.632 | |
| 2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.631 | |
| 2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.630 | |
| 3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.628 | |
| 2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.625 | |
| 4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.625 | |
| 2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.624 | |
| 3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.624 | |
| 3lql | LDT | Aldose reductase | 1.1.1.21 | 0.623 | |
| 3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.616 | |
| 3ght | LDT | Aldose reductase | 1.1.1.21 | 0.614 | |
| 2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.612 | |
| 2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.609 | |
| 3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.609 | |
| 2duz | ZST | Aldose reductase | 1.1.1.21 | 0.608 | |
| 3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.608 | |
| 1frb | ZST | Aldose reductase-related protein 2 | / | 0.607 | |
| 3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.605 | |
| 2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2i16 | LDT | Aldose reductase | 1.1.1.21 | 0.603 | |
| 2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.602 | |
| 1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.600 | |
| 1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.599 | |
| 2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.599 | |
| 3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.598 | |
| 2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.596 | |
| 2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.591 | |
| 2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.585 | |
| 2iki | 388 | Aldose reductase | 1.1.1.21 | 0.582 | |
| 3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.574 | |
| 2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.564 | |
| 1iei | ZES | Aldose reductase | 1.1.1.21 | 0.551 | |
| 2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.551 | |
| 1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.543 | |
| 2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.541 | |
| 1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.540 | |
| 2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.527 | |
| 2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.500 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.487 | |
| 1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.484 | |
| 3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.481 | |
| 1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.480 | |
| 3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.480 | |
| 4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.480 | |
| 2cbq | TH2 | Neocarzinostatin | / | 0.479 | |
| 4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.479 | |
| 2c1z | KMP | Anthocyanidin 3-O-glucosyltransferase 2 | 2.4.1.115 | 0.477 | |
| 3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.476 | |
| 4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.476 | |
| 3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.472 | |
| 4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.471 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.470 | |
| 3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.470 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.469 | |
| 1dgb | NDP | Catalase | 1.11.1.6 | 0.468 | |
| 4at4 | T6E | BDNF/NT-3 growth factors receptor | 2.7.10.1 | 0.468 | |
| 4hyf | 1AK | Tankyrase-2 | 2.4.2.30 | 0.468 | |
| 4jtq | FLP | Aldo-keto reductase family 1 member C2 | / | 0.468 | |
| 4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.468 | |
| 1rsg | FAD | Polyamine oxidase FMS1 | / | 0.467 | |
| 1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.467 | |
| 2bjs | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.467 | |
| 2hzq | STR | Apolipoprotein D | / | 0.467 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.466 | |
| 4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.466 | |
| 4k4e | K4E | Tankyrase-1 | 2.4.2.30 | 0.466 | |
| 1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.465 | |
| 2a57 | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.465 | |
| 4li8 | 1XQ | Tankyrase-1 | 2.4.2.30 | 0.465 | |
| 1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.464 | |
| 4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.464 | |
| 1tfz | 869 | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.463 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
| 3x02 | 5GP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.463 | |
| 3x04 | GNP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.463 | |
| 1kyx | CRM | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.462 | |
| 3v36 | NAP | Aldose reductase | 1.1.1.21 | 0.462 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.462 | |
| 1eve | E20 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 1zq5 | E04 | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
| 2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
| 2acl | L05 | Oxysterols receptor LXR-alpha | / | 0.460 | |
| 2agt | FID | Aldose reductase | 1.1.1.21 | 0.460 | |
| 2gvc | FAD | Thiol-specific monooxygenase | 1.14.13 | 0.460 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.460 | |
| 1nqv | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.459 | |
| 3aiq | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic | 3.2.1.182 | 0.459 | |
| 3r58 | NPS | Aldo-keto reductase family 1 member C3 | / | 0.459 | |
| 3vf6 | 0H6 | Glucokinase | 2.7.1.2 | 0.459 | |
| 4psb | GA3 | Cytokinin-specific binding protein | / | 0.459 | |
| 1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.458 | |
| 2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
| 4gvs | F4M | Methenyltetrahydromethanopterin cyclohydrolase | 3.5.4.27 | 0.458 | |
| 4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.458 | |
| 4mm7 | 29J | Na(+):neurotransmitter symporter (Snf family) | / | 0.458 | |
| 1pax | DHQ | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.457 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.457 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 3tvx | PNX | cAMP-specific 3',5'-cyclic phosphodiesterase 4A | 3.1.4.53 | 0.457 | |
| 4dz5 | NAP | Aldo-keto reductase family 1 member C3 | / | 0.457 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.456 | |
| 2zb8 | IMN | Prostaglandin reductase 2 | 1.3.1.48 | 0.456 | |
| 3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.456 | |
| 4jpg | 1OX | Pyruvate kinase PKM | 2.7.1.40 | 0.456 | |
| 4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.456 | |
| 1pj6 | FOL | Dimethylglycine oxidase | 1.5.3.10 | 0.455 | |
| 1v08 | NTZ | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1, chloroplastic | 3.2.1.182 | 0.455 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
| 1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.455 | |
| 2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.455 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial | 1.2.4.4 | 0.455 | |
| 2j9f | THV | 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial | 1.2.4.4 | 0.455 | |
| 3t31 | DCQ | Sulfide-quinone reductase | / | 0.455 | |
| 1i5r | HYC | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.454 | |
| 2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.454 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.454 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.454 | |
| 4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.454 | |
| 1dgh | NDP | Catalase | 1.11.1.6 | 0.453 | |
| 1e2l | TMC | Thymidine kinase | / | 0.453 | |
| 1u08 | PLP | Methionine aminotransferase | / | 0.453 | |
| 2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.453 | |
| 2vt4 | P32 | Beta-1 adrenergic receptor | / | 0.453 | |
| 3jq8 | DX3 | Pteridine reductase, putative | / | 0.453 | |
| 3o57 | ZG2 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.453 | |
| 3rj0 | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.453 | |
| 4kn1 | 04J | Folate receptor beta | / | 0.453 | |
| 4msk | 2C8 | Tankyrase-1 | 2.4.2.30 | 0.453 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.453 | |
| 2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.452 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
| 4eyw | L0R | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.452 | |
| 4kn2 | LYA | Folate receptor beta | / | 0.452 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.452 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.451 | |
| 1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.451 | |
| 1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 1ye6 | NAP | NAD(P)H-dependent D-xylose reductase | 1.1.1.307 | 0.451 | |
| 2v2z | CDM | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.451 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.451 | |
| 3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
| 4kmz | FOL | Folate receptor beta | / | 0.451 | |
| 1m9h | NAD | 2,5-diketo-D-gluconic acid reductase A | 1.1.1.346 | 0.450 | |
| 2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.450 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.450 | |
| 3h7r | NAP | Aldo-keto reductase family 4 member C8 | / | 0.450 | |
| 4ajf | F03 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.450 | |
| 4bvn | P32 | Beta-1 adrenergic receptor | / | 0.450 | |
| 4hmn | 16J | Aldo-keto reductase family 1 member C3 | / | 0.450 | |
| 4ia0 | 5BB | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.450 | |
| 4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.450 | |
| 5fd8 | A5A | Putative carboxypeptidase yocD | / | 0.450 | |
| 1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.449 | |
| 3fvu | IAC | Kynurenine--oxoglutarate transaminase 1 | 2.6.1.7 | 0.449 | |
| 4hlm | 16S | Tankyrase-2 | 2.4.2.30 | 0.449 | |
| 4j7h | TRH | PCZA361.3 | / | 0.449 | |
| 1h35 | R01 | Squalene--hopene cyclase | 4.2.1.129 | 0.448 | |
| 1s2c | FLF | Aldo-keto reductase family 1 member C3 | / | 0.448 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.448 | |
| 2a59 | LMZ | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.448 | |
| 2wu4 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 3h7u | NAP | NADPH-dependent aldo-keto reductase, chloroplastic | / | 0.448 | |
| 4n65 | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.448 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 4bjc | RPB | Tankyrase-2 | 2.4.2.30 | 0.447 | |
| 4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.447 | |
| 1eko | I84 | Aldose reductase | 1.1.1.21 | 0.446 | |
| 1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2gyu | HI6 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 2oaz | I96 | Methionine aminopeptidase 2 | / | 0.446 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4arb | C57 | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 1isg | AGS | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 | 3.2.2.6 | 0.445 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.445 | |
| 1y2c | 3DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 3mjr | AC2 | Deoxycytidine kinase | 2.7.1.74 | 0.445 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 4d2d | ALA_ALA_ALA | Di-or tripeptide:H+ symporter | / | 0.445 | |
| 4tjy | 3GN | Tankyrase-2 | 2.4.2.30 | 0.445 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.444 | |
| 1pj7 | FFO | Dimethylglycine oxidase | 1.5.3.10 | 0.444 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.444 | |
| 2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.444 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.444 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.444 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 3ntq | NAD | Inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase | 1.1.1.18 | 0.444 | |
| 3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.444 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4ey6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 4flk | Y10 | Methionine aminopeptidase 1 | / | 0.444 | |
| 4phl | PIL | Phosphodiesterase | / | 0.444 | |
| 5c1g | GDU | Histo-blood group ABO system transferase | / | 0.444 | |
| 1hqt | NAP | Alcohol dehydrogenase [NADP(+)] | 1.1.1.2 | 0.443 | |
| 1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.443 | |
| 2g5w | 8PG | 12-oxophytodienoate reductase 3 | 1.3.1.42 | 0.443 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.443 | |
| 3dr7 | GPD | GDP-perosamine synthase | / | 0.443 | |
| 3hmv | HBT | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
| 3sfh | 1DI | Histone deacetylase 8 | 3.5.1.98 | 0.443 | |
| 3u3o | 3QV | Sulfotransferase 1A1 | 2.8.2.1 | 0.443 | |
| 5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.443 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.443 | |
| 1gpn | HUB | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.442 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 1tbb | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 1uk0 | FRM | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.442 | |
| 2gyw | OBI | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 2ouy | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.442 | |
| 3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
| 3ghw | GHW | Dihydrofolate reductase | 1.5.1.3 | 0.442 | |
| 3keg | MRE | FMN-dependent NADH-azoreductase 1 | / | 0.442 | |
| 3p9t | TCL | Repressor | / | 0.442 | |
| 3r7m | SUZ | Aldo-keto reductase family 1 member C3 | / | 0.442 | |
| 4a0s | CO8 | Octenoyl-CoA reductase/carboxylase | / | 0.442 | |
| 4jq1 | NPS | Aldo-keto reductase family 1 member C2 | / | 0.442 | |
| 4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.442 | |
| 1rkw | PNT | HTH-type transcriptional regulator QacR | / | 0.441 | |
| 1xom | CIO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 2b01 | TUD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.441 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.441 | |
| 2ycx | P32 | Beta-1 adrenergic receptor | / | 0.441 | |
| 1efy | BZC | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.440 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 2bfa | CB3 | Pteridine reductase 1 | 1.5.1.33 | 0.440 | |
| 2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 3gyf | 51P | Dihydrofolate reductase | 1.5.1.3 | 0.440 | |
| 3hxb | BD5 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 3nhp | HGZ | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.440 | |
| 3nx2 | FER | Ferulic acid decarboxylase | / | 0.440 | |
| 3x03 | ANP | Phosphatidylinositol 5-phosphate 4-kinase type-2 beta | 2.7.1.149 | 0.440 | |
| 4a32 | 2CD | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 4bvh | OCZ | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.440 | |
| 4f79 | P53 | Putative phospho-beta-glucosidase | / | 0.440 | |
| 4gtv | 7TR | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.440 | |
| 4jq3 | ZOM | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
| 4x3u | SVR | Chromobox protein homolog 7 | / | 0.440 |