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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3t1a5MAGag-Pol polyprotein2.7.7.49

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3t1a5MAGag-Pol polyprotein2.7.7.491.000
3c6uM22Gag-Pol polyprotein2.7.7.490.673
3t195MAGag-Pol polyprotein2.7.7.490.563
4rw6494Gag-Pol polyprotein2.7.7.490.536
4h4m494Gag-Pol polyprotein2.7.7.490.534
3drpR8EGag-Pol polyprotein2.7.7.490.533
3lalKRVGag-Pol polyprotein2.7.7.490.530
3tamM06Gag-Pol polyprotein2.7.7.490.522
3dokGWJPol protein/0.520
3ffi3OBGag-Pol polyprotein2.7.7.490.511
4h4o506Gag-Pol polyprotein2.7.7.490.511
2wonZZEGag-Pol polyprotein2.7.7.490.508
4mfb29TGag-Pol polyprotein2.7.7.490.508
3c6tM14Gag-Pol polyprotein2.7.7.490.507
3is9AC7Gag-Pol polyprotein2.7.7.490.493
2jleI15Reverse transcriptase/RNaseH/0.487
2be2R22Gag-Pol polyprotein2.7.7.490.483
3lakKR1Gag-Pol polyprotein2.7.7.490.483
4rw4494Gag-Pol polyprotein2.7.7.490.480
1c1bGCAGag-Pol polyprotein2.7.7.490.479
3dmjGWEPol protein/0.479
3dleGFAGag-Pol polyprotein2.7.7.490.478
2ze2T27Gag-Pol polyprotein2.7.7.490.471
2ynhEURGag-Pol polyprotein2.7.7.490.465
3bgrT27Gag-Pol polyprotein2.7.7.490.462
3dlgGWEGag-Pol polyprotein2.7.7.490.454
4lsl1YQGag-Pol polyprotein2.7.7.490.449
3qlhT27Gag-Pol polyprotein2.7.7.490.442
1rt1MKCGag-Pol polyprotein2.7.7.490.441