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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3swcSAHHistone-lysine N-methyltransferase EHMT1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3swcSAHHistone-lysine N-methyltransferase EHMT1/1.000
2rfiSAHHistone-lysine N-methyltransferase EHMT1/0.629
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.607
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.593
3fpdSAHHistone-lysine N-methyltransferase EHMT1/0.590
4nvq2ODHistone-lysine N-methyltransferase EHMT2/0.585
3mo0SAHHistone-lysine N-methyltransferase EHMT1/0.584
3hnaSAHHistone-lysine N-methyltransferase EHMT1/0.568
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.553
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.549
4ypeSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.535
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.534
2v16C47Renin3.4.23.150.512
5hq8SAHHistone-lysine N-methyltransferase SMYD32.1.1.430.507
1z71L17Prothrombin3.4.21.50.506
2pksG44Prothrombin3.4.21.50.497
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.497
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.496
4l7h1W1Beta-secretase 13.4.23.460.495
1umaIN2Prothrombin3.4.21.50.494
3dziRGTADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.493
3fr5I4AFatty acid-binding protein, adipocyte/0.493
3sxjSAMPutative methyltransferase/0.493
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.492
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.490
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.490
1mmkH4BPhenylalanine-4-hydroxylase1.14.16.10.489
1mu6CDAProthrombin3.4.21.50.489
1pq944BOxysterols receptor LXR-beta/0.489
3kmtSAHHistone H3K27 methylase/0.488
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.487
3n0hTOPDihydrofolate reductase1.5.1.30.487
3qwpSAMHistone-lysine N-methyltransferase SMYD32.1.1.430.487
4b1e6T6Beta-secretase 13.4.23.460.487
1yciNDFHypoxia-inducible factor 1-alpha inhibitor1.14.11.300.486
3m53SAHHistone-lysine N-methyltransferase SETD72.1.1.430.486
4ms1381Gamma-aminobutyric acid type B receptor subunit 1/0.486
1h22E10Acetylcholinesterase3.1.1.70.484
3c1kT15Prothrombin3.4.21.50.484
3dzkNMNADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.484
1gky5GPGuanylate kinase2.7.4.80.483
1mueCDDProthrombin3.4.21.50.483
3s3vTOPDihydrofolate reductase1.5.1.30.483
4eplJAIJasmonic acid-amido synthetase JAR16.3.20.483
1qtiGNTAcetylcholinesterase3.1.1.70.482
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.482
4i101BSBeta-secretase 13.4.23.460.482
1pd9CO4Dihydrofolate reductase1.5.1.30.481
2r1nEPLPhosphotriesterase/0.481
4h3i10VBeta-secretase 13.4.23.460.481
1bil0IURenin3.4.23.150.480
1sb1165Prothrombin3.4.21.50.480
1jwtBLIProthrombin3.4.21.50.479
1w4lGL8Acetylcholinesterase3.1.1.70.479
5czySAMEukaryotic huntingtin interacting protein B/0.479
5ex0SAHHistone-lysine N-methyltransferase SMYD32.1.1.430.479
1ex75GPGuanylate kinase2.7.4.80.478
2bdyUNBProthrombin3.4.21.50.478
1q23FUAChloramphenicol acetyltransferase2.3.1.280.477
2a2cADPN-acetylgalactosamine kinase2.7.1.1570.477
2fs4PZ1Renin3.4.23.150.477
2nr4FMNConserved protein/0.477
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.477
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.476
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.476
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.476
1nm6L86Prothrombin3.4.21.50.475
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.475
1tllFMNNitric oxide synthase, brain1.14.13.390.474
1ypkCCRProthrombin3.4.21.50.474
2v3hI25Prothrombin3.4.21.50.474
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.474
4drjRAPSerine/threonine-protein kinase mTOR2.7.11.10.474
4drjRAPPeptidyl-prolyl cis-trans isomerase FKBP45.2.1.80.474
5choFADFlavin reductase/0.474
2cekN8TAcetylcholinesterase3.1.1.70.473
2xukTZ5Acetylcholinesterase3.1.1.70.473
1icpFMN12-oxophytodienoate reductase 11.3.1.420.472
1zgbA1EAcetylcholinesterase3.1.1.70.472
2vbdV10Isopenicillin N synthase1.21.3.10.472
3qi4IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.472
4kbyC2EStimulator of interferon genes protein/0.472
1d3dBZTProthrombin3.4.21.50.471
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.471
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.471
1votHUPAcetylcholinesterase3.1.1.70.471
2j3qTFLAcetylcholinesterase3.1.1.70.471
2zhf49UProthrombin3.4.21.50.471
4b1c1B1Beta-secretase 13.4.23.460.471
1u65CP0Acetylcholinesterase3.1.1.70.470
2f98NGVAklanonic acid methyl ester cyclase AcmA5.5.1.230.470
2xuoTZ4Acetylcholinesterase3.1.1.70.470
3zkyWT4Isopenicillin N synthase1.21.3.10.470
4briUNPEctonucleoside triphosphate diphosphohydrolase I/0.470
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.470
4q0kGA3Phytohormone-binding protein/0.470
8dfrNDPDihydrofolate reductase1.5.1.30.470
2vkeTACTetracycline repressor protein class D/0.469
2zhq27UProthrombin3.4.21.50.469
3rsv3RSBeta-secretase 13.4.23.460.469
1eveE20Acetylcholinesterase3.1.1.70.468
1mvtDTMDihydrofolate reductase1.5.1.30.468
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.468
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.468
3vw7VPXProteinase-activated receptor 1/0.468
1txtCAAHMG-CoA synthase/0.467
2g1n1IGRenin3.4.23.150.467
2zff53UProthrombin3.4.21.50.467
2znk31UProthrombin3.4.21.50.467
4acxS8ZBeta-secretase 13.4.23.460.467
4brdANPEctonucleoside triphosphate diphosphohydrolase I/0.467
4mr72BVGamma-aminobutyric acid type B receptor subunit 1/0.467
3sn6P0GBeta-2 adrenergic receptor/0.467
1pqc444Oxysterols receptor LXR-beta/0.466
1v48HA1Purine nucleoside phosphorylase2.4.2.10.466
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.466
2xuiTZ5Acetylcholinesterase3.1.1.70.466
2xupTZ5Acetylcholinesterase3.1.1.70.466
3c27DKKProthrombin3.4.21.50.466
3i6qNDPPutative leucoanthocyanidin reductase 1/0.466
4fs4H24Beta-secretase 13.4.23.460.466
4h0vNADIota toxin component Ia/0.466
1bk0ACVIsopenicillin N synthase1.21.3.10.465
1gj5130Prothrombin3.4.21.50.465
1s3uTQDDihydrofolate reductase1.5.1.30.465
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.465
3hl0NADMaleylacetate reductase/0.465
3q9bB3NAcetylpolyamine amidohydrolase/0.465
4eilUMPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.465
4g95OAGDihydrofolate reductase1.5.1.30.465
4h3g10QBeta-secretase 13.4.23.460.465
4wecNADShort chain dehydrogenase/0.465
1fapRAPPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.464
1fapRAPSerine/threonine-protein kinase mTOR2.7.11.10.464
1g60SAMModification methylase MboII2.1.1.720.464
2cftPLPPyridoxal phosphate phosphatase/0.464
2zhw12UProthrombin3.4.21.50.464
3f6rFMNFlavodoxin/0.464
4bfzZVZPantothenate kinase2.7.1.330.464
4nv14TGFormyl transferase/0.464
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
1xvaSAMGlycine N-methyltransferase2.1.1.200.463
1zxnADPDNA topoisomerase 2-alpha5.99.1.30.463
2bb3SAHCobalamin biosynthesis precorrin-6Y methylase (CbiE)/0.463
2ejzSAHDiphthine synthase/0.463
3c1oNAPEugenol synthase/0.463
3qgf46FGenome polyprotein2.7.7.480.463
3t4hMD5Alpha-ketoglutarate-dependent dioxygenase AlkB1.14.11.330.463
4a81DXCMajor pollen allergen Bet v 1-A/0.463
1e1qANPATP synthase subunit alpha, mitochondrial/0.462
1e1qANPATP synthase subunit beta, mitochondrial3.6.3.140.462
1odcA8BAcetylcholinesterase3.1.1.70.462
1ut6A8NAcetylcholinesterase3.1.1.70.462
1ypgUIRProthrombin3.4.21.50.462
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.462
3oxfSAHHistone-lysine N-methyltransferase SMYD32.1.1.430.462
4bmpFMNProtein NrdI/0.462
4mr92BXGamma-aminobutyric acid type B receptor subunit 1/0.462
1lvu9PPPurine nucleoside phosphorylase2.4.2.10.461
1w76GNTAcetylcholinesterase3.1.1.70.461
2a5kAZPReplicase polyprotein 1ab3.4.220.461
2dhfDZFDihydrofolate reductase1.5.1.30.461
2wzySQXSoluble acetylcholine receptor/0.461
2x0fTRHWsaF/0.461
2zdv37UProthrombin3.4.21.50.461
2zfq45UProthrombin3.4.21.50.461
3hatGLY_VAL_ARG_RNGProthrombin3.4.21.50.461
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.461
3v0o4GWHisto-blood group ABO system transferase/0.461
4a83DXCMajor pollen allergen Bet v 1-A/0.461
1w6rGNTAcetylcholinesterase3.1.1.70.460
2ha6SCKAcetylcholinesterase3.1.1.70.460
2zfp19UProthrombin3.4.21.50.460
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3h2sNDPPutative NADH-flavin reductase/0.460
3lm1LECAgglutinin alpha chain/0.460
3tlc7MDMicrocin C7 self-immunity protein MccF/0.460
3ufl508Beta-secretase 13.4.23.460.460
4dju0KKBeta-secretase 13.4.23.460.460
4dyp0MSNucleoprotein/0.460
5dw60T1Succinyl-CoA:acetate CoA-transferase/0.460
1cnfFADNitrate reductase [NADH]1.7.1.10.459
1obnASVIsopenicillin N synthase1.21.3.10.459
1rz1NADPhenol 2-hydroxylase component B/0.459
2f99AKVAklanonic acid methyl ester cyclase AcmA5.5.1.230.459
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.459
2y6fM9FIsopenicillin N synthase1.21.3.10.459
3i7vB4PAP4A hydrolase/0.459
3zksWZVBeta-secretase 23.4.23.450.459
5irnADPNucleotide binding oligomerization domain containing 2/0.459
1c4uIH1Prothrombin3.4.21.50.458
1nzq162Prothrombin3.4.21.50.458
1oc1ASVIsopenicillin N synthase1.21.3.10.458
1rneC60Renin3.4.23.150.458
1ta6177Prothrombin3.4.21.50.458
2e9aB28Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.458
2g1y5IGRenin3.4.23.150.458
2hs8FMN12-oxophytodienoate reductase 31.3.1.420.458
2vq7NAPPutative flavin-containing monooxygenase/0.458
2xuhTZ4Acetylcholinesterase3.1.1.70.458
3c7dNADOctopine dehydrogenase/0.458
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
3p62FMNPentaerythritol tetranitrate reductase/0.458
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.458
3vydVYDRenin3.4.23.150.458
3zeiAWHO-acetylserine sulfhydrylase/0.458
4a862ANMajor pollen allergen Bet v 1-A/0.458
1afeALZProthrombin3.4.21.50.457
1d9i00PProthrombin3.4.21.50.457
1x1aSAMC-20 methyltransferase/0.457
1xagNAD3-dehydroquinate synthase/0.457
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.457
2g247IGRenin3.4.23.150.457
2qimZEAClass 10 plant pathogenesis-related protein/0.457
2z3nPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.457
2zg050UProthrombin3.4.21.50.457
3ipkPMSSurface protein adhesin/0.457
3v2uATPProtein GAL3/0.457
3vjkM51Dipeptidyl peptidase 4/0.457
4blrUTPNTPase P4/0.457
4n4v2GYTankyrase-12.4.2.300.457
4nv10FXFormyl transferase/0.457
2ed4NAD4-hydroxyphenylacetate 3-monooxygenase reductase component1.5.1.360.456
2xkeWI2Serine/threonine-protein kinase Nek22.7.11.10.456
2zvbSAHPrecorrin-3 C17-methyltransferase/0.456
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
3g6zA7TRenin3.4.23.150.456
3nksACJProtoporphyrinogen oxidase1.3.3.40.456
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.456
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.456
4b0qGMFBeta-secretase 13.4.23.460.456
4eu9COASuccinyl-CoA:acetate CoA-transferase/0.456
4ke11R6Beta-secretase 13.4.23.460.456
4m0f1YKAcetylcholinesterase3.1.1.70.456
5ebuFMNLactate oxidase/0.456
1dr3TAPDihydrofolate reductase1.5.1.30.455
1g63FMNEpidermin decarboxylase4.1.10.455
1rt9IMHPurine nucleoside phosphorylase2.4.2.10.455
1t7o152Carnitine O-acetyltransferase2.3.1.70.455
2v3oI26Prothrombin3.4.21.50.455
3r9fGSUMccE protein/0.455
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.455
4h1e10JBeta-secretase 13.4.23.460.455
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.454
1o9bNAIQuinate/shikimate dehydrogenase/0.454
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
1ypmRA4Prothrombin3.4.21.50.454
2bjfDXCCholoylglycine hydrolase3.5.1.240.454
2y60M8FIsopenicillin N synthase1.21.3.10.454
2zgb21UProthrombin3.4.21.50.454
3hgoFMN12-oxophytodienoate reductase 31.3.1.420.454
3qto10PProthrombin3.4.21.50.454
3rthRTHBeta-secretase 13.4.23.460.454
3tg4SAMN-lysine methyltransferase SMYD2/0.454
4b70WM9Beta-secretase 13.4.23.460.454
4l0oPLPCystathionine gamma-synthase2.5.1.480.454
1d3pBT3Prothrombin3.4.21.50.453
1drfFOLDihydrofolate reductase1.5.1.30.453
1dx6GNTAcetylcholinesterase3.1.1.70.453
1e79ATPATP synthase subunit alpha, mitochondrial/0.453
1e79ATPATP synthase subunit beta, mitochondrial3.6.3.140.453
1q1rFADPutidaredoxin reductase1.18.1.50.453
1t4u81AProthrombin3.4.21.50.453
2ckmAA7Acetylcholinesterase3.1.1.70.453
2jh5895Prothrombin3.4.21.50.453
2pncCLUPrimary amine oxidase, liver isozyme/0.453
2v2zCDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.453
2xlpFADPutative flavin-containing monooxygenase/0.453
2xviFADPutative flavin-containing monooxygenase/0.453
3phiNDPShikimate dehydrogenase (NADP(+))/0.453
3qiyQI1Botulinum neurotoxin type A3.4.24.690.453
4bfd8T3Beta-secretase 13.4.23.460.453
4esoNAPPutative oxidoreductase/0.453
4f0e0RUPoly [ADP-ribose] polymerase 152.4.2.300.453
4h6kFMNNADPH dehydrogenase 11.6.99.10.453
5cc9DDFDihydrofolate reductase1.5.1.30.453
1fw0KAIGlutamate receptor 2/0.452
1ghv120Prothrombin3.4.21.50.452
1k7fIAVTryptophan synthase alpha chain/0.452
1u71MXADihydrofolate reductase1.5.1.30.452
2wueKEK4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase3.7.1.170.452
2ym2NAPPhenylacetone monooxygenase1.14.13.920.452
3fhyATPPyridoxal kinase2.7.1.350.452
3gwfNAPCyclohexanone monooxygenase/0.452
3vyeVYERenin3.4.23.150.452
3wqmB29Diterpene synthase3.1.7.80.452
3zmg6Z0Beta-secretase 13.4.23.460.452
4bahMELProthrombin3.4.21.50.452
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
4g2yNI5cGMP-specific 3',5'-cyclic phosphodiesterase/0.452
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.452
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.451
1j1zATPArgininosuccinate synthase/0.451
1kw0H4BPhenylalanine-4-hydroxylase1.14.16.10.451
1zdwFLVPrenyltransferase/0.451
2gyuHI6Acetylcholinesterase3.1.1.70.451
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.451
2jh6894Prothrombin3.4.21.50.451
2pzjNADPutative nucleotide sugar epimerase/ dehydratase/0.451
2zgx29UProthrombin3.4.21.50.451
2zi224UProthrombin3.4.21.50.451
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.451
3b6zCO7Enoyl reductase LovC10.451
3fsjD7KBenzoylformate decarboxylase4.1.1.70.451
3sqwANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.451
3wv9FEGHmd co-occurring protein HcgE/0.451
4a8v2ANMajor pollen allergen Bet v 1-J/0.451
4eu4COASuccinyl-CoA:acetate CoA-transferase/0.451
4y1bNAPAntE/0.451
1e66HUXAcetylcholinesterase3.1.1.70.450
1jdzFMBPurine nucleoside phosphorylase/0.450
1n95HFPProtein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.450
1n95HFPProtein farnesyltransferase subunit beta2.5.1.580.450
1s1rNAPAldo-keto reductase family 1 member C3/0.450
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.450
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.450
1w4zNAPPutative ketoacyl reductase1.3.10.450
2bvs2CEProthrombin3.4.21.50.450
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.450
2uuj896Prothrombin3.4.21.50.450
2xtkAZMClass III chitinase ChiA1/0.450
2zfr46UProthrombin3.4.21.50.450
3mesPT3Putative choline kinase/0.450
3qwc98PProthrombin3.4.21.50.450
3ru0SFGHistone-lysine N-methyltransferase SMYD32.1.1.430.450
3tqxPLP2-amino-3-ketobutyrate coenzyme A ligase/0.450
3upyFOMOxidoreductase, putative/0.450
3w2fNADNADH-cytochrome b5 reductase 31.6.2.20.450
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.450
4glx0XSDNA ligase6.5.1.20.450
4ha513WBeta-secretase 13.4.23.460.450
1nbiSAMGlycine N-methyltransferase2.1.1.200.449
1x1cSAHC-20 methyltransferase/0.449
2a1hGBNBranched-chain-amino-acid aminotransferase, mitochondrial2.6.1.420.449
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.449
2a9y26AAdenosine kinase2.7.1.200.449
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.449
2vetUMPThymidylate synthase/0.449
2yac937Serine/threonine-protein kinase PLK12.7.11.210.449
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.449
3hkyIX6Genome polyprotein2.7.7.480.449
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.449
3v0p4GWHisto-blood group ABO system transferase/0.449
4acuQN7Beta-secretase 13.4.23.460.449
4awsFMNNADH:flavin oxidoreductase Sye1/0.449
4b7zQ4QAcetylcholinesterase3.1.1.70.449
4cdmFO1Deoxyribodipyrimidine photolyase/0.449
4kouC04Uncharacterized protein/0.449
1ae8AZLProthrombin3.4.21.50.448
1d6w00RProthrombin3.4.21.50.448
1gpnHUBAcetylcholinesterase3.1.1.70.448
1tilATPAnti-sigma F factor/0.448
1yplRA8Prothrombin3.4.21.50.448
1zxmANPDNA topoisomerase 2-alpha5.99.1.30.448
2cn0F25Prothrombin3.4.21.50.448
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.448
2ex1C5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.448
2v7qATPATP synthase subunit alpha, mitochondrial/0.448
2v7qATPATP synthase subunit beta, mitochondrial3.6.3.140.448
2vyqFADFerredoxin--NADP reductase1.18.1.20.448
2xluNA7Putative flavin-containing monooxygenase/0.448
3d91REMRenin3.4.23.150.448
3gyaCOAGCN5-related N-acetyltransferase/0.448
3k8q22APurine nucleoside phosphorylase2.4.2.10.448
3kkzSAMUncharacterized protein/0.448
3n19FNRXenobiotic reductase/0.448
3oagLPQRenin3.4.23.150.448
3reoSAH(Iso)eugenol O-methyltransferase2.1.1.1460.448
3vjlW94Dipeptidyl peptidase 4/0.448
3vkjFNRIsopentenyl-diphosphate delta-isomerase/0.448
3w5hFADNADH-cytochrome b5 reductase 31.6.2.20.448
4ey6GNTAcetylcholinesterase3.1.1.70.448
4i1c1BEBeta-secretase 13.4.23.460.448
1acjTHAAcetylcholinesterase3.1.1.70.447
1bcuPRLProthrombin3.4.21.50.447
1lpcCMPAntiviral protein DAP-303.2.2.220.447
1o2g696Prothrombin3.4.21.50.447
1qoqIGPTryptophan synthase alpha chain/0.447
1vhnFMNtRNA-dihydrouridine synthase/0.447
2a0xDIHPurine nucleoside phosphorylase2.4.2.10.447
2cleF6FTryptophan synthase alpha chain/0.447
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.447
2lfoGCHFatty acid-binding protein, liver/0.447
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.447
2z3lPHE_ARG_TYR_LEU_GLYLeucyl/phenylalanyl-tRNA--protein transferase2.3.2.60.447
3adaNADSubunit alpha of sarocosine oxidase/0.447
3exo5MSBeta-secretase 13.4.23.460.447
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.70.447
3qgi33FGenome polyprotein2.7.7.480.447
4gg1TZDBenzoylformate decarboxylase4.1.1.70.447
4i13FOLDihydrofolate reductase1.5.1.30.447
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.430.447
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.447
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1ni12C5Protein farnesyltransferase subunit beta2.5.1.580.446
1po7TZDBenzoylformate decarboxylase4.1.1.70.446
1s7gNADNAD-dependent protein deacylase 2/0.446
1xdsDRAAclacinomycin 10-hydroxylase RdmB4.1.10.446
2a2dANPN-acetylgalactosamine kinase2.7.1.1570.446
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.446
2g1r3IGRenin3.4.23.150.446
2iviACWIsopenicillin N synthase1.21.3.10.446
2j08IRFDeoxyribodipyrimidine photo-lyase4.1.99.30.446
2rqfJH3Hemolymph juvenile hormone binding protein/0.446
2zhe13UProthrombin3.4.21.50.446
3b6pTMPThree-prime repair exonuclease 13.1.11.20.446
3ekuCY9Actin-5C/0.446
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.446
3kn03TOBeta-secretase 13.4.23.460.446
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.446
3r7kFDAProbable acyl CoA dehydrogenase/0.446
3s7dLEU_SER_LYS_LYS_MLZN-lysine methyltransferase SMYD2/0.446
3sfh1DIHistone deacetylase 83.5.1.980.446
3t0iSAHPutative methyltransferase/0.446
3vsxR32Renin3.4.23.150.446
4awtFMNNADH:flavin oxidoreductase Sye1/0.446
4flkY10Methionine aminopeptidase 1/0.446
4js1CTNBeta-galactoside alpha-2,6-sialyltransferase 12.4.99.10.446
4lc71WPBeta-secretase 13.4.23.460.446
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.446
4n3l2FNProthrombin3.4.21.50.446
4yp6NAPNicotinamide-nucleotide adenylyltransferase2.7.7.10.446
1dr5NAPDihydrofolate reductase1.5.1.30.445
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.445
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.445
1sa5BMVProtein farnesyltransferase subunit beta2.5.1.580.445
2gjlFMNNitronate monooxygenase1.13.12.160.445
2j9fTHV2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial1.2.4.40.445
2j9fTHV2-oxoisovalerate dehydrogenase subunit beta, mitochondrial1.2.4.40.445
2w6cBM4Acetylcholinesterase3.1.1.70.445
3bgsDIHPurine nucleoside phosphorylase2.4.2.10.445
3ho2N323-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.445
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.445
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.445
4a86H35Major pollen allergen Bet v 1-A/0.445
4ey7E20Acetylcholinesterase3.1.1.70.445
4qoeFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.445
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.445
4zvnFADRibosyldihydronicotinamide dehydrogenase [quinone]/0.445
1c4yIH3Prothrombin3.4.21.50.444
1j9zFADNADPH--cytochrome P450 reductase/0.444
1n95FTHProtein farnesyltransferase subunit beta2.5.1.580.444
1p0pBCHCholinesterase3.1.1.80.444
1t4v14AProthrombin3.4.21.50.444
1w34FADFerredoxin--NADP reductase1.18.1.20.444
1ypeUIPProthrombin3.4.21.50.444
2cmfF11Acetylcholinesterase3.1.1.70.444
2dshSAHDiphthine synthase/0.444
2g1s4IGRenin3.4.23.150.444
2pauD5M5'-deoxynucleotidase YfbR/0.444
2rlcCHDCholoylglycine hydrolase3.5.1.240.444
2xujTZ5Acetylcholinesterase3.1.1.70.444
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.444
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.444
3eq02TSProthrombin3.4.21.50.444
3fvqATPFe(3+) ions import ATP-binding protein FbpC/0.444
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.444
3intGDUUDP-galactopyranose mutase5.4.99.90.444
3rtnRTNBeta-secretase 13.4.23.460.444
3t7sSAMUncharacterized protein/0.444
3tydXHPDihydropteroate synthase/0.444
3w0tHPULactoylglutathione lyase4.4.1.50.444
4a6nFADTetX family tetracycline inactivation enzyme/0.444
4j1f1HLBeta-secretase 13.4.23.460.444
4j75TYMTryptophan--tRNA ligase/0.444
4lzwTHMUridine phosphorylase/0.444
4q71FADBifunctional protein PutA/0.444
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.444
4tyqAP5Adenylate kinase/0.444
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.444
5hwqCAAHydroxymethylglutaryl-CoA synthase/0.444
1ao8MTXDihydrofolate reductase1.5.1.30.443
1fxuGU7Purine nucleoside phosphorylase2.4.2.10.443
1tiqCOASpermidine/spermine N(1)-acetyltransferase/0.443
2ga9AGSPoly(A) polymerase catalytic subunit2.7.7.190.443
2ovhAS0Progesterone receptor/0.443
2q153MRBeta-secretase 13.4.23.460.443
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.443
2r2mI50Prothrombin3.4.21.50.443
2vprTDCTetracycline repressor protein class H/0.443
2wnbC5PCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 12.4.99.40.443
2xufTZ4Acetylcholinesterase3.1.1.70.443
2zda32UProthrombin3.4.21.50.443
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.443
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.443
3ggs2FDPurine nucleoside phosphorylase2.4.2.10.443
3gqvNAPEnoyl reductase LovC10.443
3i8p8403-oxoacyl-[acyl-carrier-protein] synthase 22.3.1.1790.443
3p9kSAHCaffeic acid O-methyltransferase/0.443
3q7fED2Uncharacterized protein/0.443
3sfy3FYUncharacterized protein/0.443
4eb5PLPCysteine desulfurase IscS 2/0.443
4gddNAIUDP-galactopyranose mutase/0.443
4gtp7TPProtein farnesyltransferase subunit beta2.5.1.580.443
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
4xr9NADCalS8/0.443
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.442
1icsFMN12-oxophytodienoate reductase 11.3.1.420.442
1kw8BPYBiphenyl-2,3-diol 1,2-dioxygenase1.13.11.390.442
1mu8CDBProthrombin3.4.21.50.442
1w0kADPATP synthase subunit alpha, mitochondrial/0.442
1w0kADPATP synthase subunit beta, mitochondrial3.6.3.140.442
1z6tADPApoptotic protease-activating factor 1/0.442
1zrb062Prothrombin3.4.21.50.442
2abbFMNPentaerythritol tetranitrate reductase/0.442
2e0nSAHPrecorrin-2 C20-methyltransferase/0.442
2e8qSAHDiphthine synthase/0.442
2g263LGRenin3.4.23.150.442
2q1tNADPutative nucleotide sugar epimerase/ dehydratase/0.442
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.442
3dhk23UProthrombin3.4.21.50.442
3g72A6TRenin3.4.23.150.442
3k1wBFXRenin3.4.23.150.442
3mjrAC2Deoxycytidine kinase2.7.1.740.442
3nmpPYVAbscisic acid receptor PYL2/0.442
3nxxNDPDihydrofolate reductase1.5.1.30.442
3p1799PProthrombin3.4.21.50.442
3zovWZVBeta-secretase 13.4.23.460.442
4ax9N5NProthrombin3.4.21.50.442
4cf6CBDNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
4da7AC2Purine nucleoside phosphorylase DeoD-type2.4.2.10.442
4de2DN3Beta-lactamase/0.442
4ke01R8Beta-secretase 13.4.23.460.442
5stdUNNScytalone dehydratase4.2.1.940.442
1bwsNDPGDP-L-fucose synthase/0.441
1gj4132Prothrombin3.4.21.50.441
1oytFSNProthrombin3.4.21.50.441
1qzzSAMAclacinomycin 10-hydroxylase RdmB4.1.10.441
1s63778Protein farnesyltransferase subunit beta2.5.1.580.441
1vi2NADQuinate/shikimate dehydrogenase/0.441
2bsxNOSPurine nucleoside phosphorylase/0.441
2bu9HFVIsopenicillin N synthase1.21.3.10.441
2g1o2IGRenin3.4.23.150.441
2gbyBRNHTH-type transcriptional regulator QacR/0.441
2iibC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.441
2jf0HBPAcetylcholinesterase3.1.1.70.441
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
3c36KAIGlutamate receptor ionotropic, kainate 1/0.441
3ccbB2YDipeptidyl peptidase 4/0.441
3fktSIIBeta-secretase 13.4.23.460.441
3uaxNOSPurine nucleoside phosphorylase DeoD-type/0.441
3zoiM2WIsopenicillin N synthase1.21.3.10.441
4b00I6XBeta-secretase 13.4.23.460.441
4b66NAPL-ornithine N(5)-monooxygenase/0.441
4b7754MBeta-secretase 13.4.23.460.441
4f32N323-oxoacyl-[acyl-carrier-protein] synthase 2/0.441
4friDWABeta-secretase 13.4.23.460.441
4jpe1M7Beta-secretase 13.4.23.460.441
5bn3ADPV-type ATP synthase alpha chain/0.441
5bn3ADPNEQ263/0.441
1blzACVIsopenicillin N synthase1.21.3.10.440
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.440
1q20PLOSulfotransferase family cytosolic 2B member 12.8.2.20.440
1q84TZ4Acetylcholinesterase3.1.1.70.440
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.440
1w6hTITPlasmepsin-23.4.23.390.440
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.440
1zgi382Prothrombin3.4.21.50.440
2c6c24IGlutamate carboxypeptidase 23.4.17.210.440
2cf8ESHProthrombin3.4.21.50.440
2fapRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
2fapRADSerine/threonine-protein kinase mTOR2.7.11.10.440
2il2LIXRenin3.4.23.150.440
2iu8UD1UDP-3-O-acylglucosamine N-acyltransferase2.3.10.440
2qe2452Polyprotein/0.440
3biv11UProthrombin3.4.21.50.440
3ftxRE2Leukotriene A-4 hydrolase3.3.2.60.440
3gluLYS_VAL_METNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.440
3h3t16HCollagen type IV alpha-3-binding protein/0.440
3klbFMNUncharacterized protein/0.440
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.440
4araC56Acetylcholinesterase3.1.1.70.440
4b0532DBeta-secretase 13.4.23.460.440
4b68FADL-ornithine N(5)-monooxygenase/0.440
4jxrACOAcetyltransferase/0.440
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.440
4ttjFMCPurine nucleoside phosphorylase DeoD-type/0.440
4ure1PSCyclohexanol dehydrogenase/0.440
5hwoHMGHydroxymethylglutaryl-CoA synthase/0.440
7kmeACE_0BN_CHG_PRRProthrombin3.4.21.50.440