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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sw418KCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3sw418KCyclin-dependent kinase 22.7.11.221.000
3rak03ZCyclin-dependent kinase 22.7.11.220.676
3sw719KCyclin-dependent kinase 22.7.11.220.661
3s1h56ZCyclin-dependent kinase 22.7.11.220.658
2w06FRVCyclin-dependent kinase 22.7.11.220.647
4acm7YGCyclin-dependent kinase 22.7.11.220.633
3rmf20ZCyclin-dependent kinase 22.7.11.220.630
3ral04ZCyclin-dependent kinase 22.7.11.220.613
4bgh3I6Cyclin-dependent kinase 22.7.11.220.613
4fkr45KCyclin-dependent kinase 22.7.11.220.604
4ek816KCyclin-dependent kinase 22.7.11.220.603
4fko20KCyclin-dependent kinase 22.7.11.220.603
4fkq42KCyclin-dependent kinase 22.7.11.220.603
1y91CT9Cyclin-dependent kinase 22.7.11.220.594
2xmyCDKCyclin-dependent kinase 22.7.11.220.594
3qtxX43Cyclin-dependent kinase 22.7.11.220.593
1pxmCK5Cyclin-dependent kinase 22.7.11.220.592
3rpv26ZCyclin-dependent kinase 22.7.11.220.592
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.591
3rpy27ZCyclin-dependent kinase 22.7.11.220.584
1oitHDTCyclin-dependent kinase 22.7.11.220.578
2b52D42Cyclin-dependent kinase 22.7.11.220.578
3rk708ZCyclin-dependent kinase 22.7.11.220.576
1urwI1PCyclin-dependent kinase 22.7.11.220.575
4fkv61KCyclin-dependent kinase 22.7.11.220.574
1ke5LS1Cyclin-dependent kinase 22.7.11.220.573
3sqq99ZCyclin-dependent kinase 22.7.11.220.573
1gih1PUCyclin-dependent kinase 22.7.11.220.567
1ke7LS3Cyclin-dependent kinase 22.7.11.220.566
2r3lSCWCyclin-dependent kinase 22.7.11.220.566
1ke6LS2Cyclin-dependent kinase 22.7.11.220.565
2w1hL0FCyclin-dependent kinase 22.7.11.220.565
2uzoC62Cyclin-dependent kinase 22.7.11.220.564
3rk507ZCyclin-dependent kinase 22.7.11.220.562
3ezvEZVCyclin-dependent kinase 22.7.11.220.561
3unk0BYCyclin-dependent kinase 22.7.11.220.561
3qu0X40Cyclin-dependent kinase 22.7.11.220.560
3r1sX73Cyclin-dependent kinase 22.7.11.220.559
3qtzX42Cyclin-dependent kinase 22.7.11.220.557
4fkpLS5Cyclin-dependent kinase 22.7.11.220.557
4fki09KCyclin-dependent kinase 22.7.11.220.556
1w0xOLOCyclin-dependent kinase 22.7.11.220.555
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.555
3r1yX76Cyclin-dependent kinase 22.7.11.220.555
3py0SU9Cyclin-dependent kinase 22.7.11.220.554
4ez30S0Cyclin-dependent kinase 22.7.11.220.554
2btsU32Cyclin-dependent kinase 22.7.11.220.553
3s2pPMUCyclin-dependent kinase 22.7.11.220.546
1di8DTQCyclin-dependent kinase 22.7.11.220.545
1pxoCK7Cyclin-dependent kinase 22.7.11.220.544
2c6o4SPCyclin-dependent kinase 22.7.11.220.543
3qxpX64Cyclin-dependent kinase 22.7.11.220.543
3unj0BXCyclin-dependent kinase 22.7.11.220.543
2a0cCK9Cyclin-dependent kinase 22.7.11.220.542
1ke8LS4Cyclin-dependent kinase 22.7.11.220.539
2c6iDT1Cyclin-dependent kinase 22.7.11.220.538
3r8lZ30Cyclin-dependent kinase 22.7.11.220.538
1ke9LS5Cyclin-dependent kinase 22.7.11.220.537
3qruX19Cyclin-dependent kinase 22.7.11.220.537
4fks46KCyclin-dependent kinase 22.7.11.220.536
2uznC96Cyclin-dependent kinase 22.7.11.220.534
2vthLZ2Cyclin-dependent kinase 22.7.11.220.534
3lfnA27Cyclin-dependent kinase 22.7.11.220.534
3r9oZ71Cyclin-dependent kinase 22.7.11.220.534
1h0w207Cyclin-dependent kinase 22.7.11.220.531
4fkj11KCyclin-dependent kinase 22.7.11.220.530
2r3kSCQCyclin-dependent kinase 22.7.11.220.529
3qzgX67Cyclin-dependent kinase 22.7.11.220.529
3fz1B98Cyclin-dependent kinase 22.7.11.220.528
3r7uX96Cyclin-dependent kinase 22.7.11.220.524
3rni21ZCyclin-dependent kinase 22.7.11.220.524
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.523
3r73X87Cyclin-dependent kinase 22.7.11.220.523
2r3iSCFCyclin-dependent kinase 22.7.11.220.522
3qtuX44Cyclin-dependent kinase 22.7.11.220.522
3qzhX69Cyclin-dependent kinase 22.7.11.220.522
1p2a5BNCyclin-dependent kinase 22.7.11.220.521
3r9dX6BCyclin-dependent kinase 22.7.11.220.521
3rpo24ZCyclin-dependent kinase 22.7.11.220.521
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.520
1g5sI17Cyclin-dependent kinase 22.7.11.220.519
2bhhRYUCyclin-dependent kinase 22.7.11.220.518
2btrU73Cyclin-dependent kinase 22.7.11.220.518
3qwjX6ACyclin-dependent kinase 22.7.11.220.517
3rk909ZCyclin-dependent kinase 22.7.11.220.517
1h1s4SPCyclin-dependent kinase 22.7.11.220.516
3pxyJWSCyclin-dependent kinase 22.7.11.220.516
2r64740Cyclin-dependent kinase 22.7.11.220.515
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.514
4fkw62KCyclin-dependent kinase 22.7.11.220.514
1ckpPVBCyclin-dependent kinase 22.7.11.220.513
1pxlCK4Cyclin-dependent kinase 22.7.11.220.513
1v1k3FPCyclin-dependent kinase 22.7.11.220.511
1gii1PUCyclin-dependent kinase 22.7.11.220.510
2fvdLIACyclin-dependent kinase 22.7.11.220.508
1e1xNW1Cyclin-dependent kinase 22.7.11.220.507
1oiyN41Cyclin-dependent kinase 22.7.11.220.507
3r71X86Cyclin-dependent kinase 22.7.11.220.507
3qqkX02Cyclin-dependent kinase 22.7.11.220.505
3r7vZ02Cyclin-dependent kinase 22.7.11.220.505
2vttLZDCyclin-dependent kinase 22.7.11.220.504
3qqfX07Cyclin-dependent kinase 22.7.11.220.504
3rjc06ZCyclin-dependent kinase 22.7.11.220.504
4ek610KCyclin-dependent kinase 22.7.11.220.504
3r83Z14Cyclin-dependent kinase 22.7.11.220.503
3s0o50ZCyclin-dependent kinase 22.7.11.220.503
2b55D31Cyclin-dependent kinase 22.7.11.220.502
3qxoX65Cyclin-dependent kinase 22.7.11.220.502
2xnbY8LCyclin-dependent kinase 22.7.11.220.501
3lfqA28Cyclin-dependent kinase 22.7.11.220.501
3wblPDYCyclin-dependent kinase 22.7.11.220.501
4fkg4CKCyclin-dependent kinase 22.7.11.220.501
1h1r6CPCyclin-dependent kinase 22.7.11.220.500
2vv9IM9Cyclin-dependent kinase 22.7.11.220.500
3qtrX36Cyclin-dependent kinase 22.7.11.220.500
3uli1N3Cyclin-dependent kinase 22.7.11.220.500
1oirHDYCyclin-dependent kinase 22.7.11.220.499
3iggEFQCyclin-dependent kinase 22.7.11.220.498
3rm719ZCyclin-dependent kinase 22.7.11.220.498
1pxpCK8Cyclin-dependent kinase 22.7.11.220.497
3qx2X63Cyclin-dependent kinase 22.7.11.220.496
3rkb12ZCyclin-dependent kinase 22.7.11.220.495
3r9hZ67Cyclin-dependent kinase 22.7.11.220.493
1ykr628Cyclin-dependent kinase 22.7.11.220.492
3ti1B49Cyclin-dependent kinase 22.7.11.220.492
4fklCK2Cyclin-dependent kinase 22.7.11.220.492
1pyePM1Cyclin-dependent kinase 22.7.11.220.491
3r8vZ62Cyclin-dependent kinase 22.7.11.220.491
3roy22ZCyclin-dependent kinase 22.7.11.220.490
3qzfX66Cyclin-dependent kinase 22.7.11.220.489
4fx360KCyclin-dependent kinase 22.7.11.220.489
2w17I19Cyclin-dependent kinase 22.7.11.220.488
3r7yZ04Cyclin-dependent kinase 22.7.11.220.488
4eok4SPCyclin-dependent kinase 22.7.11.220.487
4nj32KDCyclin-dependent kinase 22.7.11.220.487
2iw84SPCyclin-dependent kinase 22.7.11.220.486
3ig7EFPCyclin-dependent kinase 22.7.11.220.486
3qtqX35Cyclin-dependent kinase 22.7.11.220.485
3r1qX75Cyclin-dependent kinase 22.7.11.220.485
3qqhX0ACyclin-dependent kinase 22.7.11.220.484
2r3o2SCCyclin-dependent kinase 22.7.11.220.482
1vyzN5BCyclin-dependent kinase 22.7.11.220.481
1oguST8Cyclin-dependent kinase 22.7.11.220.480
2exmZIPCyclin-dependent kinase 22.7.11.220.480
3r7eX88Cyclin-dependent kinase 22.7.11.220.478
4qmpDKISerine/threonine-protein kinase 242.7.11.10.478
1oi9N20Cyclin-dependent kinase 22.7.11.220.477
3ql8X01Cyclin-dependent kinase 22.7.11.220.477
3r8pZ46Cyclin-dependent kinase 22.7.11.220.477
2iw94SPCyclin-dependent kinase 22.7.11.220.476
2j9mPY8Cyclin-dependent kinase 22.7.11.220.476
3gxlQIGTGF-beta receptor type-12.7.11.300.476
3pj8404Cyclin-dependent kinase 22.7.11.220.476
2vtsLZCCyclin-dependent kinase 22.7.11.220.475
4fkt48KCyclin-dependent kinase 22.7.11.220.475
1b39ATPCyclin-dependent kinase 22.7.11.220.474
1w8cN69Cyclin-dependent kinase 22.7.11.220.474
1y8yCT7Cyclin-dependent kinase 22.7.11.220.474
2duv371Cyclin-dependent kinase 22.7.11.220.474
3ddpRC8Cyclin-dependent kinase 22.7.11.220.474
3raiX85Cyclin-dependent kinase 22.7.11.220.474
1dm2HMDCyclin-dependent kinase 22.7.11.220.473
2a4lRRCCyclin-dependent kinase 22.7.11.220.471
3rm618ZCyclin-dependent kinase 22.7.11.220.470
1h0vUN4Cyclin-dependent kinase 22.7.11.220.469
4lyn1YGCyclin-dependent kinase 22.7.11.220.469
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.469
3lfsA07Cyclin-dependent kinase 22.7.11.220.468
3qwkX62Cyclin-dependent kinase 22.7.11.220.468
3r8zZ63Cyclin-dependent kinase 22.7.11.220.468
4kd11QKCyclin-dependent kinase 22.7.11.220.468
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.468
1gij2PUCyclin-dependent kinase 22.7.11.220.467
1pxkCK3Cyclin-dependent kinase 22.7.11.220.467
1r78FMDCyclin-dependent kinase 22.7.11.220.467
3r6xX84Cyclin-dependent kinase 22.7.11.220.467
4aqc88ATyrosine-protein kinase JAK2/0.467
4eon1ROCyclin-dependent kinase 22.7.11.220.467
2vtlLZ5Cyclin-dependent kinase 22.7.11.220.466
1aq1STUCyclin-dependent kinase 22.7.11.220.465
1fvv107Cyclin-dependent kinase 22.7.11.220.465
4gih0X5Non-receptor tyrosine-protein kinase TYK22.7.10.20.465
2r3r6SCCyclin-dependent kinase 22.7.11.220.464
2pvnP63Casein kinase II subunit alpha2.7.11.10.463
1fvt106Cyclin-dependent kinase 22.7.11.220.462
2r3p3SCCyclin-dependent kinase 22.7.11.220.462
2x1nX1NCyclin-dependent kinase 22.7.11.220.462
3bhtMFRCyclin-dependent kinase 22.7.11.220.462
1b38ATPCyclin-dependent kinase 22.7.11.220.461
1oiqHDUCyclin-dependent kinase 22.7.11.220.461
2c6kDT2Cyclin-dependent kinase 22.7.11.220.461
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.461
1vyw292Cyclin-dependent kinase 22.7.11.220.459
2r3jSCJCyclin-dependent kinase 22.7.11.220.459
1e9hINRCyclin-dependent kinase 22.7.11.220.458
2c5yMTWCyclin-dependent kinase 22.7.11.220.458
4dgnLU2Casein kinase II subunit alpha2.7.11.10.458
2wxvWXVCyclin-dependent kinase 22.7.11.220.457
3ddqRRCCyclin-dependent kinase 22.7.11.220.457
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.457
4dgo0JWCasein kinase II subunit alpha2.7.11.10.456
3qziX72Cyclin-dependent kinase 22.7.11.220.454
2wpa889Cyclin-dependent kinase 22.7.11.220.453
2cchATPCyclin-dependent kinase 22.7.11.220.452
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.452
2pvlP55Casein kinase II subunit alpha2.7.11.10.452
2r3mSCXCyclin-dependent kinase 22.7.11.220.452
3ggfGVDSerine/threonine-protein kinase 26/0.452
2b53D23Cyclin-dependent kinase 22.7.11.220.450
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.449
3qtwX3ACyclin-dependent kinase 22.7.11.220.449
4eor4SPCyclin-dependent kinase 22.7.11.220.449
2c6lDT4Cyclin-dependent kinase 22.7.11.220.448
2eufLQQCyclin-dependent kinase 62.7.11.220.448
4aua4AUCyclin-dependent kinase 62.7.11.220.448
2uzeC95Cyclin-dependent kinase 22.7.11.220.447
3sheI85MAP kinase-activated protein kinase 32.7.11.10.447
1om1IQACasein kinase II subunit alpha2.7.11.10.446
1vjy460TGF-beta receptor type-12.7.11.300.446
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.446
4z64ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.445
2vu3LZECyclin-dependent kinase 22.7.11.220.445
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.445
2b54D05Cyclin-dependent kinase 22.7.11.220.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
3dogNNNCyclin-dependent kinase 22.7.11.220.444
4bcmT7ZCyclin-dependent kinase 22.7.11.220.444
4bcnT9NCyclin-dependent kinase 22.7.11.220.444
1m2pHNACasein kinase II subunit alpha2.7.11.10.443
1unlRRCCyclin-dependent-like kinase 52.7.11.10.443
3be9P04Casein kinase II subunit alpha2.7.11.10.442
3r28XA0Cyclin-dependent kinase 22.7.11.220.442
4anmWULCasein kinase II subunit alpha2.7.11.10.442
2wihP48Cyclin-dependent kinase 22.7.11.220.441
3ezrEZRCyclin-dependent kinase 22.7.11.220.441
3tnwF18Cyclin-dependent kinase 22.7.11.220.441
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
4bcpT3CCyclin-dependent kinase 22.7.11.220.440
4eos1ROCyclin-dependent kinase 22.7.11.220.440