sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 3sqz | COA | Putative hydroxymethylglutaryl-CoA synthase | / | 1.000 | |
| 2wya | HMG | Hydroxymethylglutaryl-CoA synthase, mitochondrial | 2.3.3.10 | 0.599 | |
| 1txt | CAA | HMG-CoA synthase | / | 0.580 | |
| 5hwo | HMG | Hydroxymethylglutaryl-CoA synthase | / | 0.566 | |
| 2p8u | COA | Hydroxymethylglutaryl-CoA synthase, cytoplasmic | 2.3.3.10 | 0.543 | |
| 5hwp | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.537 | |
| 5hwr | COA | Hydroxymethylglutaryl-CoA synthase | / | 0.534 | |
| 1ysl | COA | Hydroxymethylglutaryl-CoA synthase | 2.3.3.10 | 0.530 | |
| 2fa3 | ACO | Hydroxymethylglutaryl-CoA synthase | / | 0.528 | |
| 5hwq | CAA | Hydroxymethylglutaryl-CoA synthase | / | 0.527 | |
| 1kvk | ATP | Mevalonate kinase | 2.7.1.36 | 0.510 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.506 | |
| 4jtq | NAP | Aldo-keto reductase family 1 member C2 | / | 0.503 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.500 | |
| 3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.497 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.494 | |
| 1t7o | 152 | Carnitine O-acetyltransferase | 2.3.1.7 | 0.493 | |
| 3g45 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.493 | |
| 3rdq | DTB | Streptavidin | / | 0.493 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.492 | |
| 1nbi | SAM | Glycine N-methyltransferase | 2.1.1.20 | 0.490 | |
| 4df2 | FMN | NADPH dehydrogenase | / | 0.490 | |
| 1z6t | ADP | Apoptotic protease-activating factor 1 | / | 0.488 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.487 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.486 | |
| 4jq3 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.486 | |
| 4ozt | P1A | Ecdysone receptor, putative | / | 0.486 | |
| 2bri | ANP | Uridylate kinase | 2.7.4.22 | 0.484 | |
| 2hdj | NDP | Aldo-keto reductase family 1 member C2 | / | 0.484 | |
| 4wdf | A2P | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.484 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.483 | |
| 1ni4 | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.483 | |
| 1w6r | GNT | Acetylcholinesterase | 3.1.1.7 | 0.483 | |
| 3atz | FMN | Prostaglandin F2a synthase | / | 0.483 | |
| 3qwb | NDP | Probable quinone oxidoreductase | 1.6.5.5 | 0.483 | |
| 4m6j | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.482 | |
| 4b67 | NAP | L-ornithine N(5)-monooxygenase | / | 0.481 | |
| 4y3j | HIC | Endothiapepsin | 3.4.23.22 | 0.481 | |
| 1h73 | ANP | Homoserine kinase | 2.7.1.39 | 0.480 | |
| 5irn | ADP | Nucleotide binding oligomerization domain containing 2 | / | 0.480 | |
| 3fun | 798 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.478 | |
| 1drh | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.477 | |
| 2c29 | NAP | Dihydroflavonol 4-reductase | / | 0.477 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.477 | |
| 3p67 | FMN | Pentaerythritol tetranitrate reductase | / | 0.477 | |
| 1qbq | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.476 | |
| 1qbq | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.476 | |
| 1qti | GNT | Acetylcholinesterase | 3.1.1.7 | 0.476 | |
| 3b1d | PLS | BetaC-S lyase | / | 0.476 | |
| 3eku | CY9 | Actin-5C | / | 0.476 | |
| 3p62 | FMN | Pentaerythritol tetranitrate reductase | / | 0.476 | |
| 1lnm | DTX | Bilin-binding protein | / | 0.475 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.475 | |
| 3dy8 | 5GP | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.475 | |
| 3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.475 | |
| 4ez8 | DHF | Thymidylate synthase | 2.1.1.45 | 0.475 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.474 | |
| 2v59 | LZK | Biotin carboxylase | 6.3.4.14 | 0.473 | |
| 1f5f | DHT | Sex hormone-binding globulin | / | 0.472 | |
| 3fp0 | FP0 | 15-O-acetyltransferase | / | 0.472 | |
| 1c7o | PPG | Hemolysin | / | 0.471 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.471 | |
| 2ekp | NAD | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.470 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.470 | |
| 3exh | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.470 | |
| 3jsw | JAR | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.470 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.470 | |
| 4f0r | MTA | 5-methylthioadenosine/S-adenosylhomocysteine deaminase | / | 0.470 | |
| 4nxx | GDP | Mitochondrial dynamics protein MID51 | / | 0.470 | |
| 1e66 | HUX | Acetylcholinesterase | 3.1.1.7 | 0.469 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 4ubt | COA | Steroid 3-ketoacyl-CoA thiolase | / | 0.469 | |
| 4xo7 | NAP | Aldo-keto reductase family 1 member C2 | / | 0.469 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.468 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.468 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.468 | |
| 2fvl | NAP | Aldo-keto reductase family 1 member C4 | 1.1.1.225 | 0.468 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.468 | |
| 2vf3 | GVS | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.468 | |
| 3ful | 52D | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.468 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.468 | |
| 4qzu | RTL | Retinol-binding protein 2 | / | 0.468 | |
| 1h63 | FMN | Pentaerythritol tetranitrate reductase | / | 0.467 | |
| 1v35 | NAI | Enoyl-ACP reductase | / | 0.467 | |
| 2fzn | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.467 | |
| 2r8o | T5X | Transketolase 1 | / | 0.467 | |
| 4k6f | NAP | Putative Acetoacetyl-CoA reductase | / | 0.467 | |
| 4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.467 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.466 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.466 | |
| 3fuj | 00G | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.466 | |
| 3k3h | BYE | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.466 | |
| 4hwk | NAP | Sepiapterin reductase | 1.1.1.153 | 0.466 | |
| 1w4l | GL8 | Acetylcholinesterase | 3.1.1.7 | 0.465 | |
| 1y2b | DEE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.465 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.465 | |
| 3duf | R1T | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.465 | |
| 3jpu | TY4 | Transcriptional activator protein LasR | / | 0.465 | |
| 4a83 | DXC | Major pollen allergen Bet v 1-A | / | 0.465 | |
| 4c4o | NAD | SADH | / | 0.465 | |
| 4e2d | FMN | Dehydrogenase | / | 0.465 | |
| 1kce | CB3 | Thymidylate synthase | / | 0.464 | |
| 1lf3 | EH5 | Plasmepsin-2 | 3.4.23.39 | 0.464 | |
| 1rfg | GMP | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 1z3c | SA8 | mRNA cap guanine-N7 methyltransferase | 2.1.1.56 | 0.464 | |
| 1zgb | A1E | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 2q1s | NAI | Putative nucleotide sugar epimerase/ dehydratase | / | 0.464 | |
| 2r5n | TPP | Transketolase 1 | / | 0.464 | |
| 3byz | H11 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.464 | |
| 3mau | EXT | Putative sphingosine-1-phosphate lyase | / | 0.464 | |
| 3tif | ADP | Uncharacterized ABC transporter ATP-binding protein MJ0796 | / | 0.464 | |
| 3zv7 | NHG | Acetylcholinesterase | 3.1.1.7 | 0.464 | |
| 4a8v | 2AN | Major pollen allergen Bet v 1-J | / | 0.464 | |
| 4bc7 | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.464 | |
| 4fiz | CUE | 17beta-hydroxysteroid dehydrogenase | / | 0.464 | |
| 4zu4 | 4TG | WxcM-like protein | / | 0.464 | |
| 1d4a | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.463 | |
| 1tkc | M6T | Transketolase 1 | 2.2.1.1 | 0.463 | |
| 2ewm | NAD | (S)-1-Phenylethanol dehydrogenase | 1.1.1.311 | 0.463 | |
| 4b1r | ITC | Tetracycline repressor protein class D | / | 0.463 | |
| 1c3x | 8IG | Purine nucleoside phosphorylase | 2.4.2.1 | 0.462 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.462 | |
| 1yw8 | A75 | Methionine aminopeptidase 2 | / | 0.462 | |
| 2bu9 | HFV | Isopenicillin N synthase | 1.21.3.1 | 0.462 | |
| 2ea2 | F77 | Methionine aminopeptidase 2 | / | 0.462 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.462 | |
| 3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.462 | |
| 3zbz | OVE | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.462 | |
| 4a86 | H35 | Major pollen allergen Bet v 1-A | / | 0.462 | |
| 4bfv | ZVV | Pantothenate kinase | 2.7.1.33 | 0.462 | |
| 4ejm | NAP | Putative zinc-binding dehydrogenase | / | 0.462 | |
| 3atr | FDA | Conserved Archaeal protein | / | 0.461 | |
| 3h3t | 16H | Collagen type IV alpha-3-binding protein | / | 0.461 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 4a81 | DXC | Major pollen allergen Bet v 1-A | / | 0.461 | |
| 4ewn | 0VR | Imidazole glycerol phosphate synthase subunit HisF | 4.1.3 | 0.461 | |
| 4j7h | TRH | PCZA361.3 | / | 0.461 | |
| 5dp2 | NAP | CurF | / | 0.461 | |
| 1h50 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 1h69 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.460 | |
| 1ix1 | BB2 | Peptide deformylase | / | 0.460 | |
| 1opm | IYG | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.460 | |
| 1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.460 | |
| 2abb | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 2fj1 | CTC | Tetracycline repressor protein class D | / | 0.460 | |
| 3f03 | FMN | Pentaerythritol tetranitrate reductase | / | 0.460 | |
| 4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.460 | |
| 4eph | 0RK | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.460 | |
| 4f32 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | / | 0.460 | |
| 4g2l | 0WL | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.460 | |
| 4opc | FDA | Conserved Archaeal protein | / | 0.460 | |
| 1i59 | ADP | Chemotaxis protein CheA | 2.7.13.3 | 0.459 | |
| 1ju2 | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.459 | |
| 1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.459 | |
| 1xl8 | 152 | Peroxisomal carnitine O-octanoyltransferase | 2.3.1.137 | 0.459 | |
| 2wo7 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.459 | |
| 2xlp | FAD | Putative flavin-containing monooxygenase | / | 0.459 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.459 | |
| 3aty | FMN | Prostaglandin F2a synthase | / | 0.459 | |
| 3fhx | PLP | Pyridoxal kinase | 2.7.1.35 | 0.459 | |
| 3fkt | SII | Beta-secretase 1 | 3.4.23.46 | 0.459 | |
| 4bft | ZVT | Pantothenate kinase | 2.7.1.33 | 0.459 | |
| 4cdm | FO1 | Deoxyribodipyrimidine photolyase | / | 0.459 | |
| 4epl | JAI | Jasmonic acid-amido synthetase JAR1 | 6.3.2 | 0.459 | |
| 4m0c | FMN | FMN-dependent NADH-azoreductase 1 | / | 0.459 | |
| 4mr9 | 2BX | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.459 | |
| 1i59 | ANP | Chemotaxis protein CheA | 2.7.13.3 | 0.458 | |
| 1n95 | HFP | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.458 | |
| 1n95 | HFP | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 1n95 | FTH | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.458 | |
| 1s3u | TQD | Dihydrofolate reductase | 1.5.1.3 | 0.458 | |
| 1toi | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.458 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.458 | |
| 2ed4 | NAD | 4-hydroxyphenylacetate 3-monooxygenase reductase component | 1.5.1.36 | 0.458 | |
| 2fon | FAD | Acyl-coenzyme A oxidase | / | 0.458 | |
| 2vke | TAC | Tetracycline repressor protein class D | / | 0.458 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.458 | |
| 3c3e | GDP | 2-phospho-L-lactate transferase | / | 0.458 | |
| 3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.458 | |
| 3otw | COA | Phosphopantetheine adenylyltransferase | / | 0.458 | |
| 3uzw | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.458 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.458 | |
| 4do3 | 0LA | Fatty-acid amide hydrolase 1 | 3.5.1.99 | 0.458 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 2cy0 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.457 | |
| 3c3x | NAP | Eugenol synthase 1 | 1.1.1.318 | 0.457 | |
| 3eks | CY9 | Actin-5C | / | 0.457 | |
| 3jzd | NAD | Maleylacetate reductase | / | 0.457 | |
| 3q33 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.457 | |
| 3q8u | ADP | Nucleoside diphosphate kinase | / | 0.457 | |
| 3qls | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 3zw9 | NAD | Peroxisomal bifunctional enzyme | 1.1.1.35 | 0.457 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.457 | |
| 4bqz | GNP | Ectonucleoside triphosphate diphosphohydrolase 2 | / | 0.457 | |
| 4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.457 | |
| 4gh6 | LUO | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.457 | |
| 4j8t | DOG | Uncharacterized PhzA/B-like protein PA3332 | / | 0.457 | |
| 4kxj | P34 | Nucleoprotein | / | 0.457 | |
| 1eno | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic | 1.3.1.9 | 0.456 | |
| 1jtu | LYB | Thymidylate synthase | / | 0.456 | |
| 1lf2 | R37 | Plasmepsin-2 | 3.4.23.39 | 0.456 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 1thn | ADP | Anti-sigma F factor | / | 0.456 | |
| 2e0n | SAH | Precorrin-2 C20-methyltransferase | / | 0.456 | |
| 2nnl | NAP | Dihydroflavonol 4-reductase | 1.1.1.219 | 0.456 | |
| 2xi4 | AFT | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
| 3h3q | H13 | Collagen type IV alpha-3-binding protein | / | 0.456 | |
| 4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
| 4dvi | 2IW | Tankyrase-1 | 2.4.2.30 | 0.456 | |
| 4g95 | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 4idg | NAD | Putative UDP-glucose 4-epimerase | / | 0.456 | |
| 4ku5 | DCC | 3-oxoacyl-[ACP] synthase III | / | 0.456 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.456 | |
| 5dhh | DGW | Nociceptin receptor | / | 0.456 | |
| 1d0l | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.455 | |
| 1e2n | RCA | Thymidine kinase | / | 0.455 | |
| 1fml | RTL | Retinol dehydratase | / | 0.455 | |
| 1g8j | MGD | Arsenite oxidase subunit AioA | 1.20.9.1 | 0.455 | |
| 1gqy | ACP | UDP-N-acetylmuramate--L-alanine ligase | 6.3.2.8 | 0.455 | |
| 1p0p | BCH | Cholinesterase | 3.1.1.8 | 0.455 | |
| 1trg | CB3 | Thymidylate synthase | / | 0.455 | |
| 2gmh | FAD | Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial | 1.5.5.1 | 0.455 | |
| 2r8p | T6F | Transketolase 1 | / | 0.455 | |
| 3dyn | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial | 1.2.4.1 | 0.455 | |
| 3exf | TPP | Pyruvate dehydrogenase E1 component subunit beta, mitochondrial | 1.2.4.1 | 0.455 | |
| 3gmd | 2M3 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.455 | |
| 3nmp | PYV | Abscisic acid receptor PYL2 | / | 0.455 | |
| 4d9e | LCS | D-cysteine desulfhydrase | / | 0.455 | |
| 4xsv | C5P | Ethanolamine-phosphate cytidylyltransferase | 2.7.7.14 | 0.455 | |
| 1dx6 | GNT | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.454 | |
| 1t9g | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.454 | |
| 2j3q | TFL | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
| 2yvg | NAD | Ferredoxin reductase | / | 0.454 | |
| 3iqh | TYR_ASP_ILE | Cysteine synthase | 2.5.1.47 | 0.454 | |
| 4emd | C5P | 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase | / | 0.454 | |
| 4jlm | 1NN | Deoxycytidine kinase | 2.7.1.74 | 0.454 | |
| 4loc | BTN | Pyruvate carboxylase | / | 0.454 | |
| 4mr7 | 2BV | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.454 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.453 | |
| 2yph | QQY | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 2yq9 | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.453 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.453 | |
| 3bk2 | U5P | Ribonuclease J | / | 0.453 | |
| 3hbf | MYC | Flavonoid 3-O-glucosyltransferase | 2.4.1 | 0.453 | |
| 3i0p | NAD | Malate dehydrogenase, putative | / | 0.453 | |
| 3t4n | ADP | 5'-AMP-activated protein kinase subunit gamma | / | 0.453 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.453 | |
| 4g67 | SAH | Uncharacterized ACR, COG1565 superfamily | / | 0.453 | |
| 4r1l | ADP | Phenylacetate-coenzyme A ligase | / | 0.453 | |
| 1mvs | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 1qrp | HH0 | Pepsin A-4 | 3.4.23.1 | 0.452 | |
| 1ycf | FMN | Nitric oxide reductase | 1 | 0.452 | |
| 2rqf | JH3 | Hemolymph juvenile hormone binding protein | / | 0.452 | |
| 3biy | 01K | Histone acetyltransferase p300 | / | 0.452 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.452 | |
| 3dyl | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.452 | |
| 3ids | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.452 | |
| 3mau | PLR | Putative sphingosine-1-phosphate lyase | / | 0.452 | |
| 3p74 | FMN | Pentaerythritol tetranitrate reductase | / | 0.452 | |
| 3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.452 | |
| 4a86 | 2AN | Major pollen allergen Bet v 1-A | / | 0.452 | |
| 4dfr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.452 | |
| 4die | C5P | Cytidylate kinase | / | 0.452 | |
| 4lm4 | JPZ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.452 | |
| 4twn | B96 | Ephrin type-A receptor 3 | 2.7.10.1 | 0.452 | |
| 1bwl | FMN | NADPH dehydrogenase 1 | 1.6.99.1 | 0.451 | |
| 1crb | RTL | Retinol-binding protein 1 | / | 0.451 | |
| 1qy5 | NEC | Endoplasmin | / | 0.451 | |
| 1rr6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.451 | |
| 1std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.451 | |
| 2fxu | BID | Actin, alpha skeletal muscle | / | 0.451 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.451 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 2ztl | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.451 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.451 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.451 | |
| 3m2u | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.451 | |
| 4dx7 | DM2 | Multidrug efflux pump subunit AcrB | / | 0.451 | |
| 4eqr | COA | Coenzyme A disulfide reductase | / | 0.451 | |
| 5b0o | ADP | Flagellum-specific ATP synthase | 3.6.3.14 | 0.451 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.450 | |
| 1h51 | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1jqi | FAD | Short-chain specific acyl-CoA dehydrogenase, mitochondrial | / | 0.450 | |
| 1kbj | FMN | Cytochrome b2, mitochondrial | 1.1.2.3 | 0.450 | |
| 1vyr | FMN | Pentaerythritol tetranitrate reductase | / | 0.450 | |
| 1xs7 | MMI | Beta-secretase 1 | 3.4.23.46 | 0.450 | |
| 1yci | NDF | Hypoxia-inducible factor 1-alpha inhibitor | 1.14.11.30 | 0.450 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.450 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.450 | |
| 2q1t | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.450 | |
| 2xlr | NAP | Putative flavin-containing monooxygenase | / | 0.450 | |
| 2yy2 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.450 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.450 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.450 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.450 | |
| 3oib | FDA | Putative acyl-CoA dehydrogenase | / | 0.450 | |
| 3zht | TD9 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.450 | |
| 4b63 | NAP | L-ornithine N(5)-monooxygenase | / | 0.450 | |
| 4e2b | FMN | Dehydrogenase | / | 0.450 | |
| 4imf | SI3 | N-acetylneuraminate lyase | / | 0.450 | |
| 4jln | 18V | Deoxycytidine kinase | 2.7.1.74 | 0.450 | |
| 1gaw | FAD | Ferredoxin | / | 0.449 | |
| 1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 1lke | DOG | Bilin-binding protein | / | 0.449 | |
| 1n2s | NAI | dTDP-4-dehydrorhamnose reductase | 1.1.1.133 | 0.449 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.449 | |
| 1obn | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 1rt9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.449 | |
| 1zdw | FLV | Prenyltransferase | / | 0.449 | |
| 2gjn | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.449 | |
| 2pk3 | A2R | GDP-6-deoxy-D-mannose reductase | / | 0.449 | |
| 2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.449 | |
| 2xvi | FAD | Putative flavin-containing monooxygenase | / | 0.449 | |
| 2yd0 | BES | Endoplasmic reticulum aminopeptidase 1 | 3.4.11 | 0.449 | |
| 3ag6 | PAJ | Pantothenate synthetase | / | 0.449 | |
| 3bxo | UPP | dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucopyranose | / | 0.449 | |
| 3dys | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 3g0y | P9A | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.449 | |
| 3int | GDU | UDP-galactopyranose mutase | 5.4.99.9 | 0.449 | |
| 4c72 | TLG | 3-oxoacyl-ACP synthase | / | 0.449 | |
| 4e90 | 7RG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.449 | |
| 4y0k | NAP | AntE | / | 0.449 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.448 | |
| 1hb3 | SCV | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
| 1lsj | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.448 | |
| 1me6 | IVS | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 1mv8 | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.448 | |
| 1olm | VTQ | SEC14-like protein 2 | / | 0.448 | |
| 1q0r | AKT | Aclacinomycin methylesterase RdmC | 3.1.1.95 | 0.448 | |
| 1rsz | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.448 | |
| 1rx8 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.448 | |
| 1vkg | CRI | Histone deacetylase 8 | 3.5.1.98 | 0.448 | |
| 1zgc | A2E | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2ejz | SAH | Diphthine synthase | / | 0.448 | |
| 2ggs | NDP | dTDP-4-dehydrorhamnose reductase | / | 0.448 | |
| 2ha6 | SCK | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
| 2hk9 | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.448 | |
| 2iku | LIY | Renin | 3.4.23.15 | 0.448 | |
| 2pzj | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.448 | |
| 2ztv | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.448 | |
| 3d3p | 20A | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.448 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3gwd | NAP | Cyclohexanone monooxygenase | / | 0.448 | |
| 3img | BZ3 | Pantothenate synthetase | 6.3.2.1 | 0.448 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.448 | |
| 3vsw | R31 | Renin | 3.4.23.15 | 0.448 | |
| 4c0b | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.448 | |
| 4ms1 | 381 | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.448 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.448 | |
| 4qi7 | FAD | Cellobiose dehydrogenase | / | 0.448 | |
| 5c1m | CLR | Mu-type opioid receptor | / | 0.448 | |
| 5cyo | GDP | Septin-9 | / | 0.448 | |
| 5e5h | 0T1 | Succinyl-CoA:acetate CoA-transferase | / | 0.448 | |
| 1a9y | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.447 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.447 | |
| 1gg5 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1h5q | NAP | NADP-dependent mannitol dehydrogenase | 1.1.1.138 | 0.447 | |
| 1ps9 | MDE | 2,4-dienoyl-CoA reductase | 1.3.1.34 | 0.447 | |
| 1w6j | R71 | Lanosterol synthase | 5.4.99.7 | 0.447 | |
| 2ed3 | SAH | Diphthine synthase | / | 0.447 | |
| 2gv8 | NDP | Thiol-specific monooxygenase | 1.14.13 | 0.447 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 2q7o | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.447 | |
| 3fuh | BES | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.447 | |
| 3g1r | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.447 | |
| 3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.447 | |
| 3oaf | OAG | Dihydrofolate reductase | 1.5.1.3 | 0.447 | |
| 4cvm | ANP | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase | / | 0.447 | |
| 4d96 | 5PA | D-cysteine desulfhydrase | / | 0.447 | |
| 4mfe | BTN | Pyruvate carboxylase | / | 0.447 | |
| 4mpr | TPP | Benzoylformate decarboxylase | 4.1.1.7 | 0.447 | |
| 4qof | FMN | Ribosyldihydronicotinamide dehydrogenase [quinone] | / | 0.447 | |
| 4yai | NAI | C alpha-dehydrogenase | / | 0.447 | |
| 4ytn | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.447 | |
| 5a3b | APR | SIR2 family protein | / | 0.447 | |
| 5il2 | SAH | N6-adenosine-methyltransferase 70 kDa subunit | / | 0.447 | |
| 1eii | RTL | Retinol-binding protein 2 | / | 0.446 | |
| 1ib0 | FAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.446 | |
| 1mvt | DTM | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.446 | |
| 1xel | UPG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.446 | |
| 1y2e | 5DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 2 | / | 0.446 | |
| 2gvd | FKP | Adenylate cyclase type 5 | / | 0.446 | |
| 2i4q | UA4 | Renin | 3.4.23.15 | 0.446 | |
| 2npi | ATP | mRNA cleavage and polyadenylation factor CLP1 | / | 0.446 | |
| 2npx | NAD | NADH peroxidase | 1.11.1.1 | 0.446 | |
| 2oc9 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.446 | |
| 2op1 | 8PC | Enoyl-ACP reductase | / | 0.446 | |
| 2vn1 | FK5 | Peptidylprolyl isomerase | / | 0.446 | |
| 3dmt | NAD | Glyceraldehyde-3-phosphate dehydrogenase, glycosomal | 1.2.1.12 | 0.446 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit alpha | 1.2.4.1 | 0.446 | |
| 3dva | TPW | Pyruvate dehydrogenase E1 component subunit beta | 1.2.4.1 | 0.446 | |
| 3elu | SAM | Methyltransferase | / | 0.446 | |
| 3ho2 | N32 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.446 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.446 | |
| 3img | BZ2 | Pantothenate synthetase | 6.3.2.1 | 0.446 | |
| 3och | 2MX | Dihydrofolate reductase | 1.5.1.3 | 0.446 | |
| 3pl8 | FAD | Pyranose 2-oxidase | / | 0.446 | |
| 3pqb | VGP | Putative oxidoreductase | / | 0.446 | |
| 3up4 | FAD | 2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase | 1.14.13.160 | 0.446 | |
| 3zhu | TD8 | Multifunctional 2-oxoglutarate metabolism enzyme | 1.2.4.2 | 0.446 | |
| 4du6 | GTP | GTP cyclohydrolase 1 | / | 0.446 | |
| 4m49 | 22Y | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.446 | |
| 5fwn | NAP | Putative dehydrogenase | / | 0.446 | |
| 1bim | 0QB | Renin | 3.4.23.15 | 0.445 | |
| 1h66 | RH1 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1kt3 | RTL | Retinol-binding protein 4 | / | 0.445 | |
| 1qyw | 5SD | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.445 | |
| 1r6t | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.445 | |
| 1tl7 | FOK | Adenylate cyclase type 2 | / | 0.445 | |
| 1tl7 | FOK | Adenylate cyclase type 5 | / | 0.445 | |
| 1u4o | NDD | L-lactate dehydrogenase | 1.1.1.27 | 0.445 | |
| 2b3d | FAD | Modulator of drug activity B | / | 0.445 | |
| 2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.445 | |
| 2g1n | 1IG | Renin | 3.4.23.15 | 0.445 | |
| 2x7h | PFN | Prostaglandin reductase 3 | 1 | 0.445 | |
| 2y99 | NAD | Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase | 1.3.1.56 | 0.445 | |
| 3c1o | NAP | Eugenol synthase | / | 0.445 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.445 | |
| 3hbb | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.445 | |
| 3l0l | HC3 | Nuclear receptor ROR-gamma | / | 0.445 | |
| 3lzw | NAP | Ferredoxin--NADP reductase 2 | 1.18.1.2 | 0.445 | |
| 4bkq | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | / | 0.445 | |
| 4hbm | 0Y7 | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.445 | |
| 4l1x | NAP | Aldo-keto reductase family 1 member C2 | / | 0.445 | |
| 4o9c | COA | Acetyl-CoA acetyltransferase | 2.3.1.9 | 0.445 | |
| 4pzs | ACO | Histone acetyltransferase p300 | / | 0.445 | |
| 4ymk | ST9 | Acyl-CoA desaturase 1 | / | 0.445 | |
| 1cjt | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cjt | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1cju | FOK | Adenylate cyclase type 2 | / | 0.444 | |
| 1cju | FOK | Adenylate cyclase type 5 | / | 0.444 | |
| 1g6k | NAD | Glucose 1-dehydrogenase | 1.1.1.47 | 0.444 | |
| 1m9n | AMZ | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.444 | |
| 1ut6 | A8N | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 1vi2 | NAD | Quinate/shikimate dehydrogenase | / | 0.444 | |
| 1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
| 2a9y | 26A | Adenosine kinase | 2.7.1.20 | 0.444 | |
| 2e8u | IPE | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 2oc4 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.444 | |
| 2pg0 | FAD | Acyl-CoA dehydrogenase | / | 0.444 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.444 | |
| 2zev | B71 | Geranylgeranyl pyrophosphate synthase | / | 0.444 | |
| 3a0t | ADP | Sensor histidine kinase | / | 0.444 | |
| 3b05 | IPE | Isopentenyl-diphosphate delta-isomerase | / | 0.444 | |
| 3bv2 | P38 | Mitogen-activated protein kinase 14 | / | 0.444 | |
| 3o4r | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.444 | |
| 3w2f | NAD | NADH-cytochrome b5 reductase 3 | 1.6.2.2 | 0.444 | |
| 4d89 | BXD | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 4wud | ANP | DNA gyrase subunit B | / | 0.444 | |
| 5b1y | NDP | 3-oxoacyl-[acyl-carrier-protein] reductase | / | 0.444 | |
| 5ch7 | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.444 | |
| 1cjk | FOK | Adenylate cyclase type 2 | / | 0.443 | |
| 1cjk | FOK | Adenylate cyclase type 5 | / | 0.443 | |
| 1j49 | NAD | D-lactate dehydrogenase | 1.1.1.28 | 0.443 | |
| 1jnz | FAD | Adenylylsulfate reductase, subunit A (AprA) | / | 0.443 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.443 | |
| 1rx1 | NAP | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 1sb8 | UD2 | WbpP | / | 0.443 | |
| 2a2d | ANP | N-acetylgalactosamine kinase | 2.7.1.157 | 0.443 | |
| 2b4t | AES | Glyceraldehyde-3-phosphate dehydrogenase | / | 0.443 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.443 | |
| 2i7p | ACO | Pantothenate kinase 3 | 2.7.1.33 | 0.443 | |
| 2r0p | K2C | Putative FAD-monooxygenase | / | 0.443 | |
| 2rgo | FAD | Alpha-Glycerophosphate Oxidase | / | 0.443 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.443 | |
| 3aw9 | NAD | NAD-dependent epimerase/dehydratase | / | 0.443 | |
| 3cz7 | ACO | Histone acetyltransferase RTT109 | 2.3.1.48 | 0.443 | |
| 3d7z | GK5 | Mitogen-activated protein kinase 14 | / | 0.443 | |
| 3dme | FAD | Putative conserved exported protein | / | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | / | 0.443 | |
| 3e34 | ED1 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.443 | |
| 3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.443 | |
| 3o0o | 5AD | Vitamin B12-dependent ribonucleotide reductase | / | 0.443 | |
| 3rvh | HQ2 | Lysine-specific demethylase 4A | 1.14.11 | 0.443 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.443 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.443 | |
| 4iql | FMN | Enoyl-(Acyl-carrier-protein) reductase II | / | 0.443 | |
| 4n1g | CEI | Obelin | / | 0.443 | |
| 4rsy | B3N | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.443 | |
| 5std | UNN | Scytalone dehydratase | 4.2.1.94 | 0.443 | |
| 1ay0 | TPP | Transketolase 1 | 2.2.1.1 | 0.442 | |
| 1iy8 | NAD | Levodione reductase | / | 0.442 | |
| 1ppj | ANY | Cytochrome b | / | 0.442 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2aqb | TL6 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.442 | |
| 2bgi | FAD | NADPH:ferredoxin reductase | / | 0.442 | |
| 2d1y | NAD | Oxidoreductase, short-chain dehydrogenase/reductase family | / | 0.442 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.442 | |
| 2rlc | CHD | Choloylglycine hydrolase | 3.5.1.24 | 0.442 | |
| 3bv7 | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3c15 | FOK | Adenylate cyclase type 2 | / | 0.442 | |
| 3c15 | FOK | Adenylate cyclase type 5 | / | 0.442 | |
| 3dop | NAP | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.442 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.442 | |
| 3fui | 812 | Leukotriene A-4 hydrolase | 3.3.2.6 | 0.442 | |
| 3ha5 | SFG | Hydroxymycolate synthase MmaA4 | 2.1.1 | 0.442 | |
| 3ipk | PMS | Surface protein adhesin | / | 0.442 | |
| 3l77 | NJP | Short-chain alcohol dehydrogenase | / | 0.442 | |
| 3orf | NAD | Dihydropteridine reductase | 1.5.1.34 | 0.442 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.442 | |
| 4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4bfu | ZVU | Pantothenate kinase | 2.7.1.33 | 0.442 | |
| 4fqs | LYA | Thymidylate synthase ThyA | / | 0.442 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.442 | |
| 4gz6 | 12V | UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit | / | 0.442 | |
| 4jzr | 4JR | Egl nine homolog 1 | / | 0.442 | |
| 4xg1 | LLP | Diaminopimelate decarboxylase | / | 0.442 | |
| 4xyb | NDP | Formate dehydrogenase | / | 0.442 | |
| 4ydd | MD1 | DMSO reductase family type II enzyme, molybdopterin subunit | / | 0.442 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.442 | |
| 1gky | 5GP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 1ia1 | NDP | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1pd9 | CO4 | Dihydrofolate reductase | 1.5.1.3 | 0.441 | |
| 1q5m | NDP | Prostaglandin-E(2) 9-reductase | 1.1.1.189 | 0.441 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 1tka | N3T | Transketolase 1 | 2.2.1.1 | 0.441 | |
| 1vot | HUP | Acetylcholinesterase | 3.1.1.7 | 0.441 | |
| 2c20 | NAD | UDP-glucose 4-epimerase | / | 0.441 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.441 | |
| 2on6 | IMH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.441 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.441 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.441 | |
| 2x06 | NAD | L-sulfolactate dehydrogenase | / | 0.441 | |
| 2yqz | SAM | Uncharacterized protein | / | 0.441 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3b05 | FNR | Isopentenyl-diphosphate delta-isomerase | / | 0.441 | |
| 3f1k | NAP | Uncharacterized oxidoreductase YciK | 1 | 0.441 | |
| 3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.441 | |
| 3gwd | FAD | Cyclohexanone monooxygenase | / | 0.441 | |
| 3gwf | FAD | Cyclohexanone monooxygenase | / | 0.441 | |
| 3i8p | 840 | 3-oxoacyl-[acyl-carrier-protein] synthase 2 | 2.3.1.179 | 0.441 | |
| 3inv | NDP | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.441 | |
| 3maa | FKP | Adenylate cyclase type 2 | / | 0.441 | |
| 3maa | FKP | Adenylate cyclase type 5 | / | 0.441 | |
| 3phj | DHK | Shikimate dehydrogenase (NADP(+)) | / | 0.441 | |
| 3qgi | 33F | Genome polyprotein | 2.7.7.48 | 0.441 | |
| 3up0 | D7S | aceDAF-12 | / | 0.441 | |
| 4bj9 | UHB | Tankyrase-2 | 2.4.2.30 | 0.441 | |
| 4e2x | TYD | Methyltransferase | / | 0.441 | |
| 4f3g | KAI | Glutamate receptor 3 | / | 0.441 | |
| 4g2y | NI5 | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
| 4i0h | 1BL | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4lxa | 1YS | Beta-secretase 1 | 3.4.23.46 | 0.441 | |
| 4m83 | ERY | Oleandomycin glycosyltransferase | 2.4.1 | 0.441 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.441 | |
| 1d0m | BLG | Membrane-bound lytic murein transglycosylase B | 4.2.2.n1 | 0.440 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.440 | |
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 0.440 | |
| 1i75 | NOJ | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.440 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.440 | |
| 1muu | GDX | GDP-mannose 6-dehydrogenase | 1.1.1.132 | 0.440 | |
| 1po7 | TZD | Benzoylformate decarboxylase | 4.1.1.7 | 0.440 | |
| 1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.440 | |
| 1r6u | TYM | Tryptophan--tRNA ligase, cytoplasmic | 6.1.1.2 | 0.440 | |
| 1sdw | IYT | Peptidyl-glycine alpha-amidating monooxygenase | 1.14.17.3 | 0.440 | |
| 1t2c | NAI | L-lactate dehydrogenase | 1.1.1.27 | 0.440 | |
| 1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.440 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.440 | |
| 2aq7 | TL5 | 3-oxoacyl-[acyl-carrier-protein] synthase 1 | 2.3.1.41 | 0.440 | |
| 2e16 | SAH | Diphthine synthase | / | 0.440 | |
| 2pam | TYD | TDP-4-oxo-6-deoxy-alpha-D-glucose-3,4-oxoisomerase | 5.3.2.3 | 0.440 | |
| 2q2v | NAD | Beta-D-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 2w6z | L21 | Biotin carboxylase | 6.3.4.14 | 0.440 | |
| 2xlr | FAD | Putative flavin-containing monooxygenase | / | 0.440 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.440 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 3gdp | FAD | (R)-mandelonitrile lyase 2 | 4.1.2.10 | 0.440 | |
| 3gka | FMN | N-ethylmaleimide reductase | / | 0.440 | |
| 3h3s | H15 | Collagen type IV alpha-3-binding protein | / | 0.440 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.440 | |
| 3kjs | NAP | Bifunctional dihydrofolate reductase-thymidylate synthase | / | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit alpha | 2.8.4.1 | 0.440 | |
| 3m1v | COM | Methyl-coenzyme M reductase I subunit beta | 2.8.4.1 | 0.440 | |
| 3o26 | NDP | Salutaridine reductase | / | 0.440 | |
| 3p8z | SAH | Genome polyprotein | 2.1.1.56 | 0.440 | |
| 3v0p | 4GW | Histo-blood group ABO system transferase | / | 0.440 | |
| 3vv8 | B02 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.440 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.440 | |
| 4cf6 | CBD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 | |
| 4dbc | 3QP | Aspartate aminotransferase | 2.6.1.1 | 0.440 | |
| 4dja | FAD | (6-4) photolyase | / | 0.440 | |
| 4f6w | 0SS | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.440 | |
| 4tlz | NAP | KtzI | / | 0.440 | |
| 4u9z | COA | Alpha-tubulin N-acetyltransferase 1 | / | 0.440 | |
| 4uug | PXG | Branched-chain amino acid aminotransferase, putative | / | 0.440 | |
| 4xbf | FAD | Lysine-specific histone demethylase 1A | 1 | 0.440 | |
| 5a88 | ADP | Riboflavin biosynthesis protein RibF | 2.7.1.26 | 0.440 | |
| 5c6c | CMP | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.440 | |
| 4mqt | 2CU | Muscarinic acetylcholine receptor M2 | / | 0.440 |