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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3sm2478Putative gag-pro-pol polyprotein

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
3sm2478Putative gag-pro-pol polyprotein/1.000
3slz3TLPutative gag-pro-pol polyprotein/0.724
3kddJZQGag-Pol polyprotein3.4.23.160.547
3ekp478Gag-Pol polyprotein3.4.23.160.534
3linE13Protease/0.533
4a6bQG8Gag-Pol polyprotein3.4.23.160.520
4a6cQG9Gag-Pol polyprotein3.4.23.160.516
3s43478Protease/0.514
3bgcLJHGag-Pol polyprotein3.4.23.160.513
4ye3G04Gag-Pol polyprotein3.4.23.160.512
3nu3478Gag-Pol polyprotein3.4.23.160.510
3a2oKNJGag-Pol polyprotein3.4.23.160.509
3dk1G05Gag-Pol polyprotein3.4.23.160.509
3kdcJZPGag-Pol polyprotein3.4.23.160.508
3livE16Protease/0.507
2ieo017Protease/0.506
1a9mU0EGag-Pol polyprotein/0.505
1msmJE2Gag-Pol polyprotein3.4.23.160.505
3fx5KNIGag-Pol polyprotein3.4.23.160.505
1sdvMK1Gag-Pol polyprotein3.4.23.160.504
3bgbLJGGag-Pol polyprotein3.4.23.160.504
3ekwDR7Gag-Pol polyprotein3.4.23.160.504
4njvRITProtease/0.504
2qd8065Gag-Pol polyprotein3.4.23.160.503
1c6yMK1Protease/0.502
3lzu017Gag-Pol polyprotein3.4.23.160.502
3liqE14Protease/0.501
3t3c017Gag-Pol polyprotein3.4.23.160.501
1idb0DOGag-Pol polyprotein/0.499
4hegG52Gag-Pol polyprotein3.4.23.160.499
2f80017Gag-Pol polyprotein3.4.23.160.498
3kf03TLGag-Pol polyprotein/0.498
3oxv478Gag-Pol polyprotein3.4.23.160.497
3vfa031Gag-Pol polyprotein3.4.23.160.497
4njsG08Protease/0.497
3d1z017Gag-Pol polyprotein3.4.23.160.496
1hshMK1Gag-Pol polyprotein/0.495
2wkz5AHGag-Pol polyprotein/0.495
2qd6065Gag-Pol polyprotein3.4.23.160.494
3nu5478Gag-Pol polyprotein3.4.23.160.494
1hpxKNIGag-Pol polyprotein/0.493
4hdbG52Gag-Pol polyprotein3.4.23.160.493
1ec2BEJGag-Pol polyprotein3.4.23.160.492
3cyw017Gag-Pol polyprotein3.4.23.160.492
1ec3MS3Gag-Pol polyprotein3.4.23.160.491
1fg62NCGag-Pol polyprotein3.4.23.160.491
2bqvA1AProtease/0.491
3litE15Protease/0.491
2bb9AKCGag-Pol polyprotein3.4.23.160.490
3kfn3TLGag-Pol polyprotein/0.490
4dfg0JVGag-Pol polyprotein3.4.23.160.490
2bpw1INGag-Pol polyprotein3.4.23.160.489
3ttp017Gag-Pol polyprotein3.4.23.160.489
1d4kPI8Gag-Pol polyprotein3.4.23.160.488
3nls016Gag-Pol polyprotein3.4.23.160.488
2fdd385Pol protein/0.486
4hla017Gag-Pol polyprotein3.4.23.160.486
1bwaXV6Gag-Pol polyprotein3.4.23.160.485
2a4fAAUV-1 protease/0.485
2wl05AHGag-Pol polyprotein/0.485
3el1DR7Gag-Pol polyprotein3.4.23.160.485
3el9DR7Gag-Pol polyprotein3.4.23.160.485
1d4iBEGGag-Pol polyprotein3.4.23.160.484
1sbgIM1Gag-Pol polyprotein/0.484
1wbmBLLPol protein/0.484
2fde385Gag-Pol polyprotein3.4.23.160.484
2r5pMK1Gag-Pol polyprotein/0.484
3kfr3TLGag-Pol polyprotein/0.484
3nu4478Gag-Pol polyprotein3.4.23.160.484
3st5G89Gag-Pol polyprotein3.4.23.160.484
1t7i017Gag-Pol polyprotein3.4.23.160.483
2i4dQFIProtease/0.483
3s85LK0Gag-Pol polyprotein/0.483
1ebk0Q4Gag-Pol polyprotein3.4.23.160.482
1hxwRITGag-Pol polyprotein/0.482
2cem2AHPol protein/0.482
3i2l2NCProtease/0.482
3i6oGR6Gag-Pol polyprotein3.4.23.160.482
1npvL27Gag-Pol polyprotein3.4.23.160.481
1yt9OISGag-Pol polyprotein/0.481
3s54017Protease/0.481
1d4hBEHGag-Pol polyprotein3.4.23.160.480
1t7kBH0Gag-Pol polyprotein3.4.23.160.480
1wbk568Pol protein/0.480
2hc0AB2Protease/0.480
2nnkROCProtease/0.480
1mrwK57Gag-Pol polyprotein3.4.23.160.479
1sdtMK1Gag-Pol polyprotein3.4.23.160.479
2pym1UNGag-Pol polyprotein3.4.23.160.479
3mws017Pol protein/0.479
3vf5031Gag-Pol polyprotein3.4.23.160.479
4j55031Gag-Pol polyprotein3.4.23.160.479
4qgiROCGag-Pol polyprotein3.4.23.160.479
1ec0BEDGag-Pol polyprotein3.4.23.160.478
1sguMK1Gag-Pol polyprotein3.4.23.160.478
2f8g017Gag-Pol polyprotein3.4.23.160.478
3sa755AProtease/0.478
3ucb017Gag-Pol polyprotein/0.478
4j5j478Gag-Pol polyprotein3.4.23.160.478
1ffi2NCGag-Pol polyprotein3.4.23.160.477
3djkG55Gag-Pol polyprotein3.4.23.160.477
3nu6478Gag-Pol polyprotein3.4.23.160.477
2cen4AHProtease/0.476
2hb3GRLProtease/0.476
2z54AB1Gag-Pol polyprotein3.4.23.160.476
3ggu017Gag-Pol polyprotein3.4.23.160.476
4q1y017Gag-Pol polyprotein3.4.23.160.476
1npa3NHGag-Pol polyprotein3.4.23.160.475
1npwLGZGag-Pol polyprotein3.4.23.160.475
2aquDR7Gag-Pol polyprotein3.4.23.160.475
2avm2NCGag-Pol polyprotein3.4.23.160.475
2i4vDJRV-1 protease/0.475
2qci065Gag-Pol polyprotein3.4.23.160.475
3cyxROCGag-Pol polyprotein3.4.23.160.475
3pwrROCGag-Pol polyprotein3.4.23.160.475
1fej2NCGag-Pol polyprotein3.4.23.160.474
1hiv1ZKGag-Pol polyprotein/0.474
1k6vXN2Gag-Pol polyprotein3.4.23.160.474
1xl5190Gag-Pol polyprotein3.4.23.160.474
2pk6O33V-1 protease/0.474
2qi3MZ5Gag-Pol polyprotein/0.474
2xyeCXGGag-Pol polyprotein/0.474
3qn8NI7Gag-Pol polyprotein3.4.23.160.474
1vikBAYGag-Pol polyprotein/0.473
1w5vBE3Gag-Pol polyprotein3.4.23.160.473
2bpv1INGag-Pol polyprotein3.4.23.160.473
2qhcAB1Protease/0.473
3em4DR7Gag-Pol polyprotein3.4.23.160.473
3oxxDR7Gag-Pol polyprotein3.4.23.160.473
1d4jMSCGag-Pol polyprotein3.4.23.160.472
2fxeDR7Gag-Pol polyprotein3.4.23.160.472
2nmyROCProtease/0.472
3nu9478Gag-Pol polyprotein3.4.23.160.472
3zptM8YGag-Pol polyprotein3.4.23.160.472
4q1w017Gag-Pol polyprotein3.4.23.160.472
1bai0Q4Gag-Pro polyprotein/0.471
1msnJE2Gag-Pol polyprotein3.4.23.160.471
2uxzHI1Gag-Pol polyprotein3.4.23.160.471
3nuo478Gag-Pol polyprotein3.4.23.160.471
3qaaG04Gag-Pol polyprotein3.4.23.160.471
1bdrIM1Gag-Pol polyprotein3.4.23.160.470
1hvrXK2Gag-Pol polyprotein/0.470
1izhQ50Protease/0.470
2i4qUA4Renin3.4.23.150.470
2z4o065Gag-Pol polyprotein3.4.23.160.470
1bdlIM1Gag-Pol polyprotein3.4.23.160.469
1ebyBEBGag-Pol polyprotein3.4.23.160.469
3ekqROCGag-Pol polyprotein3.4.23.160.469
3qp0NI8Gag-Pol polyprotein3.4.23.160.469
4djoMK5Pol polyprotein/0.469
4hdfG52Gag-Pol polyprotein3.4.23.160.469
1fgc2NCGag-Pol polyprotein3.4.23.160.468
2qi5MZ7Gag-Pol polyprotein/0.468
3jw2017Gag-Pol polyprotein3.4.23.160.468
3ndxRITGag-Pol polyprotein3.4.23.160.468
3oxw017Gag-Pol polyprotein3.4.23.160.468
3tl9ROCGag-Pol polyprotein3.4.23.160.468
2b7zMK1Gag-Pol polyprotein/0.467
2q5kAB1Protease/0.467
2rkfAB1Pol protein/0.467
3dcrKVSProtease/0.467
3kfs3TLGag-Pol polyprotein/0.467
3nduROCGag-Pol polyprotein3.4.23.160.467
1ebzBECGag-Pol polyprotein3.4.23.160.466
1hsgMK1Gag-Pol polyprotein/0.466
1odw0E8Gag-Pol polyprotein3.4.23.160.466
1w5yBE6Gag-Pol polyprotein3.4.23.160.466
1zsr0ZTGag-Pol polyprotein3.4.23.160.466
2b60RITPol polyprotein/0.466
2qnnQN1Gag-Pol polyprotein3.4.23.160.466
3ec0GRLGag-Pol polyprotein3.4.23.470.466
3ggaGGWGag-Pol polyprotein/0.466
3lixE17Protease/0.466
3own3OWRenin3.4.23.150.466
3sa5A69Protease/0.466
3saa77FProtease/0.466
4djr0KJPol polyprotein/0.466
3ekt017Gag-Pol polyprotein3.4.23.160.465
3ogqAB1Pol polyprotein/0.465
1hpoUNIGag-Pol polyprotein3.4.23.160.464
1muiAB1Protease/0.464
1t7j478Gag-Pol polyprotein3.4.23.160.464
2p3c3TLProtease/0.464
2qak1UNGag-Pol polyprotein3.4.23.160.464
3d91REMRenin3.4.23.150.464
3ekyDR7Gag-Pol polyprotein3.4.23.160.464
3ggxGGXGag-Pol polyprotein/0.464
3vfb031Gag-Pol polyprotein3.4.23.160.464
1ec1BEEGag-Pol polyprotein3.4.23.160.463
1hviA77Protease/0.463
2cej1AHPol protein/0.463
2i4wKGQProtease/0.463
3bvb017Gag-Pol polyprotein3.4.23.160.463
3el51UNGag-Pol polyprotein/0.463
4a4qUX9Pol protein/0.463
1daz0Q4Gag-Pol polyprotein3.4.23.160.462
1hosPHPGag-Pol polyprotein/0.462
1mtrPI6Gag-Pol polyprotein3.4.23.160.462
2xyfG40Gag-Pol polyprotein/0.462
3jvwDMPGag-Pol polyprotein3.4.23.160.462
3nuj478Gag-Pol polyprotein3.4.23.160.462
3sa9A68Protease/0.462
4njuTPVProtease/0.462
4q1x017Gag-Pol polyprotein3.4.23.160.462
1n49RITGag-Pol polyprotein3.4.23.160.461
2avsMK1Gag-Pol polyprotein3.4.23.160.461
2q54MU1Protease/0.461
2r5q1UNGag-Pol polyprotein/0.461
3o9hK2EGag-Pol polyprotein/0.461
3zpuM8BGag-Pol polyprotein3.4.23.160.461
4dqc017Gag-Pol polyprotein/0.461
1a8g2Z4Gag-Pol polyprotein3.4.23.160.460
1tcxIM1Gag-Pol polyprotein3.4.23.160.460
2i4uDJRProtease/0.460
2pk5075Protease/0.460
2qd7065Gag-Pol polyprotein3.4.23.160.460
2qhzMZ2Gag-Pol polyprotein/0.460
3oy4017Gag-Pol polyprotein3.4.23.160.460
4kb9G79Protease/0.460
1tcwIM1Gag-Pol polyprotein/0.459
2aoe0Q4Gag-Pol polyprotein3.4.23.160.459
2avvMK1Gag-Pol polyprotein3.4.23.160.459
2bpz3INGag-Pol polyprotein3.4.23.160.459
2fxdDR7Pol polyprotein/0.459
2i4xKGQProtease/0.459
2uy0HV1Gag-Pol polyprotein3.4.23.160.459
3o99K13Pol polyprotein/0.459
4rvj478Protease/0.459
1d4lPI9Gag-Pol polyprotein3.4.23.160.458
1iiq0ZRGag-Pol polyprotein3.4.23.160.458
1mesDMPGag-Pol polyprotein3.4.23.160.458
1sduMK1Gag-Pol polyprotein3.4.23.160.458
2g21L1BRenin3.4.23.150.458
2hs1017Protease/0.458
3aidARQGag-Pol polyprotein3.4.23.160.458
3lzv017Gag-Pol polyprotein3.4.23.160.458
3o9dK19Pol polyprotein/0.458
4dqf017Gag-Pol polyprotein/0.458
1c6zROCProtease/0.457
1difA85Gag-Pol polyprotein/0.457
1odyLP1Gag-Pol polyprotein3.4.23.160.457
1vijBAYGag-Pol polyprotein/0.457
2f3kRO1Protease/0.457
3d1yROCGag-Pol polyprotein3.4.23.160.457
3o9gF53Gag-Pol polyprotein/0.457
4dqh017Gag-Pol polyprotein/0.457
1d4yTPVGag-Pol polyprotein3.4.23.160.456
1ida0POGag-Pol polyprotein3.4.23.470.456
1jld0PPGag-Pol polyprotein/0.456
1proA88Gag-Pol polyprotein/0.456
1qbsDMPGag-Pol polyprotein3.4.23.160.456
2g263LGRenin3.4.23.150.456
2q631UNGag-Pol polyprotein3.4.23.160.456
2qnqQN3Gag-Pol polyprotein3.4.23.160.456
3qrmNK7Gag-Pol polyprotein3.4.23.160.456
3sa323XProtease/0.456
3uhl2NCGag-Pol polyprotein3.4.23.160.456
3zpsEQMGag-Pol polyprotein3.4.23.160.456
1bv7XV6Gag-Pol polyprotein3.4.23.160.455
1g35AHFGag-Pol polyprotein3.4.23.160.455
2p3b3TLV-1 PROTEASE protein/0.455
2p3b3TLV-1 protease/0.455
3bxsDRSGag-Pol polyprotein3.4.23.160.455
3nyg2NCGag-Pol polyprotein3.4.23.160.455
1hpv478Gag-Pol polyprotein/0.454
2pyn1UNGag-Pol polyprotein3.4.23.160.454
3d1xROCGag-Pol polyprotein3.4.23.160.454
3em6017Gag-Pol polyprotein3.4.23.160.454
3i7eDJRGag-Pol polyprotein/0.454
3o9iA61Gag-Pol polyprotein/0.454
3so9017Pol protein/0.454
4djqM86Pol polyprotein/0.454
4hdpG52Gag-Pol polyprotein3.4.23.160.454
1bv9XV6Gag-Pol polyprotein3.4.23.160.453
2g20L1ARenin3.4.23.150.453
2qhyMZ1Gag-Pol polyprotein/0.453
2qi7MZ9Gag-Pol polyprotein/0.453
3g6zA7TRenin3.4.23.150.453
3g72A6TRenin3.4.23.150.453
3jvy017Gag-Pol polyprotein3.4.23.160.453
3ok9G52Gag-Pol polyprotein3.4.23.160.453
3qrsNK8Gag-Pol polyprotein3.4.23.160.453
4djpM73Pol polyprotein/0.453
1hvjA78Gag-Pol polyprotein/0.452
1hvsA77Gag-Pol polyprotein/0.452
2bbbHH1Gag-Pol polyprotein3.4.23.160.452
2bpy3INGag-Pol polyprotein3.4.23.160.452
2q641UNGag-Pol polyprotein3.4.23.160.452
3d20017Gag-Pol polyprotein3.4.23.160.452
3mxeK54Gag-Pol polyprotein3.4.23.160.452
3o9cK20Pol polyprotein/0.452
3oxcROCProtease/0.452
3sacAF8Protease/0.452
1b6pPI7Gag-Pol polyprotein3.4.23.160.451
1ebwBEIGag-Pol polyprotein3.4.23.160.451
1g2kNM1Gag-Pol polyprotein3.4.23.160.451
1ivp1ZKGag-Pol polyprotein/0.451
1k2b0Q4Gag-Pol polyprotein3.4.23.160.451
1meuDMPGag-Pol polyprotein3.4.23.160.451
2bktRPFRenin3.4.23.150.451
2g1r3IGRenin3.4.23.150.451
3cktYDPGag-Pol polyprotein3.4.23.160.451
3nxe2NCProtease/0.451
3sa6F71Protease/0.451
1b6kPI5Gag-Pol polyprotein3.4.23.160.450
1bdqIM1Gag-Pol polyprotein3.4.23.160.450
1zsf0ZSGag-Pol polyprotein3.4.23.160.450
2il2LIXRenin3.4.23.150.450
3bva2NCGag-Pol polyprotein3.4.23.160.450
3o9aK14Pol polyprotein/0.450
3vf7031Gag-Pol polyprotein3.4.23.160.450
1a8k0Q4Gag-Pol polyprotein3.4.23.160.449
1a940Q4Gag-Pol polyprotein3.4.23.160.449
1ajvNMBGag-Pol polyprotein3.4.23.160.449
1bil0IURenin3.4.23.150.449
1hvlA76Gag-Pol polyprotein/0.449
1w5xBE5Gag-Pol polyprotein3.4.23.160.449
3ecg065Gag-Pol polyprotein3.4.23.470.449
3ekv478Gag-Pol polyprotein3.4.23.160.449
3el4ROCGag-Pol polyprotein3.4.23.160.449
3mxdK53Gag-Pol polyprotein3.4.23.160.449
4gb20LQGag-Pol polyprotein2.7.7.490.449
1c6x3INProtease/0.448
1d4sTPVGag-Pol polyprotein3.4.23.160.448
1hvkA79Gag-Pol polyprotein/0.448
2g247IGRenin3.4.23.150.448
3k1wBFXRenin3.4.23.150.448
4g9kFADRotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial1.6.5.90.448
4j54G52Gag-Pol polyprotein3.4.23.160.448
1rl8RITGag-Pol polyprotein3.4.23.160.447
2r38G4GGag-Pol polyprotein3.4.23.160.447
1hiiC20Gag-Pol polyprotein/0.446
2ien017Gag-Pol polyprotein3.4.23.160.446
2qi4MZ6Gag-Pol polyprotein/0.446
2qnpQN2Gag-Pol polyprotein3.4.23.160.446
3gi6D78Gag-Pol polyprotein/0.446
3oagLPQRenin3.4.23.150.446
4njt017Protease/0.446
1fg80Q4Gag-Pol polyprotein3.4.23.160.445
1k1u0Q4Gag-Pol polyprotein3.4.23.160.445
2g226IGRenin3.4.23.150.445
3hzc2NCProtease/0.445
3vsxR32Renin3.4.23.150.445
4h3j10WBeta-secretase 13.4.23.460.445
1b6mPI6Gag-Pol polyprotein3.4.23.160.444
3pwm017Gag-Pol polyprotein3.4.23.160.444
4i8zG08Gag-Pol polyprotein3.4.23.160.444
4k4p3TLGag-Pol polyprotein/0.444
9hvp0E9Gag-Pol polyprotein/0.444
2q3kMUWGag-Pol polyprotein/0.443
2qi0MZ3Gag-Pol polyprotein/0.443
3ndtROCGag-Pol polyprotein3.4.23.160.443
3oadLPORenin3.4.23.150.443
3sa4F72Protease/0.443
3sabF78Protease/0.443
3tog079Gag-Pol polyprotein2.7.7.490.443
3wsjMK1Protease/0.443
1c70L75Protease/0.442
1hihC20Gag-Pol polyprotein/0.442
1qbrXV6Gag-Pol polyprotein3.4.23.160.442
2p3a3TLPol protein/0.442
3k4vROCGag-Pol polyprotein3.4.23.160.442
3nwxKVSGag-Pol polyprotein3.4.23.160.442
3oqkS52Renin3.4.23.150.442
3tof076Gag-Pol polyprotein2.7.7.490.442
1qbu846Gag-Pol polyprotein3.4.23.160.441
1t3r017Gag-Pol polyprotein3.4.23.160.441
2g1o2IGRenin3.4.23.150.441
2hs2017Protease/0.441
3ndwRITGag-Pol polyprotein3.4.23.160.441
1k2c0Q4Gag-Pol polyprotein3.4.23.160.440
2g1y5IGRenin3.4.23.150.440
2p3d3TLProtease/0.440
3g70A5TRenin3.4.23.150.440
3o9bK2APol polyprotein/0.440
3r4b74TGag-Pol polyprotein/0.440
7upjINUGag-Pol polyprotein3.4.23.160.440